{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T16:21:07Z","timestamp":1780330867891,"version":"3.54.1"},"reference-count":12,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2022,10,20]],"date-time":"2022-10-20T00:00:00Z","timestamp":1666224000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2022,10,20]],"date-time":"2022-10-20T00:00:00Z","timestamp":1666224000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Egypt Heart J"],"abstract":"<jats:title>Abstract<\/jats:title><jats:sec>\n                <jats:title>Background<\/jats:title>\n                <jats:p>In recent years, attention has shifted to the role of right ventricular (RV) dysfunction in prediction of clinical outcome among patients with septic shock. However, very few studies have correlated RV dysfunction with survival early in the course of sepsis. In the period from September 2021 to July 2022, we included a total number of 248 patients within 24\u00a0h of their presentation with sepsis. All patients were subjected to a comprehensive echocardiographic study to evaluate different parameters of RV function and LV systolic and diastolic functions. We aimed primarily to study the predictive value of RV dysfunction on 30-day all-cause mortality rates and ventilator-free days.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>Almost half of study population (48.4%) showed evidence of RV dysfunction (in isolation or with LV dysfunction), with 25.4% showing evidence of <jats:italic>isolated<\/jats:italic> RV dysfunction. Patients with RV dysfunction had a significantly higher APACHE 2 (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001) score and 30-day all-cause mortality rates (<jats:italic>P<\/jats:italic>\u2009=\u20090.003) compared to those without RV dysfunction. A significant association was reported between 30-d mortality and dysfunction status (<jats:italic>P<\/jats:italic>\u2009=\u20090.025). Those with no dysfunction had lower mortality (14.1%) than in those with RV dysfunction only (33.3%), LV dysfunction only (20%), and RV\u2009+\u2009LV dysfunction (31.6%). No significant difference was observed in ventilator free days according to dysfunction status (<jats:italic>P<\/jats:italic>\u2009=\u20090.081). A multivariate logistic regression analysis showed that RV dysfunction was among the significant independent predictors for 30-day mortality (OR 2.01, 95% CI 1.07\u20133.81, <jats:italic>P<\/jats:italic>\u2009=\u20090.031), controlling for the effect of age and gender.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusions<\/jats:title>\n                <jats:p>In a cohort of ICU patients with early sepsis, RV dysfunction is found to be common and predictive of 30-day mortality irrespective to the LV function.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1186\/s43044-022-00316-3","type":"journal-article","created":{"date-parts":[[2022,10,20]],"date-time":"2022-10-20T08:06:00Z","timestamp":1666253160000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Right ventricular function as a predictor of short-term mortality in patients with sepsis and septic shock: an observational study"],"prefix":"10.1186","volume":"74","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0161-3779","authenticated-orcid":false,"given":"Ahmed","family":"Bendary","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hany","family":"Said","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Metwally","family":"Elemary","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohamed","family":"Mahrous","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2022,10,20]]},"reference":[{"issue":"1","key":"316_CR1","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1038\/nrdp.2016.45","volume":"2","author":"RS Hotchkiss","year":"2016","unstructured":"Hotchkiss RS, Moldawer LL, Opal SM et al (2016) Sepsis and septic shock. Nat Rev Dis Primers 2(1):1\u201321","journal-title":"Nat Rev Dis Primers"},{"issue":"1","key":"316_CR2","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/s13054-015-1014-6","volume":"19","author":"MJ Lanspa","year":"2015","unstructured":"Lanspa MJ, Pittman JE, Hirshberg EL et al (2015) Association of left ventricular longitudinal strain with central venous oxygen saturation and serum lactate in patients with early severe sepsis and septic shock. Crit Care 19(1):1\u20139","journal-title":"Crit Care"},{"issue":"4","key":"316_CR3","doi-asserted-by":"publisher","first-page":"661","DOI":"10.1016\/j.ccm.2008.07.002","volume":"29","author":"CM Chan","year":"2008","unstructured":"Chan CM, Klinger JR (2008) The right ventricle in sepsis. Clin Chest Med 29(4):661\u2013676","journal-title":"Clin Chest Med"},{"issue":"12","key":"316_CR4","doi-asserted-by":"publisher","first-page":"1474","DOI":"10.1093\/cvr\/cvx160","volume":"113","author":"R Naeije","year":"2017","unstructured":"Naeije R, Badagliacca R (2017) The overloaded right heart and ventricular interdependence. Cardiovasc Res 113(12):1474\u20131485","journal-title":"Cardiovasc Res"},{"issue":"5","key":"316_CR5","doi-asserted-by":"publisher","first-page":"630","DOI":"10.1097\/00003246-199205000-00014","volume":"20","author":"TA Mitsuo","year":"1992","unstructured":"Mitsuo TA, Shimazaki SH, Matsuda HI (1992) Right ventricular dysfunction in septic patients. Crit Care Med 20(5):630\u2013634","journal-title":"Crit Care Med"},{"issue":"6","key":"316_CR6","doi-asserted-by":"publisher","first-page":"1111","DOI":"10.1016\/j.jcrc.2013.07.059","volume":"28","author":"A Harmankaya","year":"2013","unstructured":"Harmankaya A, Akilli H, Gul M et al (2013) Assessment of right ventricular functions in patients with sepsis, severe sepsis and septic shock and its prognostic importance: a tissue Doppler study. J Crit Care 28(6):1111-e7","journal-title":"J Crit Care"},{"issue":"11","key":"316_CR7","doi-asserted-by":"publisher","first-page":"1436","DOI":"10.1161\/CIRCULATIONAHA.107.653576","volume":"117","author":"F Haddad","year":"2008","unstructured":"Haddad F, Hunt SA, Rosenthal DN et al (2008) Right ventricular function in cardiovascular disease, part I: anatomy, physiology, aging, and functional assessment of the right ventricle. Circulation 117(11):1436\u201348","journal-title":"Circulation"},{"issue":"3","key":"316_CR8","doi-asserted-by":"publisher","first-page":"1055","DOI":"10.1016\/j.chest.2020.09.274","volume":"159","author":"MJ Lanspa","year":"2021","unstructured":"Lanspa MJ, Cirulis MM, Wiley BM et al (2021) Right ventricular dysfunction in early sepsis and septic shock. Chest 159(3):1055\u201363","journal-title":"Chest"},{"issue":"10","key":"316_CR9","doi-asserted-by":"publisher","first-page":"818","DOI":"10.1097\/00003246-198510000-00009","volume":"13","author":"WA Knaus","year":"1985","unstructured":"Knaus WA, Draper EA, Wagner DP et al (1985) APACHE II: a severity of disease classification system. Crit Care Med 13(10):818\u201329","journal-title":"Crit Care Med"},{"issue":"3","key":"316_CR10","doi-asserted-by":"publisher","first-page":"233","DOI":"10.1093\/ehjci\/jev014","volume":"16","author":"RM Lang","year":"2015","unstructured":"Lang RM, Badano LP, Mor-Avi V (2015) Recommendations for cardiac chamber quantification by echocardiography in adults: an update from the American Society of Echocardiography and the European Association of Cardiovascular Imaging. Eur Heart J Cardiovasc Imaging 16(3):233\u201371","journal-title":"Eur Heart J Cardiovasc Imaging"},{"issue":"1","key":"316_CR11","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/s13613-017-0319-9","volume":"7","author":"S Vallabhajosyula","year":"2017","unstructured":"Vallabhajosyula S, Kumar M, Pandompatam G (2017) Prognostic impact of isolated right ventricular dysfunction in sepsis and septic shock: an 8-year historical cohort study. Ann Intensive Care 7(1):1\u20139","journal-title":"Ann Intensive Care"},{"issue":"1","key":"316_CR12","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/2110-5820-1-6","volume":"1","author":"A Vieillard-Baron","year":"2011","unstructured":"Vieillard-Baron A (2011) Septic cardiomyopathy. Ann Intensive Care 1(1):1\u20137","journal-title":"Ann Intensive Care"}],"container-title":["The Egyptian Heart Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s43044-022-00316-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s43044-022-00316-3\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s43044-022-00316-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,10,20]],"date-time":"2022-10-20T08:20:23Z","timestamp":1666254023000},"score":1,"resource":{"primary":{"URL":"https:\/\/tehj.springeropen.com\/articles\/10.1186\/s43044-022-00316-3"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,10,20]]},"references-count":12,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2022,12]]}},"alternative-id":["316"],"URL":"https:\/\/doi.org\/10.1186\/s43044-022-00316-3","relation":{},"ISSN":["2090-911X"],"issn-type":[{"value":"2090-911X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,10,20]]},"assertion":[{"value":"16 August 2022","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"7 October 2022","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"20 October 2022","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The study protocol was approved by the research ethics committee of Benha Faculty of Medicine at Benha University (REC-FOMBU). An informed written consent to participate in the study was provided by all participants. We excluded patients under 16\u00a0years old from the study.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare no conflict of interest.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"78"}}