{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,14]],"date-time":"2025-12-14T16:15:06Z","timestamp":1765728906848,"version":"3.37.3"},"reference-count":17,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2024,8,26]],"date-time":"2024-08-26T00:00:00Z","timestamp":1724630400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2024,8,26]],"date-time":"2024-08-26T00:00:00Z","timestamp":1724630400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Egypt Heart J"],"abstract":"<jats:title>Abstract<\/jats:title><jats:sec>\n                <jats:title>Background<\/jats:title>\n                <jats:p>Takotsubo cardiomyopathy (TTC) is an acute and usually reversible condition that often mimics the course of acute coronary syndrome (ACS), making it particularly challenging to differentiate, especially in the initial phases. In this study, we retrospectively analyzed the incidence, clinical course, examination results, and in-hospital mortality of TTC in patients with ACS hospitalized at our cardiology center from January 2018 to October 2023.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>During the study period, a total of 3835 selective coronary angiograms were urgently performed at our facility, with a diagnosis of TTC established in 52 (1.35%) patients, the majority of whom were females\u201448 (93%), with an average age of 64.2\u2009\u00b1\u200910.2 years. Stress-induced mechanisms were identified in 36 (69%) patients. The most common symptom was chest pain (86.5%). Electrocardiographic changes primarily included ST-segment elevations (61.6%) and depressions (14%). The average left ventricular ejection fraction was 45.1\u2009\u00b1\u20098.3 (33\u201357%), typically with an echocardiographic pattern of apical ballooning dysfunction followed by midventricular dyskinesia. In-hospital mortality was zero.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusions<\/jats:title>\n                <jats:p>TTC is a reversible condition with a low incidence of complications. Its occurrence in our patient cohort is lower compared to international registries. However, as demonstrated in this study, it is associated with significant in-hospital morbidity.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1186\/s43044-024-00542-x","type":"journal-article","created":{"date-parts":[[2024,8,26]],"date-time":"2024-08-26T08:02:13Z","timestamp":1724659333000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Incidence of Takotsubo cardiomyopathy in patients with acute coronary syndrome: a single center retrospective analysis"],"prefix":"10.1186","volume":"76","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6946-3765","authenticated-orcid":false,"given":"Tibor","family":"Poruban","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1678-3420","authenticated-orcid":false,"given":"Martin","family":"Studencan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter","family":"Kirsch","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert","family":"Novotny","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2024,8,26]]},"reference":[{"issue":"13","key":"542_CR1","doi-asserted-by":"publisher","first-page":"1002","DOI":"10.1161\/CIRCULATIONAHA.121.055854","volume":"145","author":"T Singh","year":"2022","unstructured":"Singh T, Khan H, Gamble DT, Scally C, Newby DE, Dawson D (2022) Takotsubo syndrome: pathophysiology, emerging concepts, and clinical implications. Circulation 145(13):1002\u20131019","journal-title":"Circulation"},{"issue":"3","key":"542_CR2","doi-asserted-by":"publisher","DOI":"10.1136\/bcr-2020-240010","volume":"14","author":"PM Conradi","year":"2021","unstructured":"Conradi PM, van Loon RB, Handoko ML (2021) Dynamic left ventricular outflow tract obstruction in Takotsubo cardiomyopathy resulting in cardiogenic shock. BMJ Case Rep 14(3):e240010","journal-title":"BMJ Case Rep"},{"issue":"3","key":"542_CR3","doi-asserted-by":"publisher","first-page":"24","DOI":"10.1097\/01.JAA.0000654368.35241.fc","volume":"33","author":"B Boyd","year":"2020","unstructured":"Boyd B, Solh T (2020) Takotsubo cardiomyopathy: review of broken heart syndrome. JAAPA 33(3):24\u201329","journal-title":"JAAPA"},{"issue":"6","key":"542_CR4","doi-asserted-by":"publisher","first-page":"1080","DOI":"10.21037\/cdt-23-283","volume":"13","author":"J Salamanca","year":"2023","unstructured":"Salamanca J, Alfonso F (2023) Takotsubo syndrome: unravelling the enigma of the broken heart syndrome?-a narrative review. Cardiovasc Diagn Ther 13(6):1080\u20131103","journal-title":"Cardiovasc Diagn Ther"},{"issue":"21","key":"542_CR5","doi-asserted-by":"publisher","first-page":"0032028","DOI":"10.1161\/JAHA.123.032028","volume":"12","author":"R Citro","year":"2023","unstructured":"Citro R, Bellino M, Merli E, Di Vece D, Sherrid MV (2023) Obstructive hypertrophic cardiomyopathy and takotsubo syndrome: how to deal with left ventricular ballooning? J Am Heart Assoc 12(21):0032028","journal-title":"J Am Heart Assoc"},{"issue":"1","key":"542_CR6","doi-asserted-by":"publisher","first-page":"22","DOI":"10.1038\/ncpcardio1066","volume":"5","author":"AR Lyon","year":"2008","unstructured":"Lyon AR, Rees PS, Prasad S, Poole-Wilson PA, Harding SE (2008) Stress (Takotsubo) cardiomyopathy\u2013a novel pathophysiological hypothesis to explain catecholamine-induced acute myocardial stunning. Nat Clin Pract Cardiovasc Med 5(1):22\u201329","journal-title":"Nat Clin Pract Cardiovasc Med"},{"key":"542_CR7","doi-asserted-by":"publisher","first-page":"1060070","DOI":"10.3389\/fcvm.2022.1060070","volume":"9","author":"T Wang","year":"2022","unstructured":"Wang T, Xiong T, Yang Y, Zuo B, Chen X, Wang D (2022) Metabolic remodeling in takotsubo syndrome. Front Cardiovasc Med 9:1060070","journal-title":"Front Cardiovasc Med"},{"issue":"3","key":"542_CR8","doi-asserted-by":"publisher","first-page":"376","DOI":"10.1093\/europace\/eun336","volume":"11","author":"S Mahida","year":"2009","unstructured":"Mahida S, Dalageorgou C, Behr ER (2009) Long-QT syndrome and torsades de pointes in a patient with Takotsubo cardiomyopathy: an unusual case. Europace 11(3):376\u2013378","journal-title":"Europace"},{"issue":"4","key":"542_CR9","doi-asserted-by":"publisher","first-page":"207","DOI":"10.4103\/jcecho.jcecho_47_21","volume":"31","author":"R Licordari","year":"2021","unstructured":"Licordari R, Manganaro R, Cusm\u00e0-Piccione M et al (2021) Assessment of intra and extra-hospital outcome after takotsubo syndrome in a single-center population. J Cardiovasc Echogr 31(4):207\u2013213","journal-title":"J Cardiovasc Echogr"},{"key":"542_CR10","doi-asserted-by":"publisher","first-page":"117954682110657","DOI":"10.1177\/11795468211065782","volume":"16","author":"J Assad","year":"2022","unstructured":"Assad J, Femia G, Pender P, Badie T, Rajaratnam R (2022) Takotsubo syndrome: a review of presentation, diagnosis and management. Clin Med Insights Cardiol 16:11795468211065782","journal-title":"Clin Med Insights Cardiol"},{"key":"542_CR11","doi-asserted-by":"crossref","unstructured":"Shadmand M, Lautze J, Md AM. Takotsubo pathophysiology and complications: what we know and what we do not know. Heart Fail Rev. Published online December 27, 2023.","DOI":"10.1007\/s10741-023-10381-8"},{"issue":"2","key":"542_CR12","doi-asserted-by":"publisher","first-page":"464","DOI":"10.3390\/biomedicines10020464","volume":"10","author":"A Topf","year":"2022","unstructured":"Topf A, Mirna M, Dienhart C et al (2022) Pretreatment with betablockers, a potential predictor of adverse cardiovascular events in takotsubo syndrome. Biomedicines 10(2):464","journal-title":"Biomedicines"},{"key":"542_CR13","doi-asserted-by":"publisher","first-page":"29","DOI":"10.1016\/j.amjcard.2020.07.015","volume":"132","author":"S Vallabhajosyula","year":"2020","unstructured":"Vallabhajosyula S, Barsness GW, Herrmann J, Anavekar NS, Gulati R, Prasad A (2020) Comparison of complications and in-hospital mortality in takotsubo (apical ballooning\/stress) cardiomyopathy versus acute myocardial infarction. Am J Cardiol 132:29\u201335","journal-title":"Am J Cardiol"},{"issue":"1","key":"542_CR14","doi-asserted-by":"publisher","first-page":"10","DOI":"10.4149\/Cardiol_2022_1_2","volume":"31","author":"F Kovar","year":"2022","unstructured":"Kovar F, Hricak V, Studencan M et al (2022) Current treatment trends of the nonST-segment elevation acute coronary syndrome in the Slovak Republic: analysis of the SLOVAKS-2 2020 register. Cardiol Lett 31(1):10\u201322","journal-title":"Cardiol Lett"},{"issue":"5\u20136","key":"542_CR15","first-page":"238","volume":"30","author":"M Studencan","year":"2021","unstructured":"Studencan M, Hricak V, Hudec M et al (2021) Management of myocardial infarction in Slovakia in the period of the 2020 COVID-19 pandemic. Current analysis of the SLOVAKS registry. Cardiol Lett. 30(5\u20136):238\u2013245","journal-title":"Cardiol Lett."},{"issue":"1","key":"542_CR16","doi-asserted-by":"publisher","first-page":"176","DOI":"10.1186\/s12872-017-0616-0","volume":"17","author":"HMMTB Herath","year":"2017","unstructured":"Herath HMMTB, Pahalagamage SP, Lindsay LC et al (2017) Takotsubo cardiomyopathy complicated with apical thrombus formation on first day of the illness: a case report and literature review. BMC Cardiovasc Disord 17(1):176","journal-title":"BMC Cardiovasc Disord"},{"issue":"8","key":"542_CR17","doi-asserted-by":"publisher","first-page":"1244","DOI":"10.3390\/jpm12081244","volume":"12","author":"I Canavero","year":"2022","unstructured":"Canavero I, Rifino N, Bussotti M et al (2022) The octopus trap of takotsubo and stroke: genetics, biomarkers and clinical management. J Pers Med 12(8):1244","journal-title":"J Pers Med"}],"container-title":["The Egyptian Heart Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s43044-024-00542-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s43044-024-00542-x\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s43044-024-00542-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,8,26]],"date-time":"2024-08-26T20:21:31Z","timestamp":1724703691000},"score":1,"resource":{"primary":{"URL":"https:\/\/tehj.springeropen.com\/articles\/10.1186\/s43044-024-00542-x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,8,26]]},"references-count":17,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2024,12]]}},"alternative-id":["542"],"URL":"https:\/\/doi.org\/10.1186\/s43044-024-00542-x","relation":{},"ISSN":["2090-911X"],"issn-type":[{"type":"electronic","value":"2090-911X"}],"subject":[],"published":{"date-parts":[[2024,8,26]]},"assertion":[{"value":"19 January 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"10 August 2024","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"26 August 2024","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"All procedures followed were in accordance with the ethical standards of the responsible committee on human experimentation (Ethics Commitee of VUSCH, Reference Number 17052021) and with the Helsinki Declaration of 1975, as revised in 2008. Informed consent, written and verbal, was obtained from all participants.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"Takotsubo cardiomyopathy (TTC) resembles acute coronary syndrome (ACS) but lacks coronary artery obstruction, featuring transient dyskinesia in the left ventricular wall. Acute and severe systolic dysfunction is reversible with a favorable long-term prognosis. Triggered by emotional or physical stress, its exact cause is unknown. This study explores single center experience of the demographics, clinical features, and mid-term outcomes of TTC in patients hospitalized for ACS over a 70-month period in a single cardiac center.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Author summary"}},{"value":"The authors declare that they have no competing interests.","order":5,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"112"}}