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This review begins with a brief introduction to m\n                    <jats:sup>6<\/jats:sup>\n                    A modification, with a particular focus on its dynamic variability in distinct malignancies and clinical staging scenarios. Moreover, we underscore the critical functions of m\n                    <jats:sup>6<\/jats:sup>\n                    A methylation in cancer biology, including cancer-related molecular networks, cancer hallmarks, cancer stem cells, and the tumor microenvironment. We further outline the implications of m\n                    <jats:sup>6<\/jats:sup>\n                    A dysregulation in cancer, emphasizing the diagnostic potential of m\n                    <jats:sup>6<\/jats:sup>\n                    A regulators, the prognostic value of m\n                    <jats:sup>6<\/jats:sup>\n                    A, and the role of m\n                    <jats:sup>6<\/jats:sup>\n                    A in treatment resistance. Additionally, we analyze the potential of m\n                    <jats:sup>6<\/jats:sup>\n                    A modification in cancer therapy, encompassing the use of m\n                    <jats:sup>6<\/jats:sup>\n                    A inhibitors, combinations with existing cancer therapies, and personalized medicine approaches. Finally, we dissect the current limitations and future directions in m\n                    <jats:sup>6<\/jats:sup>\n                    A modification research, directing resources toward the development of high-throughput platforms for the dynamic monitoring of m\n                    <jats:sup>6<\/jats:sup>\n                    A modification in living systems. Overall, this review reinforces the central significance of m\n                    <jats:sup>6<\/jats:sup>\n                    A modification in cancer biology, emphasizing its transformative capacity to reshape cancer diagnostic paradigms and therapeutic intervention strategies.\n                  <\/jats:p>","DOI":"10.1186\/s43556-025-00314-2","type":"journal-article","created":{"date-parts":[[2025,9,23]],"date-time":"2025-09-23T03:41:10Z","timestamp":1758598870000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["The m6A modification in cancer: roles, implications, and its potential in therapy"],"prefix":"10.1186","volume":"6","author":[{"given":"Yuyao","family":"Wei","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yang","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chun","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mengling","family":"Yuan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuqi","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mengran","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zili","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mei","family":"Guo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,9,23]]},"reference":[{"key":"314_CR1","doi-asserted-by":"publisher","first-page":"20","DOI":"10.1038\/s41564-024-01889-2","volume":"10","author":"H Vaysset","year":"2025","unstructured":"Vaysset H, Meers C, Cury J, Bernheim A, Sternberg SH. 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