{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T16:47:26Z","timestamp":1791478046859,"version":"4.3.4"},"reference-count":11,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2024,8,30]],"date-time":"2024-08-30T00:00:00Z","timestamp":1724976000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2024,8,30]],"date-time":"2024-08-30T00:00:00Z","timestamp":1724976000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Egypt Heart J"],"abstract":"<jats:title>Abstract<\/jats:title><jats:sec>\n                <jats:title>Background<\/jats:title>\n                <jats:p>Heart failure complicated with iron deficiency is associated with impaired functional capacity, poor quality of life,  increased hospitalization, and mortality. This systematic review and meta-analysis were conducted to assess the effect of oral and intravenous iron therapy on functional capacity, hospitalization risk, and mortality risk in patients with chronic heart failure and iron-deficiency anemia.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Methods<\/jats:title>\n                <jats:p>Search for published scientific articles using the PRISMA (Preferred Reporting, Items for Systematic Reviews and Meta-Analysis) method conducted on Cochrane Library, PubMed Central, and Medline databases published in the last 20\u00a0years. Further systematic review and meta-analysis using RevMan version 5.4 were performed based on the included published scientific articles.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>Based on the meta-analysis of included studies, the analytical results of intravenous iron therapy in patient with chronic heart failure and iron-deficiency anemia showed there is 30.82 (MD\u2009=\u200930.82: 95% CI 18.23\u201343.40) meter change in patient 6MWT, there is likelihood of 0.55 times (55%) (RR\u2009=\u20090.45: 95% CI 0.30\u20130.68) lower risk of hospitalization and lower risk of mortality (RR\u2009=\u20090.18: 95% CI 0.04\u20130.78), because heart failure worsening both with statistically significant overall effect compared with placebo.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusions<\/jats:title>\n                <jats:p>There is statistically significant effect of intravenous iron therapy to improve patient functional capacity and reduce likelihood of hospitalization risk of 0.55 times (55%) in patient with chronic heart failure and iron-deficiency anemia.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1186\/s43044-024-00545-8","type":"journal-article","created":{"date-parts":[[2024,8,30]],"date-time":"2024-08-30T19:02:18Z","timestamp":1725044538000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Iron therapy effect on chronic heart failure and iron-deficiency anemia: a systematic review and meta-analysis"],"prefix":"10.1186","volume":"76","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8843-4684","authenticated-orcid":false,"given":"Yusra","family":"Pintaningrum","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ni Putu","family":"Yunandari","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,8,30]]},"reference":[{"key":"545_CR1","doi-asserted-by":"publisher","first-page":"103","DOI":"10.1016\/j.jacc.2007.09.036","volume":"51","author":"DO Okonko","year":"2008","unstructured":"Okonko DO, Grzeslo A, Witkowski T et al (2008) Effect of intravenous Iron sucrose on exercise tolerance in anemic and nonanemic patients with symptomatic chronic heart failure and Iron deficiency. FERRIC-HF: a randomized, controlled, observer-blinded trial. J Am Coll Cardiol 51:103\u2013112","journal-title":"J Am Coll Cardiol"},{"key":"545_CR2","doi-asserted-by":"publisher","first-page":"1374","DOI":"10.1161\/CIRCULATIONAHA.117.027497","volume":"136","author":"DJ Van Veldhuisen","year":"2017","unstructured":"Van Veldhuisen DJ, Ponikowski P, Van Der Meer P et al (2017) Effect of ferric carboxymaltose on exercise capacity in patients with chronic heart failure and iron deficiency. Circulation 136:1374\u20131383","journal-title":"Circulation"},{"key":"545_CR3","doi-asserted-by":"publisher","first-page":"657","DOI":"10.1093\/eurheartj\/ehu385","volume":"36","author":"P Ponikowski","year":"2015","unstructured":"Ponikowski P, Van Veldhuisen DJ, Comin-Colet J et al (2015) Beneficial effects of long-term intravenous iron therapy with ferric carboxymaltose in patients with symptomatic heart failure and iron deficiency. Eur Heart J 36:657\u2013668","journal-title":"Eur Heart J"},{"key":"545_CR4","doi-asserted-by":"publisher","first-page":"A854","DOI":"10.1016\/S0735-1097(15)60854-3","volume":"65","author":"EA Jankowska","year":"2015","unstructured":"Jankowska EA, Suchocki T, Tkaczyszyn M et al (2015) Effects of intravenous iron therapy in Iron deficient patients with systolic heart failure: meta-analysis of randomized control trials. J Am Coll Cardiol 65:A854","journal-title":"J Am Coll Cardiol"},{"issue":"26","key":"545_CR5","doi-asserted-by":"publisher","first-page":"1986","DOI":"10.1056\/NEJM199912233412607","volume":"341","author":"NC Andrews","year":"1999","unstructured":"Andrews NC (1999) Disorders of iron metabolism. N Engl J Med 341(26):1986\u20131995","journal-title":"N Engl J Med"},{"key":"545_CR6","doi-asserted-by":"publisher","first-page":"1657","DOI":"10.1016\/j.jacc.2007.07.029","volume":"50","author":"JE Toblli","year":"2007","unstructured":"Toblli JE, Lombra\u00f1a A, Duarte P et al (2007) Intravenous Iron reduces NT-pro-brain natriuretic peptide in anemic patients with chronic heart failure and renal insufficiency. J Am Coll Cardiol 50:1657\u20131665","journal-title":"J Am Coll Cardiol"},{"key":"545_CR7","doi-asserted-by":"publisher","first-page":"2436","DOI":"10.1056\/NEJMoa0908355","volume":"361","author":"SD Anker","year":"2009","unstructured":"Anker SD, Comin Colet J, Filippatos G et al (2009) Ferric carboxymaltose in patients with heart failure and Iron deficiency. N Engl J Med 361:2436\u20132448","journal-title":"N Engl J Med"},{"key":"545_CR8","doi-asserted-by":"publisher","first-page":"1958","DOI":"10.1001\/jama.2017.5427","volume":"317","author":"GD Lewis","year":"2017","unstructured":"Lewis GD, Malhotra R, Hernandez AF et al (2017) Effect of oral iron repletion on exercise capacity in patients with heart failure with reduced ejection fraction and iron deficiency the IRONOUT HF randomized clinical trial. JAMA J Am Med Assoc 317:1958\u20131966","journal-title":"JAMA J Am Med Assoc"},{"key":"545_CR9","doi-asserted-by":"publisher","first-page":"177","DOI":"10.1016\/0197-2456(86)90046-2","volume":"7","author":"R DerSimonian","year":"1986","unstructured":"DerSimonian R, Laird N (1986) Meta-analysis in clinical trials. Control Clin Trials 7:177\u2013188","journal-title":"Control Clin Trials"},{"key":"545_CR10","doi-asserted-by":"publisher","first-page":"159","DOI":"10.1007\/s10844-006-2974-4","volume":"27","author":"J Grant","year":"2006","unstructured":"Grant J, Hunter A (2006) Measuring inconsistency in knowledgebases. J Intell Inf Syst 27:159\u2013184","journal-title":"J Intell Inf Syst"},{"key":"545_CR11","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/sux015","author":"L Suryani","year":"2017","unstructured":"Suryani L, Raharjo S, Sagita R et al (2017) Oral Iron therapy improves functional capacity of heart failure patients with iron deficiency anemia. Eur Hear J Suppl. https:\/\/doi.org\/10.1093\/eurheartj\/sux015","journal-title":"Eur Hear J Suppl."}],"container-title":["The Egyptian Heart Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s43044-024-00545-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s43044-024-00545-8\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s43044-024-00545-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,8,30]],"date-time":"2024-08-30T19:02:46Z","timestamp":1725044566000},"score":1,"resource":{"primary":{"URL":"https:\/\/tehj.springeropen.com\/articles\/10.1186\/s43044-024-00545-8"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,8,30]]},"references-count":11,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2024,12]]}},"alternative-id":["545"],"URL":"https:\/\/doi.org\/10.1186\/s43044-024-00545-8","relation":{},"ISSN":["2090-911X"],"issn-type":[{"value":"2090-911X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,8,30]]},"assertion":[{"value":"26 January 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"16 August 2024","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"30 August 2024","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Not applicable.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent for participate."}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"There is no competing interest.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"116"}}