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It ranges between 8.6 and 42% according to the population studied and the imaging technique used. We aim to prospectively assess the prevalence and characteristics of PFO and interatrial septum (IAS) abnormalities as well as the related clinical manifestations in a sample of Egyptian population.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>This study comprised 1000 patients who were referred for CT coronary angiography (CTCA). Mean age was 52.5\u2009\u00b1\u200910.9 years. The prevalence of PFO among the studied population was 16.3%; closed PFO (grade I) 44.2%, open PFO (grade II) 50.9%, and open PFO with jet (grade III) 4.9%. Anatomical high-risk PFO features\u2014defined as the presence of at least 2 or more of the following (diameter\u2009\u2265\u20092\u00a0mm, length\u2009\u2265\u200910\u00a0mm, septal aneurysm \u201cASA\u201d, or redundant septum)\u2014were found in 51.5% of PFOs\u2019 population. Other IAS abnormalities as redundant septum (8.6%), ASA (5.3%), Bachmann\u2019s bundle (4.5%), microaneurysm (2.6%), and atrial septal defect (ASD) (0.4%) were detected. There was a lower rate of coexistence of ASA with PFO (<jats:italic>p<\/jats:italic>\u2009=\u20090.031). Syncope was significantly higher in patients with PFO compared to those without PFO (6.7% vs. 1.6%, <jats:italic>p<\/jats:italic>\u2009=\u20090.001). Stroke, transient ischaemic attacks (TIA), and dizziness were similar in both groups. TIA, dizziness, and syncope were significantly higher in patients with IAS abnormalities including PFO compared to those without IAS abnormalities. Syncope was also significantly higher in PFO with high-risk anatomical features compared to those with non-high-risk PFO population (<jats:italic>p<\/jats:italic>\u2009=\u20090.02).<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusion<\/jats:title>\n                <jats:p>The prevalence of PFO in our study was approximately 16.3%, almost half of them showed anatomical high-risk features for stroke. Dizziness, syncope and TIA were significantly higher in patients with IAS abnormalities including PFO.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1186\/s43044-024-00504-3","type":"journal-article","created":{"date-parts":[[2024,6,10]],"date-time":"2024-06-10T07:01:33Z","timestamp":1718002893000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Prevalence and characteristics of patent foramen ovale in a sample of Egyptian population: a computed tomography study"],"prefix":"10.1186","volume":"76","author":[{"given":"Ahmed","family":"Shehata","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abdulaziz","family":"Nasser","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ahmed","family":"Mohsen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amir","family":"Anwar Samaan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amir","family":"Mostafa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6075-5251","authenticated-orcid":false,"given":"Mohamed","family":"Hassan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,6,10]]},"reference":[{"issue":"Suppl 24","key":"504_CR1","doi-asserted-by":"publisher","first-page":"S2837","DOI":"10.21037\/jtd.2018.02.18","volume":"10","author":"N Naqvi","year":"2018","unstructured":"Naqvi N, McCarthy KP, Ho SY (2018) Anatomy of the atrial septum and interatrial communications. 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