{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T18:16:24Z","timestamp":1789582584856,"version":"build-2803163510"},"reference-count":22,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2025,4,16]],"date-time":"2025-04-16T00:00:00Z","timestamp":1744761600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2025,4,16]],"date-time":"2025-04-16T00:00:00Z","timestamp":1744761600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Egypt Heart J"],"abstract":"<jats:title>Abstract<\/jats:title>\n          <jats:sec>\n            <jats:title>Background<\/jats:title>\n            <jats:p>Dilated cardiomyopathy (DCM) is a primary myocardial disease characterized by systolic dysfunction, which can lead to disparity and disorganized contraction, commonly referred to as dyssynchrony. Three types of dyssynchrony include atrioventricular (AVD), interventricular (inter-VD), and intra-LV dyssynchrony (intra-VD). We aimed to investigate the prevalence and interdependence of electrical and mechanical dyssynchrony in order to elucidate the optimizing patients for cardiac resynchronization therapy (CRT).<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Results<\/jats:title>\n            <jats:p>A total of 37 DCM patients (1\u201317 years, 51% female) were included in this cross-sectional study. Regarding the intra-VD, inter-VD, and AVD, the study showed inter-VD in 37%, 27%, and 48% by Doppler, Doppler tissue imaging (DTI), and color-coded DTI methods, respectively; however, 70% showed right ventricular free wall delay based on the presence of peak of strain after pulmonic valve closure. 86.5% (32\/37) of patients show intra-VD. 100% (8\/8) of DCM patients with prolonged QRS (QRSc \u2265\u2009120 ms) had intra-VD, of which 12.5% (1\/8) had mild, 25% (2\/8) mod, and 62.5% (5\/8) severe dyssynchrony. However, 82% (24\/29) of patients with narrow QRS (QRSc &lt;\u2009120 ms) also had intra-VD, of which 17% (3\/24) were mild, 62.5% (15\/24) mod, and 25% (6\/24) severe. There were 57% (21\/37) of patients with AVD. 77% (10\/13) of DCM patients with prolonged PRc (PR \u2265\u2009200 ms) had AVD of which 31% (4\/13) of patients had mild, 31% (4\/13) mod, and 15% (2\/13) severe AVD, while among PRc &lt;\u2009200 ms 46% (11\/24) had AVD, of which 37.5% (9\/24) had mild AVD, 4% (1\/24) mod, and another 4% severe AVD. LVEF was lower and LV GLS, mortality, Pro-BNP, NYHA FC, and severity of intra-VD were higher in the group with QRS \u2265\u2009120 ms, and PR \u2265\u2009200 ms. 27% of patients were expired during the year of study. There was a significant direct correlation between mortality rate, NYHA FC, and pro-BNP with the severity of intra-, inter-VD, and AVD. The most delayed horizontal segments were inferolateral, anterolateral, anterior, and anteroseptal sequentially, while the highest level of vertical dyssynchrony (base to apex) was observed in inferoseptal, inferolateral, and anteroseptal walls in order.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusions<\/jats:title>\n            <jats:p>Our findings indicated that DCM causes both intra- and inter-VD, associated with QRS duration concerning severity, which also results in AVD that are correlated with PRc interval. Notably, a substantial proportion of patients with narrow QRSc also demonstrated intra-VD and inter-VD, while nearly half of those with normal PRc exhibited AVD. Collectively, these observations suggest a lack of complete correspondence between electrical and mechanical dyssynchrony.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1186\/s43044-025-00633-3","type":"journal-article","created":{"date-parts":[[2025,4,16]],"date-time":"2025-04-16T18:52:32Z","timestamp":1744829552000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Evaluation of dyssynchrony in children with dilated cardiomyopathy: a comparison of electrical and mechanical delay using Doppler, tissue imaging and strain"],"prefix":"10.1186","volume":"77","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7813-5675","authenticated-orcid":false,"given":"Fariba","family":"Rashidi Ghader","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammad","family":"Mahdavi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hossein","family":"Mehrali","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammad","family":"Dalili","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hossein","family":"Shahzadi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Reza","family":"Abbaszade","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,4,16]]},"reference":[{"key":"633_CR1","doi-asserted-by":"publisher","DOI":"10.15761\/JCIS.1000107","author":"A Albakri","year":"2018","unstructured":"Albakri A (2018) Dilated cardiomyopathy: a review of literature on clinical status and meta-analysis of diagnostic and clinical management. 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It should be noted that our study does not involve any animal data or tissue.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Written consents to publish any demographic and echocardiographic data were obtained from all subjects and their parents, and the proof is available upon request.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"All the authors declare that they surely have no any potential or perceived financial and non-financial competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"37"}}