{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T20:48:35Z","timestamp":1792788515287,"version":"4.5.0"},"reference-count":71,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T00:00:00Z","timestamp":1791849600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T00:00:00Z","timestamp":1791849600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["12032003"],"award-info":[{"award-number":["12032003"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["12302409"],"award-info":[{"award-number":["12302409"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82074380"],"award-info":[{"award-number":["82074380"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82174201"],"award-info":[{"award-number":["82174201"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Shanghai Jiao Tong University Medical-Engineering Interdisciplinary Research Fund","award":["YG2025QNB36"],"award-info":[{"award-number":["YG2025QNB36"]}],"id":[{"id":"https:\/\/ror.org\/0220qvk04","id-type":"ROR","asserted-by":"crossref"}]},{"name":"Shaanxi Provincial Department of Science and Technology's Basic Research Program","award":["2023-JC-QN-0853"],"award-info":[{"award-number":["2023-JC-QN-0853"]}],"id":[{"id":"https:\/\/ror.org\/03rbw2w25","id-type":"ROR","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Mol Biomed"],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Aberrant cyclic stretch serves as a critical driver of vascular remodeling in hypertension, yet the underlying molecular mechanisms remain largely unknown. Here, we studied the role of a novel circRNA, termed circ_2465 (circLyst), in vascular remodeling in both human and rodent samples under high cyclic stretch. Next-generation sequencing data revealed that 165 circRNAs were differentially expressed in the thoracic aortas of spontaneously hypertensive rats (SHRs) compared with normotensive Wistar\u2013Kyoto rats (WKYs), of which 60 circRNAs were significantly upregulated while 105 circRNAs were significantly downregulated. CircLyst, verified as a novel circRNA by ribonuclease R (RNase R) digestion and Actinomycin D assays, was induced in the thoracic aortas of SHRs and stably located in the cytoplasm as detected by fluorescence in situ hybridization (FISH). This elevation was confirmed in hypertensive patients and was recapitulated in vascular smooth muscle cells (VSMCs) exposed to high cyclic stretch in vitro. Mechanistically, oxidative stress, mediated by NADPH oxidases NOX1 and NOX4, induced circLyst expression. CircLyst then functioned as a sponge for miR-298-5p, derepressing its target gene Col23a1, thereby promoting VSMC proliferation and migration\u2014key events in vascular remodeling. Importantly, both systemic and VSMC-specific targeting of circLyst attenuated pathological remodeling and blunted hypertension in animal models. Collectively, our findings establish the oxidative-stress-driven circLyst\/miR-298-5p\/Col23a1 axis as a critical regulator of vascular remodeling and highlight circLyst as a potential therapeutic target for hypertensive vascular disease.<\/jats:p>","DOI":"10.1186\/s43556-026-00593-3","type":"journal-article","created":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T19:40:06Z","timestamp":1791920406000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Mechanotransduction through oxidative stress upregulates circLyst to drive vascular remodeling in hypertensive humans and rodents"],"prefix":"10.1186","volume":"7","author":[{"given":"Juanjuan","family":"Tan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weiyi","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Shen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Biyang","family":"Luo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huajin","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Feng","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui","family":"Qin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuanwang","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haifang","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Dong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qi","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hong","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fan","family":"Lv","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yingxin","family":"Qi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kai","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhiqiang","family":"Yan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-2257-0843","authenticated-orcid":false,"given":"Kai","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,10,13]]},"reference":[{"issue":"5","key":"593_CR1","doi-asserted-by":"publisher","first-page":"333","DOI":"10.1038\/s41569-024-01103-0","volume":"22","author":"L Zhang","year":"2025","unstructured":"Zhang L, Zhou J, Kong W. Extracellular matrix in vascular homeostasis and disease. Nat Rev Cardiol. 2025;22(5):333\u201353. https:\/\/doi.org\/10.1038\/s41569-024-01103-0.","journal-title":"Nat Rev Cardiol"},{"issue":"13","key":"593_CR2","doi-asserted-by":"publisher","first-page":"817","DOI":"10.1042\/CS20220797","volume":"138","author":"J Toton-Zuranska","year":"2024","unstructured":"Toton-Zuranska J, Mikolajczyk TP, Saju B, Guzik TJ. Vascular remodelling in cardiovascular diseases: Hypertension, oxidation, and inflammation. Clin Sci (Lond). 2024;138(13):817\u201350. https:\/\/doi.org\/10.1042\/CS20220797.","journal-title":"Clin Sci (Lond)"},{"issue":"6","key":"593_CR3","doi-asserted-by":"publisher","first-page":"882","DOI":"10.1161\/ATVBAHA.125.322557","volume":"45","author":"H Deng","year":"2025","unstructured":"Deng H, Eichmann A, Schwartz MA. Fluid shear stress-regulated vascular remodeling: Past, present, and future. Arterioscler Thromb Vasc Biol. 2025;45(6):882\u2013900. https:\/\/doi.org\/10.1161\/ATVBAHA.125.322557.","journal-title":"Arterioscler Thromb Vasc Biol"},{"issue":"3","key":"593_CR4","doi-asserted-by":"publisher","first-page":"170","DOI":"10.1038\/s41569-019-0260-8","volume":"17","author":"Y Zhang","year":"2020","unstructured":"Zhang Y, Murugesan P, Huang K, Cai H. NADPH oxidases and oxidase crosstalk in cardiovascular diseases: novel therapeutic targets. Nat Rev Cardiol. 2020;17(3):170\u201394. https:\/\/doi.org\/10.1038\/s41569-019-0260-8.","journal-title":"Nat Rev Cardiol"},{"issue":"3","key":"593_CR5","doi-asserted-by":"publisher","DOI":"10.1111\/apha.13374","volume":"228","author":"H Bao","year":"2020","unstructured":"Bao H, Li HP, Shi Q, Huang K, Chen XH, Chen YX, et al. Lamin a\/c negatively regulated by mir-124-3p modulates apoptosis of vascular smooth muscle cells during cyclic stretch application in rats. Acta Physiol (Oxf). 2020;228(3):e13374. https:\/\/doi.org\/10.1111\/apha.13374.","journal-title":"Acta Physiol (Oxf)"},{"issue":"18","key":"593_CR6","doi-asserted-by":"publisher","first-page":"1367","DOI":"10.1161\/CIRCULATIONAHA.121.057178","volume":"146","author":"C Bai","year":"2022","unstructured":"Bai C, Su M, Zhang Y, Lin Y, Sun Y, Song L, et al. Oviductal glycoprotein 1 promotes hypertension by inducing vascular remodeling through an interaction with myh9. Circulation. 2022;146(18):1367\u201382. https:\/\/doi.org\/10.1161\/CIRCULATIONAHA.121.057178.","journal-title":"Circulation"},{"issue":"643","key":"593_CR7","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.abl5471","volume":"14","author":"Y Zhang","year":"2022","unstructured":"Zhang Y, Hernandez M, Gower J, Winicki N, Morataya X, Alvarez S, et al. Jagged-notch3 signaling in vascular remodeling in pulmonary arterial hypertension. Sci Transl Med. 2022;14(643):eabl5471. https:\/\/doi.org\/10.1126\/scitranslmed.abl5471.","journal-title":"Sci Transl Med"},{"issue":"1","key":"593_CR8","doi-asserted-by":"publisher","first-page":"52","DOI":"10.1038\/s41569-019-0239-5","volume":"17","author":"C Souilhol","year":"2020","unstructured":"Souilhol C, Serbanovic-Canic J, Fragiadaki M, Chico TJ, Ridger V, Roddie H, et al. Endothelial responses to shear stress in atherosclerosis: a novel role for developmental genes. Nat Rev Cardiol. 2020;17(1):52\u201363. https:\/\/doi.org\/10.1038\/s41569-019-0239-5.","journal-title":"Nat Rev Cardiol"},{"issue":"5","key":"593_CR9","doi-asserted-by":"publisher","first-page":"388","DOI":"10.1161\/CIRCULATIONAHA.122.059062","volume":"147","author":"A Canfran-Duque","year":"2023","unstructured":"Canfran-Duque A, Rotllan N, Zhang X, Andres-Blasco I, Thompson BM, Sun J, et al. Macrophage-derived 25-hydroxycholesterol promotes vascular inflammation, atherogenesis, and lesion remodeling. Circ. 2023;147(5):388\u2013408. https:\/\/doi.org\/10.1161\/CIRCULATIONAHA.122.059062.","journal-title":"Circ"},{"issue":"3","key":"593_CR10","doi-asserted-by":"publisher","first-page":"306","DOI":"10.1161\/CIRCRESAHA.122.321837","volume":"132","author":"G Zhang","year":"2023","unstructured":"Zhang G, Qin Q, Zhang C, Sun X, Kazama K, Yi B, et al. Ndrg1 signaling is essential for endothelial inflammation and vascular remodeling. Circ Res. 2023;132(3):306\u201319. https:\/\/doi.org\/10.1161\/CIRCRESAHA.122.321837.","journal-title":"Circ Res"},{"key":"593_CR11","doi-asserted-by":"publisher","DOI":"10.1016\/j.redox.2022.102521","volume":"58","author":"K Huang","year":"2022","unstructured":"Huang K, Wu Y, Zhang Y, Youn JY, Cai H. Combination of folic acid with nifedipine is completely effective in attenuating aortic aneurysm formation as a novel oral medication. Redox Biol. 2022;58:102521. https:\/\/doi.org\/10.1016\/j.redox.2022.102521.","journal-title":"Redox Biol"},{"key":"593_CR12","doi-asserted-by":"publisher","DOI":"10.1016\/j.redox.2020.101757","volume":"38","author":"K Huang","year":"2021","unstructured":"Huang K, Wang Y, Siu KL, Zhang Y, Cai H. Targeting feed-forward signaling of tgfbeta\/nox4\/dhfr\/enos uncoupling\/tgfbeta axis with anti-tgfbeta and folic acid attenuates formation of aortic aneurysms: Novel mechanisms and therapeutics. Redox Biol. 2021;38:101757. https:\/\/doi.org\/10.1016\/j.redox.2020.101757.","journal-title":"Redox Biol"},{"issue":"2","key":"593_CR13","doi-asserted-by":"publisher","first-page":"282","DOI":"10.1161\/HYPERTENSIONAHA.120.15070","volume":"78","author":"K Huang","year":"2021","unstructured":"Huang K, Narumi T, Zhang Y, Li Q, Murugesan P, Wu Y, et al. Targeting microRNA-192-5p, a downstream effector of NOXs (NADPH oxidases), reverses endothelial DHFR (dihydrofolate reductase) deficiency to attenuate abdominal aortic aneurysm formation. Hypertension. 2021;78(2):282\u201393. https:\/\/doi.org\/10.1161\/HYPERTENSIONAHA.120.15070.","journal-title":"Hypertension"},{"issue":"15","key":"593_CR14","doi-asserted-by":"publisher","first-page":"1244","DOI":"10.1161\/CIRCULATIONAHA.120.053361","volume":"144","author":"C Mao","year":"2021","unstructured":"Mao C, Ma Z, Jia Y, Li W, Xie N, Zhao G, et al. Nidogen-2 maintains the contractile phenotype of vascular smooth muscle cells and prevents neointima formation via bridging jagged1-notch3 signaling. Circulation. 2021;144(15):1244\u201361. https:\/\/doi.org\/10.1161\/CIRCULATIONAHA.120.053361.","journal-title":"Circulation"},{"issue":"9","key":"593_CR15","doi-asserted-by":"publisher","first-page":"4284","DOI":"10.1093\/nar\/gkad120","volume":"51","author":"J Guo","year":"2023","unstructured":"Guo J, Qiu J, Jia M, Li Q, Wei X, Li L, et al. BACH1 deficiency prevents neointima formation and maintains the differentiated phenotype of vascular smooth muscle cells by regulating chromatin accessibility. Nucleic Acids Res. 2023;51(9):4284\u2013301. https:\/\/doi.org\/10.1093\/nar\/gkad120.","journal-title":"Nucleic Acids Res"},{"issue":"5","key":"593_CR16","doi-asserted-by":"publisher","first-page":"488","DOI":"10.1093\/cvr\/cvw257","volume":"113","author":"K Huang","year":"2017","unstructured":"Huang K, Bao H, Yan ZQ, Wang L, Zhang P, Yao QP, et al. Microrna-33 protects against neointimal hyperplasia induced by arterial mechanical stretch in the grafted vein. Cardiovasc Res. 2017;113(5):488\u201397. https:\/\/doi.org\/10.1093\/cvr\/cvw257.","journal-title":"Cardiovasc Res"},{"issue":"25","key":"593_CR17","doi-asserted-by":"publisher","first-page":"2454","DOI":"10.1161\/CIRCULATIONAHA.119.043724","volume":"143","author":"JL Decano","year":"2021","unstructured":"Decano JL, Singh SA, Gasparotto Bueno C, Ho Lee L, Halu A, Chelvanambi S, et al. Systems approach to discovery of therapeutic targets for vein graft disease: Pparalpha pivotally regulates metabolism, activation, and heterogeneity of macrophages and lesion development. Circulation. 2021;143(25):2454\u201370. https:\/\/doi.org\/10.1161\/CIRCULATIONAHA.119.043724.","journal-title":"Circulation"},{"key":"593_CR18","doi-asserted-by":"publisher","DOI":"10.1016\/j.bioadv.2025.214427","volume":"177","author":"Y Yang","year":"2025","unstructured":"Yang Y, Qian B, Zhou D, Zhu F, Lei D, Huang S, et al. External stent ameliorates vein graft remodeling through ajuba-mediated suppression of hippo signaling pathway. Biomater Adv. 2025;177:214427. https:\/\/doi.org\/10.1016\/j.bioadv.2025.214427.","journal-title":"Biomater Adv"},{"issue":"3","key":"593_CR19","doi-asserted-by":"publisher","first-page":"762","DOI":"10.1016\/j.cell.2018.03.076","volume":"173","author":"J Xu","year":"2018","unstructured":"Xu J, Mathur J, Vessieres E, Hammack S, Nonomura K, Favre J, et al. Gpr68 senses flow and is essential for vascular physiology. Cell. 2018;173(3):762-775 e716. https:\/\/doi.org\/10.1016\/j.cell.2018.03.076.","journal-title":"Cell"},{"issue":"28","key":"593_CR20","doi-asserted-by":"publisher","first-page":"10347","DOI":"10.1073\/pnas.1409233111","volume":"111","author":"SS Ranade","year":"2014","unstructured":"Ranade SS, Qiu Z, Woo SH, Hur SS, Murthy SE, Cahalan SM, et al. Piezo1, a mechanically activated ion channel, is required for vascular development in mice. Proc Natl Acad Sci U S A. 2014;111(28):10347\u201352. https:\/\/doi.org\/10.1073\/pnas.1409233111.","journal-title":"Proc Natl Acad Sci U S A"},{"key":"593_CR21","doi-asserted-by":"publisher","DOI":"10.3389\/fcvm.2022.957340","volume":"9","author":"JY Youn","year":"2022","unstructured":"Youn JY, Wang J, Li Q, Huang K, Cai H. Robust therapeutic effects on covid-19 of novel small molecules: Alleviation of sars-cov-2 s protein induction of ace2\/tmprss2, nox2\/ros, and mcp-1. Front Cardiovasc Med. 2022;9:957340. https:\/\/doi.org\/10.3389\/fcvm.2022.957340.","journal-title":"Front Cardiovasc Med"},{"issue":"5","key":"593_CR22","doi-asserted-by":"publisher","first-page":"1817","DOI":"10.1159\/000438544","volume":"37","author":"K Huang","year":"2015","unstructured":"Huang K, Yan ZQ, Zhao D, Chen SG, Gao LZ, Zhang P, et al. Sirt1 and foxo mediate contractile differentiation of vascular smooth muscle cells under cyclic stretch. Cell Physiol Biochem. 2015;37(5):1817\u201329. https:\/\/doi.org\/10.1159\/000438544.","journal-title":"Cell Physiol Biochem"},{"key":"593_CR23","doi-asserted-by":"publisher","unstructured":"Jiang T, Zhang Y, Guo Z, Ren H, Hu W, Yao Q, et al. Mechanical stress induced nox2 promotes endothelial dysfunction in ventilator-induced lung injury: potential treatment with quercetin. Adv Sci (Weinh). 2025:e2502639. https:\/\/doi.org\/10.1002\/advs.202502639.","DOI":"10.1002\/advs.202502639"},{"issue":"2","key":"593_CR24","doi-asserted-by":"publisher","first-page":"1247","DOI":"10.1152\/physrev.00053.2021","volume":"103","author":"MJ Davis","year":"2023","unstructured":"Davis MJ, Earley S, Li YS, Chien S. Vascular mechanotransduction. Physiol Rev. 2023;103(2):1247\u2013421. https:\/\/doi.org\/10.1152\/physrev.00053.2021.","journal-title":"Physiol Rev"},{"key":"593_CR25","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2024.116545","volume":"174","author":"H Ren","year":"2024","unstructured":"Ren H, Hu W, Jiang T, Yao Q, Qi Y, Huang K. Mechanical stress induced mitochondrial dysfunction in cardiovascular diseases: Novel mechanisms and therapeutic targets. Biomed Pharmacother. 2024;174:116545. https:\/\/doi.org\/10.1016\/j.biopha.2024.116545.","journal-title":"Biomed Pharmacother"},{"issue":"1","key":"593_CR26","doi-asserted-by":"publisher","first-page":"327","DOI":"10.1152\/physrev.00047.2009","volume":"91","author":"JJ Chiu","year":"2011","unstructured":"Chiu JJ, Chien S. Effects of disturbed flow on vascular endothelium: Pathophysiological basis and clinical perspectives. Physiol Rev. 2011;91(1):327\u201387. https:\/\/doi.org\/10.1152\/physrev.00047.2009.","journal-title":"Physiol Rev"},{"issue":"6","key":"593_CR27","doi-asserted-by":"publisher","first-page":"933","DOI":"10.1093\/nsr\/nwx153","volume":"5","author":"Y Han","year":"2018","unstructured":"Han Y, Huang K, Yao QP, Jiang ZL. Mechanobiology in vascular remodeling. Natl Sci Rev. 2018;5(6):933\u201346. https:\/\/doi.org\/10.1093\/nsr\/nwx153.","journal-title":"Natl Sci Rev"},{"key":"593_CR28","doi-asserted-by":"publisher","DOI":"10.1038\/srep41058","volume":"7","author":"L Wang","year":"2017","unstructured":"Wang L, Bao H, Wang KX, Zhang P, Yao QP, Chen XH, et al. Secreted mir-27a induced by cyclic stretch modulates the proliferation of endothelial cells in hypertension via grk6. Sci Rep. 2017;7:41058. https:\/\/doi.org\/10.1038\/srep41058.","journal-title":"Sci Rep"},{"issue":"11","key":"593_CR29","doi-asserted-by":"publisher","first-page":"e26","DOI":"10.1161\/CIRCRESAHA.122.320846","volume":"130","author":"Y Tang","year":"2022","unstructured":"Tang Y, Jia Y, Fan L, Liu H, Zhou Y, Wang M, et al. Mfn2 prevents neointimal hyperplasia in vein grafts via destabilizing pfk1. Circ Res. 2022;130(11):e26\u201343. https:\/\/doi.org\/10.1161\/CIRCRESAHA.122.320846.","journal-title":"Circ Res"},{"issue":"7","key":"593_CR30","doi-asserted-by":"publisher","first-page":"993","DOI":"10.1161\/CIRCRESAHA.121.318063","volume":"128","author":"KK Griendling","year":"2021","unstructured":"Griendling KK, Camargo LL, Rios FJ, Alves-Lopes R, Montezano AC, Touyz RM. Oxidative stress and hypertension. Circ Res. 2021;128(7):993\u20131020. https:\/\/doi.org\/10.1161\/CIRCRESAHA.121.318063.","journal-title":"Circ Res"},{"issue":"4","key":"593_CR31","doi-asserted-by":"publisher","first-page":"221","DOI":"10.1016\/j.tcm.2024.12.004","volume":"35","author":"NC Zong","year":"2025","unstructured":"Zong NC, Huang K, Yang X, Cai H. Expand the success of screening to reduce aortic aneurysm mortality: progress interpretation and new fronts. Trends Cardiovasc Med. 2025;35(4):221\u20139. https:\/\/doi.org\/10.1016\/j.tcm.2024.12.004.","journal-title":"Trends Cardiovasc Med"},{"issue":"4","key":"593_CR32","doi-asserted-by":"publisher","first-page":"713","DOI":"10.1161\/CIRCRESAHA.116.309326","volume":"120","author":"U Forstermann","year":"2017","unstructured":"Forstermann U, Xia N, Li H. Roles of vascular oxidative stress and nitric oxide in the pathogenesis of atherosclerosis. Circ Res. 2017;120(4):713\u201335. https:\/\/doi.org\/10.1161\/CIRCRESAHA.116.309326.","journal-title":"Circ Res"},{"key":"593_CR33","doi-asserted-by":"publisher","DOI":"10.1016\/j.redox.2025.103570","volume":"82","author":"Y Zhang","year":"2025","unstructured":"Zhang Y, Youn JY, Huang K, Zhang Y, Cai H. Alleviation of accelerated diabetic atherogenesis in stz-treated apoe\/nox1 dko mice, apoe(-\/-)\/tg-ec-dhfr mice, and by folic acid. Redox Biol. 2025;82:103570. https:\/\/doi.org\/10.1016\/j.redox.2025.103570.","journal-title":"Redox Biol"},{"issue":"11","key":"593_CR34","doi-asserted-by":"publisher","first-page":"675","DOI":"10.1038\/s41576-019-0158-7","volume":"20","author":"LS Kristensen","year":"2019","unstructured":"Kristensen LS, Andersen MS, Stagsted LVW, Ebbesen KK, Hansen TB, Kjems J. The biogenesis, biology and characterization of circular rnas. Nat Rev Genet. 2019;20(11):675\u201391. https:\/\/doi.org\/10.1038\/s41576-019-0158-7.","journal-title":"Nat Rev Genet"},{"issue":"12","key":"593_CR35","doi-asserted-by":"publisher","first-page":"2016","DOI":"10.1016\/j.cell.2022.04.021","volume":"185","author":"CX Liu","year":"2022","unstructured":"Liu CX, Chen LL. Circular RNAs: characterization, cellular roles, and applications. Cell. 2022;185(12):2016\u201334. https:\/\/doi.org\/10.1016\/j.cell.2022.04.021.","journal-title":"Cell"},{"issue":"8","key":"593_CR36","doi-asserted-by":"publisher","first-page":"475","DOI":"10.1038\/s41580-020-0243-y","volume":"21","author":"LL Chen","year":"2020","unstructured":"Chen LL. The expanding regulatory mechanisms and cellular functions of circular RNAs. Nat Rev Mol Cell Biol. 2020;21(8):475\u201390. https:\/\/doi.org\/10.1038\/s41580-020-0243-y.","journal-title":"Nat Rev Mol Cell Biol"},{"issue":"8","key":"593_CR37","doi-asserted-by":"publisher","first-page":"503","DOI":"10.1038\/s41569-019-0185-2","volume":"16","author":"S Aufiero","year":"2019","unstructured":"Aufiero S, Reckman YJ, Pinto YM, Creemers EE. Circular rnas open a new chapter in cardiovascular biology. Nat Rev Cardiol. 2019;16(8):503\u201314. https:\/\/doi.org\/10.1038\/s41569-019-0185-2.","journal-title":"Nat Rev Cardiol"},{"issue":"10","key":"593_CR38","doi-asserted-by":"publisher","DOI":"10.3390\/biom15101455","volume":"15","author":"R Alali","year":"2025","unstructured":"Alali R, Almansori M, Vatte C, Akhtar MS, Abduljabbar SS, Al-Matroud H, et al. Circular RNAs in cardiovascular disease: mechanisms, biomarkers, and therapeutic frontiers. Biomolecules. 2025;15(10):1455. https:\/\/doi.org\/10.3390\/biom15101455.","journal-title":"Biomolecules"},{"issue":"1","key":"593_CR39","doi-asserted-by":"publisher","first-page":"216","DOI":"10.1186\/s12951-025-03199-z","volume":"23","author":"SQ He","year":"2025","unstructured":"He SQ, Huang B, Xu F, Yang JJ, Li C, Liu FR, et al. Functions and application of circrnas in vascular aging and aging-related vascular diseases. J Nanobiotechnology. 2025;23(1):216. https:\/\/doi.org\/10.1186\/s12951-025-03199-z.","journal-title":"J Nanobiotechnology"},{"issue":"1","key":"593_CR40","doi-asserted-by":"publisher","first-page":"214","DOI":"10.1038\/s41420-025-02504-x","volume":"11","author":"R Pan","year":"2025","unstructured":"Pan R, Koo C, Su W, You Q, Guo H, Liu B. Circular rnas modulate cell death in cardiovascular diseases. Cell Death Discov. 2025;11(1):214. https:\/\/doi.org\/10.1038\/s41420-025-02504-x.","journal-title":"Cell Death Discov"},{"issue":"19","key":"593_CR41","doi-asserted-by":"publisher","first-page":"5293","DOI":"10.1073\/pnas.1604569113","volume":"113","author":"YX Qi","year":"2016","unstructured":"Qi YX, Yao QP, Huang K, Shi Q, Zhang P, Wang GL, et al. Nuclear envelope proteins modulate proliferation of vascular smooth muscle cells during cyclic stretch application. Proc Natl Acad Sci U S A. 2016;113(19):5293\u20138. https:\/\/doi.org\/10.1073\/pnas.1604569113.","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"7","key":"593_CR42","doi-asserted-by":"publisher","first-page":"1651","DOI":"10.1089\/ars.2008.2390","volume":"11","author":"KG Birukov","year":"2009","unstructured":"Birukov KG. Cyclic stretch, reactive oxygen species, and vascular remodeling. Antioxid Redox Signal. 2009;11(7):1651\u201367. https:\/\/doi.org\/10.1089\/ars.2008.2390.","journal-title":"Antioxid Redox Signal"},{"key":"593_CR43","doi-asserted-by":"publisher","DOI":"10.1016\/j.redox.2020.101638","volume":"36","author":"J Jiang","year":"2020","unstructured":"Jiang J, Huang K, Xu S, Garcia JGN, Wang C, Cai H. Targeting nox4 alleviates sepsis-induced acute lung injury via attenuation of redox-sensitive activation of camkii\/erk1\/2\/mlck and endothelial cell barrier dysfunction. Redox Biol. 2020;36:101638. https:\/\/doi.org\/10.1016\/j.redox.2020.101638.","journal-title":"Redox Biol"},{"issue":"25","key":"593_CR44","doi-asserted-by":"publisher","first-page":"2857","DOI":"10.1161\/CIRCULATIONAHA.118.038361","volume":"139","author":"S Huang","year":"2019","unstructured":"Huang S, Li X, Zheng H, Si X, Li B, Wei G, et al. Loss of super-enhancer-regulated circRNA nfix induces cardiac regeneration after myocardial infarction in adult mice. Circulation. 2019;139(25):2857\u201376. https:\/\/doi.org\/10.1161\/CIRCULATIONAHA.118.038361.","journal-title":"Circulation"},{"issue":"4","key":"593_CR45","doi-asserted-by":"publisher","first-page":"354","DOI":"10.1161\/circulationaha.120.049715","volume":"143","author":"Z Zeng","year":"2021","unstructured":"Zeng Z, Xia L, Fan S, Zheng J, Qin J, Fan X, et al. Circular RNA circmap3k5 acts as a microrna-22-3p sponge to promote resolution of intimal hyperplasia via tet2-mediated smooth muscle cell differentiation. Circulation. 2021;143(4):354\u201371. https:\/\/doi.org\/10.1161\/circulationaha.120.049715.","journal-title":"Circulation"},{"key":"593_CR46","doi-asserted-by":"publisher","first-page":"46602","DOI":"10.1038\/srep46602","volume":"7","author":"J Tan","year":"2017","unstructured":"Tan J, Yang L, Liu C, Yan Z. Microrna-26a targets mapk6 to inhibit smooth muscle cell proliferation and vein graft neointimal hyperplasia. Sci Rep. 2017;7:46602. https:\/\/doi.org\/10.1038\/srep46602.","journal-title":"Sci Rep"},{"issue":"3","key":"593_CR47","doi-asserted-by":"publisher","first-page":"211","DOI":"10.1038\/s41576-023-00662-1","volume":"25","author":"K Nemeth","year":"2024","unstructured":"Nemeth K, Bayraktar R, Ferracin M, Calin GA. Non-coding RNAs in disease: from mechanisms to therapeutics. Nat Rev Genet. 2024;25(3):211\u201332. https:\/\/doi.org\/10.1038\/s41576-023-00662-1.","journal-title":"Nat Rev Genet"},{"issue":"7","key":"593_CR48","doi-asserted-by":"publisher","first-page":"3912","DOI":"10.1096\/fj.201701073R","volume":"32","author":"H Bao","year":"2018","unstructured":"Bao H, Chen YX, Huang K, Zhuang F, Bao M, Han Y, et al. Platelet-derived microparticles promote endothelial cell proliferation in hypertension via mir-142-3p. FASEB J. 2018;32(7):3912\u201323. https:\/\/doi.org\/10.1096\/fj.201701073R.","journal-title":"FASEB J"},{"issue":"4","key":"593_CR49","doi-asserted-by":"publisher","first-page":"3","DOI":"10.14715\/cmb\/2017.63.4.1","volume":"63","author":"H Bao","year":"2017","unstructured":"Bao H, Yao QP, Huang K, Chen XH, Han Y, Jiang ZL, et al. Platelet-derived mir-142-3p induces apoptosis of endothelial cells in hypertension. Cell Mol Biol (Noisy-le-grand). 2017;63(4):3\u20139. https:\/\/doi.org\/10.14715\/cmb\/2017.63.4.1.","journal-title":"Cell Mol Biol (Noisy-le-grand)"},{"issue":"7","key":"593_CR50","doi-asserted-by":"publisher","first-page":"2775","DOI":"10.1172\/JCI123825","volume":"129","author":"A Iring","year":"2019","unstructured":"Iring A, Jin YJ, Albarran-Juarez J, Siragusa M, Wang S, Dancs PT, et al. Shear stress-induced endothelial adrenomedullin signaling regulates vascular tone and blood pressure. J Clin Invest. 2019;129(7):2775\u201391. https:\/\/doi.org\/10.1172\/JCI123825.","journal-title":"J Clin Invest"},{"issue":"4","key":"593_CR51","doi-asserted-by":"publisher","DOI":"10.1016\/j.mbm.2024.100101","volume":"2","author":"K Huang","year":"2024","unstructured":"Huang K, Qi Y. MiRNA in mechanobiology: the exploration needs to continue. Mechanobiol Med. 2024;2(4):100101. https:\/\/doi.org\/10.1016\/j.mbm.2024.100101.","journal-title":"Mechanobiol Med"},{"issue":"6","key":"593_CR52","doi-asserted-by":"publisher","first-page":"1195","DOI":"10.1097\/HJH.0000000000001304","volume":"35","author":"QP Yao","year":"2017","unstructured":"Yao QP, Xie ZW, Wang KX, Zhang P, Han Y, Qi YX, et al. Profiles of long noncoding RNAs in hypertensive rats: long noncoding RNA xr007793 regulates cyclic strain-induced proliferation and migration of vascular smooth muscle cells. J Hypertens. 2017;35(6):1195\u2013203. https:\/\/doi.org\/10.1097\/HJH.0000000000001304.","journal-title":"J Hypertens"},{"issue":"1-2","key":"593_CR53","doi-asserted-by":"publisher","first-page":"163","DOI":"10.1007\/s11010-017-3065-2","volume":"435","author":"LE Mantella","year":"2017","unstructured":"Mantella LE, Singh KK, Sandhu P, Kantores C, Ramadan A, Khyzha N, et al. Fingerprint of long non-coding RNA regulated by cyclic mechanical stretch in human aortic smooth muscle cells: implications for hypertension. Mol Cell Biochem. 2017;435(1\u20132):163\u201373. https:\/\/doi.org\/10.1007\/s11010-017-3065-2.","journal-title":"Mol Cell Biochem"},{"key":"593_CR54","doi-asserted-by":"publisher","DOI":"10.1093\/rb\/rbaf119","volume":"12","author":"T Ma","year":"2025","unstructured":"Ma T, Tian W, Zhu F, Qi Y, Huang K. Injury and cyclic stretch induce vein graft failure: effective treatment with zinc oxide-loaded electrospun polycaprolactone external stent. Regen Biomater. 2025;12:rbaf119. https:\/\/doi.org\/10.1093\/rb\/rbaf119.","journal-title":"Regen Biomater"},{"issue":"3","key":"593_CR55","doi-asserted-by":"publisher","DOI":"10.1111\/acel.70443","volume":"25","author":"T Ma","year":"2026","unstructured":"Ma T, Bao H, Xu Z, Ren H, Tian W, Chen J, et al. Novel pmvs\/zip4\/zinc\/prelamin a axis promotes nuclear dysmorphism and vascular aging in humans and rodents post-injury: effective treatment with platelet membrane-coated zif-8 nanoparticles. Aging Cell. 2026;25(3):e70443. https:\/\/doi.org\/10.1111\/acel.70443.","journal-title":"Aging Cell"},{"issue":"4","key":"593_CR56","doi-asserted-by":"publisher","first-page":"498","DOI":"10.1161\/circresaha.118.314240","volume":"124","author":"IF Hall","year":"2019","unstructured":"Hall IF, Climent M, Quintavalle M, Farina FM, Schorn T, Zani S, et al. Circ_lrp6, a circular rna enriched in vascular smooth muscle cells, acts as a sponge regulating mirna-145 function. Circ Res. 2019;124(4):498\u2013510. https:\/\/doi.org\/10.1161\/circresaha.118.314240.","journal-title":"Circ Res"},{"key":"593_CR57","doi-asserted-by":"publisher","DOI":"10.1016\/j.redox.2023.102782","volume":"64","author":"S Zhang","year":"2023","unstructured":"Zhang S, Wang X, Chen G, Tong L, Dai T, Wang L, et al. Circrna galntl6 sponges mir-335 to ameliorate stress-induced hypertension through upregulating lig3 in rostral ventrolateral medulla. Redox Biol. 2023;64:102782. https:\/\/doi.org\/10.1016\/j.redox.2023.102782.","journal-title":"Redox Biol"},{"issue":"24","key":"593_CR58","doi-asserted-by":"publisher","DOI":"10.1172\/JCI147031","volume":"131","author":"X Gong","year":"2021","unstructured":"Gong X, Tian M, Cao N, Yang P, Xu Z, Zheng S, et al. Circular RNA circESYT2 regulates vascular smooth muscle cell remodeling via splicing regulation. J Clin Invest. 2021;131(24):e147031. https:\/\/doi.org\/10.1172\/JCI147031.","journal-title":"J Clin Invest"},{"issue":"7","key":"593_CR59","doi-asserted-by":"publisher","first-page":"1179","DOI":"10.1161\/ATVBAHA.122.318842","volume":"43","author":"C Ma","year":"2023","unstructured":"Ma C, Wang X, Zhang L, Zhu X, Bai J, He S, et al. Super enhancer-associated circular rna-circkrt4 regulates hypoxic pulmonary artery endothelial cell dysfunction in mice. Arterioscler Thromb Vasc Biol. 2023;43(7):1179\u201398. https:\/\/doi.org\/10.1161\/ATVBAHA.122.318842.","journal-title":"Arterioscler Thromb Vasc Biol"},{"issue":"11","key":"593_CR60","doi-asserted-by":"publisher","first-page":"2465","DOI":"10.1161\/HYPERTENSIONAHA.122.19183","volume":"79","author":"GF Lu","year":"2022","unstructured":"Lu GF, Geng F, Deng LP, Lin DC, Huang YZ, Lai SM, et al. Reduced circSMOC1 level promotes metabolic reprogramming via PTBP1 (polypyrimidine tract-binding protein) and miR-329-3p in pulmonary arterial hypertension rats. Hypertension. 2022;79(11):2465\u201379. https:\/\/doi.org\/10.1161\/HYPERTENSIONAHA.122.19183.","journal-title":"Hypertension"},{"issue":"3","key":"593_CR61","doi-asserted-by":"publisher","first-page":"668","DOI":"10.1161\/HYPERTENSIONAHA.119.13715","volume":"75","author":"J Zhang","year":"2020","unstructured":"Zhang J, Li Y, Qi J, Yu X, Ren H, Zhao X, et al. Circ-calm4 serves as an mir-337-3p sponge to regulate myo10 (myosin 10) and promote pulmonary artery smooth muscle proliferation. Hypertension. 2020;75(3):668\u201379. https:\/\/doi.org\/10.1161\/HYPERTENSIONAHA.119.13715.","journal-title":"Hypertension"},{"issue":"12","key":"593_CR62","doi-asserted-by":"publisher","first-page":"1579","DOI":"10.1164\/rccm.202005-2052LE","volume":"203","author":"P Yuan","year":"2021","unstructured":"Yuan P, Wu WH, Gong SG, Jiang R, Zhao QH, Pudasaini B, et al. Impact of circgsap in peripheral blood mononuclear cells on idiopathic pulmonary arterial hypertension. Am J Respir Crit Care Med. 2021;203(12):1579\u201383. https:\/\/doi.org\/10.1164\/rccm.202005-2052LE.","journal-title":"Am J Respir Crit Care Med"},{"issue":"2","key":"593_CR63","doi-asserted-by":"publisher","DOI":"10.1016\/j.mbm.2026.100193","volume":"4","author":"K Huang","year":"2026","unstructured":"Huang K. Mechanosensitive reactive oxygen species: a precision medicine target for oxidative stress-related diseases. Mechanobiol Med. 2026;4(2):100193. https:\/\/doi.org\/10.1016\/j.mbm.2026.100193.","journal-title":"Mechanobiol Med"},{"key":"593_CR64","doi-asserted-by":"publisher","DOI":"10.1016\/j.redox.2026.104199","volume":"94","author":"Z Shang","year":"2026","unstructured":"Shang Z, Guo Z, Tian W, Zhu F, Jiang T, Hu W, et al. Oxidative stress-induced endothelial dysfunction drives mechanical and infectious lung injury: therapeutic potential of kaempferol in males. Redox Biol. 2026;94:104199. https:\/\/doi.org\/10.1016\/j.redox.2026.104199.","journal-title":"Redox Biol"},{"issue":"1","key":"593_CR65","doi-asserted-by":"publisher","DOI":"10.1002\/ggn2.202500043","volume":"7","author":"F Zhu","year":"2026","unstructured":"Zhu F, Huang K. Antioxidation is a common defense strategy for different species under mechanical stress. Adv Genet (Hoboken). 2026;7(1):e00043. https:\/\/doi.org\/10.1002\/ggn2.202500043.","journal-title":"Adv Genet (Hoboken)"},{"issue":"2","key":"593_CR66","doi-asserted-by":"publisher","DOI":"10.1002\/mco2.70598","volume":"7","author":"H Ren","year":"2026","unstructured":"Ren H, Shang Z, Stewart AG, Qi YX, Huang K. Ventilator-induced lung injury: mechanotransduction and potential therapeutic targets. MedComm (2020). 2026;7(2):e70598. https:\/\/doi.org\/10.1002\/mco2.70598.","journal-title":"MedComm (2020)"},{"issue":"2","key":"593_CR67","doi-asserted-by":"publisher","DOI":"10.1016\/j.mbm.2025.100129","volume":"3","author":"J Zhang","year":"2025","unstructured":"Zhang J, Li Q, Ding S, Xu W, Su J, Cui J, et al. Overstretch causes lipid accumulation in vascular smooth muscle cells dependent on NADPH oxidase 1. Mechanobiol Med. 2025;3(2):100129. https:\/\/doi.org\/10.1016\/j.mbm.2025.100129.","journal-title":"Mechanobiol Med"},{"issue":"11","key":"593_CR68","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.125.326768","volume":"138","author":"K Huang","year":"2026","unstructured":"Huang K, Huang Y, Zhang Y, Zhang Y, Hatch NW, Freed JK, et al. Endothelial NOX1 drives obesity via skeletal muscle mitochondrial dysfunction. Circ Res. 2026;138(11):e326768. https:\/\/doi.org\/10.1161\/CIRCRESAHA.125.326768.","journal-title":"Circ Res"},{"issue":"15","key":"593_CR69","doi-asserted-by":"publisher","first-page":"3622","DOI":"10.1016\/j.jbiomech.2014.10.008","volume":"47","author":"YC Yang","year":"2014","unstructured":"Yang YC, Wang XD, Huang K, Wang L, Jiang ZL, Qi YX. Temporal phosphoproteomics to investigate the mechanotransduction of vascular smooth muscle cells in response to cyclic stretch. J Biomech. 2014;47(15):3622\u20139. https:\/\/doi.org\/10.1016\/j.jbiomech.2014.10.008.","journal-title":"J Biomech"},{"key":"593_CR70","doi-asserted-by":"publisher","unstructured":"Gao Y, Wang J, Zhao F. CIRI: an efficient and unbiased algorithm for de novo circular RNA identification. Genome Biol. 2015;16(1):4. https:\/\/doi.org\/10.1186\/s13059-014-0571-3.","DOI":"10.1186\/s13059-014-0571-3"},{"key":"593_CR71","doi-asserted-by":"publisher","unstructured":"Enright AJ, John B, Gaul U, Tuschl T, Sander C, Marks DS. MicroRNA targets in Drosophila. Genome Biol. 2003;5(1):R1. https:\/\/doi.org\/10.1186\/gb-2003-5-1-r1.","DOI":"10.1186\/gb-2003-5-1-r1"}],"container-title":["Molecular Biomedicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s43556-026-00593-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s43556-026-00593-3","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s43556-026-00593-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T22:02:25Z","timestamp":1791928945000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1186\/s43556-026-00593-3"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,10,13]]},"references-count":71,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2026,12]]}},"alternative-id":["593"],"URL":"https:\/\/doi.org\/10.1186\/s43556-026-00593-3","relation":{},"ISSN":["2662-8651"],"issn-type":[{"value":"2662-8651","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,10,13]]},"assertion":[{"value":"10 December 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"10 September 2026","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"11 September 2026","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"13 October 2026","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"All animal experimental protocols were approved by the Institutional Animal Care and Use Committee of Shanghai Jiao Tong University (Shanghai, China, approval No. A2023147-001). All animal experiments were performed in accordance with the recommendations of the Animal Management Rules of China (Documentation 55, 2001, Ministry of Health, China).For human sample research, this study was conducted in compliance with the ethical principles outlined in the Declaration of Helsinki. The human study protocols were approved by the Ethics Committee of the Third Hospital of Changsha (approval No. KY-EC-2023\u2013009) and the Ethics Committee of the Second Affiliated Hospital of Shaanxi University of Traditional Chinese Medicine (approval No. SZEFYIEC-KYPJ-2024001\u20132). Specifically, the project involving human hypertensive artery samples and normotensive control samples was approved by the Ethics Committee of Shanghai Xinhua Hospital, Shanghai Jiao Tong University School of Medicine (approval ID: XHEC-D-2024\u2013002). Written informed consent was obtained from all participants who provided arterial specimens in this study.","order":1,"name":"Ethics","label":"Ethics approval and consent to participate","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Informed consent was obtained from all participants included in the study.","order":2,"name":"Ethics","label":"Consent for publication","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":3,"name":"Ethics","label":"Competing interests","group":{"name":"EthicsHeading","label":"Declarations"}}],"article-number":"209"}}