{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,26]],"date-time":"2026-05-26T08:03:40Z","timestamp":1779782620092,"version":"3.53.1"},"reference-count":11,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2026,5,26]],"date-time":"2026-05-26T00:00:00Z","timestamp":1779753600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2026,5,26]],"date-time":"2026-05-26T00:00:00Z","timestamp":1779753600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Egypt Natl Canc Inst"],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Worldwide, breast cancer is the most commonly diagnosed cancer among women accounting for over a million cases each year. Mammography still remains the gold standard for early detection of breast cancer. Contrast Enhanced Spectral Mammography (CESM) allows better estimation of the lesion size and detection of multifocal breast cancers. Automated breast ultrasound (ABUS) is an innovation of breast ultrasound that attains 3-D images of the entire breast overcoming the limitations of hand-held ultrasound. The aim is to evaluate the impact of 3D ABUS in correlation with CESM on the characterization and assessment of disease extent.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Design &amp; population<\/jats:title>\n                    <jats:p>The study was performed at the Female Imaging Unit of the National Cancer Institute (NCI), Cairo University and in Baheya Foundation. One hundred and six patients were randomly chosen out of patients who were initially given BIRADS IV \u2013 V by standard mammography. The contrast enhanced digital mammography and 3D automated ultrasound data were evaluated by two experienced radiologists; both observers were blinded to the pathological data of each patient.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Regarding primary outcome of our study in assessment of tumor size, extension and multiplicity, the use of ABUS after CESM showed significant increase in the sensitivity of the test (80% for combined test versus 40% for CESM alone), while it showed almost no significant difference in specificity (70% for CESM and Combined tests).The ABUS also showed more accuracy in detection of suspicious lesions (61%) than the CESM (40%.)<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>ABUS is considered a revolution in breast scanning by ultrasound imaging that can be used as a non-invasive complementary tool to CESM in assessment of suspicious breast lesions showing increased accuracy of study and patient outcome upon combing both of them.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1186\/s43046-026-00357-8","type":"journal-article","created":{"date-parts":[[2026,5,26]],"date-time":"2026-05-26T07:27:24Z","timestamp":1779780444000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["The additive value of 3D automated breast ultrasound and contrast enhanced spectral mammography in the assessment of suspicious breast lesions"],"prefix":"10.1186","volume":"38","author":[{"given":"Lamiaa Hassan","family":"ELmalatawy","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Noha Abd El- Shafy","family":"Elsaid","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,5,26]]},"reference":[{"issue":"1","key":"357_CR1","first-page":"7","volume":"67","author":"R Siegel","year":"2017","unstructured":"Siegel R, Miller K, Jemal A. Cancer statistics, 2017. CA Cancer J Clin. 2017;67(1):7\u201330.","journal-title":"CA Cancer J Clin"},{"issue":"2","key":"357_CR2","doi-asserted-by":"publisher","first-page":"279","DOI":"10.1016\/j.clinimag.2015.05.017","volume":"40","author":"A Chetlen","year":"2016","unstructured":"Chetlen A, Mack J, Chan T. Breast cancer screening controversies: who, when, why, and how? Clin Imaging. 2016;40(2):279\u201382.","journal-title":"Clin Imaging"},{"issue":"9","key":"357_CR3","doi-asserted-by":"publisher","first-page":"1554","DOI":"10.1016\/j.ejrad.2016.06.004","volume":"85","author":"B Wilczek","year":"2016","unstructured":"Wilczek B, Wilczek H, Rasouliyan L, Leifland K. Adding 3D automated breast ultrasound to mammography screening in women with heterogeneously and extremely dense breasts: report from a hospital-based, high-volume, single-center breast cancer screening program. Eur J Radiol. 2016;85(9):1554\u201363.","journal-title":"Eur J Radiol"},{"issue":"3","key":"357_CR4","doi-asserted-by":"publisher","first-page":"743","DOI":"10.1148\/radiol.12121084","volume":"266","author":"M Jochelson","year":"2013","unstructured":"Jochelson M, Dershaw D, Sung J, Heerdt A, Thornton C, Moskowitz C, et al. Bilateral contrast-enhanced dual-energy digital mammography: feasibility and comparison with conventional digital mammography and MR imaging in women with known breast carcinoma. Radiology. 2013;266(3):743\u201351.","journal-title":"Radiology"},{"issue":"2","key":"357_CR5","doi-asserted-by":"publisher","first-page":"371","DOI":"10.1007\/s10549-014-3023-6","volume":"146","author":"E Fallenberg","year":"2014","unstructured":"Fallenberg E, Dromain C, Diekmann F, Renz D, Amer H, Ingold-Heppner B, et al. Contrast-enhanced spectral mammography: does mammography provide additional clinical benefits or can some radiation exposure be avoided. Breast Cancer Res Treat. 2014;146(2):371\u201381.","journal-title":"Breast Cancer Res Treat"},{"issue":"2","key":"357_CR6","doi-asserted-by":"publisher","first-page":"592","DOI":"10.1007\/s00330-017-5011-9","volume":"28","author":"A Vourtsis","year":"2017","unstructured":"Vourtsis A, Kachulis A. The performance of 3D ABUS versus HHUS in the visualisation and BI-RADS characterisation of breast lesions in a large cohort of 1,886 women. Eur Radiol. 2017;28(2):592\u2013601.","journal-title":"Eur Radiol"},{"key":"357_CR7","first-page":"391","volume":"44","author":"Y Chan","year":"2003","unstructured":"Chan Y, et al. Biostatistics 102: quantitative data-parametric & non-para- metric tests. Singapore Med J. 2003;44:391\u20136.","journal-title":"Singapore Med J"},{"issue":"1064","key":"357_CR8","doi-asserted-by":"publisher","first-page":"20160157","DOI":"10.1259\/bjr.20160157","volume":"89","author":"R Kamal","year":"2016","unstructured":"Kamal R, Helal M, Mansour S, Haggag M, Nada O, Farahat I, et al. Can we apply the MRI BI-RADS lexicon morphology descriptors on contrast-enhanced spectral mammography. Br J Radiol. 2016;89(1064):20160157.","journal-title":"Br J Radiol"},{"key":"357_CR9","doi-asserted-by":"publisher","first-page":"15","DOI":"10.3348\/kjr.2019.0176","volume":"21","author":"SH Kim","year":"2020","unstructured":"Kim SH, Kim HH, Moon WK. Automated breast ultrasound screening for dense breasts. Korean J Radiol. 2020;21:15\u201324.","journal-title":"Korean J Radiol"},{"issue":"8","key":"357_CR10","doi-asserted-by":"publisher","first-page":"703","DOI":"10.3390\/jpm11080703","volume":"11","author":"I Boca","year":"2021","unstructured":"Boca I, Ciurea AI, Ciortea CA, Dudea SM. Pros and cons for automated breast ultrasound (ABUS): a narrative review. J Pers Med. 2021;11(8):703. https:\/\/doi.org\/10.3390\/jpm11080703.","journal-title":"J Pers Med"},{"key":"357_CR11","doi-asserted-by":"publisher","first-page":"21","DOI":"10.4103\/jnsbm.JNSBM_167_19","volume":"11","author":"K Raju","year":"2020","unstructured":"Raju K, Rajanna VS. A comparative study of three scoring systems on palpable breast aspirates at a tertiary health-care center: a cross-sectional study. J Nat Sci Biol Med. 2020;11:21\u20136.","journal-title":"J Nat Sci Biol Med"}],"container-title":["Journal of the Egyptian National Cancer Institute"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s43046-026-00357-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s43046-026-00357-8","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s43046-026-00357-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,26]],"date-time":"2026-05-26T07:27:27Z","timestamp":1779780447000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1186\/s43046-026-00357-8"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,5,26]]},"references-count":11,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2026,12]]}},"alternative-id":["357"],"URL":"https:\/\/doi.org\/10.1186\/s43046-026-00357-8","relation":{},"ISSN":["2589-0409"],"issn-type":[{"value":"2589-0409","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,5,26]]},"assertion":[{"value":"30 December 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"19 April 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"26 May 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The study was approved by the Ethics Committee of the radiology department in both the National Cancer Institute NCI and Baheya Foundation on date: 11th of March 2019 (IRB review date), IRB review number: 2018119028.3, Study ID: 1903-30805, and was conducted in accordance with the Declaration of Helsinki and the International Conference on Harmonization Guidelines for Good Clinical Practice. Verbal and written consents were obtained from all eligible women before starting the study.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Informed consent for the publication of clinical details disclosure and pictures was obtained from all participants.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"29"}}