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The nucleoside diphosphate kinase 1 <jats:italic>(NME1)<\/jats:italic> and netrin 1 receptor <jats:italic>(DCC)<\/jats:italic> genes have been associated with resistance against tumorigenesis and tumor metastasis. This study investigates the potential association between <jats:italic>NME1<\/jats:italic> (rs34214448 G\u2009&gt;\u2009T and rs2302254 C\u2009&gt;\u2009T) and <jats:italic>DCC<\/jats:italic> (rs2229080 G\u2009&gt;\u2009C and rs714 A\u2009&gt;\u2009G) variants and susceptibility to colorectal cancer development.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Methods<\/jats:title>\n                <jats:p>Samples from 232 colorectal cancer patients and 232 healthy blood donors underwent analysis. Variants were identified using polymerase chain reaction-restriction fragment length polymorphism (PCR\u2013RFLP) methodology. Associations were assessed using odds ratios (OR), and the <jats:italic>p<\/jats:italic> values were adjusted with Bonferroni test.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>Individuals carrying the G\/T and T\/T genotypes for the <jats:italic>NME1<\/jats:italic> rs34214448 variant exhibited a higher susceptibility for develop colorectal cancer (OR\u2009=\u20092.68, 95% CI: 1.76\u20134.09, <jats:italic>P<\/jats:italic>\u2009=\u20090.001 and OR\u2009=\u20092.47, 95% CI: 1.37\u20134.47, <jats:italic>P<\/jats:italic>\u2009=\u20090.001, respectively). These genotypes showed significant associations in patients over 50\u00a0years (OR\u2009=\u20092.87, 95% CI: 1.81\u20134.54, <jats:italic>P<\/jats:italic>\u2009=\u20090.001 and OR\u2009=\u20092.99, 95% CI: 1.54\u20135.79, <jats:italic>P<\/jats:italic>\u2009=\u20090.001 respectively) and with early Tumor-Nodule-Metastasis (TNM) stage (<jats:italic>P<\/jats:italic>\u2009=\u20090.001), and tumor location in the rectum (<jats:italic>P<\/jats:italic>\u2009=\u20090.001). Furthermore, the <jats:italic>DCC<\/jats:italic> rs2229080 variant revealed that carriers of the G\/C genotype had an increased risk for develop colorectal cancer (OR\u2009=\u20092.00, 95% CI: 1.28\u20133.11, <jats:italic>P<\/jats:italic>\u2009=\u20090.002) and were associated with age over 50\u00a0years, sex, and advanced TNM stages (<jats:italic>P<\/jats:italic>\u2009=\u20090.001).<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusions<\/jats:title>\n                <jats:p>These findings suggest that the <jats:italic>NME1<\/jats:italic> rs34214448 and <jats:italic>DCC<\/jats:italic> rs2229080 variants play a significant role in colorectal cancer development.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1186\/s43046-024-00213-7","type":"journal-article","created":{"date-parts":[[2024,4,1]],"date-time":"2024-04-01T02:08:41Z","timestamp":1711937321000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["NME1 and DCC variants are associated with susceptibility and tumor characteristics in Mexican patients with colorectal cancer"],"prefix":"10.1186","volume":"36","author":[{"given":"Rosa Mar\u00eda","family":"M\u00e1rquez-Gonz\u00e1lez","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anil\u00fa Margarita","family":"Saucedo-Sari\u00f1ana","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C\u00e9sar","family":"de Jes\u00fas Tovar-Jacome","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patricio","family":"Barros-N\u00fa\u00f1ez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martha Patricia","family":"Gallegos-Arreola","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mario Humberto","family":"Orozco-Guti\u00e9rrez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ignacio","family":"Mariscal-Ram\u00edrez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomas Daniel","family":"Pineda-Razo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aldo Antonio","family":"Alcaraz-Wong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mar\u00eda Eugenia","family":"Mar\u00edn-Contreras","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0387-4996","authenticated-orcid":false,"given":"M\u00f3nica Alejandra","family":"Rosales-Reynoso","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,4,1]]},"reference":[{"key":"213_CR1","unstructured":"Ferlay J EM, Lam F, Laversanne M, Colombet M, Mery L, Pi\u00f1eros M, Znaor A, Soerjomataram I, Bray F. 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