{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,14]],"date-time":"2025-12-14T20:02:21Z","timestamp":1765742541874,"version":"3.48.0"},"reference-count":25,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2025,12,14]],"date-time":"2025-12-14T00:00:00Z","timestamp":1765670400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2025,12,14]],"date-time":"2025-12-14T00:00:00Z","timestamp":1765670400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Egypt Heart J"],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>The supply of donor hearts has fallen short of the increasing demand. This widening gap has led to a crisis marked by long waiting times and high mortality rates among those on waiting lists. This study aimed to compare the echocardiographic data of individuals whose hearts were eligible for transplant.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      This retrospective, cross-sectional study investigated all eligible brain-death cases conducted at Sina Hospital in Tehran, Iran. Based on echocardiographic data, patients were evaluated for heart donation (59 hearts that were deemed eligible vs. 39 hearts that were non-eligible for donation). The study used a custom checklist based on transthoracic echocardiography data. Data were analyzed using SPSS 18 software. A\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&lt;\u20090.05 was considered statistically significant.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Result<\/jats:title>\n                    <jats:p>\n                      The average age of the cases was 29.28\u2009\u00b1\u200910.59 years. Gender was not significantly associated with transplant eligibility (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u20090.46). In contrast, the cause of brain death was a significant factor (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u20090.04).\u00a0There were statistically significant differences between the cause of brain death and left ventricular ejection fraction (LVEF) (F\u2009=\u20093.14, \u03b7\u00b2 = 0.094, P\u2009=\u20090.029). No significant relationship was found between the cause of brain death and regional wall motion abnormality (RWMA) or pulmonary artery systolic pressure (PASP).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Borderline cases should undergo reevaluation using repeat transthoracic echocardiogram or echocardiographic assessments of heart function with inotropic medications to increase the pool of potential heart donors due to limited organ donor options.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1186\/s43044-025-00709-0","type":"journal-article","created":{"date-parts":[[2025,12,14]],"date-time":"2025-12-14T19:59:02Z","timestamp":1765742342000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["A comparative analysis of echocardiographic data for heart transplant eligibility in brain death cases"],"prefix":"10.1186","volume":"77","author":[{"given":"Azadeh","family":"Sadatnaseri","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marzieh","family":"Latifi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Habib","family":"Rahban","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrew","family":"Boshara","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elahe","family":"Pourhosein","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Abbas","family":"Soleimani","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shahrokh","family":"Karbalai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mostafa","family":"Rouzitalab","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zahra","family":"Shajari","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Saeeid","family":"Ghodsi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sanaz","family":"Dehghani","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2025,12,14]]},"reference":[{"issue":"23","key":"709_CR1","doi-asserted-by":"publisher","first-page":"2231","DOI":"10.1016\/j.jacc.2023.04.007","volume":"81","author":"R Mohebi","year":"2023","unstructured":"Mohebi R, Wang D, Lau ES, Parekh JK, Allen N, Psaty BM et al (2023) Effect of 2022 ACC\/AHA\/HFSA criteria on stages of heart failure in a pooled community cohort. J Am Coll Cardiol 81(23):2231\u201342","journal-title":"J Am Coll Cardiol"},{"issue":"1","key":"709_CR2","doi-asserted-by":"publisher","first-page":"4","DOI":"10.1002\/ehf2.12005","volume":"1","author":"P Ponikowski","year":"2014","unstructured":"Ponikowski P, Anker SD, AlHabib KF, Cowie MR, Force TL, Hu S et al (2014) Heart failure: preventing disease and death worldwide. ESC Heart Fail 1(1):4\u201325","journal-title":"ESC Heart Fail"},{"issue":"2","key":"709_CR3","doi-asserted-by":"publisher","first-page":"97","DOI":"10.1016\/j.repce.2017.11.017","volume":"37","author":"C Fonseca","year":"2018","unstructured":"Fonseca C, Br\u00e1s D, Ara\u00fajo I, Ceia F (2018) Heart failure in numbers: estimates for the 21st century in Portugal. Revista Portuguesa De Cardiologia (English Edition) 37(2):97\u2013104","journal-title":"Revista Portuguesa De Cardiologia (English Edition)"},{"key":"709_CR4","doi-asserted-by":"publisher","first-page":"445","DOI":"10.1007\/s13167-019-00188-9","volume":"10","author":"M Barrett","year":"2019","unstructured":"Barrett M, Boyne J, Brandts J, Brunner-La Rocca H-P, De Maesschalck L, De Wit K et al (2019) Artificial intelligence supported patient self-care in chronic heart failure: a paradigm shift from reactive to predictive, preventive and personalised care. EPMA J 10:445\u201364","journal-title":"EPMA J"},{"issue":"6","key":"709_CR5","doi-asserted-by":"publisher","first-page":"368","DOI":"10.1038\/nrcardio.2016.25","volume":"13","author":"B Ziaeian","year":"2016","unstructured":"Ziaeian B, Fonarow GC (2016) Epidemiology and aetiology of heart failure. Nat Rev Cardiol 13(6):368\u2013378","journal-title":"Nat Rev Cardiol"},{"issue":"1","key":"709_CR6","doi-asserted-by":"publisher","first-page":"11","DOI":"10.3904\/kjim.2018.428","volume":"34","author":"H-M Choi","year":"2019","unstructured":"Choi H-M, Park M-S, Youn J-C (2019) Update on heart failure management and future directions. Korean J Intern Med 34(1):11","journal-title":"Korean J Intern Med"},{"issue":"4","key":"709_CR7","doi-asserted-by":"publisher","first-page":"1333","DOI":"10.1016\/j.jtcvs.2019.06.070","volume":"159","author":"J Oras","year":"2020","unstructured":"Oras J, Doueh R, Norberg E, Redfors B, Omerovic E, Dellgren G (2020) Left ventricular dysfunction in potential heart donors and its influence on recipient outcomes. J Thorac Cardiovasc Surg 159(4):1333\u20131341 e6","journal-title":"J Thorac Cardiovasc Surg"},{"key":"709_CR8","first-page":"15","volume-title":"Heart failure","author":"F Orso","year":"2017","unstructured":"Orso F, Fabbri G, Maggioni AP (2017) Epidemiology of heart failure. Heart failure. Springer, Cham, pp 15\u201333"},{"issue":"2","key":"709_CR9","doi-asserted-by":"publisher","first-page":"136","DOI":"10.4285\/kjt.22.0004","volume":"36","author":"B Shakerian","year":"2022","unstructured":"Shakerian B, Dehghani S, Ashraf H, Karbalai S, Soleimani A, Rezaeefar A et al (2022) The outcomes of marginal donor hearts compared with ideal donors: a single-center experience in Iran. Korean J Transplant 36(2):136\u201342","journal-title":"Korean J Transplant"},{"issue":"5","key":"709_CR10","doi-asserted-by":"publisher","first-page":"475","DOI":"10.1007\/s00059-018-4745-8","volume":"45","author":"E Tackmann","year":"2020","unstructured":"Tackmann E (2020) Health-related quality of life in adult heart-transplant recipients\u2014a systematic review. Herz 45(5):475\u2013482","journal-title":"Herz"},{"issue":"8","key":"709_CR11","doi-asserted-by":"publisher","first-page":"235","DOI":"10.3390\/jcdd11080235","volume":"11","author":"M Leon","year":"2024","unstructured":"Leon M (2024) Revolutionizing donor heart procurement: innovations and future directions for enhanced transplantation outcomes. J Cardiovasc Dev Disease 11(8):235","journal-title":"J Cardiovasc Dev Disease"},{"issue":"5","key":"709_CR12","doi-asserted-by":"publisher","first-page":"1819","DOI":"10.1007\/s10741-021-10178-7","volume":"27","author":"R Tatum","year":"2022","unstructured":"Tatum R, Briasoulis A, Tchantchaleishvili V, Massey HT (2022) Evaluation of donor heart for transplantation. Heart Fail Rev 27(5):1819\u20131827","journal-title":"Heart Fail Rev"},{"key":"709_CR13","doi-asserted-by":"publisher","first-page":"150","DOI":"10.1007\/s11897-019-00432-3","volume":"16","author":"KS Shah","year":"2019","unstructured":"Shah KS, Kittleson MM, Kobashigawa JA (2019) Updates on heart transplantation. Curr Heart Fail Rep 16:150\u2013156","journal-title":"Curr Heart Fail Rep"},{"issue":"1","key":"709_CR14","doi-asserted-by":"publisher","first-page":"126","DOI":"10.21037\/acs.2017.09.09","volume":"7","author":"KK Khush","year":"2018","unstructured":"Khush KK (2018) Donor selection in the modern era. Ann Cardiothorac Surg 7(1):126","journal-title":"Ann Cardiothorac Surg"},{"key":"709_CR15","doi-asserted-by":"publisher","first-page":"14","DOI":"10.1016\/j.ejim.2024.11.010","volume":"133","author":"DB Olawade","year":"2025","unstructured":"Olawade DB, Marinze S, Qureshi N, Weerasinghe K, Teke J (2025) Transforming organ donation and transplantation: strategies for increasing donor participation and system efficiency. Eur J Intern Med 133:14\u201324","journal-title":"Eur J Intern Med"},{"issue":"3","key":"709_CR16","doi-asserted-by":"publisher","first-page":"343","DOI":"10.1007\/s00134-019-05551-y","volume":"45","author":"G Meyfroidt","year":"2019","unstructured":"Meyfroidt G, Gunst J, Martin-Loeches I, Smith M, Robba C, Taccone FS et al (2019) Management of the brain-dead donor in the ICU: general and specific therapy to improve transplantable organ quality. Intensive Care Med 45(3):343\u2013353","journal-title":"Intensive Care Med"},{"issue":"3","key":"709_CR17","doi-asserted-by":"publisher","first-page":"233","DOI":"10.1093\/ehjci\/jev014","volume":"16","author":"RM Lang","year":"2015","unstructured":"Lang RM, Badano LP, Mor-Avi V, Afilalo J, Armstrong A, Ernande L et al (2015) Recommendations for cardiac chamber quantification by echocardiography in adults: an update from the American Society of Echocardiography and the European Association of Cardiovascular Imaging. Eur Heart J Cardiovasc Imaging 16(3):233\u201371","journal-title":"Eur Heart J Cardiovasc Imaging"},{"issue":"2","key":"709_CR18","doi-asserted-by":"publisher","first-page":"179","DOI":"10.1161\/CIRCIMAGING.110.959817","volume":"4","author":"BD Hoit","year":"2011","unstructured":"Hoit BD (2011) Strain and strain rate echocardiography and coronary artery disease. Circ Cardiovasc Imaging 4(2):179\u2013190","journal-title":"Circ Cardiovasc Imaging"},{"issue":"1","key":"709_CR19","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.healun.2015.10.023","volume":"35","author":"MR Mehra","year":"2016","unstructured":"Mehra MR, Canter CE, Hannan MM, Semigran MJ, Uber PA, Baran DA et al (2016) The 2016 International Society for Heart Lung Transplantation listing criteria for heart transplantation: a 10-year update. J Heart Lung Transplant 35(1):1\u201323","journal-title":"J Heart Lung Transplant"},{"issue":"1","key":"709_CR20","doi-asserted-by":"publisher","first-page":"7","DOI":"10.1016\/j.healun.2022.08.030","volume":"42","author":"H Copeland","year":"2023","unstructured":"Copeland H, Knezevic I, Baran DA, Rao V, Pham M, Gustafsson F et al (2023) Donor heart selection: evidence-based guidelines for providers. J Heart Lung Transplant 42(1):7\u201329","journal-title":"J Heart Lung Transplant"},{"issue":"2","key":"709_CR21","doi-asserted-by":"publisher","first-page":"300","DOI":"10.1161\/CIRCHEARTFAILURE.112.000165","volume":"6","author":"KK Khush","year":"2013","unstructured":"Khush KK, Menza R, Nguyen J, Zaroff JG, Goldstein BA (2013) Donor predictors of allograft use and recipient outcomes after heart transplantation. Circ Heart Fail 6(2):300\u2013309","journal-title":"Circ Heart Fail"},{"issue":"14","key":"709_CR22","doi-asserted-by":"publisher","first-page":"1750","DOI":"10.1093\/eurheartj\/ehr254","volume":"33","author":"M-aGGiCH Failure","year":"2012","unstructured":"Failure M-aGGiCH (2012) The survival of patients with heart failure with preserved or reduced left ventricular ejection fraction: an individual patient data meta-analysis. Eur Heart J 33(14):1750\u20137","journal-title":"Eur Heart J"},{"issue":"10","key":"709_CR23","doi-asserted-by":"publisher","first-page":"1085","DOI":"10.1161\/CIRCULATIONAHA.113.001475","volume":"128","author":"R Zakeri","year":"2013","unstructured":"Zakeri R, Chamberlain AM, Roger VL, Redfield MM (2013) Temporal relationship and prognostic significance of atrial fibrillation in heart failure patients with preserved ejection fraction: a community-based study. Circulation 128(10):1085\u20131093","journal-title":"Circulation"},{"key":"709_CR24","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/s13293-016-0088-4","volume":"7","author":"F Puoti","year":"2016","unstructured":"Puoti F, Ricci A, Nanni-Costa A, Ricciardi W, Malorni W, Ortona E (2016) Organ transplantation and gender differences: a paradigmatic example of intertwining between biological and sociocultural determinants. Biol Sex Differ 7:1\u20135","journal-title":"Biol Sex Differ"},{"issue":"10","key":"709_CR25","doi-asserted-by":"publisher","first-page":"2570","DOI":"10.1097\/01.ASN.0000030078.74889.69","volume":"13","author":"M Zeier","year":"2002","unstructured":"Zeier M, Do B, Opelz G, Ritz E (2002) The effect of donor gender on graft survival. J Am Soc Nephrol 13(10):2570\u20132576","journal-title":"J Am Soc Nephrol"}],"container-title":["The Egyptian Heart Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s43044-025-00709-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s43044-025-00709-0\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s43044-025-00709-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,14]],"date-time":"2025-12-14T19:59:03Z","timestamp":1765742343000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1186\/s43044-025-00709-0"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,12,14]]},"references-count":25,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2025,12]]}},"alternative-id":["709"],"URL":"https:\/\/doi.org\/10.1186\/s43044-025-00709-0","relation":{},"ISSN":["2090-911X"],"issn-type":[{"value":"2090-911X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,12,14]]},"assertion":[{"value":"30 March 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"3 December 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"14 December 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The study was approved by the research ethics committees of Sina Hospital, Tehran University of Medical Sciences (TUMS), (Protocol no. IR.TUMS.SINAHOSPITAL.REC.1403.024), and was performed according to the principles of the Declaration of Helsinki.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"This is a retrospective study using de-identified data and it does not contain any harmful or illegal intervention on human participants or animals by any of the authors and all recipients and responsible relatives completed the consent form before the procedure; therefore, the IRB did not require consent from the patient.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"111"}}