{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,28]],"date-time":"2026-03-28T13:11:19Z","timestamp":1774703479356,"version":"3.50.1"},"reference-count":10,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2024,8,9]],"date-time":"2024-08-09T00:00:00Z","timestamp":1723161600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2024,8,9]],"date-time":"2024-08-09T00:00:00Z","timestamp":1723161600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Egypt Heart J"],"abstract":"<jats:title>Abstract<\/jats:title><jats:sec>\n                <jats:title>Background<\/jats:title>\n                <jats:p>Takayasu arteritis (TA) is a chronic inflammatory disease of unknown etiology characterized by a large vessel vasculitis involving the aorta and its branches. Myocardial involvement is extremely unusual in TA and is mostly in the form of myocarditis, ventricular hypertrophy, and ventricular dysfunction secondary to coronary ischemia. Submitral aneurysms have been reported in TA and has been attributed to the chronic inflammatory process in TA.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Case presentation<\/jats:title>\n                <jats:p>We report a novel instance of left ventricular apical aneurysm in a 37-year-old lady with TA and normal epicardial coronaries. She was diagnosed with a left ventricular apical aneurysm, moderate aortic regurgitation, and moderate pericardial effusion. The coronary arteries were normal. The patient had concomitant chronic active Epstein\u2013Barr virus infection complicating patient outcome.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusions<\/jats:title>\n                <jats:p>Left ventricular apical aneurysm with normal epicardial coronaries is a rare cause of heart failure in Takayasu arteritis. Concomitant chronic active Epstein\u2013Barr virus infection can potentially accentuate the inflammatory process in Takayasu arteritis and complicate management and patient outcomes.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1186\/s43044-024-00540-z","type":"journal-article","created":{"date-parts":[[2024,8,9]],"date-time":"2024-08-09T10:12:18Z","timestamp":1723198338000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Left ventricular apical aneurysm in Takayasu arteritis and chronic active Epstein\u2013Barr virus infection"],"prefix":"10.1186","volume":"76","author":[{"given":"Karthik","family":"Raghuram","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1350-8076","authenticated-orcid":false,"given":"Arun","family":"Gopalakrishnan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Krishna Kumar Mohanan","family":"Nair","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Narayanan","family":"Namboodiri","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ajitkumar","family":"Valaparambil","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2024,8,9]]},"reference":[{"issue":"2","key":"540_CR1","doi-asserted-by":"publisher","first-page":"63","DOI":"10.29245\/2572-9411\/2017\/2.1048","volume":"2","author":"N Setty","year":"2017","unstructured":"Setty N (2017) Takayasu\u2019s arteritis\u2014a comprehensive review. J Rare Dis Res Treat 2(2):63\u201368","journal-title":"J Rare Dis Res Treat"},{"issue":"4","key":"540_CR2","doi-asserted-by":"publisher","first-page":"357","DOI":"10.1016\/j.amjms.2018.06.021","volume":"356","author":"Y Zhang","year":"2018","unstructured":"Zhang Y, Yang K, Meng X, Tian T, Fan P, Zhang H et al (2018) Cardiac valve involvement in Takayasu arteritis is common: a retrospective study of 1069 patients over 25 years. Am J Med Sci 356(4):357\u2013364","journal-title":"Am J Med Sci"},{"key":"540_CR3","doi-asserted-by":"publisher","first-page":"S85","DOI":"10.1016\/S0167-5273(98)00155-7","volume":"66","author":"BK Sharma","year":"1998","unstructured":"Sharma BK, Jain S, Radotra BD (1998) An autopsy study of Takayasu arteritis in India. 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Indian Heart J 51(5):527\u2013531","journal-title":"Indian Heart J"},{"issue":"1","key":"540_CR6","doi-asserted-by":"publisher","first-page":"233","DOI":"10.1186\/s43055-021-00621-y","volume":"52","author":"A Ayyappan","year":"2021","unstructured":"Ayyappan A, Gopalakrishnan A, Pitchai S (2021) Concurrent coronary artery and subclavian arterial aneurysms in Takayasu arteritis. Egypt J Radiol Nucl Med 52(1):233","journal-title":"Egypt J Radiol Nucl Med"},{"issue":"1","key":"540_CR7","doi-asserted-by":"publisher","first-page":"76","DOI":"10.1111\/j.1747-0803.2011.00537.x","volume":"7","author":"AE Baruteau","year":"2012","unstructured":"Baruteau AE, Martins RP, Boulmier D, Basquin A, Briard D, Gandemer V et al (2012) Acquired left ventricular submitral aneurysms in the course of Takayasu arteritis in a child: submitral aneurysms and Takayasu arteritis. Congenit Heart Dis 7(1):76\u201379","journal-title":"Congenit Heart Dis"},{"issue":"1","key":"540_CR8","doi-asserted-by":"publisher","first-page":"e237700","DOI":"10.1136\/bcr-2020-237700","volume":"14","author":"FB Rivera","year":"2021","unstructured":"Rivera FB, Tuazon CAM, Ramiro VR, Abola MT (2021) Takayasu\u2019s arteritis with giant left ventricular pseudoaneurysm presenting as heart failure. BMJ Case Rep CP 14(1):e237700","journal-title":"BMJ Case Rep CP"},{"issue":"2","key":"540_CR9","doi-asserted-by":"publisher","first-page":"111","DOI":"10.1016\/j.carpath.2006.09.003","volume":"16","author":"DV Miller","year":"2007","unstructured":"Miller DV, Mookadam F, Mookadam M, Edwards WD, Macon WR (2007) Primary cardiac plasmablastic (diffuse large B-cell) lymphoma mimicking left ventricular aneurysm with mural thrombus. Cardiovasc Pathol 16(2):111\u2013114","journal-title":"Cardiovasc Pathol"},{"issue":"2","key":"540_CR10","doi-asserted-by":"publisher","first-page":"369","DOI":"10.1002\/1529-0131(199802)41:2<369::AID-ART22>3.0.CO;2-S","volume":"41","author":"K Murakami","year":"1998","unstructured":"Murakami K, Ohsawa M, Hu SX, Kanno H, Aozasa K, Nose M (1998) Large-vessel arteritis associated with chronic active Epstein-Barr virus infection. Arthritis Rheum 41(2):369\u2013373","journal-title":"Arthritis Rheum"}],"container-title":["The Egyptian Heart Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s43044-024-00540-z.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s43044-024-00540-z\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s43044-024-00540-z.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,8,9]],"date-time":"2024-08-09T21:05:57Z","timestamp":1723237557000},"score":1,"resource":{"primary":{"URL":"https:\/\/tehj.springeropen.com\/articles\/10.1186\/s43044-024-00540-z"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,8,9]]},"references-count":10,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2024,12]]}},"alternative-id":["540"],"URL":"https:\/\/doi.org\/10.1186\/s43044-024-00540-z","relation":{},"ISSN":["2090-911X"],"issn-type":[{"value":"2090-911X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,8,9]]},"assertion":[{"value":"9 March 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"5 August 2024","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"9 August 2024","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"All procedures followed were in accordance with the ethical standards of the responsible committee on human experimentation (institutional and national) and with the Helsinki Declaration of 1964 and later revisions. Informed written consent was obtained from the parents of the patient for being included in the case report. No patient identity particulars have been disclosed.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Informed written consent was obtained from the close kin of the patient for using the data without patient particulars for publication.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare that there are no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"100"}}