{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,22]],"date-time":"2026-06-22T16:48:52Z","timestamp":1782146932398,"version":"3.54.5"},"reference-count":142,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2026,6,22]],"date-time":"2026-06-22T00:00:00Z","timestamp":1782086400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2026,6,22]],"date-time":"2026-06-22T00:00:00Z","timestamp":1782086400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Egypt Natl Canc Inst"],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Oral cancer is a significant global health challenge, ranking as the sixth most prevalent cancer worldwide, with approximately 377,000 new cases diagnosed annually. The high morbidity and mortality rates are largely attributed to tobacco and alcohol use. While conventional treatments such as surgery, radiation, and chemotherapy have improved survival rates, they often lead to unfavourable aesthetic and functional outcomes. Tissue engineering offers a promising alternative, providing regenerative solutions aimed at restoring both oral function and appearance. By integrating biomaterials, biological systems, and engineering principles, tissue engineering enables the creation of functional tissue replacements. The current review examines different t pathways the potential applications of autologous tissue, oral cancer cell lines, CRISPR, gene-editing technologies, and epigenetic modifications for tissue regeneration. Advanced scaffold technologies that mimic the natural extracellular matrix, along with stem cell-based therapies and bioactive molecules, are employed to support tissue growth and differentiation. Mesenchymal stem cells (MSCs) and induced pluripotent stem cells (iPSCs) show significant potential in regenerating hard and soft oral tissues, while also targeting cancer stem cells (CSCs) to prevent recurrence. Furthermore, innovative technologies like 3D bio printing, combined with vascularization strategies, hold promise for developing patient-specific tissue constructs for reconstructive procedures. In conclusion, tissue engineering offers transformative potential for oral cancer treatment, presenting regenerative therapies that can significantly enhance patient outcomes and quality of life.<\/jats:p>","DOI":"10.1186\/s43046-026-00378-3","type":"journal-article","created":{"date-parts":[[2026,6,22]],"date-time":"2026-06-22T15:06:25Z","timestamp":1782140785000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Tissue engineering driven regeneration in oral squamous cell carcinoma: from biomaterials to precision gene editing"],"prefix":"10.1186","volume":"38","author":[{"given":"B","family":"Deva darshinii","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N","family":"Subhapradha","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S","family":"Raghavi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K","family":"Anbarasu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,6,22]]},"reference":[{"key":"378_CR1","doi-asserted-by":"crossref","unstructured":"Atia GA, Ali MA, Abdeen A, Alghonemy WY, Aborayah NH, Gebba MA, et al. Halloysite nanotubes-based nanomaterials as drug carriers and scaffolds for personalized oral and maxillofacial applications. J Drug Deliv Sci Technol. 2026;119:108141.","DOI":"10.1016\/j.jddst.2026.108141"},{"issue":"13","key":"378_CR2","doi-asserted-by":"publisher","first-page":"22184","DOI":"10.1016\/j.ceramint.2024.04.035","volume":"50","author":"GAN Atia","year":"2024","unstructured":"Atia GAN, Mohamed SZ, Halim HA, Ghobashy MM, Foda T, Shalaby HK, et al. Advances in bioceramic silicates for therapeutic and regenerative dentofacial reconstruction. Ceram Int. 2024;50(13):22184\u2013208.","journal-title":"Ceram Int"},{"issue":"1","key":"378_CR3","doi-asserted-by":"publisher","first-page":"e202400653","DOI":"10.1002\/biot.202400653","volume":"20","author":"M Alkandari","year":"2025","unstructured":"Alkandari M, Barai P, Atia GAN, Mohamed SZ, Ghobashy MM, Shalaby HK, et al. Bioactive functionalized chitosan thermo-responsive hydrogels as promising platforms for therapeutic, regenerative oral, and maxillofacial applications. Biotechnol J. 2025;20(1):e202400653.","journal-title":"Biotechnol J"},{"issue":"49","key":"378_CR4","doi-asserted-by":"publisher","first-page":"3545","DOI":"10.1038\/s41388-024-03183-1","volume":"43","author":"R Antoon","year":"2024","unstructured":"Antoon R, Overdevest N, Saleh AH, Keating A. Mesenchymal stromal cells as cancer promoters. Oncogene. 2024;43(49):3545\u201355.","journal-title":"Oncogene"},{"issue":"1","key":"378_CR5","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1080\/08977194.2025.2606675","volume":"44","author":"M Alkandari","year":"2026","unstructured":"Alkandari M, Alkandari M, Atia GAN, El-Halim EA, Ghobashy MM, Shalaby HK, et al. Growth factors loaded chitosan scaffolds as bioactive biomimetic multifunctional platforms in periodontal tissue engineering: a review. Growth Factors. 2026;44(1):1\u201341.","journal-title":"Growth Factors"},{"key":"378_CR6","doi-asserted-by":"crossref","unstructured":"Taymour N, Ali MA, Taher ES, Atia GA, Abdeen A, Chaudhary AA, et al. Functionalized nanodiamonds in dentistry: multifunctional frontiers for oral and maxillofacial regeneration. J Drug Deliv Sci Technol. 2025;114:107448. Part A.","DOI":"10.1016\/j.jddst.2025.107448"},{"key":"378_CR7","doi-asserted-by":"crossref","unstructured":"Atia GA, Ali MA, Abdeen A, Alghonemy WY, Zakarya A, Shaban EE, et al. Recombinant biologics in periodontal and peri-implant reconstruction: advances, delivery strategies, and translational challenges. J Drug Deliv Sci Technol. 2026;119:108140.","DOI":"10.1016\/j.jddst.2026.108140"},{"issue":"1","key":"378_CR8","doi-asserted-by":"publisher","first-page":"31","DOI":"10.66585\/ohmi.2025.1.0006","volume":"1","author":"GA Atia","year":"2025","unstructured":"Atia GA, Ramah A, Rehan IF, Hetta HF, Elmorsy EM, El-Far A, et al. Mouth-heart axis: contribution of oral dysbiotic bacteria in the initiation and development of cardiovascular conditions. One Health Microbiol Infect. 2025;1(1):31\u20138.","journal-title":"One Health Microbiol Infect"},{"issue":"10","key":"378_CR9","doi-asserted-by":"publisher","first-page":"4566","DOI":"10.1002\/ptr.70040","volume":"39","author":"GA Atia","year":"2025","unstructured":"Atia GA, Abdeen A, Taher ES, Alghonemy WY, El Nashar EM, Al-Zahrani NS, et al. From plants to patients: advancing cancer therapy with bioengineered exosomes and AI-driven innovations. Phytother Res. 2025;39(10):4566\u2013614.","journal-title":"Phytother Res"},{"key":"378_CR10","doi-asserted-by":"crossref","unstructured":"Young E. Cells, tissues, and organs on chips: Challenges and opportunities for the cancer tumor microenvironment. Integr Biol Quant Biosci Nano Macro. 2013;5:1096\u2013109.","DOI":"10.1039\/c3ib40076j"},{"key":"378_CR11","doi-asserted-by":"publisher","first-page":"100622","DOI":"10.1016\/j.oor.2024.100622","volume":"11","author":"N Buldak","year":"2024","unstructured":"Buldak N, Veeraraghavan VP, Mony U. Revolutionizing precision medicine in oral squamous cell carcinoma: Harnessing 3D in vitro models for translation. Oral Oncol Rep. 2024;11:100622.","journal-title":"Oral Oncol Rep"},{"issue":"3","key":"378_CR12","doi-asserted-by":"publisher","first-page":"E319","DOI":"10.1210\/jc.2011-2671","volume":"97","author":"L Zhang","year":"2012","unstructured":"Zhang L, He M, Zhang Y, Nilubol N, Shen M, Kebebew E. Quantitative high-throughput drug screening identifies novel classes of drugs with anticancer activity in thyroid cancer cells: opportunities for repurposing. J Clin Endocrinol Metab. 2012;97(3):E319-328.","journal-title":"J Clin Endocrinol Metab"},{"key":"378_CR13","doi-asserted-by":"crossref","unstructured":"Zuchowska A, Skorupska S. Multi-organ-on-chip approach in cancer research. Organs---Chip. 2021;4:100014.","DOI":"10.1016\/j.ooc.2021.100014"},{"key":"378_CR14","doi-asserted-by":"publisher","first-page":"101677","DOI":"10.1016\/j.tranon.2023.101677","volume":"33","author":"W Wahbi","year":"2023","unstructured":"Wahbi W, Korelin K, Sievil\u00e4inen M, Karihtala P, Wilkman T, Tarkkanen J, et al. Evaluation of in vitro and in vivo personalized cancer treatment assays for oral squamous cell carcinoma. Transl Oncol. 2023;33:101677.","journal-title":"Transl Oncol"},{"issue":"8A","key":"378_CR15","doi-asserted-by":"publisher","first-page":"1417","DOI":"10.1111\/j.1582-4934.2009.00853.x","volume":"13","author":"DW Hutmacher","year":"2009","unstructured":"Hutmacher DW, Horch RE, Loessner D, Rizzi S, Sieh S, Reichert JC, et al. Translating tissue engineering technology platforms into cancer research. J Cell Mol Med. 2009;13(8A):1417\u201327.","journal-title":"J Cell Mol Med"},{"issue":"18","key":"378_CR16","doi-asserted-by":"publisher","first-page":"10646","DOI":"10.1039\/D1RA00855B","volume":"11","author":"J Esmaeili","year":"2021","unstructured":"Esmaeili J, Barati A, Ai J, Nooshabadi VT, Mirzaei Z. Employing hydrogels in tissue engineering approaches to boost conventional cancer-based research and therapies. RSC Adv. 2021;11(18):10646\u201369.","journal-title":"RSC Adv"},{"key":"378_CR17","doi-asserted-by":"publisher","first-page":"30","DOI":"10.36348\/sjodr.2020.v05i01.005","volume":"05","author":"L Alothman","year":"2020","unstructured":"Alothman L, Alsenani M, Alrabiah R, Ras A, Abulhassan E, Aldayel R, et al. Insights into Epigenetics Mechanisms in Oral Squamous Cell Carcinoma. Saudi J Oral Dent Res. 2020;05:30\u20135.","journal-title":"Saudi J Oral Dent Res"},{"issue":"Suppl 1","key":"378_CR18","doi-asserted-by":"publisher","first-page":"7","DOI":"10.1111\/j.1601-0825.2011.01789.x","volume":"17","author":"MW Lingen","year":"2011","unstructured":"Lingen MW, Pinto A, Mendes RA, Franchini R, Czerninski R, Tilakaratne WM, et al. Genetics\/epigenetics of oral premalignancy: current status and future research. Oral Dis. 2011;17(Suppl 1):7\u201322.","journal-title":"Oral Dis"},{"key":"378_CR19","doi-asserted-by":"publisher","first-page":"109113","DOI":"10.1016\/j.intimp.2022.109113","volume":"111","author":"SC Yang","year":"2022","unstructured":"Yang SC, Wang WY, Zhou JJ, Wu L, Zhang MJ, Yang QC, et al. Inhibition of DNMT1 potentiates antitumor immunity in oral squamous cell carcinoma. Int Immunopharmacol. 2022;111:109113.","journal-title":"Int Immunopharmacol"},{"issue":"6","key":"378_CR20","doi-asserted-by":"publisher","first-page":"1091","DOI":"10.2174\/0929867327666200114114802","volume":"28","author":"R Emfietzoglou","year":"2021","unstructured":"Emfietzoglou R, Pachymanolis E, Piperi C. Impact of Epigenetic Alterations in the Development of Oral Diseases. Curr Med Chem. 2021;28(6):1091\u2013103.","journal-title":"Curr Med Chem"},{"key":"378_CR21","doi-asserted-by":"publisher","first-page":"422","DOI":"10.1016\/j.semcancer.2021.03.013","volume":"83","author":"M Singh","year":"2022","unstructured":"Singh M, Kumar V, Sehrawat N, Yadav M, Chaudhary M, Upadhyay SK, et al. Current paradigms in epigenetic anticancer therapeutics and future challenges. Semin Cancer Biol. 2022;83:422\u201340.","journal-title":"Semin Cancer Biol"},{"key":"378_CR22","doi-asserted-by":"publisher","first-page":"503","DOI":"10.1016\/j.semcancer.2020.12.006","volume":"83","author":"P Mondal","year":"2022","unstructured":"Mondal P, Natesh J, Penta D, Meeran SM. Progress and promises of epigenetic drugs and epigenetic diets in cancer prevention and therapy: A clinical update. Semin Cancer Biol. 2022;83:503\u201322.","journal-title":"Semin Cancer Biol"},{"key":"378_CR23","doi-asserted-by":"publisher","DOI":"10.1016\/j.oor.2024.100678","volume":"12","author":"S Ramachandran","year":"2024","unstructured":"Ramachandran S. Oral cancer: Recent breakthroughs in pathology and therapeutic approaches. Oral Oncol Rep. 2024;12:100678.","journal-title":"Oral Oncol Rep"},{"issue":"4","key":"378_CR24","doi-asserted-by":"publisher","first-page":"220","DOI":"10.1016\/j.gpb.2016.11.005","volume":"15","author":"HFM Kamel","year":"2017","unstructured":"Kamel HFM, Al-Amodi HSAB. Exploitation of Gene Expression and Cancer Biomarkers in Paving the Path to Era of Personalized Medicine. Genomics Proteomics Bioinformatics. 2017;15(4):220\u201335.","journal-title":"Genomics Proteomics Bioinformatics"},{"issue":"1","key":"378_CR25","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1186\/s12943-023-01925-5","volume":"23","author":"M Chehelgerdi","year":"2024","unstructured":"Chehelgerdi M, Chehelgerdi M, Khorramian-Ghahfarokhi M, Shafieizadeh M, Mahmoudi E, Eskandari F, et al. Comprehensive review of CRISPR-based gene editing: mechanisms, challenges, and applications in cancer therapy. Mol Cancer. 2024;23(1):9.","journal-title":"Mol Cancer"},{"issue":"1","key":"378_CR26","doi-asserted-by":"publisher","first-page":"47","DOI":"10.1038\/s41392-024-01750-2","volume":"9","author":"Y Zheng","year":"2024","unstructured":"Zheng Y, Li Y, Zhou K, Li T, VanDusen NJ, Hua Y. Precise genome-editing in human diseases: mechanisms, strategies and applications. Signal Transduct Target Ther. 2024;9(1):47.","journal-title":"Signal Transduct Target Ther"},{"key":"378_CR27","doi-asserted-by":"publisher","first-page":"1383062","DOI":"10.3389\/fonc.2024.1383062","volume":"14","author":"S Sv","year":"2024","unstructured":"Sv S, Augustine D, Mushtaq S, Baeshen HA, Ashi H, Hassan RN, et al. Revitalizing oral cancer research: CRISPR-Cas9 technology the promise of genetic editing. Front Oncol. 2024;14:1383062.","journal-title":"Front Oncol"},{"issue":"5","key":"378_CR28","doi-asserted-by":"publisher","first-page":"164","DOI":"10.1007\/s10142-024-01455-3","volume":"24","author":"J Rajanathadurai","year":"2024","unstructured":"Rajanathadurai J, Perumal E, Sindya J. Advances in targeting cancer epigenetics using CRISPR-dCas9 technology: a comprehensive review and future prospects. Funct Integr Genomics. 2024;24(5):164.","journal-title":"Funct Integr Genomics"},{"key":"378_CR29","doi-asserted-by":"publisher","first-page":"100681","DOI":"10.1016\/j.oor.2024.100681","volume":"12","author":"M Krishnan","year":"2024","unstructured":"Krishnan M, Basappa S, Babu S. Epigenetic alterations in oral cancer: mechanisms, biomarkers, and therapeutic targets. Oral Oncol Rep. 2024;12:100681.","journal-title":"Oral Oncol Rep"},{"issue":"8","key":"378_CR30","doi-asserted-by":"publisher","first-page":"1422","DOI":"10.1016\/j.chembiol.2024.07.007","volume":"31","author":"GV Roth","year":"2024","unstructured":"Roth GV, Gengaro IR, Qi LS. Precision epigenetic editing: technological advances, enduring challenges, and therapeutic applications. Cell Chem Biol. 2024;31(8):1422\u201346.","journal-title":"Cell Chem Biol"},{"key":"378_CR31","doi-asserted-by":"publisher","first-page":"117959722412880","DOI":"10.1177\/11795972241288099","volume":"15","author":"S Zoghi","year":"2024","unstructured":"Zoghi S. Advancements in tissue engineering: a review of bioprinting techniques, scaffolds, and bioinks. Biomed Eng Comput Biol. 2024;15:11795972241288100.","journal-title":"Biomed Eng Comput Biol"},{"key":"378_CR32","doi-asserted-by":"publisher","first-page":"1400472","DOI":"10.3389\/fbioe.2024.1400472","volume":"12","author":"M El-Nablaway","year":"2024","unstructured":"El-Nablaway M, Rashed F, Taher ES, Abdeen A, Taymour N, Soliman MM, et al. Prospective and challenges of locally applied repurposed pharmaceuticals for periodontal tissue regeneration. Front Bioeng Biotechnol. 2024;12:1400472.","journal-title":"Front Bioeng Biotechnol"},{"key":"378_CR33","doi-asserted-by":"publisher","first-page":"0045","DOI":"10.1038\/s41551-017-0045","volume":"1","author":"A Guan","year":"2017","unstructured":"Guan A, Hamilton P, Wang Y, Gorbet M, Li Z, Phillips KS. Medical devices on chips. Nat Biomed Eng. 2017;1:0045.","journal-title":"Nat Biomed Eng"},{"key":"378_CR34","doi-asserted-by":"publisher","unstructured":"Pickering CR, Zhang J, Yoo SY, Bengtsson L, Moorthy S, Neskey DM, et al. Integrative genomic characterization of oral squamous cell carcinoma identifies frequent somatic drivers. Cancer discovery. Zhang J, Yoo SY, Malgerud L, Moorthy S, Neskey D, et al. Integrative Genomic Characterization of Oral Squamous Cell Carcinoma Identifies Frequent Somatic Drivers. Cancer Discov. 2013;3(7):770\u201381. https:\/\/doi.org\/10.1158\/2159-8290.CD-12-0537Pickering.","DOI":"10.1158\/2159-8290.CD-12-0537Pickering"},{"key":"378_CR35","doi-asserted-by":"publisher","first-page":"407","DOI":"10.3892\/ijo.2018.4661","volume":"54","author":"V Schirrmacher","year":"2019","unstructured":"Schirrmacher V. From chemotherapy to biological therapy: A review of novel concepts to reduce the side effects of systemic cancer treatment (Review). Int J Oncol. 2019;54:407\u201319.","journal-title":"Int J Oncol"},{"issue":"1","key":"378_CR36","first-page":"16","volume":"10","author":"S Liu","year":"2023","unstructured":"Liu S, Yu JM, Gan YC, Qiu XZ, Gao ZC, Wang H, et al. Biomimetic natural biomaterials for tissue engineering and regenerative medicine: new biosynthesis methods, recent advances, and emerging applications. Mil Med Res. 2023;10(1):16.","journal-title":"Mil Med Res"},{"issue":"1","key":"378_CR37","doi-asserted-by":"publisher","first-page":"7","DOI":"10.1186\/s12929-024-00994-y","volume":"31","author":"WH Abuwatfa","year":"2024","unstructured":"Abuwatfa WH, Pitt WG, Husseini GA. Scaffold-based 3D cell culture models in cancer research. J Biomed Sci. 2024;31(1):7.","journal-title":"J Biomed Sci"},{"key":"378_CR38","doi-asserted-by":"crossref","unstructured":"Chen Y, Dong X, Shafiq M, Myles G, Radacsi N, Mo X. Recent Advancements on Three-Dimensional Electrospun Nanofiber Scaffolds for Tissue Engineering. Adv Fiber Mater. 2022;4.Pages 1096\u2013109.","DOI":"10.1007\/s42765-022-00170-7"},{"key":"378_CR39","doi-asserted-by":"crossref","unstructured":"Fischer N, M\u00fcnchow E, Tamerler C, Bottino M, Aparicio C. Harnessing Biomolecules for Bioinspired Dental Biomaterials. J Mater Chem B. 2020;8.8713\u201347.","DOI":"10.1039\/D0TB01456G"},{"key":"378_CR40","doi-asserted-by":"crossref","unstructured":"Sivashankari PR, Prabaharan M. Prospects of chitosan-based scaffolds for growth factor release in tissue engineering. Int J Biol Macromol. 2016;93:1382\u20139.","DOI":"10.1016\/j.ijbiomac.2016.02.043"},{"key":"378_CR41","doi-asserted-by":"publisher","first-page":"1948","DOI":"10.3390\/cancers12071948","volume":"12","author":"A Cassoni","year":"2020","unstructured":"Cassoni A, Brauner E, Pucci R, Terenzi V, Mangini N, Battisti A, et al. Head and Neck Osteosarcoma\u2014The Ongoing Challenge about Reconstruction and Dental Rehabilitation. Cancers. 2020;12:1948.","journal-title":"Cancers"},{"issue":"3","key":"378_CR42","first-page":"666","volume":"6","author":"F Shang","year":"2021","unstructured":"Shang F, Yu Y, Liu S, Ming L, Zhang Y, Zhou Z, et al. Advancing application of mesenchymal stem cell-based bone tissue regeneration. Bioact Mater. 2021;6(3):666\u201383.","journal-title":"Bioact Mater"},{"issue":"1","key":"378_CR43","first-page":"1","volume":"4","author":"S Yousefiasl","year":"2023","unstructured":"Yousefiasl S, Sharifi E, Salahinejad E, Makvandi P, Irani S. Bioactive 3D-printed chitosan-based scaffolds for personalized craniofacial bone tissue engineering. Eng Regen. 2023;4(1):1\u201311.","journal-title":"Eng Regen"},{"key":"378_CR44","doi-asserted-by":"crossref","unstructured":"Gelin A, Masson-Meyers D, Amini F, Moharamzadeh K, Tayebi L. Collagen: The Superior Material for Full-Thickness Oral Mucosa Tissue Engineering. J Oral Biosci. 2024;66:511\u20138.","DOI":"10.1016\/j.job.2024.06.006"},{"key":"378_CR45","first-page":"16","volume":"23","author":"F Wang","year":"2023","unstructured":"Wang F, Cai X, Shen Y, Meng L. Cell\u2013scaffold interactions in tissue engineering for oral and craniofacial reconstruction. Bioact Mater. 2023;23:16\u201344.","journal-title":"Bioact Mater"},{"key":"378_CR46","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1007\/s00396-022-04997-9","volume":"300","author":"L Muthukrishnan","year":"2022","unstructured":"Muthukrishnan L. An overview on electrospinning and its advancement toward hard and soft tissue engineering applications. Colloid Polym Sci. 2022;300:1\u201327.","journal-title":"Colloid Polym Sci"},{"key":"378_CR47","doi-asserted-by":"publisher","first-page":"83","DOI":"10.1016\/B978-0-12-822476-2.00005-4","volume-title":"Biomedical applications of electrospinning and electrospraying","author":"A Aggarwal","year":"2021","unstructured":"Aggarwal A, Sah MK. Chapter three - electrospun materials as scaffolds in tissue engineering and regenerative medicine. In: Kasoju N, Ye H, editors. Biomedical applications of electrospinning and electrospraying. Woodhead Publishing; 2021. p. 83\u2013121."},{"issue":"9","key":"378_CR48","doi-asserted-by":"publisher","first-page":"897","DOI":"10.4252\/wjsc.v12.i9.897","volume":"12","author":"CL Granz","year":"2020","unstructured":"Granz CL, Gorji A. Dental stem cells: The role of biomaterials and scaffolds in developing novel therapeutic strategies. World J Stem Cells. 2020;12(9):897\u2013921.","journal-title":"World J Stem Cells"},{"issue":"5","key":"378_CR49","doi-asserted-by":"publisher","first-page":"785","DOI":"10.3892\/ol.2021.13046","volume":"22","author":"SK Lim","year":"2021","unstructured":"Lim SK, Khoo BY. An overview of mesenchymal stem cells and their potential therapeutic benefits in cancer therapy. Oncol Lett. 2021;22(5):785.","journal-title":"Oncol Lett"},{"key":"378_CR50","doi-asserted-by":"crossref","unstructured":"Zhao J, Zhou YH, Zhao YQ, Gao ZR, Ouyang ZY, Ye Q, et al. Oral cavity-derived stem cells and preclinical models of jaw-bone defects for bone tissue engineering. Stem Cell Res Ther. 2023;14.","DOI":"10.1186\/s13287-023-03265-z"},{"key":"378_CR51","doi-asserted-by":"crossref","unstructured":"Wertz PW, de Szalay S. Innate Antimicrobial Defense of Skin and Oral Mucosa. Antibiot Basel Switz. 2020;9(4).","DOI":"10.3390\/antibiotics9040159"},{"key":"378_CR52","doi-asserted-by":"publisher","first-page":"83","DOI":"10.1007\/5584_2022_734","volume":"1409","author":"A Tayanloo-Beik","year":"2023","unstructured":"Tayanloo-Beik A, Nikkhah A, Roudsari PP, Aghayan H, Rezaei-Tavirani M, Nasli-Esfahani E, et al. Application of Biocompatible Scaffolds in Stem-Cell-Based Dental Tissue Engineering. Adv Exp Med Biol. 2023;1409:83\u2013110.","journal-title":"Adv Exp Med Biol"},{"key":"378_CR53","doi-asserted-by":"crossref","unstructured":"Shamsian A, Sahebnasagh R, Norouzy A, Hussein S, Ghahremani M, Azizi Z. Cancer cells as a new source of induced pluripotent stem cells. Stem Cell Res Ther. 2022;13.","DOI":"10.1186\/s13287-022-03145-y"},{"issue":"1","key":"378_CR54","doi-asserted-by":"publisher","first-page":"158","DOI":"10.1186\/s12935-021-01836-9","volume":"21","author":"S Aravindhan","year":"2021","unstructured":"Aravindhan S, Ejam SS, Lafta MH, Markov A, Yumashev AV, Ahmadi M. Mesenchymal stem cells and cancer therapy: insights into targeting the tumour vasculature. Cancer Cell Int. 2021;21(1):158.","journal-title":"Cancer Cell Int"},{"key":"378_CR55","doi-asserted-by":"publisher","first-page":"30","DOI":"10.1016\/j.cytogfr.2024.01.004","volume":"76","author":"M Taheri","year":"2024","unstructured":"Taheri M, Tehrani HA, Dehghani S, Rajabzadeh A, Alibolandi M, Zamani N, et al. Signaling crosstalk between mesenchymal stem cells and tumor cells: implications for tumor suppression or progression. Cytokine Growth Factor Rev. 2024;76:30\u201347.","journal-title":"Cytokine Growth Factor Rev"},{"issue":"1","key":"378_CR56","doi-asserted-by":"publisher","first-page":"64","DOI":"10.1186\/s40164-024-00532-4","volume":"13","author":"Y Zhang","year":"2024","unstructured":"Zhang Y, Wang C, Li JJ. Revisiting the role of mesenchymal stromal cells in cancer initiation, metastasis and immunosuppression. Exp Hematol Oncol. 2024;13(1):64.","journal-title":"Exp Hematol Oncol"},{"key":"378_CR57","doi-asserted-by":"publisher","first-page":"102749","DOI":"10.1016\/j.ctrv.2024.102749","volume":"127","author":"SS Acharya","year":"2024","unstructured":"Acharya SS, Kundu CN. Havoc in harmony: unravelling the intricacies of angiogenesis orchestrated by the tumor microenvironment. Cancer Treat Rev. 2024;127:102749.","journal-title":"Cancer Treat Rev"},{"key":"378_CR58","doi-asserted-by":"crossref","unstructured":"\u0160terberov\u00e1 A, Dincu A, Oudshoorn S, van Duinen V, Cao L. Modeling iPSC-derived endothelial cell transition in tumor angiogenesis using Petri nets. arXiv. 2024;2403.06555.","DOI":"10.5220\/0012268800003657"},{"issue":"03","key":"378_CR59","doi-asserted-by":"publisher","first-page":"712","DOI":"10.1055\/s-0043-1776315","volume":"18","author":"M Shekatkar","year":"2024","unstructured":"Shekatkar M, Kheur S, Deshpande S, Sanap A, Kharat A, Navalakha S, et al. Angiogenic potential of various oral cavity-derived mesenchymal stem cells and cell-derived secretome: a systematic review and meta-analysis. Eur J Dent. 2024;18(03):712\u201342.","journal-title":"Eur J Dent"},{"issue":"1","key":"378_CR60","doi-asserted-by":"publisher","first-page":"449","DOI":"10.1186\/s13287-024-04061-z","volume":"15","author":"Q Li","year":"2024","unstructured":"Li Q, He G, Yu Y, Li X, Peng X, Yang L. Exosome crosstalk between cancer stem cells and tumor microenvironment: cancer progression and therapeutic strategies. Stem Cell Res Ther. 2024;15(1):449.","journal-title":"Stem Cell Res Ther"},{"issue":"1","key":"378_CR61","doi-asserted-by":"publisher","first-page":"296","DOI":"10.1186\/s12935-024-03476-1","volume":"24","author":"J Zhou","year":"2024","unstructured":"Zhou J, Liu X, Dong Q, Li J, Niu W, Liu T. Extracellular vesicle-bound VEGF in oral squamous cell carcinoma and its role in resistance to bevacizumab therapy. Cancer Cell Int. 2024;24(1):296.","journal-title":"Cancer Cell Int"},{"issue":"1","key":"378_CR62","doi-asserted-by":"publisher","first-page":"179","DOI":"10.1007\/s00018-024-05210-6","volume":"81","author":"Q Yan","year":"2024","unstructured":"Yan Q, Liu J, Liu Y, Wen Z, Jin D, Wang F, et al. Tumor-associated macrophage-derived exosomal miR21-5p promotes tumor angiogenesis by regulating YAP1\/HIF-1\u03b1 axis in head and neck squamous cell carcinoma. Cell Mol Life Sci. 2024;81(1):179.","journal-title":"Cell Mol Life Sci"},{"key":"378_CR63","doi-asserted-by":"publisher","first-page":"116725","DOI":"10.1016\/j.bcp.2024.116725","volume":"232","author":"Y Yu","year":"2025","unstructured":"Yu Y, Tao Y, Ma J, Li J, Song Z. Targeting the tumor microenvironment with mesenchymal stem cells based delivery approach for efficient delivery of anticancer agents: an updated review. Biochem Pharmacol. 2025;232:116725.","journal-title":"Biochem Pharmacol"},{"issue":"15","key":"378_CR64","doi-asserted-by":"publisher","first-page":"1294","DOI":"10.3390\/cells13151294","volume":"13","author":"S Pomella","year":"2024","unstructured":"Pomella S, Melaiu O, Dri M, Martelli M, Gargari M, Barillari G. Effects of angiogenic factors on the epithelial-to-mesenchymal transition and their impact on the onset and progression of oral squamous cell carcinoma: an overview. Cells. 2024;13(15):1294.","journal-title":"Cells"},{"issue":"6","key":"378_CR65","doi-asserted-by":"publisher","first-page":"464","DOI":"10.1038\/s41580-023-00697-6","volume":"25","author":"L Villiger","year":"2024","unstructured":"Villiger L, Joung J, Koblan L, Weissman J, Abudayyeh OO, Gootenberg JS. CRISPR technologies for genome, epigenome and transcriptome editing. Nat Rev Mol Cell Biol. 2024;25(6):464\u201387.","journal-title":"Nat Rev Mol Cell Biol"},{"issue":"25","key":"378_CR66","doi-asserted-by":"publisher","first-page":"2825","DOI":"10.1200\/JCO.21.01208","volume":"39","author":"V Mercadante","year":"2021","unstructured":"Mercadante V, Jensen SB, Smith DK, Bohlke K, Bauman J, Brennan MT, et al. Salivary Gland Hypofunction and\/or Xerostomia Induced by Nonsurgical Cancer Therapies: ISOO\/MASCC\/ASCO Guideline. J Clin Oncol Off J Am Soc Clin Oncol. 2021;39(25):2825\u201343.","journal-title":"J Clin Oncol Off J Am Soc Clin Oncol"},{"issue":"4","key":"378_CR67","doi-asserted-by":"publisher","first-page":"55","DOI":"10.1007\/s40135-024-00326-1","volume":"12","author":"AC Lieu","year":"2024","unstructured":"Lieu AC, Shoji MK, Aakalu VK, Liu CY. Approaches to Restoring Lacrimal Gland Function: From stem Cells to Tissue Engineering. Curr Ophthalmol Rep. 2024;12(4):55\u201362.","journal-title":"Curr Ophthalmol Rep"},{"issue":"23\u201324","key":"378_CR68","doi-asserted-by":"publisher","first-page":"1332","DOI":"10.1089\/ten.tea.2020.0184","volume":"26","author":"CML Barrows","year":"2020","unstructured":"Barrows CML, Wu D, Farach-Carson MC, Young S. Building a Functional Salivary Gland for Cell-Based Therapy: More than Secretory Epithelial Acini. Tissue Eng Part A. 2020;26(23\u201324):1332\u201348.","journal-title":"Tissue Eng Part A"},{"issue":"51","key":"378_CR69","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.adc8753","volume":"8","author":"J Li","year":"2022","unstructured":"Li J, Sudiwala S, Berthoin L, Mohabbat S, Gaylord EA, Sinada H, et al. Long-term functional regeneration of radiation-damaged salivary glands through delivery of a neurogenic hydrogel. Sci Adv. 2022;8(51):eadc8753.","journal-title":"Sci Adv"},{"key":"378_CR70","doi-asserted-by":"publisher","first-page":"76","DOI":"10.1016\/j.cobme.2017.05.004","volume":"2","author":"DJ Cornelissen","year":"2017","unstructured":"Cornelissen DJ, Faulkner-Jones A, Shu W (Will). Current developments in 3D bioprinting for tissue engineering. Curr Opin Biomed Eng. 2017;2:76\u201382.","journal-title":"Curr Opin Biomed Eng"},{"issue":"1","key":"378_CR71","doi-asserted-by":"publisher","first-page":"148","DOI":"10.1007\/s10439-016-1612-8","volume":"45","author":"YS Zhang","year":"2017","unstructured":"Zhang YS, Yue K, Aleman J, Moghaddam KM, Bakht SM, Yang J, et al. 3D Bioprinting for Tissue and Organ Fabrication. Ann Biomed Eng. 2017;45(1):148\u201363.","journal-title":"Ann Biomed Eng"},{"issue":"4","key":"378_CR72","doi-asserted-by":"publisher","first-page":"650","DOI":"10.1016\/j.jobcr.2020.08.011","volume":"10","author":"R Dwivedi","year":"2020","unstructured":"Dwivedi R, Mehrotra D. 3D bioprinting and craniofacial regeneration. J Oral Biol Craniofacial Res. 2020;10(4):650\u20139.","journal-title":"J Oral Biol Craniofacial Res"},{"issue":"3","key":"378_CR73","doi-asserted-by":"publisher","first-page":"035020","DOI":"10.1088\/1758-5090\/ab906e","volume":"12","author":"W Zhang","year":"2020","unstructured":"Zhang W, Shi W, Wu S, Kuss M, Jiang X, Untrauer JB, et al. 3D printed composite scaffolds with dual small molecule delivery for mandibular bone regeneration. Biofabrication. 2020;12(3):035020.","journal-title":"Biofabrication"},{"issue":"9","key":"378_CR74","doi-asserted-by":"publisher","first-page":"700","DOI":"10.1016\/j.tibtech.2016.04.001","volume":"34","author":"DO Visscher","year":"2016","unstructured":"Visscher DO, Farr\u00e9-Guasch E, Helder MN, Gibbs S, Forouzanfar T, van Zuijlen PP, et al. Advances in bioprinting technologies for craniofacial reconstruction. Trends Biotechnol. 2016;34(9):700\u201310.","journal-title":"Trends Biotechnol"},{"issue":"2","key":"378_CR75","first-page":"94","volume":"54","author":"JN Cormier","year":"2004","unstructured":"Cormier JN, Pollock RE. Soft tissue sarcomas. CA Cancer J Clin. 2004;54(2):94\u2013109.","journal-title":"CA Cancer J Clin"},{"issue":"3","key":"378_CR76","doi-asserted-by":"publisher","DOI":"10.1002\/cpz1.88","volume":"1","author":"M Madrid","year":"2021","unstructured":"Madrid M, Sumen C, Aivio S, Saklayen N. Autologous induced pluripotent stem cell-based cell therapies: promise, progress, and challenges. Curr Protoc. 2021;1(3):e88.","journal-title":"Curr Protoc"},{"issue":"10","key":"378_CR77","doi-asserted-by":"publisher","first-page":"2288","DOI":"10.1007\/s00268-012-1710-1","volume":"36","author":"VW Wong","year":"2012","unstructured":"Wong VW, Wan DC, Gurtner GC, Longaker MT. Regenerative surgery: tissue engineering in general surgical practice. World J Surg. 2012;36(10):2288\u201399.","journal-title":"World J Surg"},{"issue":"5S Suppl 3","key":"378_CR78","doi-asserted-by":"publisher","first-page":"S202","DOI":"10.1097\/SAP.0000000000002367","volume":"84","author":"A Abula","year":"2020","unstructured":"Abula A, Yushan M, Ren P, Abulaiti A, Ma C, Yusufu A. Reconstruction of soft tissue defects and bone loss in the tibia by flap transfer and bone transport by distraction osteogenesis: a case series and our experience. Ann Plast Surg. 2020;84(5S Suppl 3):S202\u20137.","journal-title":"Ann Plast Surg"},{"key":"378_CR79","doi-asserted-by":"publisher","first-page":"328","DOI":"10.1134\/S1990519X23040065","volume":"17","author":"O Payushina","year":"2023","unstructured":"Payushina O, Tsomartova D, Chereshneva Y, Ivanova M, Lomanovskaya T, Pavlova M, et al. Activation of endogenous mesenchymal stromal cells as an approach to tissue regeneration. Cell Tissue Biol. 2023;17:328\u201338.","journal-title":"Cell Tissue Biol"},{"key":"378_CR80","doi-asserted-by":"crossref","unstructured":"Gundu S, Varshney N, Sahi A, Mahto S. Recent developments of biomaterial scaffolds and regenerative approaches for craniomaxillofacial bone tissue engineering. J Polym Res. 2022;29.","DOI":"10.1007\/s10965-022-02928-4"},{"issue":"1","key":"378_CR81","doi-asserted-by":"publisher","DOI":"10.1038\/s41368-023-00224-5","volume":"15","author":"M Marinkovic","year":"2023","unstructured":"Marinkovic M, Tran ON, Wang H, Abdul-Azees P, Dean DD, Chen XD, et al. Autologous mesenchymal stem cells offer a new paradigm for salivary gland regeneration. Int J Oral Sci. 2023;15(1):18.","journal-title":"Int J Oral Sci"},{"key":"378_CR82","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2021.120908","volume":"275","author":"Z Jiang","year":"2021","unstructured":"Jiang Z, Li N, Zhu D, Ren L, Shao Q, Yu K, et al. Genetically modified cell sheets in regenerative medicine and tissue engineering. Biomaterials. 2021;275:120908.","journal-title":"Biomaterials"},{"issue":"1","key":"378_CR83","doi-asserted-by":"publisher","first-page":"41","DOI":"10.1007\/s11845-020-02264-w","volume":"190","author":"C Hayes","year":"2021","unstructured":"Hayes C. Cellular immunotherapies for cancer. Ir J Med Sci. 2021;190(1):41\u201357.","journal-title":"Ir J Med Sci"},{"issue":"7","key":"378_CR84","doi-asserted-by":"publisher","first-page":"1745","DOI":"10.1016\/j.bmcl.2016.02.047","volume":"26","author":"M Ngu-Schwemlein","year":"2016","unstructured":"Ngu-Schwemlein M, Chin SF, Hileman R, Drozdowski C, Upchurch C, Hargrove R. Carbon nanodots as molecular scaffolds for development of antimicrobial agents. Bioorg Med Chem Lett. 2016;26(7):1745\u20139.","journal-title":"Bioorg Med Chem Lett"},{"issue":"1","key":"378_CR85","first-page":"23","volume":"22","author":"A Hassanzadeh","year":"2022","unstructured":"Hassanzadeh A, Shamlou S, Yousefi N, Nikoo M, Verdi J. Genetically-modified Stem Cell in Regenerative Medicine and Cancer Therapy. A New Era Curr Gene Ther. 2022;22(1):23\u201339.","journal-title":"A New Era Curr Gene Ther"},{"issue":"2","key":"378_CR86","doi-asserted-by":"publisher","first-page":"788","DOI":"10.7150\/thno.90492","volume":"14","author":"H Wang","year":"2024","unstructured":"Wang H, Ning X, Zhao F, Zhao H, Li D. Human organoids-on-chips for biomedical research and applications. Theranostics. 2024;14(2):788\u2013818.","journal-title":"Theranostics"},{"issue":"507","key":"378_CR87","doi-asserted-by":"publisher","first-page":"55","DOI":"10.1016\/j.canlet.2021.03.009","volume":"1","author":"G Wang","year":"2021","unstructured":"Wang G, Zhang M, Cheng M, Wang X, Li K, Chen J, et al. Tumor microenvironment in head and neck squamous cell carcinoma: Functions and regulatory mechanisms. Cancer Lett. 2021;1(507):55\u201369.","journal-title":"Cancer Lett"},{"issue":"2","key":"378_CR88","doi-asserted-by":"publisher","first-page":"103","DOI":"10.4274\/tao.2021.2021-1-9","volume":"59","author":"B Ba\u015faran","year":"2021","unstructured":"Ba\u015faran B, \u00dcnsaler S, Kesimli MC, Aslan \u0130. Free Flap Reconstruction of the Head and Neck Region: A Series of 127 Flaps Performed by Otolaryngologists. Turk Arch Otorhinolaryngol. 2021;59(2):103\u201310.","journal-title":"Turk Arch Otorhinolaryngol"},{"issue":"3","key":"378_CR89","doi-asserted-by":"publisher","first-page":"150","DOI":"10.3892\/or.2022.8362","volume":"48","author":"N Dwivedi","year":"2022","unstructured":"Dwivedi N, Gangadharan C, Pillai V, Kuriakose MA, Suresh A, Das M. Establishment and characterization of novel autologous pair cell lines from two Indian non-habitual tongue carcinoma patients. Oncol Rep. 2022;48(3):150.","journal-title":"Oncol Rep"},{"key":"378_CR90","doi-asserted-by":"publisher","first-page":"1203071","DOI":"10.3389\/fimmu.2023.1203071","volume":"14","author":"H Jiang","year":"2023","unstructured":"Jiang H, Dong Z, Xia X, Li X. Cathepsins in oral diseases: mechanisms and therapeutic implications. Front Immunol. 2023;14:1203071.","journal-title":"Front Immunol"},{"issue":"1","key":"378_CR91","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1038\/s41368-021-00113-9","volume":"13","author":"B Tan","year":"2021","unstructured":"Tan B, Tang Q, Zhong Y, Wei Y, He L, Wu Y, et al. Biomaterial-based strategies for maxillofacial tumour therapy and bone defect regeneration. Int J Oral Sci. 2021;13(1):9.","journal-title":"Int J Oral Sci"},{"key":"378_CR92","doi-asserted-by":"crossref","unstructured":"Mijiritsky E, Assaf HD, Kolerman R, Mangani L, Ivanova V, Zlatev S. Autologous Platelet Concentrates (APCs) for hard tissue regeneration in oral implantology, sinus floor elevation, peri-implantitis, socket preservation, and medication-related osteonecrosis of the jaw (mronj): a literature review. Biology. 2022;11(9).","DOI":"10.3390\/biology11091254"},{"issue":"10","key":"378_CR93","first-page":"3137","volume":"8","author":"TE Reichert","year":"2002","unstructured":"Reichert TE, Strauss L, Wagner EM, Gooding W, Whiteside TL. Signaling abnormalities, apoptosis, and reduced proliferation of circulating and tumor-infiltrating lymphocytes in patients with oral carcinoma. Clin Cancer Res Off J Am Assoc Cancer Res. 2002;8(10):3137\u201345.","journal-title":"Clin Cancer Res Off J Am Assoc Cancer Res"},{"issue":"3","key":"378_CR94","doi-asserted-by":"publisher","first-page":"222","DOI":"10.1097\/00002820-200306000-00008","volume":"26","author":"A Shih","year":"2003","unstructured":"Shih A, Miaskowski C, Dodd MJ, Stotts NA, MacPhail L. Mechanisms for radiation-induced oral mucositis and the consequences. Cancer Nurs. 2003;26(3):222\u20139.","journal-title":"Cancer Nurs"},{"issue":"Suppl 1","key":"378_CR95","doi-asserted-by":"publisher","first-page":"S394","DOI":"10.4103\/jpbs.JPBS_116_20","volume":"12","author":"PP Panicker","year":"2020","unstructured":"Panicker PP, Mohan SP, Nallusamy J, Lakshmi SJ, Johny J, Bhaskaran MK. Reconstruction of Craniofacial Bone Defects with Autologous Human Bone Marrow Stem Cells and Autogenous Bone Grafts: A Case Report with Review of Literature. J Pharm Bioallied Sci. 2020;12(Suppl 1):S394\u20138.","journal-title":"J Pharm Bioallied Sci"},{"key":"378_CR96","doi-asserted-by":"crossref","unstructured":"Venkatesiah SS, Augustine D, Mishra D, Gujjar N, Haragannavar VC, Awan KH, et al. Immunology of oral squamous cell carcinoma-a comprehensive insight with recent concepts. Life Basel Switz. 2022;12(11).","DOI":"10.3390\/life12111807"},{"issue":"5","key":"378_CR97","doi-asserted-by":"publisher","first-page":"6606","DOI":"10.1021\/acsami.0c19892","volume":"13","author":"SH Han","year":"2021","unstructured":"Han SH, Kim SI, Lee HR, Lim SM, Yeon SY, Oh MA, et al. Hydrogel-based iontronics on a polydimethylsiloxane microchip. ACS Appl Mater Interfaces. 2021;13(5):6606\u201314.","journal-title":"ACS Appl Mater Interfaces"},{"issue":"5","key":"378_CR98","doi-asserted-by":"publisher","first-page":"432","DOI":"10.1007\/s13238-018-0547-2","volume":"9","author":"M Doestzada","year":"2018","unstructured":"Doestzada M, Vila AV, Zhernakova A, Koonen DPY, Weersma RK, Touw DJ, et al. Pharmacomicrobiomics: a novel route towards personalized medicine? Protein Cell. 2018;9(5):432\u201345.","journal-title":"Protein Cell"},{"issue":"1","key":"378_CR99","doi-asserted-by":"publisher","DOI":"10.1186\/s12943-016-0512-8","volume":"15","author":"M Manikandan","year":"2016","unstructured":"Manikandan M, Deva Magendhra Rao AK, Arunkumar G, Manickavasagam M, Rajkumar KS, Rajaraman R, et al. Oral squamous cell carcinoma: microRNA expression profiling and integrative analyses for elucidation of tumourigenesis mechanism. Mol Cancer. 2016;15(1):28.","journal-title":"Mol Cancer"},{"issue":"2","key":"378_CR100","doi-asserted-by":"publisher","first-page":"1773","DOI":"10.1007\/s11033-020-06054-6","volume":"48","author":"M Mughees","year":"2021","unstructured":"Mughees M, Sengupta A, Khowal S, Wajid S. Mechanism of tumour microenvironment in the progression and development of oral cancer. Mol Biol Rep. 2021;48(2):1773\u201386.","journal-title":"Mol Biol Rep"},{"issue":"8","key":"378_CR101","doi-asserted-by":"publisher","first-page":"1720","DOI":"10.1016\/j.molonc.2015.05.005","volume":"9","author":"G Srivastava","year":"2015","unstructured":"Srivastava G, Matta A, Fu G, Somasundaram RT, Datti A, Walfish PG, et al. Anticancer activity of pyrithione zinc in oral cancer cells identified in small molecule screens and xenograft model: Implications for oral cancer therapy. Mol Oncol. 2015;9(8):1720\u201335.","journal-title":"Mol Oncol"},{"issue":"2","key":"378_CR102","doi-asserted-by":"publisher","first-page":"262","DOI":"10.1016\/j.tranon.2019.11.008","volume":"13","author":"F Perri","year":"2020","unstructured":"Perri F, Ionna F, Longo F, Della Vittoria Scarpati G, De Angelis C, Ottaiano A, et al. Immune Response Against Head and Neck Cancer: Biological Mechanisms and Implication on Therapy. Transl Oncol. 2020;13(2):262\u201374.","journal-title":"Transl Oncol"},{"key":"378_CR103","doi-asserted-by":"crossref","unstructured":"Hegab A. The cutting edge in oral and maxillofacial surgery. J Oral Hyg Health. 2015;3(184):2332\u20130702.","DOI":"10.4172\/2332-0702.1000184"},{"issue":"1","key":"378_CR104","doi-asserted-by":"publisher","first-page":"14","DOI":"10.1186\/s13036-019-0144-9","volume":"13","author":"A Grath","year":"2019","unstructured":"Grath A, Dai G. Direct cell reprogramming for tissue engineering and regenerative medicine. J Biol Eng. 2019;13(1):14.","journal-title":"J Biol Eng"},{"issue":"9","key":"378_CR105","first-page":"11884","volume":"8","author":"C Rivera","year":"2015","unstructured":"Rivera C. Essentials of oral cancer. Int J Clin Exp Pathol. 2015;8(9):11884\u201394.","journal-title":"Int J Clin Exp Pathol"},{"issue":"7","key":"378_CR106","doi-asserted-by":"publisher","first-page":"777","DOI":"10.1038\/s41565-022-01122-3","volume":"17","author":"D Zhang","year":"2022","unstructured":"Zhang D, Wang G, Yu X, Wei T, Farbiak L, Johnson LT, et al. Enhancing CRISPR\/Cas gene editing through modulating cellular mechanical properties for cancer therapy. Nat Nanotechnol. 2022;17(7):777\u201387.","journal-title":"Nat Nanotechnol"},{"issue":"1","key":"378_CR107","doi-asserted-by":"publisher","first-page":"126","DOI":"10.1186\/s12943-021-01431-6","volume":"20","author":"H Zhang","year":"2021","unstructured":"Zhang H, Qin C, An C, Zheng X, Wen S, Chen W, et al. Application of the CRISPR\/Cas9-based gene editing technique in basic research, diagnosis, and therapy of cancer. Mol Cancer. 2021;20(1):126.","journal-title":"Mol Cancer"},{"issue":"11","key":"378_CR108","doi-asserted-by":"publisher","first-page":"100840","DOI":"10.1016\/j.tranon.2020.100840","volume":"13","author":"C Liu","year":"2020","unstructured":"Liu C, Qin T, Huang Y, Li Y, Chen G, Sun C. Drug screening model meets cancer organoid technology. Transl Oncol. 2020;13(11):100840.","journal-title":"Transl Oncol"},{"issue":"1","key":"378_CR109","doi-asserted-by":"publisher","first-page":"14","DOI":"10.1177\/154405910808700104","volume":"87","author":"S Choi","year":"2008","unstructured":"Choi S, Myers JN. Molecular pathogenesis of oral squamous cell carcinoma: implications for therapy. J Dent Res. 2008;87(1):14\u201332.","journal-title":"J Dent Res"},{"key":"378_CR110","doi-asserted-by":"publisher","first-page":"39","DOI":"10.1186\/s13036-019-0170-7","volume":"13","author":"CP Healy","year":"2019","unstructured":"Healy CP, Deans TL. Genetic circuits to engineer tissues with alternative functions. J Biol Eng. 2019;13:39.","journal-title":"J Biol Eng"},{"issue":"32","key":"378_CR111","doi-asserted-by":"publisher","first-page":"52541","DOI":"10.18632\/oncotarget.9646","volume":"7","author":"FA Khan","year":"2016","unstructured":"Khan FA, Pandupuspitasari NS, Chun-Jie H, Ao Z, Jamal M, Zohaib A, et al. CRISPR\/Cas9 therapeutics: a cure for cancer and other genetic diseases. Oncotarget. 2016;7(32):52541\u201352.","journal-title":"Oncotarget"},{"issue":"1","key":"378_CR112","doi-asserted-by":"publisher","first-page":"37","DOI":"10.1186\/s13005-024-00437-x","volume":"20","author":"M Geyer","year":"2024","unstructured":"Geyer M, Geyer F, Reuning U, Klapproth S, Wolff KD, Nieberler M. CRISPR\/Cas9-mediated knock out of ITGB6 in human OSCC cells reduced migration and proliferation ability. Head Face Med. 2024;20(1):37.","journal-title":"Head Face Med"},{"issue":"9","key":"378_CR113","doi-asserted-by":"publisher","first-page":"810","DOI":"10.1038\/ncb0904-810","volume":"6","author":"J Pomerantz","year":"2004","unstructured":"Pomerantz J, Blau HM. Nuclear reprogramming: a key to stem cell function in regenerative medicine. Nat Cell Biol. 2004;6(9):810\u20136.","journal-title":"Nat Cell Biol"},{"issue":"2","key":"378_CR114","first-page":"132","volume":"22","author":"NG Shah","year":"2007","unstructured":"Shah NG, Trivedi TI, Tankshali RA, Goswami JA, Shah JS, Jetly DH, et al. Molecular alterations in oral carcinogenesis: significant risk predictors in malignant transformation and tumor progression. Int J Biol Markers. 2007;22(2):132\u201343.","journal-title":"Int J Biol Markers"},{"issue":"7","key":"378_CR115","doi-asserted-by":"publisher","first-page":"653","DOI":"10.1016\/j.tibtech.2018.01.014","volume":"36","author":"S Chira","year":"2018","unstructured":"Chira S, Gulei D, Hajitou A, Berindan-Neagoe I. Restoring the p53 \u201cguardian\u201d phenotype in p53-deficient tumor cells with CRISPR\/Cas9. Trends Biotechnol. 2018;36(7):653\u201360.","journal-title":"Trends Biotechnol"},{"key":"378_CR116","doi-asserted-by":"crossref","unstructured":"Kinouchi M, Izumi S, Nakashiro KI, Haruyama Y, Kobashi G, Uchida D, et al. Determination of the origin of oral squamous cell carcinoma by microarray analysis: Squamous epithelium or minor salivary gland?: Oral SCC originating from minor salivary glands. Int J Cancer. 2018;143.2551\u201360.","DOI":"10.1002\/ijc.31811"},{"issue":"1\u20132","key":"378_CR117","doi-asserted-by":"publisher","first-page":"79","DOI":"10.1038\/sj.bjc.6690505","volume":"80","author":"M Sartor","year":"1999","unstructured":"Sartor M, Steingrimsdottir H, Elamin F, G\u00e4ken J, Warnakulasuriya S, Partridge M, et al. Role of p16\/MTS1, cyclin D1 and RB in primary oral cancer and oral cancer cell lines. Br J Cancer. 1999;80(1\u20132):79\u201386.","journal-title":"Br J Cancer"},{"issue":"3","key":"378_CR118","first-page":"453","volume":"19","author":"S Hamid","year":"2007","unstructured":"Hamid S, Lim KP, Zain RB, Ismail SM, Lau SH, Mustafa WMW, et al. Establishment and characterization of Asian oral cancer cell lines as in vitro models to study a disease prevalent in Asia. Int J Mol Med. 2007;19(3):453\u201360.","journal-title":"Int J Mol Med"},{"issue":"5","key":"378_CR119","doi-asserted-by":"publisher","first-page":"379","DOI":"10.1038\/emm.2005.48","volume":"37","author":"EJ Lee","year":"2005","unstructured":"Lee EJ, Kim J, Lee SA, Kim EJ, Chun YC, Ryu MH, et al. Characterization of newly established oral cancer cell lines derived from six squamous cell carcinoma and two mucoepidermoid carcinoma cells. Exp Mol Med. 2005;37(5):379\u201390.","journal-title":"Exp Mol Med"},{"issue":"5","key":"378_CR120","doi-asserted-by":"publisher","first-page":"254","DOI":"10.1016\/j.micres.2012.12.007","volume":"168","author":"YH Shih","year":"2013","unstructured":"Shih YH, Chang KW, Hsia SM, Yu CC, Fuh LJ, Chi TY, et al. In vitro antimicrobial and anticancer potential of hinokitiol against oral pathogens and oral cancer cell lines. Microbiol Res. 2013;168(5):254\u201362.","journal-title":"Microbiol Res"},{"issue":"11","key":"378_CR121","doi-asserted-by":"publisher","first-page":"e204","DOI":"10.1016\/j.oraloncology.2009.06.001","volume":"45","author":"L Jiang","year":"2009","unstructured":"Jiang L, Ji N, Zhou Y, Li J, Liu X, Wang Z, et al. CAL 27 is an oral adenosquamous carcinoma cell line. Oral Oncol. 2009;45(11):e204.","journal-title":"Oral Oncol"},{"issue":"5","key":"378_CR122","doi-asserted-by":"publisher","first-page":"461","DOI":"10.1016\/j.oraloncology.2003.09.012","volume":"40","author":"S Hsu","year":"2004","unstructured":"Hsu S, Singh B, Schuster G. Induction of apoptosis in oral cancer cells: agents and mechanisms for potential therapy and prevention. Oral Oncol. 2004;40(5):461\u201373.","journal-title":"Oral Oncol"},{"key":"378_CR123","doi-asserted-by":"publisher","first-page":"23","DOI":"10.1016\/j.oraloncology.2017.05.004","volume":"70","author":"J Ali","year":"2017","unstructured":"Ali J, Sabiha B, Jan HU, Haider SA, Khan AA, Ali SS. Genetic etiology of oral cancer. Oral Oncol. 2017;70:23\u20138.","journal-title":"Oral Oncol"},{"key":"378_CR124","doi-asserted-by":"crossref","unstructured":"Saka-Herr\u00e1n C, Jan\u00e9-Salas E, Mari-Roig A, Estrugo-Devesa A, L\u00f3pez-L\u00f3pez J. Time-to-treatment in oral cancer: causes and implications for survival. Cancers. 2021;13(6).","DOI":"10.3390\/cancers13061321"},{"issue":"1","key":"378_CR125","doi-asserted-by":"publisher","DOI":"10.1186\/s12935-020-01192-0","volume":"20","author":"G Baniebrahimi","year":"2020","unstructured":"Baniebrahimi G, Mir F, Khanmohammadi R. Cancer stem cells and oral cancer: insights into molecular mechanisms and therapeutic approaches. Cancer Cell Int. 2020;20(1):113.","journal-title":"Cancer Cell Int"},{"key":"378_CR126","doi-asserted-by":"publisher","unstructured":"Khan SU, Fatima K, Aisha S, Malik F. Unveiling the mechanisms and challenges of cancer drug resistance. Cell communication and signaling: CCS. the mechanisms and challenges of cancer drug resistance. England; 2024;22(1):109. https:\/\/doi.org\/10.1186\/s12964-023-01302-1Unveiling.","DOI":"10.1186\/s12964-023-01302-1Unveiling"},{"issue":"2","key":"378_CR127","doi-asserted-by":"publisher","first-page":"346","DOI":"10.1200\/JCO.2005.09.128","volume":"23","author":"SM Lippman","year":"2005","unstructured":"Lippman SM, Sudb\u00f8 J, Hong WK. Oral cancer prevention and the evolution of molecular-targeted drug development. J Clin Oncol Off J Am Soc Clin Oncol. 2005;23(2):346\u201356.","journal-title":"J Clin Oncol Off J Am Soc Clin Oncol"},{"issue":"25","key":"378_CR128","doi-asserted-by":"publisher","first-page":"2552","DOI":"10.1056\/NEJMoa073770","volume":"357","author":"ML Poeta","year":"2007","unstructured":"Poeta ML, Manola J, Goldwasser MA, Forastiere A, Benoit N, Califano JA, et al. TP53 mutations and survival in squamous-cell carcinoma of the head and neck. N Engl J Med. 2007;357(25):2552\u201361.","journal-title":"N Engl J Med"},{"issue":"4","key":"378_CR129","doi-asserted-by":"publisher","first-page":"612","DOI":"10.1200\/JCO.2007.14.1713","volume":"26","author":"AK Chaturvedi","year":"2008","unstructured":"Chaturvedi AK, Engels EA, Anderson WF, Gillison ML. Incidence Trends for Human Papillomavirus-Related and \u2013Unrelated Oral Squamous Cell Carcinomas in the United States. J Clin Oncol. 2008;26(4):612\u20139.","journal-title":"J Clin Oncol"},{"key":"378_CR130","doi-asserted-by":"publisher","DOI":"10.1016\/j.matdes.2024.112886","volume":"241","author":"H Xu","year":"2024","unstructured":"Xu H, Zhang Y, Zhang Y, Zhao Z, Xue T, Wang J, et al. 3D bioprinting advanced biomaterials for craniofacial and dental tissue engineering: a review. Mater Des. 2024;241:112886.","journal-title":"Mater Des"},{"key":"378_CR131","doi-asserted-by":"publisher","DOI":"10.1016\/j.bprint.2024.e00381","volume":"45","author":"A Chaurasia","year":"2025","unstructured":"Chaurasia A, Sivaramakrishnan G, Asa\u2019ad F, Larsson L, Daghrery A, Marques J, et al. Modeling of oral squamous cell carcinoma microenvironment-a 3D bioprinting approach. Bioprinting. 2025;45:e00381.","journal-title":"Bioprinting"},{"issue":"4","key":"378_CR132","doi-asserted-by":"publisher","first-page":"1113","DOI":"10.1007\/s13402-024-00935-9","volume":"47","author":"Z Zhang","year":"2024","unstructured":"Zhang Z, Chen X, Gao S, Fang X, Ren S. 3D bioprinted tumor model: a prompt and convenient platform for overcoming immunotherapy resistance by recapitulating the tumor microenvironment. Cell Oncol (Dordr). 2024;47(4):1113\u201326.","journal-title":"Cell Oncol (Dordr)"},{"issue":"1","key":"378_CR133","doi-asserted-by":"publisher","first-page":"e2384662","DOI":"10.1080\/17452759.2024.2384662","volume":"19","author":"X Sun","year":"2024","unstructured":"Sun X, Ren W, Xie L, Ren Q, Zhu Z, Jia Q, et al. Recent advances in 3D bioprinting of tissues and organs for transplantation and drug screening. Virtual Phys Prototyp. 2024;19(1):e2384662.","journal-title":"Virtual Phys Prototyp"},{"issue":"10","key":"378_CR134","doi-asserted-by":"publisher","first-page":"5414","DOI":"10.3390\/ijms25105414","volume":"25","author":"A Angelopoulou","year":"2024","unstructured":"Angelopoulou A. Nanostructured biomaterials in 3D tumor tissue engineering scaffolds: regenerative medicine and immunotherapies. Int J Mol Sci. 2024;25(10):5414.","journal-title":"Int J Mol Sci"},{"issue":"7","key":"378_CR135","doi-asserted-by":"publisher","first-page":"4145","DOI":"10.1021\/acsbiomaterials.4c00166","volume":"10","author":"DK Chandra","year":"2024","unstructured":"Chandra DK, Reis RL, Kundu SC, Kumar A, Mahapatra C. Nanomaterials-based hybrid bioink platforms in advancing 3D bioprinting technologies for regenerative medicine. ACS Biomater Sci Eng. 2024;10(7):4145\u201374.","journal-title":"ACS Biomater Sci Eng"},{"issue":"44","key":"378_CR136","doi-asserted-by":"publisher","first-page":"44076","DOI":"10.1021\/acsomega.4c06051","volume":"9","author":"J Yang","year":"2024","unstructured":"Yang J, Wang L, Wu R, He Y, Zhao Y, Wang W, et al. 3D bioprinting in cancer modeling and biomedicine: from print categories to biological applications. ACS Omega. 2024;9(44):44076\u2013100.","journal-title":"ACS Omega"},{"issue":"8","key":"378_CR137","doi-asserted-by":"publisher","first-page":"777","DOI":"10.3390\/bioengineering11080777","volume":"11","author":"NA Mirsky","year":"2024","unstructured":"Mirsky NA, Ehlen QT, Greenfield JA, Antonietti M, Slavin BV, Nayak VV, et al. Three-dimensional bioprinting: a comprehensive review for applications in tissue engineering and regenerative medicine. Bioengineering. 2024;11(8):777.","journal-title":"Bioengineering"},{"issue":"1","key":"378_CR138","doi-asserted-by":"publisher","first-page":"e2419411","DOI":"10.1080\/17452759.2024.2419411","volume":"19","author":"S D\u2019Alessandro","year":"2024","unstructured":"D\u2019Alessandro S, Mohammadi S, Iafrate L, Bastioli M, Marcotulli M, Franco S, et al. Hybrid 3D microfluidic bioprinting for the engineering of cancer models and tissue substitutes. Virtual Phys Prototyp. 2024;19(1):e2419411.","journal-title":"Virtual Phys Prototyp"},{"key":"378_CR139","first-page":"100777","volume":"58","author":"Z Su","year":"2021","unstructured":"Su Z, Dong S, Zhao SC, Liu K, Tan Y, Jiang X, et al. Novel nanomedicines to overcome cancer multidrug resistance. Drug Resist Updat Rev Comment Antimicrob Anticancer Chemother. 2021;58:100777.","journal-title":"Drug Resist Updat Rev Comment Antimicrob Anticancer Chemother"},{"issue":"6","key":"378_CR140","doi-asserted-by":"publisher","first-page":"70","DOI":"10.3892\/ijo.2022.5360","volume":"60","author":"T Tan","year":"2022","unstructured":"Tan T, Shi P, Abbas MN, Wang Y, Xu J, Chen Y, et al. Epigenetic modification regulates tumor progression and metastasis through EMT (review). Int J Oncol. 2022;60(6):70.","journal-title":"Int J Oncol"},{"issue":"2","key":"378_CR141","doi-asserted-by":"publisher","first-page":"1954","DOI":"10.3390\/curroncol30020152","volume":"30","author":"AA Rabaan","year":"2023","unstructured":"Rabaan AA, AlSaihati H, Bukhamsin R, Bakhrebah MA, Nassar MS, Alsaleh AA, et al. Application of CRISPR\/Cas9 technology in cancer treatment: a future direction. Curr Oncol. 2023;30(2):1954\u201376.","journal-title":"Curr Oncol"},{"key":"378_CR142","doi-asserted-by":"publisher","first-page":"441","DOI":"10.1016\/j.semcancer.2021.06.023","volume":"83","author":"S Hussain","year":"2022","unstructured":"Hussain S, Tulsyan S, Dar SA, Sisodiya S, Abiha U, Kumar R, et al. Role of epigenetics in carcinogenesis: recent advancements in anticancer therapy. Semin Cancer Biol. 2022;83:441\u201351.","journal-title":"Semin Cancer Biol"}],"container-title":["Journal of the Egyptian National Cancer Institute"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s43046-026-00378-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s43046-026-00378-3","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s43046-026-00378-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,22]],"date-time":"2026-06-22T16:03:48Z","timestamp":1782144228000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1186\/s43046-026-00378-3"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6,22]]},"references-count":142,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2026,12]]}},"alternative-id":["378"],"URL":"https:\/\/doi.org\/10.1186\/s43046-026-00378-3","relation":{},"ISSN":["2589-0409"],"issn-type":[{"value":"2589-0409","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,6,22]]},"assertion":[{"value":"2 April 2026","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"9 June 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"22 June 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Not applicable.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"37"}}