{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,7]],"date-time":"2025-07-07T06:30:13Z","timestamp":1751869813764},"reference-count":6,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2021,3,4]],"date-time":"2021-03-04T00:00:00Z","timestamp":1614816000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2021,3,4]],"date-time":"2021-03-04T00:00:00Z","timestamp":1614816000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Egypt Natl Canc Inst"],"published-print":{"date-parts":[[2021,12]]},"abstract":"Abstract<\/jats:title>\n Background<\/jats:title>\n Acral vascular syndrome clinically presents as digital ischemia with Raynaud\u2019s phenomenon and erythromelalgia but can be rarely seen in the malignant condition. Patients may present pain, permanent digital blanching or cyanosis, and desquamation or ulceration of the fingers. Acral vascular syndrome is rarely associated with lymphoid neoplasm and is associated with smoking, autoimmune connective tissue diseases, and vasculitis. Here, we describe a 79-year-old female who was diagnosed with vitiligo and peripheral T cell lymphoma Lennert type stage 4 with anemia of chronic disease with digital acral vascular syndrome.<\/jats:p>\n <\/jats:sec>\n Case presentation<\/jats:title>\n A 79-year-old female with vitiligo presented with gangrene of the distal extremities associated with pain and intermittent fever for 2\u2009months. On evaluation, she was found to have anemia of chronic disease and generalized lymphadenopathy and diagnosed as peripheral T cell lymphoma Lennert type with bone marrow involvement and digital acral vascular syndrome.<\/jats:p>\n <\/jats:sec>\n Conclusion<\/jats:title>\n Acral vascular syndrome can be a presentation of lymphoma; if intervened earlier, the patient can be saved from the amputation of fingers or affected limb. Though it is a rare presentation of lymphoma, it should be considered if there is a rapid progression of gangrene. Early initiation of chemotherapy may result in the reduction of further progression of digital gangrene and thus prevents functional dependence on caregivers. In our patient, gangrene of other fingers was prevented even though it is an aggressive variant of T cell lymphoma.<\/jats:p>\n <\/jats:sec>","DOI":"10.1186\/s43046-021-00063-7","type":"journal-article","created":{"date-parts":[[2021,3,4]],"date-time":"2021-03-04T14:03:26Z","timestamp":1614866606000},"update-policy":"http:\/\/dx.doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Acral vascular syndrome Lennert type T cell lymphoma\u2014a case report"],"prefix":"10.1186","volume":"33","author":[{"given":"Kamal Bandhu","family":"Klanidhi","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S. Ashwin","family":"Monian","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Avinash","family":"Chakrawarty","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2021,3,4]]},"reference":[{"issue":"10","key":"63_CR1","doi-asserted-by":"publisher","first-page":"e47","DOI":"10.1097\/MD.0000000000000047","volume":"93","author":"M Le Besnerais","year":"2014","unstructured":"Le Besnerais M, Miranda S, Cailleux N, Girszyn N, Marie I, et al. Digital ischemia associated with cancer results from a cohort study. Medicine. 2014;93(10):e47. https:\/\/doi.org\/10.1097\/MD.0000000000000047.","journal-title":"Medicine"},{"issue":"20","key":"63_CR2","doi-asserted-by":"publisher","first-page":"2375","DOI":"10.1182\/blood-2016-01-643569","volume":"127","author":"SH Swerdlow","year":"2016","unstructured":"Swerdlow SH, Campo E, Pileri SA, et al. The 2016 revision of the World Health Organization classification of lymphoid neoplasms. Blood. 2016;127(20):2375\u201390.","journal-title":"Blood"},{"issue":"11","key":"63_CR3","doi-asserted-by":"publisher","first-page":"2099","DOI":"10.1080\/10428190802455867","volume":"49","author":"AN Abouyabis","year":"2008","unstructured":"Abouyabis AN, Shenoy PJ, Lechowicz MJ, Flowers CR. Incidence and outcomes of the peripheral T-cell lymphoma subtypes in the United States. Leuk Lymphoma. 2008;49(11):2099\u2013107.","journal-title":"Leuk Lymphoma"},{"issue":"25","key":"63_CR4","doi-asserted-by":"publisher","first-page":"4124","DOI":"10.1200\/JCO.2008.16.4558","volume":"26","author":"J Vose","year":"2008","unstructured":"Vose J, Armitage J, Weisenburger D, International TCLP. International peripheral T-cell and natural killer\/T-cell lymphoma study: pathology findings and clinical outcomes. J Clin Oncol. 2008;26(25):4124\u201330.","journal-title":"J Clin Oncol"},{"key":"63_CR5","doi-asserted-by":"publisher","first-page":"780","DOI":"10.3389\/fgene.2019.00780","volume":"10","author":"M Etebari","year":"2019","unstructured":"Etebari M, Navari M, Agostinelli C, Visani A, et al. Transcriptional analysis of Lennert lymphoma reveals a unique profile and identifies novel therapeutic targets. Front Genet. 2019;10:780. https:\/\/doi.org\/10.3389\/fgene.2019.00780.","journal-title":"Front Genet"},{"key":"63_CR6","doi-asserted-by":"publisher","first-page":"929","DOI":"10.1002\/ajh.25513","volume":"94","author":"M Jasmine","year":"2019","unstructured":"Jasmine M. Zain Aggressive T-cell lymphomas: 2019 updates on diagnosis, risk stratification, and management. Am J Hematol. 2019;94:929\u201346. https:\/\/doi.org\/10.1002\/ajh.25513.","journal-title":"Am J Hematol"}],"container-title":["Journal of the Egyptian National Cancer Institute"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/s43046-021-00063-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1186\/s43046-021-00063-7\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/s43046-021-00063-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,3,4]],"date-time":"2021-03-04T14:22:38Z","timestamp":1614867758000},"score":1,"resource":{"primary":{"URL":"https:\/\/jenci.springeropen.com\/articles\/10.1186\/s43046-021-00063-7"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,3,4]]},"references-count":6,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2021,12]]}},"alternative-id":["63"],"URL":"https:\/\/doi.org\/10.1186\/s43046-021-00063-7","relation":{},"ISSN":["2589-0409"],"issn-type":[{"value":"2589-0409","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,3,4]]},"assertion":[{"value":"7 October 2020","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"18 February 2021","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"4 March 2021","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"Taken.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Written consent for publication was taken.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare that they have no competing interests.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"8"}}