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Effective interventions to alleviate these symptoms are crucial for improving patient quality of life. The objective was to investigate the effects of gradient pressure therapy on symptoms of paclitaxel-induced peripheral neuropathy and daily activities.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Eighty patients with breast cancer receiving a 125-mg\/m\n                      <jats:sup>2<\/jats:sup>\n                      paclitaxel chemotherapy regimen at a class III hospital in Tangshan from October 2022 to October 2023 were randomly divided into a control group (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200940) and an intervention group (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200940). The control group received routine treatment and health guidance, whereas the intervention group received additional II-level hand and foot gradient pressure therapy. Chemotherapy-induced peripheral neuropathy (CIPN) symptoms and activities of daily living (ADL) impact scores were compared after the second, fourth, and sixth chemotherapy cycles and at the 3-month follow-up.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      No significant differences were found in CIPN symptoms and ADL impact scores between the groups after the second chemotherapy cycle (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&gt;\u20090.05). However, after the fourth cycle, the intervention group showed significant improvements in nine items: hand numbness, foot numbness, discomfort in fingers\/hands or toes\/feet, walking, exercise, sleep, sexual activity, chores, and enjoyment of life (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&lt;\u20090.05). At the sixth cycle and at the 3-month follow-up, additional improvements were noted in cold sensitivity and total scores (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&lt;\u20090.05).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Gradient pressure therapy effectively reduces symptoms of paclitaxel-induced peripheral neuropathy, improving patients\u2019 daily activities. This intervention is recommended for clinical promotion and application.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1186\/s43046-025-00331-w","type":"journal-article","created":{"date-parts":[[2025,11,24]],"date-time":"2025-11-24T00:01:44Z","timestamp":1763942504000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["A case\u2013control study investigating the impact of gradient pressure therapy on chemotherapy-induced peripheral neuropathy symptoms and daily activities in paclitaxel-treated patients"],"prefix":"10.1186","volume":"37","author":[{"given":"Dongxue","family":"Guo","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fangfei","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"JiWei","family":"Hu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"JingHua","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aijun","family":"Du","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lizhi","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2025,11,24]]},"reference":[{"key":"331_CR1","doi-asserted-by":"publisher","first-page":"209","DOI":"10.3322\/caac.21660","volume":"71","author":"H Sung","year":"2021","unstructured":"Sung H, Ferlay J, Siegel RL, Laversanne M, Soerjomataram I, Jemal A, et al. 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