{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T03:58:26Z","timestamp":1790740706781,"version":"4.1.0"},"reference-count":30,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2023,10,13]],"date-time":"2023-10-13T00:00:00Z","timestamp":1697155200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2023,10,13]],"date-time":"2023-10-13T00:00:00Z","timestamp":1697155200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Egypt Heart J"],"abstract":"<jats:title>Abstract<\/jats:title><jats:sec>\n                <jats:title>Background<\/jats:title>\n                <jats:p>Aortic aneurysm enlargement over time causes rupture, which frequently results in death. The family of proteases known as matrix metalloproteinases (MMP) is assumed to be proteolytic activity involved in the growth of aortic aneurysms. Statins are pleiotropic lipid-lowering medications with anti-inflammatory action. Statins can lower aneurysmal enlargement and MMP secretion, according to a number of studies, however the evidence is still up for debate. The purpose of this study is to assess how statins affect aortic aneurysm patient's aneurysm diameter size, growth rate, and MMP-9 levels.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Methods<\/jats:title>\n                <jats:p>From January 2000 to December 2022, electronic journal searches in PubMed, ScienceDirect, and Cochrane were conducted to discover papers evaluating the effects of statin treatment in patients with aortic aneurysm. Aneurysm diameter size, growth rate, and MMP-9 levels were the outcomes we were looking for. Meta-analyses were run on the included studies, and mean differences (MD) and 95% CIs were calculated with Review Manager v5.4.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>Our analysis includes a total of ten research. Statin medication substantially reduced aneurysm diameter size by 0.30\u00a0mm (<jats:italic>P<\/jats:italic>\u2009=\u20090.04; MD \u2212\u20090.30; 95% CI \u2212\u20090.58 to \u2212\u20090.01) and growth rate by 0.34\u00a0mm\/year (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.00001; MD \u2212\u20090.34; 95% CI \u2212\u20090.40 to \u2212\u20090.29) compared to placebo. There was no significant change in MMP-9 concentrations between individuals with aortic aneurysm who took a statin and those who did not.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusion<\/jats:title>\n                <jats:p>Overall, this meta-analysis demonstrates that statin medication is considerably helpful in reducing aneurysm diameter size and aneurysmal growth rate in individuals with aortic aneurysm.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1186\/s43044-023-00407-9","type":"journal-article","created":{"date-parts":[[2023,10,13]],"date-time":"2023-10-13T14:03:01Z","timestamp":1697205781000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["The effects of statin therapy on aneurysm size, growth rate, and matrix metalloproteinases-9 levels in patients with aortic aneurysm: a systematic review and meta-analysis"],"prefix":"10.1186","volume":"75","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9875-4449","authenticated-orcid":false,"given":"Ketut Angga Aditya Putra","family":"Pramana","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yusra","family":"Pintaningrum","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Basuki","family":"Rahmat","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2023,10,13]]},"reference":[{"key":"407_CR1","doi-asserted-by":"crossref","unstructured":"Johnston KW, Rutherford RB, Tilson MD, Shah DM, Hollier L, Stanley JC. Suggested standards for reporting on arterial aneurysms. Subcommittee on Reporting Standards for Arterial Aneurysms, Ad Hoc Committee on Reporting Standards, Society for Vascular Surgery and North American Chapter, International Society for Cardiovascular Surgery. J Vasc Surg. 1991;13(3):452\u20138.","DOI":"10.1067\/mva.1991.26737"},{"issue":"8","key":"407_CR2","doi-asserted-by":"publisher","first-page":"1239","DOI":"10.2310\/JIM.0b013e31823548e8","volume":"59","author":"W Karrowni","year":"2011","unstructured":"Karrowni W, Dughman S, Hajj GP, Miller FJ (2011) Statin therapy reduces growth of abdominal aortic aneurysms. J Investig Med 59(8):1239\u20131243","journal-title":"J Investig Med"},{"issue":"4","key":"407_CR3","doi-asserted-by":"publisher","first-page":"560","DOI":"10.1161\/CIRCULATIONAHA.109.880724","volume":"121","author":"PE Norman","year":"2010","unstructured":"Norman PE, Powell JT (2010) Site specificity of aneurysmal disease. Circulation 121(4):560\u2013568","journal-title":"Circulation"},{"issue":"1","key":"407_CR4","doi-asserted-by":"publisher","first-page":"32","DOI":"10.1016\/j.avsg.2010.06.006","volume":"25","author":"MNAA Rahman","year":"2011","unstructured":"Rahman MNAA, Khan JA, Mazari FA, Mockford K, McCollum PT, Chetter IC (2011) A randomized placebo controlled trial of the effect of preoperative statin use on matrix metalloproteinases and tissue inhibitors of matrix metalloproteinases in areas of low and peak wall stress in patients undergoing elective open repair of abdominal aortic aneurysm. Ann Vasc Surg 25(1):32\u201338","journal-title":"Ann Vasc Surg"},{"issue":"4","key":"407_CR5","doi-asserted-by":"publisher","first-page":"578","DOI":"10.1510\/icvts.2008.178103","volume":"7","author":"M Mosorin","year":"2008","unstructured":"Mosorin M, Niemela E, Heikkinen J, Lahtinen J, Tiozzo V, Satta J, Juvonen T, Biancari F (2008) The use of statins and fate of small abdominal aortic aneurysms. Interact Cardiovasc Thorac Surg 7(4):578\u2013581","journal-title":"Interact Cardiovasc Thorac Surg"},{"issue":"1","key":"407_CR6","doi-asserted-by":"publisher","first-page":"18","DOI":"10.1093\/cvr\/cvq337","volume":"90","author":"JB Michel","year":"2011","unstructured":"Michel JB, Martin-Ventura JL, Egido J, Sakalihasan N, Treska V, Lindholt J et al (2011) Novel aspects of the pathogenesis of aneurysms of the abdominal aorta in humans. Cardiovasc Res 90(1):18\u201327","journal-title":"Cardiovasc Res"},{"issue":"3","key":"407_CR7","first-page":"215","volume":"32","author":"EE Joviliano","year":"2017","unstructured":"Joviliano EE, Ribeiro MS, Tenorio EJ (2017) MicroRNAs and current concepts on the pathogenesis of abdominal aortic aneurysm. Braz J Cardiovasc Surg 32(3):215\u2013224","journal-title":"Braz J Cardiovasc Surg"},{"issue":"3","key":"407_CR8","doi-asserted-by":"publisher","first-page":"333","DOI":"10.1002\/bjs.5989","volume":"95","author":"S Abisi","year":"2007","unstructured":"Abisi S, Burnand KG, Humphries J, Waltham M, Taylor P, Smith A (2007) Effect of statins on proteolytic activity in the wall of abdominal aortic aneurysms. Br J Surg 95(3):333\u2013337","journal-title":"Br J Surg"},{"issue":"7","key":"407_CR9","doi-asserted-by":"publisher","first-page":"2228","DOI":"10.1161\/01.CIR.96.7.2228","volume":"96","author":"WD McMillan","year":"1997","unstructured":"McMillan WD, Tamarina NA, Cipollone M, Johnson DA, Parker MA, Pearce WH (1997) Size matters: the relationship between MMP-9 expression and aortic diameter. Circulation 96(7):2228\u20132232","journal-title":"Circulation"},{"issue":"2","key":"407_CR10","doi-asserted-by":"publisher","first-page":"168","DOI":"10.1172\/JCI22309","volume":"114","author":"JA Curci","year":"2004","unstructured":"Curci JA, Thompson RW (2004) Adaptive cellular immunity in aortic aneurysms: cause, consequence, or context? J Clin Investig 114(2):168\u2013171","journal-title":"J Clin Investig"},{"key":"407_CR11","doi-asserted-by":"publisher","first-page":"401","DOI":"10.1002\/bjs.1800780407","volume":"78","author":"D Strachan","year":"1991","unstructured":"Strachan D (1991) Predictors of death from aortic aneurysm among middle aged men: the Whitehall study. Br J Surg 78:401\u2013404","journal-title":"Br J Surg"},{"key":"407_CR12","doi-asserted-by":"publisher","first-page":"1368","DOI":"10.1161\/01.CIR.0000086460.55494.AF","volume":"108","author":"R Kleemann","year":"2003","unstructured":"Kleemann R, Princen HM, Emeis JJ, Jukema JW, Fontijn RD, Horrevoets AJ, Kooistra T, Havekes LM (2003) Rosuvastatin reduces atherosclerosis development beyond and independent of its plasma cholesterol-lowering effect in APOE*3-Leiden transgenic mice: evidence for antiinflammatory effects of rosuvastatin. Circulation 108:1368\u20131374","journal-title":"Circulation"},{"key":"407_CR13","doi-asserted-by":"publisher","first-page":"161","DOI":"10.1161\/01.ATV.0000148866.29829.19","volume":"25","author":"L Verschuren","year":"2005","unstructured":"Verschuren L, Kleemann R, Offerman EH, Szalai AJ, Emeis SJ, Princen HM, Kooistra T (2005) Effect of low dose atorvastatin versus diet-induced cholesterol lowering on atherosclerotic lesion progression and inflammation in apolipoprotein E*3-Leiden transgenic mice. Arterioscler Thromb Vasc Biol 25:161\u2013167","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"407_CR14","unstructured":"Wells GA, Shea B, O\u2019Connell D, Peterson J, Welch V, Losos M, Tugwell P. The Newcastle-Ottawa Scale (NOS) for assessing the quality if nonrandomized studies in meta-analyses. 2012. https:\/\/www.ohrica\/programs\/clinical_epidemiology\/oxfordasp."},{"issue":"3","key":"407_CR15","doi-asserted-by":"publisher","first-page":"302","DOI":"10.1016\/j.ejvs.2007.04.011","volume":"34","author":"J Evans","year":"2007","unstructured":"Evans J, Powell JT, Schwalbe E, Loftus IM, Thompson MM (2007) Simvastatin attenuates the activity of Matrix Metalloprotease-9 in aneurysmal aortic tissue. Eur J Vasc Endovasc Surg 34(3):302\u2013303","journal-title":"Eur J Vasc Endovasc Surg"},{"issue":"5","key":"407_CR16","doi-asserted-by":"publisher","first-page":"569","DOI":"10.1016\/j.ejvs.2010.01.030","volume":"39","author":"R Hurks","year":"2010","unstructured":"Hurks R, Hoefer IE, Vink A, Pasterkamp G, Schoneveld A, Kerver M, de Vries J-PPM, Tangelder MJ, Moll FL (2010) Different effects of commonly prescribed statins on abdominal aortic aneurysm wall biology. Eur J Vasc Endovasc Surg 39(5):569\u2013576","journal-title":"Eur J Vasc Endovasc Surg"},{"issue":"2","key":"407_CR17","doi-asserted-by":"publisher","first-page":"392","DOI":"10.1016\/j.jvs.2017.11.084","volume":"68","author":"TFX O'Donnell","year":"2018","unstructured":"O\u2019Donnell TFX, Deery SE, Shean KE, Mittleman MA, Darling JD, Eslami MH, DeMartino RR, Schermerhorn ML (2018) Statin therapy is associated with higher long-term but not perioperative survival after abdominal aortic aneurysm repair. J Vasc Surg 68(2):392\u2013399","journal-title":"J Vasc Surg"},{"issue":"6","key":"407_CR18","doi-asserted-by":"publisher","first-page":"1587","DOI":"10.1016\/j.jvs.2011.12.040","volume":"55","author":"M Raux","year":"2012","unstructured":"Raux M, Cochennec F, Becquemin J-P (2012) Statin therapy is associated with aneurysm sac regression after endovascular aortic repair. J Vasc Surg 55(6):1587\u20131592","journal-title":"J Vasc Surg"},{"issue":"8","key":"407_CR19","doi-asserted-by":"publisher","first-page":"1240","DOI":"10.1016\/j.amjcard.2013.05.081","volume":"112","author":"LH Stein","year":"2013","unstructured":"Stein LH, Berger J, Tranquilli M, Elefteraides JA (2013) Effect of statin drugs on thoracic aortic aneurysms. Am J Cardiol 112(8):1240\u20131245","journal-title":"Am J Cardiol"},{"issue":"2","key":"407_CR20","doi-asserted-by":"publisher","first-page":"279","DOI":"10.1016\/j.amjcard.2005.08.033","volume":"97","author":"R Sukhija","year":"2006","unstructured":"Sukhija R, Aronow WS, Sandhu R, Kakar P, Babu S (2006) Mortality and size of abdominal aortic aneurysm at long-term follow-up of patients not treated surgically and treated with and without statins. Am J Cardiol 97(2):279\u2013280","journal-title":"Am J Cardiol"},{"issue":"3","key":"407_CR21","doi-asserted-by":"publisher","first-page":"259","DOI":"10.1016\/j.ejvs.2005.02.044","volume":"30","author":"WRW Wilson","year":"2005","unstructured":"Wilson WRW, Evans J, Bell PRF, Thompson MM (2005) HMG-COA reductase inhibitors (statins) decrease MMP-3 and MMP-9 concentrations in abdominal aortic aneurysms. Eur J Vasc Endovasc Surg 30(3):259\u2013262","journal-title":"Eur J Vasc Endovasc Surg"},{"issue":"117","key":"407_CR22","first-page":"e39","volume":"43","author":"A Kalyanasundaram","year":"2006","unstructured":"Kalyanasundaram A, Elmore JR, Manazer JR et al (2006) Simvastatin suppresses experimental aortic aneurysm expansion. J Vasc Surg 43(117):e39","journal-title":"J Vasc Surg"},{"key":"407_CR23","doi-asserted-by":"publisher","first-page":"1145","DOI":"10.1161\/01.ATV.15.8.1145","volume":"15","author":"T Freestone","year":"1995","unstructured":"Freestone T, Turner RJ, Coady A, Higman DJ, Greenhalgh RM, Powell JT (1995) Inflammation and matrix metalloproteinases in the enlarging abdominal aortic aneurysm. Arterioscler Thromb Vasc Biol 15:1145\u20131151","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"407_CR24","doi-asserted-by":"publisher","first-page":"221","DOI":"10.1007\/s100169900144","volume":"12","author":"JR Elmore","year":"1998","unstructured":"Elmore JR, Keister BF, Franklin DP, Youkey JR, Carey DJ (1998) Expression of matrix metalloproteinases and TIMPs in human abdominal aortic aneurysms. Ann Vasc Surg 12:221\u2013228","journal-title":"Ann Vasc Surg"},{"key":"407_CR25","doi-asserted-by":"publisher","first-page":"304","DOI":"10.1161\/01.CIR.104.3.304","volume":"104","author":"S Goodall","year":"2001","unstructured":"Goodall S, Crowther M, Hemingway DM, Bell PR, Thompson MM (2001) Ubiquitous elevation of matrix metalloproteinase-2 expression in the vasculature of patients with abdominal aneurysms. Circulation 104:304","journal-title":"Circulation"},{"key":"407_CR26","doi-asserted-by":"publisher","first-page":"436","DOI":"10.1093\/cvr\/cvp155","volume":"83","author":"T Miyake","year":"2009","unstructured":"Miyake T, Morishita R (2009) Pharmacological treatment of abdominal aortic aneurysm. Cardiovasc Res 83:436","journal-title":"Cardiovasc Res"},{"key":"407_CR27","doi-asserted-by":"publisher","first-page":"158","DOI":"10.1067\/mva.2002.123680","volume":"36","author":"H Nagashima","year":"2002","unstructured":"Nagashima H, Aoka Y, Sakomura Y et al (2002) A 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitor, cerivastatin, suppresses production of matrix metalloproteinase-9 in human abdominal aortic aneurysm wall. J Vasc Surg 36:158\u2013163","journal-title":"J Vasc Surg"},{"key":"407_CR28","doi-asserted-by":"publisher","first-page":"237","DOI":"10.2174\/157016108785909724","volume":"6","author":"KI Paraskevas","year":"2008","unstructured":"Paraskevas KI, Stathopoulos V, Mikhailidis DP (2008) Pleiotropic effects of statins: implications for a wide range of diseases. Curr Vasc Pharmacol 6:237\u2013239","journal-title":"Curr Vasc Pharmacol"},{"key":"407_CR29","doi-asserted-by":"publisher","first-page":"137","DOI":"10.1177\/0003319709335514","volume":"61","author":"A Saratzis","year":"2010","unstructured":"Saratzis A, Kitas GD, Saratzis N, Melas N (2010) Can statins suppress the development of abdominal aortic aneurysms? A review of the current evidence. Angiology 61:137","journal-title":"Angiology"},{"key":"407_CR30","doi-asserted-by":"publisher","first-page":"34","DOI":"10.1016\/j.atherosclerosis.2008.03.020","volume":"202","author":"S Shiraya","year":"2009","unstructured":"Shiraya S, Miyake T, Aoki M et al (2009) Inhibition of development of experimental aortic abdominal aneurysm in rat model by atorvastatin through inhibition of macrophage migration. Atherosclerosis 202:34\u201340","journal-title":"Atherosclerosis"}],"container-title":["The Egyptian Heart Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s43044-023-00407-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s43044-023-00407-9\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s43044-023-00407-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,18]],"date-time":"2023-11-18T19:09:16Z","timestamp":1700334556000},"score":1,"resource":{"primary":{"URL":"https:\/\/tehj.springeropen.com\/articles\/10.1186\/s43044-023-00407-9"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,10,13]]},"references-count":30,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2023,12]]}},"alternative-id":["407"],"URL":"https:\/\/doi.org\/10.1186\/s43044-023-00407-9","relation":{},"ISSN":["2090-911X"],"issn-type":[{"value":"2090-911X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,10,13]]},"assertion":[{"value":"11 July 2023","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"29 August 2023","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"13 October 2023","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Not applicable.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent for participate"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"There is no competing interest.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"88"}}