{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T09:54:26Z","timestamp":1791280466300,"version":"4.1.0"},"reference-count":22,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T00:00:00Z","timestamp":1791244800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T00:00:00Z","timestamp":1791244800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Egypt Heart J"],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Right ventricular (RV) function is a major determinant of outcomes in heart failure (HF), yet RV systolic performance and venous congestion (VC) are often evaluated separately. We investigated the relationship between tricuspid annular systolic velocity (S\u2032), a tissue Doppler marker of RV systolic function and systemic VC measured by the Venous Excess Ultrasound (VExUS) score in patients with HF. In addition, RV\u2013pulmonary artery (RV\u2013PA) coupling parameters including TAPSE\/PASP and S\u2032\/PASP were evaluated across VExUS grades.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>In this prospective, single-center observational study, 155 patients admitted with decompensated HF underwent standardized echocardiography, including VExUS assessment and S\u2032 measurement. Lung Ultrasound Score (LUS), RV\u2013PA coupling indices, clinical characteristics, in-hospital mortality, and acute kidney injury (AKI) were also recorded.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The mean age was 57.5 years, with 68% of the cohort being males. A significant inverse correlation was observed between VExUS grade and S\u2032 velocity (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001). Patients with VExUS Grade 0 had higher S\u2032 velocities (median\u2009=\u200911.0\u00a0cm\/s), while those with Grade 3 had the lowest (8.5\u00a0cm\/s). Increasing VExUS grades were also associated with progressive worsening of TAPSE, TAPSE\/PASP, and S\u2032\/PASP ratios, suggesting impaired RV\u2013PA coupling with increasing venous congestion. Both higher VExUS grades and reduced S\u2032 were associated with more severe pulmonary congestion on LUS (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001 and\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.003, respectively). Although patients with higher VExUS grades and lower S\u2032 values trended towards worse outcomes, neither parameter significantly predicted in-hospital mortality or AKI.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Systemic VC and RV systolic function are strongly and inversely related in HF. The combined use of VExUS and S\u2032 provides an integrated bedside assessment of hemodynamic status that may help guide decongestive therapy. Integration of RV\u2013PA coupling parameters may further enhance bedside evaluation of hemodynamic compromise in HF patients. Additionally, S\u2032\/PASP and TAPSE\/PASP demonstrated comparable trends across all HF groups, suggesting that S\u2032\/PASP may serve as a practical alternative marker of RV\u2013PA coupling in heart failure patients. Larger studies are needed to determine their prognostic utility for predicting mortality and organ injury.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Trial registration<\/jats:title>\n                    <jats:p>\n                      This trial was registered with Clinical Trial Registry-India (\n                      <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"https:\/\/www.ctri.nic.in\/\" ext-link-type=\"uri\">https:\/\/www.ctri.nic.in\/<\/jats:ext-link>\n                      ), Trial Number - CTRI\/2024\/10\/075219 on 14\/10\/2024.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1186\/s43044-026-00788-7","type":"journal-article","created":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T09:25:52Z","timestamp":1791278752000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Utilizing bedside VExUS and the S-prime velocity for real-time assessment of venous congestion on right ventricular function in heart failure"],"prefix":"10.1186","volume":"78","author":[{"given":"Pramukh","family":"Hegde","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Malvika P.","family":"Prasad","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kingshuk","family":"Saha","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vimal","family":"Bhardwaj","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vikneswaran","family":"Gunaseelan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicolas","family":"Orozco","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arjun","family":"Alva","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,10,6]]},"reference":[{"key":"788_CR1","doi-asserted-by":"publisher","unstructured":"Carluccio E, Biagioli P, Alunni G et al (2018) Prognostic value of right ventricular dysfunction in heart failure with reduced ejection fraction. 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