{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T19:08:08Z","timestamp":1780513688751,"version":"3.54.1"},"reference-count":12,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T00:00:00Z","timestamp":1780444800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T00:00:00Z","timestamp":1780444800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Egypt Heart J"],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>\n                      Infective endocarditis carries high mortality in hemodialysis patients, particularly when caused by methicillin\u2011resistant\n                      <jats:italic>Staphylococcus aureus<\/jats:italic>\n                      . Concomitant fungemia further worsens prognosis but remains rare.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Case summary<\/jats:title>\n                    <jats:p>\n                      A 52\u2011year\u2011old woman with type 2 diabetes mellitus and stage V chronic kidney disease on thrice\u2011weekly hemodialysis presented with atypical chest pain, fatigue, night sweats, and splinter hemorrhages. She was afebrile. Transthoracic echocardiography showed preserved left\u2011ventricular ejection fraction and grade II mitral\/tricuspid regurgitation; transesophageal echocardiography revealed a 0.7\u2009\u00d7\u20092.1\u00a0cm pedunculated vegetation on the septal leaflet of the tricuspid valve. Three sets of peripheral and catheter blood cultures were drawn, and empiric renally adjusted daptomycin plus gentamicin were started. On day 3, C\u2011reactive protein had fallen. Cultures grew methicillin\u2011resistant\n                      <jats:italic>Staphylococcus aureus<\/jats:italic>\n                      in two peripheral sets and in the tunneled catheter, and Candida tropicalis in one peripheral set. The infected catheter was removed and a brachio\u2011axillary graft was placed. Gentamicin was discontinued; daptomycin was continued for six weeks. Voriconazole was administered for 21 days, ending 14 days after negative fungal cultures. Follow\u2011up echocardiography at week 6 showed complete resolution of the vegetation. The patient remained asymptomatic at three\u2011month follow\u2011up.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>In immunocompromised hemodialysis patients, dual bacterial\u2011fungal bloodstream infections can occur, yet not every positive fungal culture indicates endocardial involvement. Serial cultures, prompt removal of infected hardware, and targeted antimicrobial therapy can achieve cure without surgery even in the presence of sizable vegetations.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1186\/s43044-026-00754-3","type":"journal-article","created":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T18:13:24Z","timestamp":1780510404000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Successful conservative treatment of MRSA-associated infective endocarditis with concurrent candidemia in a hemodialysis patient"],"prefix":"10.1186","volume":"78","author":[{"given":"\u00d6mer Faruk","family":"Yilmaz","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"O\u011fuzhan","family":"Dilek","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u00d6mer Kutsi","family":"Misirlio\u011flu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tuba","family":"Bozoklu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Havva","family":"T\u00fcnay","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Serkan","family":"G\u00f6kaslan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ne\u015fe","family":"Demirt\u00fcrk","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,6,3]]},"reference":[{"key":"754_CR1","doi-asserted-by":"publisher","first-page":"1287","DOI":"10.1093\/eurjpc\/zwab211","volume":"29","author":"S Momtazmanesh","year":"2022","unstructured":"Momtazmanesh S, Saeedi Moghaddam S, Malakan Rad E et al (2022) Global, regional, and national burden and quality of care index of endocarditis: the global burden of disease study 1990\u20132019. Eur J Prev Cardiol 29:1287\u20131297. https:\/\/doi.org\/10.1093\/eurjpc\/zwab211","journal-title":"Eur J Prev Cardiol"},{"key":"754_CR2","doi-asserted-by":"publisher","first-page":"3948","DOI":"10.1093\/eurheartj\/ehad193","volume":"44","author":"V Delgado","year":"2023","unstructured":"Delgado V, Ajmone Marsan N, de Waha S et al (2023) 2023 ESC Guidelines for the management of endocarditis. Eur Heart J 44:3948\u20134042. https:\/\/doi.org\/10.1093\/eurheartj\/ehad193","journal-title":"Eur Heart J"},{"key":"754_CR3","doi-asserted-by":"publisher","first-page":"100680","DOI":"10.1016\/j.cpcardiol.2020.100680","volume":"46","author":"M Sadeghi","year":"2021","unstructured":"Sadeghi M, Behdad S, Shahsanaei F (2021) Infective Endocarditis and Its Short and Long-Term Prognosis in Hemodialysis Patients: A Systematic Review and Meta-analysis. Curr Probl Cardiol 46:100680. https:\/\/doi.org\/10.1016\/j.cpcardiol.2020.100680","journal-title":"Curr Probl Cardiol"},{"key":"754_CR4","doi-asserted-by":"publisher","first-page":"463","DOI":"10.1001\/archinternmed.2008.603","volume":"169","author":"DR Murdoch","year":"2009","unstructured":"Murdoch DR (2009) Clinical Presentation, Etiology, and Outcome of Infective Endocarditis in the 21st Century. Arch Intern Med 169:463. https:\/\/doi.org\/10.1001\/archinternmed.2008.603","journal-title":"Arch Intern Med"},{"key":"754_CR5","doi-asserted-by":"publisher","first-page":"455","DOI":"10.3390\/antibiotics12030455","volume":"12","author":"JB Parsons","year":"2023","unstructured":"Parsons JB, Westgeest AC, Conlon BP, Fowler VG (2023) Persistent Methicillin-Resistant Staphylococcus aureus Bacteremia: Host, Pathogen, and Treatment. Antibiotics 12:455. https:\/\/doi.org\/10.3390\/antibiotics12030455","journal-title":"Antibiotics"},{"key":"754_CR6","doi-asserted-by":"publisher","DOI":"10.5543\/tkda.2020.89689","author":"S \u015eim\u015fek-Yavuz","year":"2020","unstructured":"\u015eim\u015fek-Yavuz S (2020) Diagnosis, treatment and prevention of infective endocarditis: Turkish consensus report-2019. Turk Kardiyol Dern Ars. https:\/\/doi.org\/10.5543\/tkda.2020.89689","journal-title":"Turk Kardiyol Dern Ars"},{"key":"754_CR7","doi-asserted-by":"publisher","first-page":"423","DOI":"10.1002\/clc.22688","volume":"40","author":"N Bhatia","year":"2017","unstructured":"Bhatia N, Agrawal S, Garg A et al (2017) Trends and outcomes of infective endocarditis in patients on dialysis. Clin Cardiol 40:423\u2013429. https:\/\/doi.org\/10.1002\/clc.22688","journal-title":"Clin Cardiol"},{"key":"754_CR8","doi-asserted-by":"publisher","first-page":"1076","DOI":"10.1016\/j.cmi.2022.03.015","volume":"28","author":"AD Bai","year":"2022","unstructured":"Bai AD, Lo CKL, Komorowski AS et al (2022) Staphylococcus aureus bacteraemia mortality: a systematic review and meta-analysis. Clin Microbiol Infect 28:1076\u20131084. https:\/\/doi.org\/10.1016\/j.cmi.2022.03.015","journal-title":"Clin Microbiol Infect"},{"key":"754_CR9","doi-asserted-by":"publisher","first-page":"e1","DOI":"10.1093\/cid\/civ933","volume":"62","author":"PG Pappas","year":"2016","unstructured":"Pappas PG, Kauffman CA, Andes DR et al (2016) Clinical Practice Guideline for the Management of Candidiasis: 2016 Update by the Infectious Diseases Society of America. Clin Infect Dis 62:e1\u201350. https:\/\/doi.org\/10.1093\/cid\/civ933","journal-title":"Clin Infect Dis"},{"key":"754_CR10","doi-asserted-by":"publisher","first-page":"1057","DOI":"10.1007\/s11046-020-00492-3","volume":"185","author":"F Hitzenbichler","year":"2020","unstructured":"Hitzenbichler F, Joha T, Simon M et al (2020) Candida Endocarditis in Patients with Candidemia: A Single-Center Experience of 14 Cases. Mycopathologia 185:1057\u20131067. https:\/\/doi.org\/10.1007\/s11046-020-00492-3","journal-title":"Mycopathologia"},{"key":"754_CR11","doi-asserted-by":"publisher","DOI":"10.3390\/microorganisms13040707","author":"P Jancic","year":"2025","unstructured":"Jancic P, Milutinovic S, Ward M et al (2025) Fungal pericarditis-a systematic review of 101 cases. Microorganisms. https:\/\/doi.org\/10.3390\/microorganisms13040707","journal-title":"Microorganisms"},{"key":"754_CR12","doi-asserted-by":"publisher","first-page":"819","DOI":"10.1016\/j.amjmed.2010.03.021","volume":"123","author":"BC Pien","year":"2010","unstructured":"Pien BC, Sundaram P, Raoof N et al (2010) The Clinical and Prognostic Importance of Positive Blood Cultures in Adults. Am J Med 123:819\u2013828. https:\/\/doi.org\/10.1016\/j.amjmed.2010.03.021","journal-title":"Am J Med"}],"container-title":["The Egyptian Heart Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s43044-026-00754-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s43044-026-00754-3","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s43044-026-00754-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T18:13:24Z","timestamp":1780510404000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1186\/s43044-026-00754-3"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6,3]]},"references-count":12,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2026,12]]}},"alternative-id":["754"],"URL":"https:\/\/doi.org\/10.1186\/s43044-026-00754-3","relation":{},"ISSN":["2090-911X"],"issn-type":[{"value":"2090-911X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,6,3]]},"assertion":[{"value":"10 April 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"22 May 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"3 June 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Written informed consent was obtained from both the patient and the patient\u2019s next of kin.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Informed consent"}},{"value":"The authors declare no competing interests.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"41"}}