{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T23:39:45Z","timestamp":1792798785510,"version":"4.5.0"},"reference-count":375,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T00:00:00Z","timestamp":1792800000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T00:00:00Z","timestamp":1792800000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Mol Biomed"],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Ferroptosis is an iron-dependent, non-apoptotic form of regulated cell death that is driven by lipid peroxidation. In the past decade, it has emerged as a core pathogenic mechanism in a wide range of human diseases, such as neurodegenerative disorders, cardiovascular disease, cancer, and notably, reproductive dysfunction. This review provides a comprehensive overview of the molecular mechanisms underlying ferroptosis with a specific focus on the System Xc\u207b\u2013GSH\u2013GPX4 axis, iron metabolism, lipid peroxidation, and the regulatory roles of key modulators such as Nrf2, ACSL4, and CISD2. This review also explores the physiological roles of ferroptosis in development, tissue homeostasis, and immune regulation, as well as its pathological contributions to obesity, diabetes mellitus, atherosclerosis, neurodegeneration, stroke, cancer, infectious diseases, and reproductive disorders. A substantial part of this review discusses the role of ferroptosis in the pathogenesis of reproductive disorders, such as male reproductive pathologies, including varicocele, testicular ischemia\u2013reperfusion, cryptorchidism, oligospermia, erectile dysfunction, and testicular cancer, and female pathologies like primary ovarian insufficiency, polycystic ovary syndrome, endometriosis, ovarian cancer, and pre-eclampsia. Moreover, the interplay between ferroptosis and immune dysfunction in reproductive tract infections was highlighted. Furthermore, we evaluated current biomarkers, emerging therapeutic strategies, and key translational challenges, highlighting the promise of ferroptosis-modulating agents for novel diagnostic and therapeutic interventions in reproductive medicine and beyond.<\/jats:p>","DOI":"10.1186\/s43556-026-00637-8","type":"journal-article","created":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T23:02:26Z","timestamp":1792796546000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Ferroptosis in health and disease"],"prefix":"10.1186","volume":"7","author":[{"given":"Precious Adeoye","family":"Oyedokun","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Victory Jesutoyosi","family":"Ashonibare","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tunmise Maryanne","family":"Akhigbe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Precious Jesutofunmi","family":"Ashonibare","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adetomiwa Ezekiel","family":"Adeogun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cecilia Adedeji","family":"Adegbola","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ayomide Isaac","family":"Omole","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3874-5927","authenticated-orcid":false,"given":"Roland Eghoghosoa","family":"Akhigbe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,10,24]]},"reference":[{"key":"637_CR1","doi-asserted-by":"publisher","first-page":"782915","DOI":"10.3389\/frph.2022.782915","volume":"4","author":"RE Akhigbe","year":"2022","unstructured":"Akhigbe RE, Dutta S, Hamed MA, Ajayi AF, Sengupta P, Ahmad G. Viral infections and male infertility: a comprehensive review of the role of oxidative stress. Front Reprod Health. 2022;4:782915. https:\/\/doi.org\/10.3389\/frph.2022.782915.","journal-title":"Front Reprod Health"},{"key":"637_CR2","doi-asserted-by":"publisher","first-page":"116645","DOI":"10.1016\/j.ecoenv.2024.116645","volume":"281","author":"RE Akhigbe","year":"2024","unstructured":"Akhigbe RE, Akhigbe TM, Adegbola CA, Oyedokun PA, Adesoye OB, Adeogun AE. Toxic impacts of arsenic bioaccumulation on urinary arsenic metabolites and semen quality: a systematic and meta-analysis. Ecotoxicol Environ Saf. 2024;281:116645. https:\/\/doi.org\/10.1016\/j.ecoenv.2024.116645.","journal-title":"Ecotoxicol Environ Saf"},{"key":"637_CR3","doi-asserted-by":"publisher","first-page":"1227836","DOI":"10.3389\/fendo.2023.1227836","volume":"14","author":"MA Hamed","year":"2023","unstructured":"Hamed MA, Akhigbe TM, Adeogun AE, Adesoye OB, Akhigbe RE. Impact of organophosphate pesticides exposure on human semen parameters and testosterone: a systematic review and meta-analysis. Front Endocrinol (Lausanne). 2023;14:1227836. https:\/\/doi.org\/10.3389\/fendo.2023.1227836.","journal-title":"Front Endocrinol (Lausanne)"},{"key":"637_CR4","doi-asserted-by":"publisher","first-page":"115415","DOI":"10.1016\/j.biopha.2023.115415","volume":"166","author":"M Liu","year":"2022","unstructured":"Liu M, Wu K, Wu Y. The emerging role of ferroptosis in female reproductive disorders. Biomed Pharmacother. 2022;166:115415. https:\/\/doi.org\/10.1016\/j.biopha.2023.115415.","journal-title":"Biomed Pharmacother"},{"issue":"7","key":"637_CR5","doi-asserted-by":"publisher","first-page":"579","DOI":"10.1038\/s41419-022-05037-8","volume":"13","author":"Z Ni","year":"2022","unstructured":"Ni Z, Li Y, Song D, Ding J, Mei S, Sun S, et al. Iron-overloaded follicular fluid increases the risk of endometriosis-related infertility by triggering granulosa cell ferroptosis and oocyte dysmaturity. Cell Death Dis. 2022;13(7):579. https:\/\/doi.org\/10.1038\/s41419-022-05037-8.","journal-title":"Cell Death Dis"},{"issue":"1","key":"637_CR6","doi-asserted-by":"publisher","first-page":"43","DOI":"10.3390\/genes14010043","volume":"14","author":"Y Su","year":"2022","unstructured":"Su Y, Liu Z, Xie K, Ren Y, Li C, Chen W. Ferroptosis: a novel type of cell death in male reproduction. Genes (Basel). 2022;14(1):43. https:\/\/doi.org\/10.3390\/genes14010043.","journal-title":"Genes (Basel)"},{"issue":"12","key":"637_CR7","doi-asserted-by":"publisher","first-page":"e70010","DOI":"10.1002\/mco2.70010","volume":"5","author":"Q Zhou","year":"2024","unstructured":"Zhou Q, Meng Y, Le J, Sun Y, Dian Y, Yao L, et al. Ferroptosis: Mechanisms and therapeutic targets. MedComm (2020). 2024;5(12):e70010. https:\/\/doi.org\/10.1002\/mco2.70010.","journal-title":"MedComm (2020)"},{"issue":"1","key":"637_CR8","doi-asserted-by":"publisher","first-page":"164","DOI":"10.3390\/cancers12010164","volume":"12","author":"CM Bebber","year":"2020","unstructured":"Bebber CM, M\u00fcller F, Prieto Clemente L, Weber J, von Karstedt S. Ferroptosis in cancer cell biology. Cancers (Basel). 2020;12(1):164. https:\/\/doi.org\/10.3390\/cancers12010164.","journal-title":"Cancers (Basel)"},{"issue":"22","key":"637_CR9","doi-asserted-by":"publisher","first-page":"8765","DOI":"10.3390\/ijms21228765","volume":"21","author":"CO Reichert","year":"2020","unstructured":"Reichert CO, de Freitas FA, Sampaio-Silva J, Rokita-Rosa L, Barros PD, Levy D, et al. Ferroptosis mechanisms involved in neurodegenerative diseases. Int J Mol Sci. 2020;21(22):8765. https:\/\/doi.org\/10.3390\/ijms21228765.","journal-title":"Int J Mol Sci"},{"issue":"1","key":"637_CR10","doi-asserted-by":"publisher","first-page":"193","DOI":"10.1038\/s41420-021-00579-w","volume":"7","author":"Y Yu","year":"2021","unstructured":"Yu Y, Yan Y, Niu F, Wang Y, Chen X, Su G, et al. Ferroptosis: a cell death connecting oxidative stress, inflammation and cardiovascular diseases. Cell Death Discov. 2021;7(1):193. https:\/\/doi.org\/10.1038\/s41420-021-00579-w.","journal-title":"Cell Death Discov"},{"issue":"3","key":"637_CR11","doi-asserted-by":"publisher","first-page":"234","DOI":"10.1016\/j.chembiol.2008.02.010","volume":"15","author":"WS Yang","year":"2008","unstructured":"Yang WS, Stockwell BR. Synthetic lethal screening identifies compounds activating iron-dependent, nonapoptotic cell death in oncogenic-RAS-harboring cancer cells. Chem Biol. 2008;15(3):234\u201345. https:\/\/doi.org\/10.1016\/j.chembiol.2008.02.010.","journal-title":"Chem Biol"},{"issue":"5","key":"637_CR12","doi-asserted-by":"publisher","first-page":"1060","DOI":"10.1016\/j.cell.2012.03.042","volume":"149","author":"SJ Dixon","year":"2012","unstructured":"Dixon SJ, Lemberg KM, Lamprecht MR, Skouta R, Zaitsev EM, Gleason CE, et al. Ferroptosis: an iron-dependent form of nonapoptotic cell death. Cell. 2012;149(5):1060\u201372. https:\/\/doi.org\/10.1016\/j.cell.2012.03.042.","journal-title":"Cell"},{"issue":"19","key":"637_CR13","doi-asserted-by":"publisher","first-page":"4968","DOI":"10.3390\/ijms20194968","volume":"20","author":"N Kajarabille","year":"2019","unstructured":"Kajarabille N, Latunde-Dada GO. Programmed cell-death by ferroptosis: antioxidants as mitigators. Int J Mol Sci. 2019;20(19):4968. https:\/\/doi.org\/10.3390\/ijms20194968.","journal-title":"Int J Mol Sci"},{"issue":"9","key":"637_CR14","doi-asserted-by":"publisher","first-page":"2180","DOI":"10.1158\/2159-8290.CD-22-0043","volume":"12","author":"N Santana-Codina","year":"2022","unstructured":"Santana-Codina N, Del Rey MQ, Kapner KS, Zhang H, Gikandi A, Malcolm C, et al. NCOA4-mediated ferritinophagy is a pancreatic cancer dependency via maintenance of iron bioavailability for iron\u2013sulfur cluster proteins. Cancer Discov. 2022;12(9):2180\u201397. https:\/\/doi.org\/10.1158\/2159-8290.CD-22-0043.","journal-title":"Cancer Discov"},{"issue":"45","key":"637_CR15","doi-asserted-by":"publisher","first-page":"5617","DOI":"10.1038\/onc.2015.32","volume":"34","author":"X Sun","year":"2015","unstructured":"Sun X, Ou Z, Xie M, Kang R, Fan Y, Niu X, et al. HSPB1 as a novel regulator of ferroptotic cancer cell death. Oncogene. 2015;34(45):5617\u201325. https:\/\/doi.org\/10.1038\/onc.2015.32.","journal-title":"Oncogene"},{"issue":"12","key":"637_CR16","doi-asserted-by":"publisher","first-page":"9179","DOI":"10.1002\/jcp.26954","volume":"233","author":"M Tang","year":"2018","unstructured":"Tang M, Chen Z, Wu D, Chen L. Ferritinophagy\/ferroptosis: Iron-related newcomers in human diseases. J Cell Physiol. 2018;233(12):9179\u201390. https:\/\/doi.org\/10.1002\/jcp.26954.","journal-title":"J Cell Physiol"},{"issue":"3","key":"637_CR17","doi-asserted-by":"publisher","first-page":"e0224052","DOI":"10.1371\/journal.pone.0224052","volume":"15","author":"R Akhigbe","year":"2020","unstructured":"Akhigbe R, Ajayi A. Testicular toxicity following chronic codeine administration is via oxidative DNA damage and up-regulation of NO\/TNF-\u03b1 and caspase 3 activities. PLoS ONE. 2020;15(3):e0224052. https:\/\/doi.org\/10.1371\/journal.pone.0224052.","journal-title":"PLoS ONE"},{"issue":"3","key":"637_CR18","doi-asserted-by":"publisher","first-page":"409","DOI":"10.1016\/j.cell.2017.11.048","volume":"172","author":"I Ingold","year":"2018","unstructured":"Ingold I, Berndt C, Schmitt S, Doll S, Poschmann G, Buday K, et al. Selenium utilization by GPX4 is required to prevent hydroperoxide-induced ferroptosis. Cell. 2018;172(3):409\u201322. https:\/\/doi.org\/10.1016\/j.cell.2017.11.048.","journal-title":"Cell"},{"issue":"11","key":"637_CR19","doi-asserted-by":"publisher","first-page":"11355","DOI":"10.1021\/acsnano.8b06201","volume":"12","author":"Z Shen","year":"2018","unstructured":"Shen Z, Liu T, Li Y, Lau J, Yang Z, Fan W, et al. Fenton-reaction-acceleratable magnetic nanoparticles for ferroptosis therapy of orthotopic brain tumors. ACS Nano. 2018;12(11):11355\u201365. https:\/\/doi.org\/10.1021\/acsnano.8b06201.","journal-title":"ACS Nano"},{"issue":"6","key":"637_CR20","doi-asserted-by":"publisher","first-page":"2672","DOI":"10.1007\/s12011-023-03860-4","volume":"202","author":"EE Besong","year":"2024","unstructured":"Besong EE, Akhigbe TM, Obimma JN, Obembe OO, Akhigbe RE. Acetate abates arsenic-induced male reproductive toxicity by suppressing HDAC and uric acid\u2013driven oxido-inflammatory NF-\u03baB\/iNOS\/NO response in rats. Biol Trace Elem Res. 2024;202(6):2672\u201387. https:\/\/doi.org\/10.1007\/s12011-023-03860-4.","journal-title":"Biol Trace Elem Res"},{"issue":"17","key":"637_CR21","doi-asserted-by":"publisher","first-page":"1756","DOI":"10.1089\/ars.2017.7176","volume":"29","author":"MJ Kerins","year":"2018","unstructured":"Kerins MJ, Ooi A. The roles of NRF2 in modulating cellular iron homeostasis. Antioxid Redox Signal. 2018;29(17):1756\u201373. https:\/\/doi.org\/10.1089\/ars.2017.7176.","journal-title":"Antioxid Redox Signal"},{"key":"637_CR22","doi-asserted-by":"crossref","unstructured":"Tao W, Wang N, Ruan J, Cheng X, Fan L, Zhang P, et al. Enhanced ROS-boosted phototherapy against pancreatic cancer via Nrf2-mediated stress-defense pathway suppression and ferroptosis induction. ACS Appl Mater Interfaces. 2022;14(5):6404\u201316. https:\/\/pubs.acs.org\/doi\/10.1021\/acsami.1c22861?goto=supporting-inf.","DOI":"10.1021\/acsami.1c22861"},{"issue":"1","key":"637_CR23","doi-asserted-by":"publisher","first-page":"423","DOI":"10.1007\/s00210-023-02620-4","volume":"397","author":"DH Adeyemi","year":"2024","unstructured":"Adeyemi DH, Obembe OO, Hamed MA, Akhigbe RE. Sodium acetate ameliorates doxorubicin-induced cardiac injury via upregulation of Nrf2\/HO-1 signaling and downregulation of NF-\u03baB-mediated apoptotic signaling in Wistar rats. Naunyn Schmiedebergs Arch Pharmacol. 2024;397(1):423\u201335. https:\/\/doi.org\/10.1007\/s00210-023-02620-4.","journal-title":"Naunyn Schmiedebergs Arch Pharmacol"},{"key":"637_CR24","doi-asserted-by":"publisher","first-page":"116019","DOI":"10.1016\/j.biopha.2023.116019","volume":"170","author":"DH Adeyemi","year":"2024","unstructured":"Adeyemi DH, Hamed MA, Oluwole DT, Omole AI, Akhigbe RE. Acetate attenuates cyclophosphamide-induced cardiac injury via inhibition of NF-\u03baB signaling and suppression of caspase 3-dependent apoptosis in Wistar rats. Biomed Pharmacother. 2024;170:116019. https:\/\/doi.org\/10.1016\/j.biopha.2023.116019.","journal-title":"Biomed Pharmacother"},{"key":"637_CR25","doi-asserted-by":"publisher","first-page":"199","DOI":"10.1007\/s00726-011-0864-8","volume":"42","author":"GJ McBean","year":"2012","unstructured":"McBean GJ. The transsulfuration pathway: a source of cysteine for glutathione in astrocytes. Amino Acids. 2012;42:199\u2013205. https:\/\/doi.org\/10.1007\/s00726-011-0864-8.","journal-title":"Amino Acids"},{"issue":"6","key":"637_CR26","doi-asserted-by":"publisher","first-page":"920","DOI":"10.1016\/j.cmet.2020.10.011","volume":"32","author":"J Zheng","year":"2020","unstructured":"Zheng J, Conrad M. The metabolic underpinnings of ferroptosis. Cell Metab. 2020;32(6):920\u201337. https:\/\/doi.org\/10.1016\/j.cmet.2020.10.011.","journal-title":"Cell Metab"},{"issue":"1","key":"637_CR27","doi-asserted-by":"publisher","first-page":"23","DOI":"10.1186\/s12944-021-01435-7","volume":"20","author":"R Akhigbe","year":"2021","unstructured":"Akhigbe R, Ajayi A. The impact of reactive oxygen species in the development of cardiometabolic disorders: a review. Lipids Health Dis. 2021;20(1):23. https:\/\/doi.org\/10.1186\/s12944-021-01435-7.","journal-title":"Lipids Health Dis"},{"issue":"1","key":"637_CR28","doi-asserted-by":"publisher","first-page":"41","DOI":"10.1021\/acscentsci.9b01063","volume":"6","author":"VA Kraft","year":"2020","unstructured":"Kraft VA, Bezjian CT, Pfeiffer S, Ringelstetter L, M\u00fcller C, Zandkarimi F, et al. GTP cyclohydrolase 1\/tetrahydrobiopterin counteract ferroptosis through lipid remodeling. ACS Cent Sci. 2020;6(1):41\u201353. https:\/\/doi.org\/10.1021\/acscentsci.9b01063.","journal-title":"ACS Cent Sci"},{"issue":"7860","key":"637_CR29","doi-asserted-by":"publisher","first-page":"586","DOI":"10.1038\/s41586-021-03820-9","volume":"593","author":"C Mao","year":"2021","unstructured":"Mao C, Liu X, Zhang Y, Lei G, Yan Y, Lee H, et al. DHODH-mediated ferroptosis defence is a targetable vulnerability in cancer. Nature. 2021;593(7860):586\u201390. https:\/\/doi.org\/10.1038\/s41586-021-03820-9.","journal-title":"Nature"},{"issue":"2","key":"637_CR30","doi-asserted-by":"publisher","first-page":"354","DOI":"10.1016\/j.molcel.2018.10.042","volume":"73","author":"M Gao","year":"2019","unstructured":"Gao M, Yi J, Zhu J, Minikes AM, Monian P, Thompson CB, et al. Role of mitochondria in ferroptosis. Mol Cell. 2019;73(2):354\u201363. https:\/\/doi.org\/10.1016\/j.molcel.2018.10.042.","journal-title":"Mol Cell"},{"issue":"12","key":"637_CR31","doi-asserted-by":"publisher","first-page":"1137","DOI":"10.1038\/s41589-019-0408-1","volume":"15","author":"M Conrad","year":"2019","unstructured":"Conrad M, Pratt DA. The chemical basis of ferroptosis. Nat Chem Biol. 2019;15(12):1137\u201347. https:\/\/doi.org\/10.1038\/s41589-019-0408-1.","journal-title":"Nat Chem Biol"},{"issue":"5","key":"637_CR32","doi-asserted-by":"publisher","first-page":"e2006203","DOI":"10.1371\/journal.pbio.2006203","volume":"16","author":"H Feng","year":"2018","unstructured":"Feng H, Stockwell BR. Unsolved mysteries: How does lipid peroxidation cause ferroptosis? PLoS Biol. 2018;16(5):e2006203. https:\/\/doi.org\/10.1371\/journal.pbio.2006203.","journal-title":"PLoS Biol"},{"issue":"9","key":"637_CR33","doi-asserted-by":"publisher","first-page":"566","DOI":"10.1038\/nrm3412","volume":"13","author":"R Rizzuto","year":"2012","unstructured":"Rizzuto R, De Stefani D, Raffaello A, Mammucari C. Mitochondria as sensors and regulators of calcium signalling. Nat Rev Mol Cell Biol. 2012;13(9):566\u201378. https:\/\/doi.org\/10.1038\/nrm3412.","journal-title":"Nat Rev Mol Cell Biol"},{"issue":"2","key":"637_CR34","doi-asserted-by":"publisher","first-page":"298","DOI":"10.1016\/j.molcel.2015.06.011","volume":"59","author":"M Gao","year":"2015","unstructured":"Gao M, Monian P, Quadri N, Ramasamy R, Jiang X. Glutaminolysis and transferrin regulate ferroptosis. Mol Cell. 2015;59(2):298\u2013308. https:\/\/doi.org\/10.1016\/j.molcel.2015.06.011.","journal-title":"Mol Cell"},{"issue":"2","key":"637_CR35","doi-asserted-by":"publisher","first-page":"449","DOI":"10.1002\/hep.29117","volume":"66","author":"H Wang","year":"2017","unstructured":"Wang H, An P, Xie E, Wu Q, Fang X, Gao H, et al. Characterization of ferroptosis in murine models of hemochromatosis. Hepatology. 2017;66(2):449\u201365. https:\/\/doi.org\/10.1002\/hep.29117.","journal-title":"Hepatology"},{"issue":"2","key":"637_CR36","doi-asserted-by":"publisher","first-page":"445","DOI":"10.4143\/crt.2016.572","volume":"50","author":"J Guo","year":"2018","unstructured":"Guo J, Xu B, Han Q, Zhou H, Xia Y, Gong C, et al. Ferroptosis: a novel anti-tumor action for cisplatin. Cancer Res Treat. 2018;50(2):445\u201360. https:\/\/doi.org\/10.4143\/crt.2016.572.","journal-title":"Cancer Res Treat"},{"issue":"9","key":"637_CR37","doi-asserted-by":"publisher","first-page":"1260","DOI":"10.1161\/CIRCRESAHA.120.315937","volume":"126","author":"A Abbate","year":"2020","unstructured":"Abbate A, Toldo S, Marchetti C, Kron J, Van Tassell BW, Dinarello CA. Interleukin-1 and the inflammasome as therapeutic targets in cardiovascular disease. Circ Res. 2020;126(9):1260\u201380. https:\/\/doi.org\/10.1161\/CIRCRESAHA.120.315937.","journal-title":"Circ Res"},{"issue":"2","key":"637_CR38","doi-asserted-by":"publisher","first-page":"273","DOI":"10.1016\/j.cell.2017.09.021","volume":"171","author":"BR Stockwell","year":"2017","unstructured":"Stockwell BR, Angeli JP, Bayir H, Bush AI, Conrad M, Dixon SJ, et al. Ferroptosis: a regulated cell death nexus linking metabolism, redox biology, and disease. Cell. 2017;171(2):273\u201385. https:\/\/doi.org\/10.1016\/j.cell.2017.09.021.","journal-title":"Cell"},{"issue":"2","key":"637_CR39","doi-asserted-by":"publisher","first-page":"88","DOI":"10.1038\/s41419-020-2298-2","volume":"11","author":"J Li","year":"2020","unstructured":"Li J, Cao F, Yin HL, Huang ZJ, Lin ZT, Mao N, et al. Ferroptosis: past, present and future. Cell Death Dis. 2020;11(2):88. https:\/\/doi.org\/10.1038\/s41419-020-2298-2.","journal-title":"Cell Death Dis"},{"key":"637_CR40","doi-asserted-by":"publisher","first-page":"101107","DOI":"10.1016\/j.redox.2019.101107","volume":"23","author":"M Dodson","year":"2019","unstructured":"Dodson M, Castro-Portuguez R, Zhang DD. NRF2 plays a critical role in mitigating lipid peroxidation and ferroptosis. Redox Biol. 2019;23:101107. https:\/\/doi.org\/10.1016\/j.redox.2019.101107.","journal-title":"Redox Biol"},{"issue":"1","key":"637_CR41","doi-asserted-by":"publisher","first-page":"6318","DOI":"10.1038\/s41467-022-34096-w","volume":"13","author":"X Chen","year":"2022","unstructured":"Chen X, Huang J, Yu C, Liu J, Gao W, Li J, et al. A noncanonical function of EIF4E limits ALDH1B1 activity and increases susceptibility to ferroptosis. Nat Commun. 2022;13(1):6318. https:\/\/doi.org\/10.1038\/s41467-022-34096-w.","journal-title":"Nat Commun"},{"issue":"5","key":"637_CR42","doi-asserted-by":"publisher","first-page":"952","DOI":"10.1111\/joim.13265","volume":"290","author":"L Erlandsson","year":"2021","unstructured":"Erlandsson L, Masoumi Z, Hansson LR, Hansson SR. The roles of free iron, heme, haemoglobin, and the scavenger proteins haemopexin and alpha-1-microglobulin in preeclampsia and fetal growth restriction. J Intern Med. 2021;290(5):952\u201368. https:\/\/doi.org\/10.1111\/joim.13265.","journal-title":"J Intern Med"},{"key":"637_CR43","doi-asserted-by":"publisher","DOI":"10.1016\/j.toxrep.2025.102064","author":"E Ajani","year":"2025","unstructured":"Ajani E, Akhigbe TM, Oyedokun PA, Adegbola CA, Adeyemi DH, Akhigbe RE. Ferroptotic-and non-ferroptotic mechanisms associated with doxorubicin-induced male reproductive dysfunction. Toxicol Rep. 2025. https:\/\/doi.org\/10.1016\/j.toxrep.2025.102064.","journal-title":"Toxicol Rep"},{"issue":"3","key":"637_CR44","doi-asserted-by":"publisher","first-page":"188890","DOI":"10.1016\/j.bbcan.2023.188890","volume":"1878","author":"Y Liu","year":"2023","unstructured":"Liu Y, Wan Y, Jiang Y, Zhang L, Cheng W. GPX4: The hub of lipid oxidation, ferroptosis, disease and treatment. Biochim Biophys Acta Rev Cancer. 2023;1878(3):188890. https:\/\/doi.org\/10.1016\/j.bbcan.2023.188890.","journal-title":"Biochim Biophys Acta Rev Cancer"},{"issue":"3","key":"637_CR45","doi-asserted-by":"publisher","first-page":"389","DOI":"10.1093\/abbs\/gmad005","volume":"57","author":"D Wu","year":"2024","unstructured":"Wu D, Wang Z, Zhang Y, et al. IL15RA-STAT3-GPX4\/ACSL3 signaling leads to ferroptosis resistance in pancreatic cancer. Acta Biochim Biophys Sin (Shanghai). 2024;57(3):389. https:\/\/doi.org\/10.1093\/abbs\/gmad005.","journal-title":"Acta Biochim Biophys Sin (Shanghai)"},{"issue":"1","key":"637_CR46","doi-asserted-by":"publisher","first-page":"33","DOI":"10.1186\/s43556-023-00142-2","volume":"4","author":"S Feng","year":"2023","unstructured":"Feng S, Tang D, Wang Y, Li X, Bao H, Tang C, et al. The mechanism of ferroptosis and its related diseases. Mol Biomed. 2023;4(1):33. https:\/\/doi.org\/10.1186\/s43556-023-00142-2.","journal-title":"Mol Biomed"},{"issue":"1","key":"637_CR47","doi-asserted-by":"publisher","first-page":"207","DOI":"10.14218\/JCTH.2022.00255","volume":"11","author":"Z Huang","year":"2023","unstructured":"Huang Z, Xia H, Cui Y, Yam JWP, Xu Y. Ferroptosis: from basic research to clinical therapeutics in hepatocellular carcinoma. J Clin Transl Hepatol. 2023;11(1):207\u201318. https:\/\/doi.org\/10.14218\/JCTH.2022.00255.","journal-title":"J Clin Transl Hepatol"},{"issue":"1\u20132","key":"637_CR48","doi-asserted-by":"publisher","first-page":"317","DOI":"10.1016\/j.cell.2013.12.0","volume":"156","author":"WS Yang","year":"2014","unstructured":"Yang WS, SriRamaratnam R, Welsch ME, Shimada K, Skouta R, Viswanathan VS, et al. Regulation of ferroptotic cancer cell death by GPX4. Cell. 2014;156(1\u20132):317\u201331. https:\/\/doi.org\/10.1016\/j.cell.2013.12.0.","journal-title":"Cell"},{"key":"637_CR49","doi-asserted-by":"publisher","first-page":"911860","DOI":"10.3389\/fnut.2022.911860","volume":"9","author":"C Zimiao","year":"2022","unstructured":"Zimiao C, Dongdong L, Shuoping C, Peng Z, Fan Z, Rujun C, et al. Correlations between iron status and body composition in patients with type 2 diabetes mellitus. Front Nutr. 2022;9:911860. https:\/\/doi.org\/10.3389\/fnut.2022.911860.","journal-title":"Front Nutr"},{"issue":"7498","key":"637_CR50","doi-asserted-by":"publisher","first-page":"105","DOI":"10.1038\/nature13148","volume":"509","author":"JD Mancias","year":"2014","unstructured":"Mancias JD, Wang X, Gygi SP, Harper JW, Kimmelman AC. Quantitative proteomics identifies NCOA4 as the cargo receptor mediating ferritinophagy. Nature. 2014;509(7498):105\u20139. https:\/\/doi.org\/10.1038\/nature13148.","journal-title":"Nature"},{"issue":"1","key":"637_CR51","doi-asserted-by":"publisher","first-page":"49","DOI":"10.1038\/s41392-020-00428-9","volume":"6","author":"HF Yan","year":"2021","unstructured":"Yan HF, Zou T, Tuo QZ, Xu S, Li H, Belaidi AA, et al. Ferroptosis: mechanisms and links with diseases. Signal Transduct Target Ther. 2021;6(1):49. https:\/\/doi.org\/10.1038\/s41392-020-00428-9.","journal-title":"Signal Transduct Target Ther"},{"key":"637_CR52","doi-asserted-by":"publisher","first-page":"102276","DOI":"10.1016\/j.redox.2022.102276","volume":"51","author":"J Lee","year":"2022","unstructured":"Lee J, You JH, Roh JL. Poly (rC)-binding protein 1 represses ferritinophagy-mediated ferroptosis in head and neck cancer. Redox Biol. 2022;51:102276. https:\/\/doi.org\/10.1016\/j.redox.2022.102276.","journal-title":"Redox Biol"},{"issue":"1","key":"637_CR53","doi-asserted-by":"publisher","first-page":"163","DOI":"10.1186\/s13578-022-00887-6","volume":"12","author":"J Wang","year":"2022","unstructured":"Wang J, Zhu Q, Li R, Zhang J, Ye X, Li X. YAP1 protects against septic liver injury via ferroptosis resistance. Cell Biosci. 2022;12(1):163. https:\/\/doi.org\/10.1186\/s13578-022-00887-6.","journal-title":"Cell Biosci"},{"key":"637_CR54","doi-asserted-by":"publisher","first-page":"1071864","DOI":"10.3389\/fmed.2022.1071864","volume":"9","author":"Y Yang","year":"2023","unstructured":"Yang Y, Cheng J, Lin Q, Ni Z. Autophagy-dependent ferroptosis in kidney disease. Front Med (Lausanne). 2023;9:1071864. https:\/\/doi.org\/10.3389\/fmed.2022.1071864.","journal-title":"Front Med (Lausanne)"},{"key":"637_CR55","doi-asserted-by":"publisher","first-page":"87","DOI":"10.1016\/j.freeradbiomed.2022.12.007","volume":"200","author":"K Sun","year":"2023","unstructured":"Sun K, Hou L, Guo Z, Wang G, Guo J, Xu J, et al. JNK-JUN-NCOA4 axis contributes to chondrocyte ferroptosis and aggravates osteoarthritis via ferritinophagy. Free Radic Biol Med. 2023;200:87\u2013101. https:\/\/doi.org\/10.1016\/j.freeradbiomed.2022.12.007.","journal-title":"Free Radic Biol Med"},{"issue":"3","key":"637_CR56","doi-asserted-by":"publisher","first-page":"e70253","DOI":"10.1002\/ctm2.70253","volume":"15","author":"X Xia","year":"2025","unstructured":"Xia X, Wu H, Chen Y, Peng H, Wang S. Ferroptosis of T cell in inflammation and tumour immunity. Clin Transl Med. 2025;15(3):e70253. https:\/\/doi.org\/10.1002\/ctm2.70253.","journal-title":"Clin Transl Med"},{"issue":"4","key":"637_CR57","doi-asserted-by":"publisher","first-page":"365","DOI":"10.1016\/j.ccell.2022.02.003","volume":"40","author":"P Liao","year":"2022","unstructured":"Liao P, Wang W, Wang W, Kryczek I, Li X, Bian Y, et al. CD8+ T cells and fatty acids orchestrate tumor ferroptosis and immunity via ACSL4. Cancer Cell. 2022;40(4):365-78.e6. https:\/\/doi.org\/10.1016\/j.ccell.2022.02.003.","journal-title":"Cancer Cell"},{"key":"637_CR58","doi-asserted-by":"publisher","first-page":"765859","DOI":"10.3389\/fcell.2021.765859","volume":"9","author":"Z Tang","year":"2021","unstructured":"Tang Z, Huang Z, Huang Y, Chen Y, Huang M, Liu H, et al. Ferroptosis: the silver lining of cancer therapy. Front Cell Dev Biol. 2021;9:765859. https:\/\/doi.org\/10.3389\/fcell.2021.765859.","journal-title":"Front Cell Dev Biol"},{"issue":"1","key":"637_CR59","doi-asserted-by":"publisher","first-page":"55","DOI":"10.1038\/s41392-024-01769-5","volume":"9","author":"Q Zhou","year":"2024","unstructured":"Zhou Q, Meng Y, Li D, Yao L, Le J, Liu Y, et al. Ferroptosis in cancer: from molecular mechanisms to therapeutic strategies. Signal Transduct Target Ther. 2024;9(1):55. https:\/\/doi.org\/10.1038\/s41392-024-01769-5.","journal-title":"Signal Transduct Target Ther"},{"issue":"10","key":"637_CR60","doi-asserted-by":"publisher","first-page":"2954","DOI":"10.3390\/nu12102954","volume":"12","author":"D Li","year":"2020","unstructured":"Li D, Jiang C, Mei G, Zhao Y, Chen L, Liu J, et al. Quercetin alleviates ferroptosis of pancreatic \u03b2 cells in type 2 diabetes. Nutrients. 2020;12(10):2954. https:\/\/doi.org\/10.3390\/nu12102954.","journal-title":"Nutrients"},{"issue":"2","key":"637_CR61","doi-asserted-by":"publisher","first-page":"270","DOI":"10.1038\/cdd.2015.93","volume":"23","author":"M Hayano","year":"2016","unstructured":"Hayano M, Yang WS, Corn CK, Pagano NC, Stockwell BR. Loss of cysteinyl-tRNA synthetase (CARS) induces the transsulfuration pathway and inhibits ferroptosis induced by cystine deprivation. Cell Death Differ. 2016;23(2):270\u20138. https:\/\/doi.org\/10.1038\/cdd.2015.93.","journal-title":"Cell Death Differ"},{"key":"637_CR62","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/s40478-021-01236-0","volume":"9","author":"AC Wehn","year":"2021","unstructured":"Wehn AC, Khalin I, Duering M, Hellal F, Culmsee C, Vandenabeele P, et al. RIPK1 or RIPK3 deletion prevents progressive neuronal cell death and improves memory function after traumatic brain injury. Acta Neuropathol Commun. 2021;9:1\u20138. https:\/\/doi.org\/10.1186\/s40478-021-01236-0.","journal-title":"Acta Neuropathol Commun"},{"issue":"1","key":"637_CR63","first-page":"5","volume":"23","author":"B Zhou","year":"2002","unstructured":"Zhou B. Predictive values of body mass index and waist circumference to risk factors of related diseases in Chinese adult population. Zhonghua Liu Xing Bing Xue Za Zhi. 2002;23(1):5\u201310.","journal-title":"Zhonghua Liu Xing Bing Xue Za Zhi"},{"issue":"1","key":"637_CR64","doi-asserted-by":"publisher","first-page":"165","DOI":"10.1007\/s00038-017-1002-5","volume":"63","author":"C El Bcheraoui","year":"2018","unstructured":"El Bcheraoui C, Afshin A, Charara R, Khalil I, Moradi-Lakeh M, Kassebaum NJ, et al. Burden of obesity in the Eastern Mediterranean Region: findings from the Global Burden of Disease 2015 study. Int J Public Health. 2018;63(1):165\u201376. https:\/\/doi.org\/10.1007\/s00038-017-1002-5.","journal-title":"Int J Public Health"},{"issue":"5","key":"637_CR65","doi-asserted-by":"publisher","first-page":"318","DOI":"10.4103\/1319-3767.84486","volume":"17","author":"AA Mahfouz","year":"2011","unstructured":"Mahfouz AA, Shatoor AS, Khan MY, Daffalla AA, Mostafa OA, Hassanein MA. Nutrition, physical activity, and gender risks for adolescent obesity in Southwestern Saudi Arabia. Saudi J Gastroenterol. 2011;17(5):318\u201322. https:\/\/doi.org\/10.4103\/1319-3767.84486.","journal-title":"Saudi J Gastroenterol"},{"issue":"15","key":"637_CR66","doi-asserted-by":"publisher","first-page":"5529","DOI":"10.3390\/ijms21155529","volume":"21","author":"\u00c1 Gonz\u00e1lez-Dom\u00ednguez","year":"2020","unstructured":"Gonz\u00e1lez-Dom\u00ednguez \u00c1, Visiedo-Garc\u00eda FM, Dom\u00ednguez-Riscart J, Gonz\u00e1lez-Dom\u00ednguez R, Mateos RM, Lechuga-Sancho AM. Iron metabolism in obesity and metabolic syndrome. Int J Mol Sci. 2020;21(15):5529. https:\/\/doi.org\/10.3390\/ijms21155529.","journal-title":"Int J Mol Sci"},{"issue":"2","key":"637_CR67","first-page":"164","volume":"19","author":"N Abbaspour","year":"2014","unstructured":"Abbaspour N, Hurrell R, Kelishadi R. Review on iron and its importance for human health. J Res Med Sci. 2014;19(2):164.","journal-title":"J Res Med Sci"},{"issue":"1","key":"637_CR68","doi-asserted-by":"publisher","first-page":"1350","DOI":"10.1038\/s41467-018-03853-1","volume":"9","author":"AR Folgueras","year":"2018","unstructured":"Folgueras AR, Freitas-Rodr\u00edguez S, Ramsay AJ, Garabaya C, Rodr\u00edguez F, Velasco G, et al. Matriptase-2 deficiency protects from obesity by modulating iron homeostasis. Nat Commun. 2018;9(1):1350. https:\/\/doi.org\/10.1038\/s41467-018-03853-1.","journal-title":"Nat Commun"},{"key":"637_CR69","doi-asserted-by":"publisher","first-page":"116","DOI":"10.1111\/liv.13020","volume":"36","author":"A Pietrangelo","year":"2016","unstructured":"Pietrangelo A. Iron and the liver. Liver Int. 2016;36:116\u201323. https:\/\/doi.org\/10.1111\/liv.13020.","journal-title":"Liver Int"},{"issue":"5\u20136","key":"637_CR70","doi-asserted-by":"publisher","first-page":"446","DOI":"10.1159\/000336423","volume":"4","author":"T Ganz","year":"2012","unstructured":"Ganz T. Macrophages and systemic iron homeostasis. J Innate Immun. 2012;4(5\u20136):446\u201353. https:\/\/doi.org\/10.1159\/000336423.","journal-title":"J Innate Immun"},{"issue":"11","key":"637_CR71","doi-asserted-by":"publisher","first-page":"1814","DOI":"10.3324\/haematol.2010.023879","volume":"95","author":"G Corna","year":"2010","unstructured":"Corna G, Campana L, Pignatti E, Castiglioni A, Tagliafico E, Bosurgi L, et al. Polarization dictates iron handling by inflammatory and alternatively activated macrophages. Haematologica. 2010;95(11):1814. https:\/\/doi.org\/10.3324\/haematol.2010.023879.","journal-title":"Haematologica"},{"issue":"2","key":"637_CR72","doi-asserted-by":"publisher","first-page":"421","DOI":"10.2337\/db13-0213","volume":"63","author":"JS Orr","year":"2014","unstructured":"Orr JS, Kennedy A, Anderson-Baucum EK, Webb CD, Fordahl SC, Erikson KM, et al. Obesity alters adipose tissue macrophage iron content and tissue iron distribution. Diabetes. 2014;63(2):421\u201332. https:\/\/doi.org\/10.2337\/db13-0213.","journal-title":"Diabetes"},{"issue":"6","key":"637_CR73","doi-asserted-by":"publisher","first-page":"e0179889","DOI":"10.1371\/journal.pone.0179889","volume":"12","author":"X Ma","year":"2017","unstructured":"Ma X, Pham VT, Mori H, MacDougald OA, Shah YM, Bodary PF. Iron elevation and adipose tissue remodeling in the epididymal depot of a mouse model of polygenic obesity. PLoS ONE. 2017;12(6):e0179889. https:\/\/doi.org\/10.1371\/journal.pone.0179889.","journal-title":"PLoS ONE"},{"key":"637_CR74","doi-asserted-by":"publisher","first-page":"80","DOI":"10.1007\/BF02912918","volume":"21","author":"M Maneesh","year":"2006","unstructured":"Maneesh M, Jayalekshmi H. Role of reactive oxygen species and antioxidants on pathophysiology of male reproduction. Indian J Clin Biochem. 2006;21:80\u20139. https:\/\/doi.org\/10.1007\/BF02912918.","journal-title":"Indian J Clin Biochem"},{"issue":"17","key":"637_CR75","doi-asserted-by":"publisher","first-page":"1309","DOI":"10.1002\/bdr2.1135","volume":"109","author":"MJ Soares","year":"2017","unstructured":"Soares MJ, Iqbal K, Kozai K. Hypoxia and Placental Development. Birth Defects Res. 2017;109(17):1309\u201329. https:\/\/doi.org\/10.1002\/bdr2.1135.","journal-title":"Birth Defects Res"},{"key":"637_CR76","volume-title":"Greenspan's basic & clinical endocrinology","year":"2018","unstructured":"Shoback D, Gardner DG, editors. Greenspan\u2019s basic & clinical endocrinology. McGraw-Hill Education; 2018."},{"issue":"1","key":"637_CR77","doi-asserted-by":"publisher","first-page":"45","DOI":"10.1186\/s12939-018-0759-3","volume":"17","author":"AP De Silva","year":"2018","unstructured":"De Silva AP, De Silva SHP, Haniffa R, Liyanage IK, Jayasinghe S, Katulanda P, et al. Inequalities in the prevalence of diabetes mellitus and its risk factors in Sri Lanka: a lower middle income country. Int J Equity Health. 2018;17(1):45. https:\/\/doi.org\/10.1186\/s12939-018-0759-3.","journal-title":"Int J Equity Health"},{"issue":"6","key":"637_CR78","doi-asserted-by":"publisher","first-page":"282","DOI":"10.1038\/ncpuro0211","volume":"2","author":"D Fedele","year":"2005","unstructured":"Fedele D. Therapy insight: sexual and bladder dysfunction associated with diabetes mellitus. Nat Clin Pract Urol. 2005;2(6):282\u201390. https:\/\/doi.org\/10.1038\/ncpuro0211.","journal-title":"Nat Clin Pract Urol"},{"issue":"1","key":"637_CR79","doi-asserted-by":"publisher","first-page":"6","DOI":"10.4103\/2305-0500.220978","volume":"7","author":"SO Temidayo","year":"2018","unstructured":"Temidayo SO, Du Plessis SS. Diabetes mellitus and male infertility. Asian Pac J Reprod. 2018;7(1):6\u201314. https:\/\/doi.org\/10.4103\/2305-0500.220978.","journal-title":"Asian Pac J Reprod"},{"issue":"4","key":"637_CR80","doi-asserted-by":"publisher","first-page":"266","DOI":"10.1038\/s41580-020-00324-8","volume":"22","author":"X Jiang","year":"2021","unstructured":"Jiang X, Stockwell BR, Conrad M. Ferroptosis: mechanisms, biology and role in disease. Nat Rev Mol Cell Biol. 2021;22(4):266\u201382. https:\/\/doi.org\/10.1038\/s41580-020-00324-8.","journal-title":"Nat Rev Mol Cell Biol"},{"issue":"14","key":"637_CR81","doi-asserted-by":"publisher","first-page":"2401","DOI":"10.1016\/j.cell.2022.06.003","volume":"185","author":"BR Stockwell","year":"2022","unstructured":"Stockwell BR. Ferroptosis turns 10: Emerging mechanisms, physiological functions, and therapeutic applications. Cell. 2022;185(14):2401\u201321. https:\/\/doi.org\/10.1016\/j.cell.2022.06.003.","journal-title":"Cell"},{"key":"637_CR82","doi-asserted-by":"publisher","first-page":"1930261","DOI":"10.1155\/2017\/1930261","volume":"2017","author":"J Wang","year":"2017","unstructured":"Wang J, Wang H. Oxidative stress in pancreatic beta cell regeneration. Oxid Med Cell Longev. 2017;2017:1930261. https:\/\/doi.org\/10.1155\/2017\/1930261.","journal-title":"Oxid Med Cell Longev"},{"issue":"6","key":"637_CR83","doi-asserted-by":"publisher","first-page":"e0198626","DOI":"10.1371\/journal.pone.0198626","volume":"13","author":"FK Lutchmansingh","year":"2018","unstructured":"Lutchmansingh FK, Hsu JW, Bennett FI, Badaloo AV, McFarlane-Anderson N, Gordon-Strachan GM, et al. Glutathione metabolism in type 2 diabetes and its relationship with microvascular complications and glycemia. PLoS ONE. 2018;13(6):e0198626. https:\/\/doi.org\/10.1371\/journal.pone.0198626.","journal-title":"PLoS ONE"},{"issue":"10","key":"637_CR84","doi-asserted-by":"publisher","first-page":"2422","DOI":"10.2337\/diacare.27.10.2422","volume":"27","author":"M Jehn","year":"2004","unstructured":"Jehn M, Clark JM, Guallar E. Serum ferritin and risk of the metabolic syndrome in US adults. Diabetes Care. 2004;27(10):2422\u20138. https:\/\/doi.org\/10.2337\/diacare.27.10.2422.","journal-title":"Diabetes Care"},{"issue":"11","key":"637_CR85","doi-asserted-by":"publisher","first-page":"5305","DOI":"10.1210\/en.2004-0392","volume":"145","author":"RC Cooksey","year":"2004","unstructured":"Cooksey RC, Jouihan HA, Ajioka RS, Hazel MW, Jones DL, Kushner JP, et al. Oxidative stress, \u03b2-cell apoptosis, and decreased insulin secretory capacity in mouse models of hemochromatosis. Endocrinology. 2004;145(11):5305\u201312. https:\/\/doi.org\/10.1210\/en.2004-0392.","journal-title":"Endocrinology"},{"key":"637_CR86","doi-asserted-by":"publisher","first-page":"117","DOI":"10.3389\/fphar.2014.00117","volume":"5","author":"D Basuli","year":"2014","unstructured":"Basuli D, Stevens RG, Torti FM, Torti SV. Epidemiological associations between iron and cardiovascular disease and diabetes. Front Pharmacol. 2014;5:117. https:\/\/doi.org\/10.3389\/fphar.2014.00117.","journal-title":"Front Pharmacol"},{"issue":"1","key":"637_CR87","doi-asserted-by":"publisher","first-page":"80","DOI":"10.2337\/db10-0593","volume":"60","author":"J Huang","year":"2011","unstructured":"Huang J, Jones D, Luo B, Sanderson M, Soto J, Abel ED, et al. Iron overload and diabetes risk: a shift from glucose to fatty acid oxidation and increased hepatic glucose production in a mouse model of hereditary hemochromatosis. Diabetes. 2011;60(1):80\u20137. https:\/\/doi.org\/10.2337\/db10-0593.","journal-title":"Diabetes"},{"issue":"3","key":"637_CR88","doi-asserted-by":"publisher","first-page":"150","DOI":"10.1530\/EC-18-0516","volume":"8","author":"T Shu","year":"2019","unstructured":"Shu T, Lv Z, Xie Y, Tang J, Mao X. Hepcidin as a key iron regulator mediates glucotoxicity-induced pancreatic \u03b2-cell dysfunction. Endocr Connect. 2019;8(3):150\u201361. https:\/\/doi.org\/10.1530\/EC-18-0516.","journal-title":"Endocr Connect"},{"issue":"3","key":"637_CR89","doi-asserted-by":"publisher","first-page":"343","DOI":"10.1042\/BST0360343","volume":"36","author":"S Lenzen","year":"2008","unstructured":"Lenzen S. Oxidative stress: the vulnerable \u03b2-cell. Biochem Soc Trans. 2008;36(3):343\u20137. https:\/\/doi.org\/10.1042\/BST0360343.","journal-title":"Biochem Soc Trans"},{"key":"637_CR90","doi-asserted-by":"publisher","first-page":"121","DOI":"10.1016\/j.freeradbiomed.2017.07.021","volume":"112","author":"I Mehmeti","year":"2017","unstructured":"Mehmeti I, Lortz S, Avezov E, J\u00f6rns A, Lenzen S. ER-resident antioxidative GPx7 and GPx8 enzyme isoforms protect insulin-secreting INS-1E \u03b2-cells against lipotoxicity by improving the ER antioxidative capacity. Free Radic Biol Med. 2017;112:121\u201330. https:\/\/doi.org\/10.1016\/j.freeradbiomed.2017.07.021.","journal-title":"Free Radic Biol Med"},{"issue":"3","key":"637_CR91","doi-asserted-by":"publisher","first-page":"301","DOI":"10.1530\/JME-13-0261","volume":"52","author":"S Lortz","year":"2014","unstructured":"Lortz S, Schroter S, Stuckemann V, Mehmeti I, Lenzen S. Influence of cytokines on Dmt1 iron transporter and ferritin expression in insulin-secreting cells. J Mol Endocrinol. 2014;52(3):301\u201310. https:\/\/doi.org\/10.1530\/JME-13-0261.","journal-title":"J Mol Endocrinol"},{"issue":"6","key":"637_CR92","doi-asserted-by":"publisher","first-page":"166114","DOI":"10.1016\/j.bbadis.2021.166114","volume":"1867","author":"B Kr\u00fcmmel","year":"2021","unstructured":"Kr\u00fcmmel B, Pl\u00f6tz T, J\u00f6rns A, Lenzen S, Mehmeti I. The central role of glutathione peroxidase 4 in the regulation of ferroptosis and its implications for pro-inflammatory cytokine-mediated beta-cell death. Biochim Biophys Acta Mol Basis Dis. 2021;1867(6):166114. https:\/\/doi.org\/10.1016\/j.bbadis.2021.166114.","journal-title":"Biochim Biophys Acta Mol Basis Dis"},{"issue":"1","key":"637_CR93","first-page":"89","volume":"26","author":"YP Cheon","year":"2001","unstructured":"Cheon YP, Kim CH, Kang BM, Chang YS, Nam JH, Kim YS, et al. Spermatozoa Characteristics of Streptozotocin-induced Diabetic Wistar Rat: Acrosome Reaction and Spermatozoa Concentration. Korean J Fertil Sterility. 2001;26(1):89\u201396.","journal-title":"Korean J Fertil Sterility"},{"issue":"5","key":"637_CR94","doi-asserted-by":"publisher","first-page":"2636","DOI":"10.1210\/jc.2004-2190","volume":"90","author":"N Pitteloud","year":"2005","unstructured":"Pitteloud N, Hardin M, Dwyer AA, Valassi E, Yialamas M, Elahi D, et al. Increasing insulin resistance is associated with a decrease in Leydig cell testosterone secretion in men. J Clin Endocrinol Metab. 2005;90(5):2636\u201341. https:\/\/doi.org\/10.1210\/jc.2004-2190.","journal-title":"J Clin Endocrinol Metab"},{"issue":"2","key":"637_CR95","doi-asserted-by":"publisher","first-page":"524","DOI":"10.1210\/jcem.75.2.1639955","volume":"75","author":"K Kjaer","year":"1992","unstructured":"Kjaer K, Hagen C, Sand\u00f8 SH, Esh\u00f8j O. Epidemiology of menarche and menstrual disturbances in an unselected group of women with insulin-dependent diabetes mellitus compared to controls. J Clin Endocrinol Metab. 1992;75(2):524\u20139. https:\/\/doi.org\/10.1210\/jcem.75.2.1639955.","journal-title":"J Clin Endocrinol Metab"},{"issue":"2","key":"637_CR96","doi-asserted-by":"publisher","first-page":"327","DOI":"10.1093\/humrep\/dei353","volume":"21","author":"RF Arrais","year":"2006","unstructured":"Arrais RF, Dib SA. The hypothalamus\u2013pituitary\u2013ovary axis and type 1 diabetes mellitus: a mini review. Hum Reprod. 2006;21(2):327\u201337. https:\/\/doi.org\/10.1093\/humrep\/dei353.","journal-title":"Hum Reprod"},{"issue":"5","key":"637_CR97","doi-asserted-by":"publisher","first-page":"281","DOI":"10.1038\/s41581-023-00694-0","volume":"19","author":"AB Sanz","year":"2023","unstructured":"Sanz AB, Sanchez-Ni\u00f1o MD, Ramos AM, Ortiz A. Regulated cell death pathways in kidney disease. Nat Rev Nephrol. 2023;19(5):281\u201399. https:\/\/doi.org\/10.1038\/s41581-023-00694-0.","journal-title":"Nat Rev Nephrol"},{"issue":"10","key":"637_CR98","doi-asserted-by":"publisher","first-page":"1630","DOI":"10.1016\/j.cell.2022.04.004","volume":"185","author":"JL Bj\u00f6rkegren","year":"2022","unstructured":"Bj\u00f6rkegren JL, Lusis AJ. Atherosclerosis: recent developments. Cell. 2022;185(10):1630\u201345. https:\/\/doi.org\/10.1016\/j.cell.2022.04.004.","journal-title":"Cell"},{"issue":"6","key":"637_CR99","doi-asserted-by":"publisher","first-page":"3346","DOI":"10.3390\/ijms23063346","volume":"23","author":"S Jebari-Benslaiman","year":"2022","unstructured":"Jebari-Benslaiman S, Galicia-Garc\u00eda U, Larrea-Sebal A, Olaetxea JR, Alloza I, Vandenbroeck K, et al. Pathophysiology of atherosclerosis. Int J Mol Sci. 2022;23(6):3346. https:\/\/doi.org\/10.3390\/ijms23063346.","journal-title":"Int J Mol Sci"},{"issue":"28","key":"637_CR100","doi-asserted-by":"publisher","first-page":"2681","DOI":"10.1093\/eurheartj\/ehz112","volume":"41","author":"F Vinchi","year":"2020","unstructured":"Vinchi F, Porto G, Simmelbauer A, Altamura S, Passos ST, Garbowski M, et al. Atherosclerosis is aggravated by iron overload and ameliorated by dietary and pharmacological iron restriction. Eur Heart J. 2020;41(28):2681\u201395. https:\/\/doi.org\/10.1093\/eurheartj\/ehz112.","journal-title":"Eur Heart J"},{"issue":"3","key":"637_CR101","doi-asserted-by":"publisher","first-page":"343","DOI":"10.1016\/j.freeradbiomed.2007.09.009","volume":"44","author":"Z Guo","year":"2008","unstructured":"Guo Z, Ran Q, Roberts LJ 2nd, Zhou L, Richardson A, Sharan C, et al. Suppression of atherogenesis by overexpression of glutathione peroxidase-4 in apolipoprotein E-deficient mice. Free Radic Biol Med. 2008;44(3):343\u201352. https:\/\/doi.org\/10.1016\/j.freeradbiomed.2007.09.009.","journal-title":"Free Radic Biol Med"},{"key":"637_CR102","doi-asserted-by":"publisher","first-page":"112367","DOI":"10.1016\/j.biopha.2021.112367","volume":"145","author":"Y Wang","year":"2022","unstructured":"Wang Y, Kuang X, Yin Y, Han N, Chang L, Wang H, et al. Tongxinluo prevents chronic obstructive pulmonary disease complicated with atherosclerosis by inhibiting ferroptosis and protecting against pulmonary microvascular barrier dysfunction. Biomed Pharmacother. 2022;145:112367. https:\/\/doi.org\/10.1016\/j.biopha.2021.112367.","journal-title":"Biomed Pharmacother"},{"issue":"8","key":"637_CR103","doi-asserted-by":"publisher","first-page":"782","DOI":"10.1038\/s41419-021-04054-3","volume":"12","author":"S Ouyang","year":"2021","unstructured":"Ouyang S, You J, Zhi C, Li P, Lin X, Tan X, et al. Ferroptosis: the potential value target in atherosclerosis. Cell Death Dis. 2021;12(8):782. https:\/\/doi.org\/10.1038\/s41419-021-04054-3.","journal-title":"Cell Death Dis"},{"key":"637_CR104","doi-asserted-by":"publisher","first-page":"117183","DOI":"10.1016\/j.biopha.2024.117183","volume":"178","author":"M Zhang","year":"2024","unstructured":"Zhang M, Li J, Hu W. The complex interplay between ferroptosis and atherosclerosis. Biomed Pharmacother. 2024;178:117183. https:\/\/doi.org\/10.1016\/j.biopha.2024.117183.","journal-title":"Biomed Pharmacother"},{"key":"637_CR105","doi-asserted-by":"publisher","first-page":"114333","DOI":"10.1016\/j.biopha.2023.114333","volume":"161","author":"G Hu","year":"2023","unstructured":"Hu G, Yuan Z, Wang J. Autophagy inhibition and ferroptosis activation during atherosclerosis: Hypoxia-inducible factor-1\u03b1 inhibitor PX-478 alleviates atherosclerosis by inducing autophagy and suppressing ferroptosis in macrophages. Biomed Pharmacother. 2023;161:114333. https:\/\/doi.org\/10.1016\/j.biopha.2023.114333.","journal-title":"Biomed Pharmacother"},{"issue":"1","key":"637_CR106","doi-asserted-by":"publisher","first-page":"199","DOI":"10.1002\/tox.23958","volume":"39","author":"Y Hu","year":"2024","unstructured":"Hu Y, Gu X, Zhang Y, Ma W, Sun L, Wang C, et al. Adrenomedullin, transcriptionally regulated by vitamin D receptors, alleviates atherosclerosis in mice through suppressing AMPK-mediated endothelial ferroptosis. Environ Toxicol. 2024;39(1):199\u2013211. https:\/\/doi.org\/10.1002\/tox.23958.","journal-title":"Environ Toxicol"},{"key":"637_CR107","doi-asserted-by":"publisher","first-page":"e942733","DOI":"10.12659\/MSM.942733","volume":"30","author":"J Du","year":"2024","unstructured":"Du J, Wu J, Zhang Y, Liu Q, Luo X, Huang X, et al. CTRP13 mitigates endothelial cell ferroptosis via the AMPK\/KLF4 pathway: Implications for atherosclerosis protection. Med Sci Monit. 2024;30:e942733. https:\/\/doi.org\/10.12659\/MSM.942733.","journal-title":"Med Sci Monit"},{"key":"637_CR108","doi-asserted-by":"publisher","first-page":"116702","DOI":"10.1016\/j.lfs.2019.116702","volume":"233","author":"VB Marques","year":"2019","unstructured":"Marques VB, Leal MAS, Mageski JGA, Fidelis HG, Nogueira BV, Vasquez EC, et al. Chronic iron overload intensifies atherosclerosis in apolipoprotein E-deficient mice: Role of oxidative stress and endothelial dysfunction. Life Sci. 2019;233:116702. https:\/\/doi.org\/10.1016\/j.lfs.2019.116702.","journal-title":"Life Sci"},{"issue":"9","key":"637_CR109","doi-asserted-by":"publisher","first-page":"3951","DOI":"10.1002\/ptr.7854","volume":"37","author":"X Wang","year":"2023","unstructured":"Wang X, Zhang M, Mao C, Zhang C, Ma W, Tang J, et al. Icariin alleviates ferroptosis-related atherosclerosis by promoting autophagy in ox-LDL-induced vascular endothelial cell injury and atherosclerotic mice. Phytother Res. 2023;37(9):3951\u201363. https:\/\/doi.org\/10.1002\/ptr.7854.","journal-title":"Phytother Res"},{"issue":"1","key":"637_CR110","doi-asserted-by":"publisher","first-page":"404","DOI":"10.1080\/13880209.2023.2225543","volume":"61","author":"J Rong","year":"2023","unstructured":"Rong J, Li C, Zhang Q, Zheng G, Fan W, Pan Z, et al. Hydroxysafflor yellow A inhibits endothelial cell ferroptosis in diabetic atherosclerosis mice by regulating miR-429\/SLC7A11. Pharm Biol. 2023;61(1):404\u201315. https:\/\/doi.org\/10.1080\/13880209.2023.2225543.","journal-title":"Pharm Biol"},{"key":"637_CR111","doi-asserted-by":"publisher","first-page":"828161","DOI":"10.3389\/fphar.2022.828161","volume":"13","author":"Y Zhang","year":"2022","unstructured":"Zhang Y, Du M, Wang J, Liu P. Astragaloside IV relieves atherosclerosis and hepatic steatosis via MAPK\/NF-\u03baB signaling pathway in LDLR\u2212\/\u2212 mice. Front Pharmacol. 2022;13:828161. https:\/\/doi.org\/10.3389\/fphar.2022.828161.","journal-title":"Front Pharmacol"},{"issue":"1","key":"637_CR112","doi-asserted-by":"publisher","first-page":"910","DOI":"10.18632\/aging.202202","volume":"13","author":"J Wen","year":"2020","unstructured":"Wen J, Chang Y, Huo S, Li W, Huang H, Gao Y, et al. Tanshinone IIA attenuates atherosclerosis via inhibiting NLRP3 inflammasome activation. Aging (Albany NY). 2020;13(1):910. https:\/\/doi.org\/10.18632\/aging.202202.","journal-title":"Aging (Albany NY)"},{"key":"637_CR113","doi-asserted-by":"publisher","first-page":"116112","DOI":"10.1016\/j.biopha.2023.116112","volume":"171","author":"X Xu","year":"2024","unstructured":"Xu X, Xu XD, Ma MQ, Liang Y, Cai YB, Zhu ZX, et al. The mechanisms of ferroptosis and its role in atherosclerosis. Biomed Pharmacother. 2024;171:116112. https:\/\/doi.org\/10.1016\/j.biopha.2023.116112.","journal-title":"Biomed Pharmacother"},{"issue":"3","key":"637_CR114","doi-asserted-by":"publisher","first-page":"2995","DOI":"10.1007\/s12035-024-04443-7","volume":"62","author":"Y Xu","year":"2025","unstructured":"Xu Y, Liu Y, Wu Y, Sun J, Lu X, Dai K, et al. Curcumin alleviates microglia-mediated neuroinflammation and neuronal ferroptosis following experimental subarachnoid hemorrhage by modulating the Nrf2\/HO-1 signaling pathway. Mol Neurobiol. 2025;62(3):2995\u20133010. https:\/\/doi.org\/10.1007\/s12035-024-04443-7.","journal-title":"Mol Neurobiol"},{"issue":"2","key":"637_CR115","doi-asserted-by":"publisher","first-page":"457","DOI":"10.1038\/s41418-022-01099-5","volume":"30","author":"QX Ji","year":"2023","unstructured":"Ji QX, Zeng FY, Zhou J, Wu WB, Wang XJ, Zhang Z, et al. Ferroptotic stress facilitates smooth muscle cell dedifferentiation in arterial remodelling by disrupting mitochondrial homeostasis. Cell Death Differ. 2023;30(2):457\u201374. https:\/\/doi.org\/10.1038\/s41418-022-01099-5.","journal-title":"Cell Death Differ"},{"issue":"5","key":"637_CR116","doi-asserted-by":"publisher","first-page":"315","DOI":"10.1038\/s41581-023-00689-x","volume":"19","author":"H Bay\u0131r","year":"2023","unstructured":"Bay\u0131r H, Dixon SJ, Tyurina YY, Kellum JA, Kagan VE. Ferroptotic mechanisms and therapeutic targeting of iron metabolism and lipid peroxidation in the kidney. Nat Rev Nephrol. 2023;19(5):315\u201336. https:\/\/doi.org\/10.1038\/s41581-023-00689-x.","journal-title":"Nat Rev Nephrol"},{"key":"637_CR117","doi-asserted-by":"publisher","first-page":"65","DOI":"10.3389\/fnagi.2018.00065","volume":"10","author":"A Ashraf","year":"2018","unstructured":"Ashraf A, Clark M, So PW. The aging of iron man. Front Aging Neurosci. 2018;10:65. https:\/\/doi.org\/10.3389\/fnagi.2018.00065.","journal-title":"Front Aging Neurosci"},{"key":"637_CR118","doi-asserted-by":"publisher","first-page":"169","DOI":"10.1016\/j.nbd.2016.05.011","volume":"94","author":"B Van Do","year":"2016","unstructured":"Van Do B, Gouel F, Jonneaux A, Timmerman K, Gel\u00e9 P, P\u00e9trault M, et al. Ferroptosis, a newly characterized form of cell death in Parkinson\u2019s disease that is regulated by PKC. Neurobiol Dis. 2016;94:169\u201378. https:\/\/doi.org\/10.1016\/j.nbd.2016.05.011.","journal-title":"Neurobiol Dis"},{"issue":"11","key":"637_CR119","doi-asserted-by":"publisher","first-page":"1520","DOI":"10.1038\/mp.2017.171","volume":"22","author":"QZ Tuo","year":"2017","unstructured":"Tuo QZ, Lei P, Jackman KA, Li XL, Xiong H, Liuyang ZY, et al. Tau-mediated iron export prevents ferroptotic damage after ischemic stroke. Mol Psychiatry. 2017;22(11):1520\u201330. https:\/\/doi.org\/10.1038\/mp.2017.171.","journal-title":"Mol Psychiatry"},{"issue":"4","key":"637_CR120","doi-asserted-by":"publisher","first-page":"e298","DOI":"10.1002\/mco2.298","volume":"4","author":"H Long","year":"2023","unstructured":"Long H, Zhu W, Wei L, Zhao J. Iron homeostasis imbalance and ferroptosis in brain diseases. MedComm. 2023;4(4):e298. https:\/\/doi.org\/10.1002\/mco2.298.","journal-title":"MedComm"},{"issue":"7","key":"637_CR121","doi-asserted-by":"publisher","first-page":"e90777","DOI":"10.1172\/jci.insight.90777","volume":"2","author":"Q Li","year":"2017","unstructured":"Li Q, Han X, Lan X, Gao Y, Wan J, Durham F, et al. Inhibition of neuronal ferroptosis protects hemorrhagic brain. JCI Insight. 2017;2(7):e90777. https:\/\/doi.org\/10.1172\/jci.insight.90777.","journal-title":"JCI Insight"},{"issue":"5","key":"637_CR122","doi-asserted-by":"publisher","first-page":"280","DOI":"10.1038\/s41571-020-00462-0","volume":"18","author":"X Chen","year":"2021","unstructured":"Chen X, Kang R, Kroemer G, Tang D. Broadening horizons: the role of ferroptosis in cancer. Nat Rev Clin Oncol. 2021;18(5):280\u201396. https:\/\/doi.org\/10.1038\/s41571-020-00462-0.","journal-title":"Nat Rev Clin Oncol"},{"key":"637_CR123","doi-asserted-by":"publisher","first-page":"590226","DOI":"10.3389\/fcell.2020.590226","volume":"8","author":"X Chen","year":"2020","unstructured":"Chen X, Yu C, Kang R, Tang D. Iron metabolism in ferroptosis. Front Cell Dev Biol. 2020;8:590226. https:\/\/doi.org\/10.3389\/fcell.2020.590226.","journal-title":"Front Cell Dev Biol"},{"key":"637_CR124","doi-asserted-by":"publisher","first-page":"4880","DOI":"10.1007\/s12035-018-1403-3","volume":"56","author":"A Weiland","year":"2019","unstructured":"Weiland A, Wang Y, Wu W, Lan X, Han X, Li Q, et al. Ferroptosis and its role in diverse brain diseases. Mol Neurobiol. 2019;56:4880\u201393. https:\/\/doi.org\/10.1007\/s12035-018-1403-3.","journal-title":"Mol Neurobiol"},{"key":"637_CR125","doi-asserted-by":"publisher","first-page":"947530","DOI":"10.3389\/fonc.2022.947530","volume":"12","author":"G Zhang","year":"2022","unstructured":"Zhang G, Fang Y, Li X, Zhang Z. Ferroptosis: a novel therapeutic strategy and mechanism of action in glioma. Front Oncol. 2022;12:947530. https:\/\/doi.org\/10.3389\/fonc.2022.947530.","journal-title":"Front Oncol"},{"key":"637_CR126","doi-asserted-by":"publisher","first-page":"216","DOI":"10.1016\/j.freeradbiomed.2018.07.015","volume":"133","author":"S Recalcati","year":"2019","unstructured":"Recalcati S, Gammella E, Cairo G. Dysregulation of iron metabolism in cancer stem cells. Free Radical Biol Med. 2019;133:216\u201320. https:\/\/doi.org\/10.1016\/j.freeradbiomed.2018.07.015.","journal-title":"Free Radical Biol Med"},{"issue":"1","key":"637_CR127","doi-asserted-by":"publisher","first-page":"63","DOI":"10.1111\/his.13847","volume":"75","author":"M Adachi","year":"2019","unstructured":"Adachi M, Kai K, Yamaji K, Ide T, Noshiro H, Kawaguchi A, et al. Transferrin receptor 1 overexpression is associated with tumour de\u2010differentiation and acts as a potential prognostic indicator of hepatocellular carcinoma. Histopathology. 2019;75(1):63\u201373. https:\/\/doi.org\/10.1111\/his.13847.","journal-title":"Histopathology"},{"issue":"51","key":"637_CR128","doi-asserted-by":"publisher","first-page":"1904197","DOI":"10.1002\/adma.201904197","volume":"31","author":"C Liang","year":"2019","unstructured":"Liang C, Zhang X, Yang M, Dong X. Recent progress in ferroptosis inducers for cancer therapy. Adv Mater. 2019;31(51):1904197. https:\/\/doi.org\/10.1002\/adma.201904197.","journal-title":"Adv Mater"},{"issue":"2","key":"637_CR129","doi-asserted-by":"publisher","first-page":"201","DOI":"10.3390\/antiox14020201","volume":"14","author":"S Li","year":"2025","unstructured":"Li S, Yuan H, Li L, Li Q, Lin P, Li K. Oxidative stress and reprogramming of lipid metabolism in cancers. Antioxidants. 2025;14(2):201. https:\/\/doi.org\/10.3390\/antiox14020201.","journal-title":"Antioxidants"},{"key":"637_CR130","doi-asserted-by":"publisher","first-page":"363474","DOI":"10.3389\/fonc.2018.00117","volume":"8","author":"V Gouirand","year":"2018","unstructured":"Gouirand V, Guillaumond F, Vasseur S. Influence of the tumor microenvironment on cancer cells metabolic reprogramming. Front Oncol. 2018;8:363474. https:\/\/doi.org\/10.3389\/fonc.2018.00117.","journal-title":"Front Oncol"},{"issue":"1","key":"637_CR131","doi-asserted-by":"publisher","first-page":"19396","DOI":"10.1038\/s41598-022-23906-2","volume":"12","author":"KR Sekhar","year":"2022","unstructured":"Sekhar KR, Hanna DN, Cyr S, Baechle JJ, Kuravi S, Balusu R, et al. Glutathione peroxidase 4 inhibition induces ferroptosis and mTOR pathway suppression in thyroid cancer. Sci Rep. 2022;12(1):19396. https:\/\/doi.org\/10.1038\/s41598-022-23906-2.","journal-title":"Sci Rep"},{"key":"637_CR132","doi-asserted-by":"publisher","first-page":"817643","DOI":"10.3389\/fcell.2022.817643","volume":"10","author":"J Shi","year":"2022","unstructured":"Shi J, Lai D, Zuo X, Liu D, Chen B, Zheng Y, et al. Identification of ferroptosis-related biomarkers for prognosis and immunotherapy in patients with glioma. Front Cell Dev Biol. 2022;10:817643. https:\/\/doi.org\/10.3389\/fcell.2022.817643.","journal-title":"Front Cell Dev Biol"},{"issue":"10387","key":"637_CR133","doi-asserted-by":"publisher","first-page":"1531","DOI":"10.1016\/S0140-6736(23)00020-X","volume":"401","author":"DW Chen","year":"2023","unstructured":"Chen DW, Lang BH, McLeod DS, Newbold K, Haymart MR. Thyroid cancer. Lancet. 2023;401(10387):1531\u201344. https:\/\/doi.org\/10.1016\/S0140-6736(23)00020-X.","journal-title":"Lancet"},{"issue":"6","key":"637_CR134","doi-asserted-by":"publisher","first-page":"e1298","DOI":"10.1002\/ctm2.1298","volume":"13","author":"E Cararo Lopes","year":"2023","unstructured":"Cararo Lopes E, Sawant A, Moore D, Ke H, Shi F, Laddha S, et al. Integrated metabolic and genetic analysis reveals distinct features of human differentiated thyroid cancer. Clin Transl Med. 2023;13(6):e1298. https:\/\/doi.org\/10.1002\/ctm2.1298.","journal-title":"Clin Transl Med"},{"issue":"10","key":"637_CR135","doi-asserted-by":"publisher","first-page":"e24688","DOI":"10.1002\/jcla.24688","volume":"36","author":"D Chen","year":"2022","unstructured":"Chen D, Jiang X, Luo H, Hua Q, Zhang F. CircPTPRM accelerates malignancy of papillary thyroid cancer via miR-885-5p\/DNMT3A axis. J Clin Lab Anal. 2022;36(10):e24688. https:\/\/doi.org\/10.1002\/jcla.24688.","journal-title":"J Clin Lab Anal"},{"issue":"1","key":"637_CR136","doi-asserted-by":"publisher","first-page":"6058","DOI":"10.1038\/s41467-021-26343-3","volume":"12","author":"W Pu","year":"2021","unstructured":"Pu W, Shi X, Yu P, Zhang M, Liu Z, Tan L, et al. Single-cell transcriptomic analysis of the tumor ecosystems underlying initiation and progression of papillary thyroid carcinoma. Nat Commun. 2021;12(1):6058. https:\/\/doi.org\/10.1038\/s41467-021-26343-3.","journal-title":"Nat Commun"},{"key":"637_CR137","doi-asserted-by":"publisher","first-page":"253","DOI":"10.1016\/j.semcancer.2021.03.027","volume":"83","author":"RX Lin","year":"2022","unstructured":"Lin RX, Yang SL, Jia Y, Wu JC, Xu Z, Zhang H. Epigenetic regulation of papillary thyroid carcinoma by long non-coding RNAs. Semin Cancer Biol. 2022;83:253\u201360. https:\/\/doi.org\/10.1016\/j.semcancer.2021.03.027.","journal-title":"Semin Cancer Biol"},{"issue":"1\u20132","key":"637_CR138","doi-asserted-by":"publisher","first-page":"117","DOI":"10.1159\/000486422","volume":"85","author":"E Chmielik","year":"2018","unstructured":"Chmielik E, Rusinek D, Oczko-Wojciechowska M, Jarzab M, Krajewska J, Czarniecka A, et al. Heterogeneity of thyroid cancer. Pathobiology. 2018;85(1\u20132):117\u201329. https:\/\/doi.org\/10.1159\/000486422.","journal-title":"Pathobiology"},{"issue":"47","key":"637_CR139","doi-asserted-by":"publisher","first-page":"5121","DOI":"10.1038\/s41388-022-02499-0","volume":"41","author":"S Hong","year":"2022","unstructured":"Hong S, Xie Y, Cheng Z, Li J, He W, Guo Z, et al. Distinct molecular subtypes of papillary thyroid carcinoma and gene signature with diagnostic capability. Oncogene. 2022;41(47):5121\u201332. https:\/\/doi.org\/10.1038\/s41388-022-02499-0.","journal-title":"Oncogene"},{"issue":"6","key":"637_CR140","doi-asserted-by":"publisher","first-page":"R67","DOI":"10.1530\/ERC-21-0414","volume":"29","author":"LL Cunha","year":"2022","unstructured":"Cunha LL, Ward LS. Translating the immune microenvironment of thyroid cancer into clinical practice. Endocr Relat Cancer. 2022;29(6):R67\u201383. https:\/\/doi.org\/10.1530\/ERC-21-0414.","journal-title":"Endocr Relat Cancer"},{"issue":"11","key":"637_CR141","doi-asserted-by":"publisher","first-page":"e13260","DOI":"10.1111\/acel.13260","volume":"19","author":"BR Gauthier","year":"2020","unstructured":"Gauthier BR, Sola-Garc\u00eda A, C\u00e1liz-Molina M\u00c1, Lorenzo PI, Cobo-Vuilleumier N, Capilla-Gonz\u00e1lez V, et al. Thyroid hormones in diabetes, cancer, and aging. Aging Cell. 2020;19(11):e13260. https:\/\/doi.org\/10.1111\/acel.13260.","journal-title":"Aging Cell"},{"issue":"12","key":"637_CR142","doi-asserted-by":"publisher","first-page":"635","DOI":"10.1530\/ERC-22-0094","volume":"29","author":"TH Kim","year":"2022","unstructured":"Kim TH, Lee MY, Jin SM, Lee SH. The association between serum concentration of thyroid hormones and thyroid cancer: a cohort study. Endocr Relat Cancer. 2022;29(12):635\u201344. https:\/\/doi.org\/10.1530\/ERC-22-0094.","journal-title":"Endocr Relat Cancer"},{"issue":"5","key":"637_CR143","doi-asserted-by":"publisher","first-page":"550","DOI":"10.1007\/s00391-017-1219-1","volume":"51","author":"J Wu","year":"2018","unstructured":"Wu J, Cai XH, Qin XX, Liu YX. The effects of sclerostin antibody plus parathyroid hormone (1\u201334) on bone formation in ovariectomized rats. Z Gerontol Geriatr. 2018;51(5):550\u20136. https:\/\/doi.org\/10.1007\/s00391-017-1219-1.","journal-title":"Z Gerontol Geriatr"},{"issue":"1","key":"637_CR144","doi-asserted-by":"publisher","first-page":"97","DOI":"10.1007\/s11255-017-1756-y","volume":"50","author":"Y Chen","year":"2018","unstructured":"Chen Y, Wu G, Xu M. The effect of L-thyroxine substitution on oxidative stress in early-stage diabetic nephropathy patients with subclinical hypothyroidism: a randomized double-blind and placebo-controlled study. Int Urol Nephrol. 2018;50(1):97\u2013103. https:\/\/doi.org\/10.1007\/s11255-017-1756-y.","journal-title":"Int Urol Nephrol"},{"issue":"16","key":"637_CR145","doi-asserted-by":"publisher","first-page":"e18587","DOI":"10.1111\/jcmm.18587","volume":"28","author":"L Yin","year":"2024","unstructured":"Yin L, Luo X, Zhang X, Cheng B. The evolving process of ferroptosis in thyroid cancer: Novel mechanisms and opportunities. J Cell Mol Med. 2024;28(16):e18587. https:\/\/doi.org\/10.1111\/jcmm.18587.","journal-title":"J Cell Mol Med"},{"key":"637_CR146","doi-asserted-by":"publisher","first-page":"157","DOI":"10.2147\/PGPM.S352225","volume":"15","author":"Z Xiao","year":"2022","unstructured":"Xiao Z, Zhao H. Ferroptosis-related APOE, BCL3 and ALOX5AP gene polymorphisms are associated with the risk of thyroid cancer. Pharmacogenomics Pers Med. 2022;15:157\u201365. https:\/\/doi.org\/10.2147\/PGPM.S352225.","journal-title":"Pharmacogenomics Pers Med"},{"issue":"1","key":"637_CR147","doi-asserted-by":"publisher","first-page":"8","DOI":"10.1186\/s13045-022-01224-4","volume":"15","author":"J Qu","year":"2022","unstructured":"Qu J, Yan H, Hou Y, Cao W, Liu Y, Zhang E, et al. RNA demethylase ALKBH5 in cancer: from mechanisms to therapeutic potential. J Hematol Oncol. 2022;15(1):8. https:\/\/doi.org\/10.1186\/s13045-022-01224-4.","journal-title":"J Hematol Oncol"},{"issue":"1","key":"637_CR148","doi-asserted-by":"publisher","first-page":"34","DOI":"10.1186\/s12943-022-01522-y","volume":"21","author":"Y Hu","year":"2022","unstructured":"Hu Y, Gong C, Li Z, Liu J, Chen Y, Huang Y, et al. Demethylase ALKBH5 suppresses invasion of gastric cancer via PKMYT1 m6A modification. Mol Cancer. 2022;21(1):34. https:\/\/doi.org\/10.1186\/s12943-022-01522-y.","journal-title":"Mol Cancer"},{"issue":"4","key":"637_CR149","doi-asserted-by":"publisher","first-page":"729","DOI":"10.1007\/s11010-022-04541-x","volume":"478","author":"W Li","year":"2023","unstructured":"Li W, Huang G, Wei J, Cao H, Jiang G. ALKBH5 inhibits thyroid cancer progression by promoting ferroptosis through TIAM1-Nrf2\/HO-1 axis. Mol Cell Biochem. 2023;478(4):729\u201341. https:\/\/doi.org\/10.1007\/s11010-022-04541-x.","journal-title":"Mol Cell Biochem"},{"key":"637_CR150","doi-asserted-by":"publisher","first-page":"18519","DOI":"10.1038\/s41598-023-43198-4","volume":"13","author":"Y Li","year":"2023","unstructured":"Li Y, Wang X, Zhang Z, Zhao Y, Liu P, Chen M, et al. Identification and validation of ferroptosis-related biomarkers and therapeutic targets in precancerous lesions of gastric cancer. Sci Rep. 2023;13:18519. https:\/\/doi.org\/10.1038\/s41598-023-43198-4.","journal-title":"Sci Rep"},{"issue":"1","key":"637_CR151","doi-asserted-by":"publisher","first-page":"88","DOI":"10.1038\/s41589-018-0184-3","volume":"15","author":"H Ma","year":"2019","unstructured":"Ma H, Wang X, Cai J, Dai Q, Natchiar SK, Lv R, et al. N6-Methyladenosine methyltransferase ZCCHC4 mediates ribosomal RNA methylation. Nat Chem Biol. 2019;15(1):88\u201394. https:\/\/doi.org\/10.1038\/s41589-018-0184-3.","journal-title":"Nat Chem Biol"},{"issue":"30","key":"637_CR152","doi-asserted-by":"publisher","first-page":"e2104805118","DOI":"10.1073\/pnas.2104805118","volume":"118","author":"KP Srinivas","year":"2021","unstructured":"Srinivas KP, Depledge DP, Abebe JS, Rice SA, Mohr I, Wilson AC. Widespread remodeling of the m6A RNA-modification landscape by a viral regulator of RNA processing and export. Proc Natl Acad Sci U S A. 2021;118(30):e2104805118. https:\/\/doi.org\/10.1073\/pnas.2104805118.","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"1","key":"637_CR153","doi-asserted-by":"publisher","first-page":"5","DOI":"10.1038\/nrc.2017.99","volume":"18","author":"E Anastasiadou","year":"2018","unstructured":"Anastasiadou E, Jacob LS, Slack FJ. Non-coding RNA networks in cancer. Nat Rev Cancer. 2018;18(1):5\u201318. https:\/\/doi.org\/10.1038\/nrc.2017.99.","journal-title":"Nat Rev Cancer"},{"issue":"7784","key":"637_CR154","doi-asserted-by":"publisher","first-page":"688","DOI":"10.1038\/s41586-019-1705-2","volume":"575","author":"K Bersuker","year":"2019","unstructured":"Bersuker K, Hendricks JM, Li Z, Magtanong L, Ford B, Tang PH, et al. The CoQ oxidoreductase FSP1 acts parallel to GPX4 to inhibit ferroptosis. Nature. 2019;575(7784):688\u201392. https:\/\/doi.org\/10.1038\/s41586-019-1705-2.","journal-title":"Nature"},{"issue":"1","key":"637_CR155","doi-asserted-by":"publisher","first-page":"780","DOI":"10.1186\/s12967-023-04664-9","volume":"21","author":"S D\u2019Aprile","year":"2023","unstructured":"D\u2019Aprile S, Denaro S, Pavone AM, Giallongo S, Giallongo C, Distefano A, et al. Anaplastic thyroid cancer cells reduce CD71 levels to increase iron overload tolerance. J Transl Med. 2023;21(1):780. https:\/\/doi.org\/10.1186\/s12967-023-04664-9.","journal-title":"J Transl Med"},{"issue":"8","key":"637_CR156","doi-asserted-by":"publisher","first-page":"685","DOI":"10.1016\/S2213-2600(23)00050-4","volume":"11","author":"W Liao","year":"2023","unstructured":"Liao W, Coupland CAC, Burchardt J, Baldwin DR, Gleeson FV, Hippisley-Cox J, et al. Predicting the future risk of lung cancer: development, and internal and external validation of the CanPredict (lung) model in 19\u00b767 million people and evaluation of model performance against seven other risk prediction models. Lancet Respir Med. 2023;11(8):685\u201397. https:\/\/doi.org\/10.1016\/S2213-2600(23)00050-4.","journal-title":"Lancet Respir Med"},{"issue":"1","key":"637_CR157","doi-asserted-by":"publisher","first-page":"145","DOI":"10.1152\/physrev.00030.2018","volume":"100","author":"AR Chang","year":"2020","unstructured":"Chang AR, Ferrer CM, Mostoslavsky R. SIRT6, a mammalian deacylase with multitasking abilities. Physiol Rev. 2020;100(1):145\u201369. https:\/\/doi.org\/10.1152\/physrev.00030.2018.","journal-title":"Physiol Rev"},{"issue":"7545","key":"637_CR158","doi-asserted-by":"publisher","first-page":"57","DOI":"10.1038\/nature14344","volume":"520","author":"L Jiang","year":"2015","unstructured":"Jiang L, Kon N, Li T, Wang SJ, Su T, Hibshoosh H, et al. Ferroptosis as a p53-mediated activity during tumour suppression. Nature. 2015;520(7545):57\u201362. https:\/\/doi.org\/10.1038\/nature14344.","journal-title":"Nature"},{"issue":"1","key":"637_CR159","doi-asserted-by":"publisher","first-page":"41","DOI":"10.1186\/s13045-024-01564-3","volume":"17","author":"F Chen","year":"2024","unstructured":"Chen F, Kang R, Tang D, Liu J. Ferroptosis: principles and significance in health and disease. J Hematol Oncol. 2024;17(1):41. https:\/\/doi.org\/10.1186\/s13045-024-01564-3.","journal-title":"J Hematol Oncol"},{"issue":"1","key":"637_CR160","doi-asserted-by":"publisher","first-page":"372","DOI":"10.1038\/s41392-023-01606-1","volume":"8","author":"S Sun","year":"2023","unstructured":"Sun S, Shen J, Jiang J, Wang F, Min J. Targeting ferroptosis opens new avenues for the development of novel therapeutics. Signal Transduct Target Ther. 2023;8(1):372. https:\/\/doi.org\/10.1038\/s41392-023-01606-1.","journal-title":"Signal Transduct Target Ther"},{"issue":"1","key":"637_CR161","doi-asserted-by":"publisher","first-page":"7","DOI":"10.1007\/s12185-017-2366-2","volume":"107","author":"T Ganz","year":"2018","unstructured":"Ganz T. Iron and infection. Int J Hematol. 2018;107(1):7\u201315. https:\/\/doi.org\/10.1007\/s12185-017-2366-2.","journal-title":"Int J Hematol"},{"issue":"12","key":"637_CR162","doi-asserted-by":"publisher","first-page":"2373","DOI":"10.3390\/v15122373","volume":"15","author":"R Huang","year":"2023","unstructured":"Huang R, Wu J, Ma Y, Kang K. Molecular mechanisms of ferroptosis and its role in viral pathogenesis. Viruses. 2023;15(12):2373. https:\/\/doi.org\/10.3390\/v15122373.","journal-title":"Viruses"},{"key":"637_CR163","doi-asserted-by":"publisher","first-page":"104382","DOI":"10.1016\/j.ebiom.2022.104382","volume":"86","author":"Q Xiao","year":"2022","unstructured":"Xiao Q, Yan L, Han J, Yang S, Tang Y, Li Q, et al. Metabolism-dependent ferroptosis promotes mitochondrial dysfunction and inflammation in CD4+ T lymphocytes in HIV-infected immune non-responders. EBioMedicine. 2022;86:104382. https:\/\/doi.org\/10.1016\/j.ebiom.2022.104382.","journal-title":"EBioMedicine"},{"key":"637_CR164","doi-asserted-by":"publisher","unstructured":"Zhu H, Santo A, Jia Z, Li YR. GPx4 in bacterial infection and polymicrobial sepsis: involvement of ferroptosis and pyroptosis. React Oxygen Species (Apex, NC). 2019;7(21):154. https:\/\/doi.org\/10.20455\/ros.2019.835.","DOI":"10.20455\/ros.2019.835"},{"issue":"1","key":"637_CR165","doi-asserted-by":"publisher","first-page":"185","DOI":"10.1186\/s12985-024-02462-3","volume":"21","author":"A Letafati","year":"2024","unstructured":"Letafati A, Taghiabadi Z, Ardekani OS, Abbasi S, Najafabadi AQ, Jazi NN, et al. Unveiling the intersection: ferroptosis in influenza virus infection. Virol J. 2024;21(1):185. https:\/\/doi.org\/10.1186\/s12985-024-02462-3.","journal-title":"Virol J"},{"issue":"1","key":"637_CR166","doi-asserted-by":"publisher","first-page":"463","DOI":"10.1038\/s42003-024-06756-8","volume":"7","author":"DC Rinker","year":"2024","unstructured":"Rinker DC, Sauters TJC, Steffen K, Gumilang A, Raja HA, Rangel-Grimaldo M, et al. Strain heterogeneity in a non-pathogenic Aspergillus fungus highlights factors associated with virulence. Commun Biol. 2024;7(1):463. https:\/\/doi.org\/10.1038\/s42003-024-06756-8.","journal-title":"Commun Biol"},{"key":"637_CR167","doi-asserted-by":"publisher","first-page":"956361","DOI":"10.3389\/fimmu.2022.956361","volume":"13","author":"L Xl","year":"2022","unstructured":"Xl L, Gy Z, R G, N C. Ferroptosis in sepsis: the mechanism, the role and the therapeutic potential. Front Immunol. 2022;13:956361. https:\/\/doi.org\/10.3389\/fimmu.2022.956361.","journal-title":"Front Immunol"},{"key":"637_CR168","doi-asserted-by":"publisher","first-page":"A93","DOI":"10.1136\/sextrans-2021-sti.246","volume":"97","author":"B Zhang","year":"2021","unstructured":"Zhang B, Xie Q, Xue Y, Zheng H. P131 Chlamydia trachomatis induces ferroptosis to promote its own dissemination by inhibiting SLC7A11\/GPx4 signaling. Sex Transm Infect. 2021;97:A93\u20134. https:\/\/doi.org\/10.1136\/sextrans-2021-sti.246.","journal-title":"Sex Transm Infect"},{"issue":"1","key":"637_CR169","doi-asserted-by":"publisher","first-page":"59","DOI":"10.1186\/s12864-022-08295-0","volume":"23","author":"J Fan","year":"2022","unstructured":"Fan J, Chen M, Cao S, Yao Q, Zhang X, Du S, et al. Identification of a ferroptosis-related gene pair biomarker with immune infiltration landscapes in ischemic stroke: a bioinformatics-based comprehensive study. BMC Genomics. 2022;23(1):59. https:\/\/doi.org\/10.1186\/s12864-022-08295-0.","journal-title":"BMC Genomics"},{"issue":"suppl","key":"637_CR170","doi-asserted-by":"publisher","first-page":"S5","DOI":"10.3350\/cmh.2022.0424","volume":"29","author":"SK Han","year":"2023","unstructured":"Han SK, Baik SK, Kim MY. Non-alcoholic fatty liver disease: definition and subtypes. Clin Mol Hepatol. 2023;29(suppl):S5\u201316. https:\/\/doi.org\/10.3350\/cmh.2022.0424.","journal-title":"Clin Mol Hepatol"},{"key":"637_CR171","doi-asserted-by":"publisher","first-page":"122230","DOI":"10.1016\/j.biomaterials.2023.122230","volume":"301","author":"M Zhao","year":"2023","unstructured":"Zhao M, Jin Z, Xia C, Chen S, Zeng L, Qin S, et al. Inhibition of free heme-catalyzed Fenton-like reaction prevents non-alcoholic fatty liver disease by hepatocyte-targeted hydrogen delivery. Biomaterials. 2023;301:122230. https:\/\/doi.org\/10.1016\/j.biomaterials.2023.122230.","journal-title":"Biomaterials"},{"issue":"8","key":"637_CR172","doi-asserted-by":"publisher","first-page":"1201","DOI":"10.1016\/j.cmet.2022.07.006","volume":"34","author":"H Gao","year":"2022","unstructured":"Gao H, Jin Z, Bandyopadhyay G, Wang G, Zhang D, Rocha KCE, et al. Aberrant iron distribution via hepatocyte-stellate cell axis drives liver lipogenesis and fibrosis. Cell Metab. 2022;34(8):1201-1213.e5. https:\/\/doi.org\/10.1016\/j.cmet.2022.07.006.","journal-title":"Cell Metab"},{"issue":"15","key":"637_CR173","doi-asserted-by":"publisher","first-page":"3361","DOI":"10.7150\/ijms.62903","volume":"18","author":"Q Pan","year":"2021","unstructured":"Pan Q, Luo Y, Xia Q, He K. Ferroptosis and liver fibrosis. Int J Med Sci. 2021;18(15):3361\u20136. https:\/\/doi.org\/10.7150\/ijms.62903.","journal-title":"Int J Med Sci"},{"issue":"32","key":"637_CR174","doi-asserted-by":"publisher","first-page":"22974","DOI":"10.1074\/jbc.M602098200","volume":"281","author":"DD Harrison-Findik","year":"2006","unstructured":"Harrison-Findik DD, Schafer D, Klein E, Timchenko NA, Kulaksiz H, Clemens D, et al. Alcohol metabolism-mediated oxidative stress down-regulates hepcidin transcription and leads to increased duodenal iron transporter expression. J Biol Chem. 2006;281(32):22974\u201382. https:\/\/doi.org\/10.1074\/jbc.M602098200.","journal-title":"J Biol Chem"},{"issue":"4","key":"637_CR175","doi-asserted-by":"publisher","first-page":"201","DOI":"10.1007\/s00018-022-04239-9","volume":"79","author":"LX Li","year":"2022","unstructured":"Li LX, Guo FF, Liu H, Zeng T. Iron overload in alcoholic liver disease: underlying mechanisms, detrimental effects, and potential therapeutic targets. Cell Mol Life Sci. 2022;79(4):201. https:\/\/doi.org\/10.1007\/s00018-022-04239-9.","journal-title":"Cell Mol Life Sci"},{"issue":"3","key":"637_CR176","doi-asserted-by":"publisher","first-page":"390","DOI":"10.3390\/antiox10030390","volume":"10","author":"M Villanueva-Paz","year":"2021","unstructured":"Villanueva-Paz M, Mor\u00e1n L, L\u00f3pez-Alc\u00e1ntara N, Freixo C, Andrade RJ, Lucena MI, et al. Oxidative stress in drug-induced liver injury (DILI): from mechanisms to biomarkers for use in clinical practice. Antioxidants (Basel). 2021;10(3):390. https:\/\/doi.org\/10.3390\/antiox10030390.","journal-title":"Antioxidants (Basel)"},{"issue":"2","key":"637_CR177","doi-asserted-by":"publisher","first-page":"190","DOI":"10.1038\/s41416-022-01998-x","volume":"128","author":"A Ajoolabady","year":"2023","unstructured":"Ajoolabady A, Tang D, Kroemer G, Ren J. Ferroptosis in hepatocellular carcinoma: mechanisms and targeted therapy. Br J Cancer. 2023;128(2):190\u2013205. https:\/\/doi.org\/10.1038\/s41416-022-01998-x.","journal-title":"Br J Cancer"},{"issue":"2","key":"637_CR178","doi-asserted-by":"publisher","first-page":"328","DOI":"10.3390\/cancers13020328","volume":"13","author":"V Castelli","year":"2021","unstructured":"Castelli V, Giordano A, Benedetti E, Giansanti F, Quintiliani M, Cimini A, et al. The great escape: The power of cancer stem cells to evade programmed cell death. Cancers (Basel). 2021;13(2):328. https:\/\/doi.org\/10.3390\/cancers13020328.","journal-title":"Cancers (Basel)"},{"issue":"8","key":"637_CR179","doi-asserted-by":"publisher","first-page":"507.e1","DOI":"10.1016\/j.jtct.2023.04.016","volume":"29","author":"T Pan","year":"2023","unstructured":"Pan T, Ji Y, Liu H, Tang B, Song K, Wan X, et al. Impact of iron overload and iron chelation with deferasirox on outcomes of patients with severe aplastic anemia after allogeneic hematopoietic stem cell transplantation. Transplant Cell Ther. 2023;29(8):507.e1-507.e8. https:\/\/doi.org\/10.1016\/j.jtct.2023.04.016.","journal-title":"Transplant Cell Ther"},{"issue":"3","key":"637_CR180","doi-asserted-by":"publisher","first-page":"185","DOI":"10.1111\/j.1423-0410.2009.01207.x","volume":"97","author":"A Shander","year":"2009","unstructured":"Shander A, Cappellini MD, Goodnough LT. Iron overload and toxicity: the hidden risk of multiple blood transfusions. Vox Sang. 2009;97(3):185\u201397. https:\/\/doi.org\/10.1111\/j.1423-0410.2009.01207.x.","journal-title":"Vox Sang"},{"issue":"1","key":"637_CR181","doi-asserted-by":"publisher","first-page":"406","DOI":"10.1186\/s13046-019-1397-3","volume":"38","author":"F Wang","year":"2019","unstructured":"Wang F, Lv H, Zhao B, Zhou L, Wang S, Luo J, et al. Iron and leukemia: new insights for future treatments. J Exp Clin Cancer Res. 2019;38(1):406. https:\/\/doi.org\/10.1186\/s13046-019-1397-3.","journal-title":"J Exp Clin Cancer Res"},{"key":"637_CR182","doi-asserted-by":"publisher","first-page":"910292","DOI":"10.3389\/fphar.2022.910292","volume":"13","author":"FJ Li","year":"2022","unstructured":"Li FJ, Long HZ, Zhou ZW, Luo HY, Xu SG, Gao LC. System Xc-\/GSH\/GPX4 axis: An important antioxidant system for the ferroptosis in drug-resistant solid tumor therapy. Front Pharmacol. 2022;13:910292. https:\/\/doi.org\/10.3389\/fphar.2022.910292.","journal-title":"Front Pharmacol"},{"issue":"1","key":"637_CR183","doi-asserted-by":"publisher","first-page":"108","DOI":"10.1038\/s41392-020-00216-5","volume":"5","author":"D Li","year":"2020","unstructured":"Li D, Li Y. The interaction between ferroptosis and lipid metabolism in cancer. Signal Transduct Target Ther. 2020;5(1):108. https:\/\/doi.org\/10.1038\/s41392-020-00216-5.","journal-title":"Signal Transduct Target Ther"},{"issue":"3","key":"637_CR184","doi-asserted-by":"publisher","first-page":"184","DOI":"10.3390\/biology10030184","volume":"10","author":"JY Lee","year":"2021","unstructured":"Lee JY, Kim WK, Bae KH, Lee SC, Lee EW. Lipid metabolism and ferroptosis. Biology. 2021;10(3):184. https:\/\/doi.org\/10.3390\/biology10030184.","journal-title":"Biology"},{"issue":"2","key":"637_CR185","doi-asserted-by":"publisher","first-page":"674","DOI":"10.1095\/biolreprod64.2.674","volume":"64","author":"H Imai","year":"2001","unstructured":"Imai H, Suzuki K, Ishizaka K, Ichinose S, Oshima H, Okayasu I, et al. Failure of the expression of phospholipid hydroperoxide glutathione peroxidase in the spermatozoa of human infertile males. Biol Reprod. 2001;64(2):674\u201383. https:\/\/doi.org\/10.1095\/biolreprod64.2.674.","journal-title":"Biol Reprod"},{"issue":"47","key":"637_CR186","doi-asserted-by":"publisher","first-page":"32522","DOI":"10.1074\/jbc.M109.016139","volume":"284","author":"H Imai","year":"2009","unstructured":"Imai H, Hakkaku N, Iwamoto R, Suzuki J, Suzuki T, Tajima Y, et al. Depletion of selenoprotein GPx4 in spermatocytes causes male infertility in mice. J Biol Chem. 2009;284(47):32522\u201332. https:\/\/doi.org\/10.1074\/jbc.M109.016139.","journal-title":"J Biol Chem"},{"key":"637_CR187","doi-asserted-by":"publisher","first-page":"637162","DOI":"10.3389\/fcell.2021.637162","volume":"9","author":"X Chen","year":"2021","unstructured":"Chen X, Comish PB, Tang D, Kang R. Characteristics and Biomarkers of Ferroptosis. Front Cell Dev Biol. 2021;9:637162. https:\/\/doi.org\/10.3389\/fcell.2021.637162.","journal-title":"Front Cell Dev Biol"},{"key":"637_CR188","doi-asserted-by":"publisher","DOI":"10.1556\/2060.2021.00176","author":"NM Madi","year":"2021","unstructured":"Madi NM, Abo El Gheit RE, Barhoma RA, El Saadany A, Alghazaly GM, Marea K, et al. Beneficial impact of Nesfatin-1 on reproductive dysfunction induced by nicotine in male rats: possible modulation of autophagy and pyroptosis signaling pathways. Physiol Int. 2021. https:\/\/doi.org\/10.1556\/2060.2021.00176.","journal-title":"Physiol Int"},{"issue":"2","key":"637_CR189","doi-asserted-by":"publisher","first-page":"e14320","DOI":"10.1111\/and.14320","volume":"54","author":"A Hasani","year":"2022","unstructured":"Hasani A, Khosravi A, Behnam P, Ramezani F, Eslami Farsani B, Aliaghaei A, et al. Non-apoptotic cell death such as pyroptosis, autophagy, necroptosis and ferroptosis acts as partners to induce testicular cell death after scrotal hyperthermia in mice. Andrologia. 2022;54(2):e14320. https:\/\/doi.org\/10.1111\/and.14320.","journal-title":"Andrologia"},{"issue":"13","key":"637_CR190","doi-asserted-by":"publisher","first-page":"7139","DOI":"10.3390\/ijms23137139","volume":"23","author":"Y Liu","year":"2022","unstructured":"Liu Y, Cao X, He C, Guo X, Cai H, Aierken A, et al. Effects of Ferroptosis on Male Reproduction. Int J Mol Sci. 2022;23(13):7139. https:\/\/doi.org\/10.3390\/ijms23137139.","journal-title":"Int J Mol Sci"},{"issue":"12","key":"637_CR191","doi-asserted-by":"publisher","first-page":"e70010","DOI":"10.1002\/mco2.70010","volume":"5","author":"Q Zhou","year":"2020","unstructured":"Zhou Q, Meng Y, Le J, Sun Y, Dian Y, Yao L, et al. Ferroptosis: mechanisms and therapeutic targets. MedComm. 2020;5(12):e70010. https:\/\/doi.org\/10.1002\/mco2.70010.","journal-title":"MedComm"},{"key":"637_CR192","doi-asserted-by":"publisher","first-page":"1091438","DOI":"10.3389\/fcell.2023.1091438","volume":"11","author":"TC Sun","year":"2023","unstructured":"Sun TC, Li DM, Yu H, Song LL, Jia YJ, Lin L, et al. Bilateral varicocele leads to ferroptosis, pyroptosis and necroptosis of human spermatozoa and affects semen quality in infertile men. Front Cell Dev Biol. 2023;11:1091438. https:\/\/doi.org\/10.3389\/fcell.2023.1091438.","journal-title":"Front Cell Dev Biol"},{"issue":"2","key":"637_CR193","doi-asserted-by":"publisher","first-page":"294","DOI":"10.1016\/S0090-4295(98)00178-2","volume":"52","author":"MR Abdulmaaboud","year":"1998","unstructured":"Abdulmaaboud MR, Shokeir AA, Farage Y, Abd El-Rahman A, El-Rakhawy MM, Mutabagani H. Treatment of varicocele: a comparative study of conventional open surgery, percutaneous retrograde sclerotherapy, and laparoscopy. Urology. 1998;52(2):294\u2013300. https:\/\/doi.org\/10.1016\/S0090-4295(98)00178-2.","journal-title":"Urology"},{"issue":"2","key":"637_CR194","doi-asserted-by":"publisher","first-page":"179","DOI":"10.4103\/1008-682X.172640","volume":"18","author":"B Alsaikhan","year":"2016","unstructured":"Alsaikhan B, Alrabeeah K, Delouya G, Zini A. Epidemiology of varicocele. Asian J Androl. 2016;18(2):179\u201381. https:\/\/doi.org\/10.4103\/1008-682X.172640.","journal-title":"Asian J Androl"},{"issue":"10","key":"637_CR195","doi-asserted-by":"publisher","first-page":"1121","DOI":"10.1001\/jama.1966.03110230137039","volume":"198","author":"BG Clarke","year":"1966","unstructured":"Clarke BG. Incidence of varicocele in normal men and among men of different ages. JAMA. 1966;198(10):1121\u20132.","journal-title":"JAMA"},{"issue":"3","key":"637_CR196","doi-asserted-by":"publisher","first-page":"613","DOI":"10.1016\/S0015-0282(16)55809-9","volume":"59","author":"JI Gorelick","year":"1993","unstructured":"Gorelick JI, Goldstein M. Loss of fertility in men with varicocele. Fertil Steril. 1993;59(3):613\u20136.","journal-title":"Fertil Steril"},{"issue":"5","key":"637_CR197","doi-asserted-by":"publisher","first-page":"541","DOI":"10.1016\/0090-4295(93)90268-F","volume":"42","author":"MA Witt","year":"1993","unstructured":"Witt MA, Lipshultz LI. Varicocele: a progressive or static lesion? Urology. 1993;42(5):541\u20133. https:\/\/doi.org\/10.1016\/0090-4295(93)90268-F.","journal-title":"Urology"},{"issue":"2","key":"637_CR198","doi-asserted-by":"publisher","first-page":"194","DOI":"10.1159\/000314226","volume":"85","author":"G Vivas-Acevedo","year":"2010","unstructured":"Vivas-Acevedo G, Lozano JR, Camejo MI. Effect of varicocele grade and age on seminal parameters. Urol Int. 2010;85(2):194\u20139. https:\/\/doi.org\/10.1159\/000314226.","journal-title":"Urol Int"},{"issue":"6","key":"637_CR199","doi-asserted-by":"publisher","first-page":"1012","DOI":"10.4103\/1008-682X.148075","volume":"17","author":"T Zhou","year":"2015","unstructured":"Zhou T, Zhang W, Chen Q, Li L, Cao H, Xu CL, et al. Effect of varicocelectomy on testis volume and semen parameters in adolescents: a meta-analysis. Asian J Androl. 2015;17(6):1012\u20136. https:\/\/doi.org\/10.4103\/1008-682X.148075.","journal-title":"Asian J Androl"},{"issue":"4","key":"637_CR200","doi-asserted-by":"publisher","first-page":"346","DOI":"10.21037\/tau.2019.06.23","volume":"8","author":"TA Teixeira","year":"2019","unstructured":"Teixeira TA, Pariz JR, Dutra RT, Saldiva PH, Costa E, Hallak J. Cut-off values of the Johnsen score and Copenhagen index as histopathological prognostic factors for postoperative semen quality in selected infertile patients undergoing microsurgical correction of bilateral subclinical varicocele. Transl Androl Urol. 2019;8(4):346\u201355. https:\/\/doi.org\/10.21037\/tau.2019.06.23.","journal-title":"Transl Androl Urol"},{"issue":"5","key":"637_CR201","doi-asserted-by":"publisher","first-page":"2115","DOI":"10.3892\/etm.2017.4289","volume":"13","author":"S Arena","year":"2017","unstructured":"Arena S, Iacona R, Antonuccio P, Russo T, Salvo V, Gitto E, et al. Medical perspective in testicular ischemia-reperfusion injury. Exp Ther Med. 2017;13(5):2115\u201322. https:\/\/doi.org\/10.3892\/etm.2017.4289.","journal-title":"Exp Ther Med"},{"key":"637_CR202","doi-asserted-by":"publisher","unstructured":"Akhigbe RE, Odetayo AF, Akhigbe TM, Hamed MA, Ashonibare PJ. Pathophysiology and management of testicular ischemia\/reperfusion injury: Lessons from animal models. Heliyon. 2024;10(9). https:\/\/doi.org\/10.1016\/j.heliyon.2024.e27760.","DOI":"10.1016\/j.heliyon.2024.e27760"},{"key":"637_CR203","doi-asserted-by":"publisher","first-page":"111975","DOI":"10.1016\/j.biopha.2021.111975","volume":"142","author":"RE Akhigbe","year":"2021","unstructured":"Akhigbe RE, Hamed MA, Odetayo AF, Akhigbe TM, Ajayi AF, Ajibogun FA. Omega-3 fatty acid rescues ischaemia\/perfusion-induced testicular and sperm damage via modulation of lactate transport and xanthine oxidase\/uric acid signaling. Biomed Pharmacother. 2021;142:111975. https:\/\/doi.org\/10.1016\/j.biopha.2021.111975.","journal-title":"Biomed Pharmacother"},{"key":"637_CR204","doi-asserted-by":"publisher","first-page":"104901","DOI":"10.1016\/j.yexmp.2024.104901","volume":"137","author":"EE Besong","year":"2024","unstructured":"Besong EE, Akhigbe RE. Sodium acetate prevents testicular damage in Wistar rats subjected to testicular ischaemia\/reperfusion injury. Exp Mol Pathol. 2024;137:104901. https:\/\/doi.org\/10.1016\/j.yexmp.2024.104901.","journal-title":"Exp Mol Pathol"},{"key":"637_CR205","doi-asserted-by":"publisher","first-page":"113056","DOI":"10.1016\/j.biopha.2022.113056","volume":"150","author":"OA Afolabi","year":"2022","unstructured":"Afolabi OA, Anyogu DC, Hamed MA, Odetayo AF, Adeyemi DH, Akhigbe RE. Glutamine prevents upregulation of NF-kB signaling and caspase 3 activation in ischaemia\/reperfusion-induced testicular damage: an animal model. Biomed Pharmacother. 2022;150:113056. https:\/\/doi.org\/10.1016\/j.biopha.2022.113056.","journal-title":"Biomed Pharmacother"},{"key":"637_CR206","doi-asserted-by":"publisher","first-page":"e67181","DOI":"10.3791\/67181","volume":"225","author":"OA Afolabi","year":"2025","unstructured":"Afolabi OA, Odesanya JO, Ajike RA, Oyekunle OS, Alabi BA, Ogunleye OD, et al. Anchorage of Twisted Testis: A Rat Model of Ischemia-Reperfusion Injury of the Testis. JoVE (Journal of Visualized Experiments). 2025;225:e67181. https:\/\/doi.org\/10.3791\/67181.","journal-title":"JoVE (Journal of Visualized Experiments)"},{"issue":"1","key":"637_CR207","doi-asserted-by":"publisher","DOI":"10.1186\/s12301-026-00584-4","volume":"32","author":"OD Ogunleye","year":"2026","unstructured":"Ogunleye OD, Ajike RA, Alabi BA, Hammed SO, Akhigbe RE, Afolabi OA. Co-administration of vitamins C and E attenuates testicular ischemia-reperfusion injury by targeting oxidative stress and NF-\u03baB-mediated inflammation in rats. Afr J Urol. 2026;32(1):34. https:\/\/doi.org\/10.1186\/s12301-026-00584-4.","journal-title":"Afr J Urol"},{"issue":"7","key":"637_CR208","doi-asserted-by":"publisher","first-page":"391","DOI":"10.1038\/nrurol.2014.135","volume":"11","author":"E Karaguzel","year":"2014","unstructured":"Karaguzel E, Kadihasanoglu M, Kutlu O. Mechanisms of testicular torsion and potential protective agents. Nat Rev Urol. 2014;11(7):391\u20139. https:\/\/doi.org\/10.1038\/nrurol.2014.135.","journal-title":"Nat Rev Urol"},{"issue":"3","key":"637_CR209","doi-asserted-by":"publisher","first-page":"521","DOI":"10.1016\/S0733-8627(20)30545-9","volume":"6","author":"JS Edelsberg","year":"1988","unstructured":"Edelsberg JS, Surh YS. The acute scrotum. Emerg Med Clin N Am. 1988;6(3):521\u201346. https:\/\/doi.org\/10.1016\/S0733-8627(20)30545-9.","journal-title":"Emerg Med Clin N Am"},{"issue":"10","key":"637_CR210","first-page":"1739","volume":"74","author":"E Ringdahl","year":"2006","unstructured":"Ringdahl E, Teague L. Testicular torsion. Am Fam Physician. 2006;74(10):1739\u201343.","journal-title":"Am Fam Physician"},{"key":"637_CR211","unstructured":"Sharp VJ, Kieran K, Arlen AM. Testicular torsion: diagnosis, evaluation, and management. Am. Fam. Physician. 2013;88(12):835\u201340. https:\/\/www.aafp.org\/pubs\/afp\/issues\/2013\/1215\/p835.html."},{"issue":"3","key":"637_CR212","doi-asserted-by":"publisher","first-page":"220","DOI":"10.24272\/j.issn.2095-8137.2020.042","volume":"41","author":"HF Yan","year":"2020","unstructured":"Yan HF, Tuo QZ, Yin QZ, Lei P. The pathological role of ferroptosis in ischemia\/reperfusion-related injury. Zool Res. 2020;41(3):220. https:\/\/doi.org\/10.24272\/j.issn.2095-8137.2020.042.","journal-title":"Zool Res"},{"issue":"5","key":"637_CR213","doi-asserted-by":"publisher","first-page":"3051","DOI":"10.3892\/ijmm.2018.3469","volume":"41","author":"L Li","year":"2018","unstructured":"Li L, Hao Y, Zhao Y, Wang H, Zhao X, Jiang Y, et al. Ferroptosis is associated with oxygen-glucose deprivation\/reoxygenation-induced Sertoli cell death. Int J Mol Med. 2018;41(5):3051\u201362. https:\/\/doi.org\/10.3892\/ijmm.2018.3469.","journal-title":"Int J Mol Med"},{"key":"637_CR214","doi-asserted-by":"publisher","first-page":"1377836","DOI":"10.3389\/fphar.2024.1377836","volume":"15","author":"YP Jiang","year":"2024","unstructured":"Jiang YP, Liu BG, Dang Y, Liu LJ, Pang Y, Bai XD, et al. Integrative analysis of transcriptomics and metabolomics reveals the protective effect and mechanism of salidroside on testicular ischemia-reperfusion injury. Front Pharmacol. 2024;15:1377836. https:\/\/doi.org\/10.3389\/fphar.2024.1377836.","journal-title":"Front Pharmacol"},{"issue":"3","key":"637_CR215","doi-asserted-by":"publisher","first-page":"766","DOI":"10.1111\/andr.70163","volume":"14","author":"T Zou","year":"2026","unstructured":"Zou T, Xiao J, Wei S, Qing Y, Song H, Hu Z. Sophocarpine alleviates testicular ischemia-reperfusion injury by modulating ferroptosis via the AKT pathway in rats. Andrology. 2026;14(3):766\u201381. https:\/\/doi.org\/10.1111\/andr.70163.","journal-title":"Andrology"},{"issue":"6","key":"637_CR216","doi-asserted-by":"publisher","first-page":"2499","DOI":"10.1007\/s00431-023-04947-9","volume":"182","author":"M Florou","year":"2023","unstructured":"Florou M, Tsilidis KK, Siomou E, Koletsa T, Syrnioti A, Spyridakis I, et al. Orchidopexy for congenital cryptorchidism in childhood and adolescence and testicular cancer in adults: an updated systematic review and meta-analysis of observational studies. Eur J Pediatr. 2023;182(6):2499\u2013507. https:\/\/doi.org\/10.1007\/s00431-023-04947-9.","journal-title":"Eur J Pediatr"},{"key":"637_CR217","doi-asserted-by":"publisher","first-page":"1345","DOI":"10.1201\/9781315113982","volume-title":"Kelalis-King-Belman textb. Clin. Pediatr. Urol.","author":"TF Kolon","year":"2018","unstructured":"Kolon TF, Tasian GE. Cryptorchidism. In: Kelalis-King-Belman textb. Clin. Pediatr. Urol. CRC Press; 2018. p. 1345\u201358. https:\/\/doi.org\/10.1201\/9781315113982."},{"key":"637_CR218","doi-asserted-by":"publisher","unstructured":"Fawzy F, Hussein A, Eid MM, Kashash AM, Salem HK. Cryptorchidism and fertility. Clin. Med. Insights Reprod. Health. 2015;9:CMRH-S25056. https:\/\/doi.org\/10.4137\/CMRH.S25056.","DOI":"10.4137\/CMRH.S25056"},{"key":"637_CR219","doi-asserted-by":"publisher","first-page":"906","DOI":"10.3389\/fendo.2019.00906","volume":"10","author":"W Rodprasert","year":"2020","unstructured":"Rodprasert W, Virtanen HE, M\u00e4kel\u00e4 JA, Toppari J. Hypogonadism and cryptorchidism. Front Endocrinol. 2020;10:906. https:\/\/doi.org\/10.3389\/fendo.2019.00906.","journal-title":"Front Endocrinol"},{"issue":"1","key":"637_CR220","doi-asserted-by":"publisher","first-page":"843569","DOI":"10.5402\/2012\/843569","volume":"2012","author":"AO Afolabi","year":"2012","unstructured":"Afolabi AO, Olotu OO, Alagbonsi IA. Vitamins E and C alleviate the germ cell loss and oxidative stress in cryptorchidism when administered separately but not when combined in rats. Int Sch Res Not. 2012;2012(1):843569. https:\/\/doi.org\/10.5402\/2012\/843569.","journal-title":"Int Sch Res Not"},{"issue":"1","key":"637_CR221","first-page":"109","volume":"24","author":"OA Afolabi","year":"2021","unstructured":"Afolabi OA, Philip SI, Shittu ST. Antioxidant activity of moringa oleifera leaf extract on testicular oxidative stress during experimental cryptorchidism was optimal at low dose. Afr J Biomed Res. 2021;24(1):109\u201314.","journal-title":"Afr J Biomed Res"},{"issue":"2\u20133","key":"637_CR222","doi-asserted-by":"publisher","first-page":"249","DOI":"10.1016\/j.neulet.2005.09.085","volume":"393","author":"J Rogalska","year":"2006","unstructured":"Rogalska J, Danielisova V, Caputa M. Effect of neonatal body temperature on postanoxic, potentially neurotoxic iron accumulation in the rat brain. Neurosci Lett. 2006;393(2\u20133):249\u201354. https:\/\/doi.org\/10.1016\/j.neulet.2005.09.085.","journal-title":"Neurosci Lett"},{"key":"637_CR223","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/s12958-020-00615-x","volume":"18","author":"Z Ou","year":"2020","unstructured":"Ou Z, Wen Q, Deng Y, Yu Y, Chen Z, Sun L. Cigarette smoking is associated with high level of ferroptosis in seminal plasma and affects semen quality. Reprod Biol Endocrinol. 2020;18:1\u20138. https:\/\/doi.org\/10.1186\/s12958-020-00615-x.","journal-title":"Reprod Biol Endocrinol"},{"key":"637_CR224","doi-asserted-by":"publisher","first-page":"152489","DOI":"10.1016\/j.tox.2020.152489","volume":"440","author":"X Zhao","year":"2020","unstructured":"Zhao X, Liu Z, Gao J, Li H, Wang X, Li Y, et al. Inhibition of ferroptosis attenuates busulfan-induced oligospermia in mice. Toxicology. 2020;440:152489. https:\/\/doi.org\/10.1016\/j.tox.2020.152489.","journal-title":"Toxicology"},{"key":"637_CR225","doi-asserted-by":"publisher","first-page":"421","DOI":"10.1016\/j.freeradbiomed.2022.10","volume":"193","author":"P Han","year":"2022","unstructured":"Han P, Wang X, Zhou T, Cheng J, Wang C, Sun F, et al. Inhibition of ferroptosis attenuates oligospermia in male Nrf2 knockout mice. Free Radic Biol Med. 2022;193:421\u20139. https:\/\/doi.org\/10.1016\/j.freeradbiomed.2022.10.","journal-title":"Free Radic Biol Med"},{"key":"637_CR226","doi-asserted-by":"publisher","first-page":"100137","DOI":"10.1016\/j.endmts.2023.100137","volume":"12","author":"LA Almashhedy","year":"2023","unstructured":"Almashhedy LA, Fadhil HA, Alsalman AR, Al-Kawaz HS, Alta\u2019ee AH, Al-Hassnawi AT, et al. Low levels of peroxiredoxins are associated with high iron content and lipid peroxidation in seminal plasma from asthenozoospermic infertile men. Endocr Metab Sci. 2023;12:100137. https:\/\/doi.org\/10.1016\/j.endmts.2023.100137.","journal-title":"Endocr Metab Sci"},{"issue":"1","key":"637_CR227","doi-asserted-by":"publisher","first-page":"247","DOI":"10.1007\/s43032-022-01004-y","volume":"30","author":"X Hao","year":"2023","unstructured":"Hao X, Wang H, Cui F, Yang Z, Ye L, Huang R, et al. Reduction of SLC7A11 and GPX4 contributing to ferroptosis in sperm from asthenozoospermia individuals. Reprod Sci. 2023;30(1):247\u201357. https:\/\/doi.org\/10.1007\/s43032-022-01004-y.","journal-title":"Reprod Sci"},{"issue":"6","key":"637_CR228","doi-asserted-by":"publisher","first-page":"410","DOI":"10.1080\/19396368.2023.2257352","volume":"69","author":"C Liao","year":"2023","unstructured":"Liao C, Peng TW, Li XM, Chen ZC, Wang MY, Ye X, et al. Identification of ferroptotic genes and phenotypes in idiopathic nonobstructive azoospermia. Syst Biol Reprod Med. 2023;69(6):410\u201322. https:\/\/doi.org\/10.1080\/19396368.2023.2257352.","journal-title":"Syst Biol Reprod Med"},{"issue":"1","key":"637_CR229","doi-asserted-by":"publisher","first-page":"19","DOI":"10.1007\/s10815-022-02674-y","volume":"40","author":"R Pu","year":"2023","unstructured":"Pu R, Liu J, Zhang A, Yang J, Zhang W, Long X, et al. Modeling methods for busulfan-induced oligospermia and asthenozoospermia in mice: a systematic review and meta-analysis. J Assist Reprod Genet. 2023;40(1):19\u201332. https:\/\/doi.org\/10.1007\/s10815-022-02674-y.","journal-title":"J Assist Reprod Genet"},{"key":"637_CR230","doi-asserted-by":"publisher","first-page":"102584","DOI":"10.1016\/j.redox.2022.102584","volume":"59","author":"Y Zhao","year":"2023","unstructured":"Zhao Y, Zhang H, Cui JG, Wang JX, Chen MS, Wang HR, et al. Ferroptosis is critical for phthalates driving the blood-testis barrier dysfunction via targeting transferrin receptor. Redox Biol. 2023;59:102584. https:\/\/doi.org\/10.1016\/j.redox.2022.102584.","journal-title":"Redox Biol"},{"issue":"3","key":"637_CR231","doi-asserted-by":"publisher","first-page":"1751","DOI":"10.1007\/s12013-024-01361-2","volume":"82","author":"D Adeyemi","year":"2024","unstructured":"Adeyemi D, Arokoyo D, Hamed M, Dare A, Oyedokun P, Akhigbe R. Cardiometabolic disorder and erectile dysfunction. Cell Biochem Biophys. 2024;82(3):1751\u201362. https:\/\/doi.org\/10.1007\/s12013-024-01361-2.","journal-title":"Cell Biochem Biophys"},{"key":"637_CR232","doi-asserted-by":"publisher","first-page":"1492771","DOI":"10.3389\/fphys.2024.1492771","volume":"15","author":"OE Adelowo","year":"2024","unstructured":"Adelowo OE, Akindele BM, Adegbola CA, Oyedokun PA, Akhigbe TM, Akhigbe RE. Unraveling the complexity of the impact of physical exercise on male reproductive functions: a review of both sides of a coin. Front Physiol. 2024;15:1492771. https:\/\/doi.org\/10.3389\/fphys.2024.1492771.","journal-title":"Front Physiol"},{"key":"637_CR233","doi-asserted-by":"publisher","DOI":"10.1186\/s10020-026-01637-8","author":"RE Akhigbe","year":"2026","unstructured":"Akhigbe RE, Adewole MA, Adegbola CA, Akhigbe TM. Oxidative stress and endothelial dysfunction: linking cellular damage to cardiovascular disease and erectile dysfunction. Mol Med. 2026. https:\/\/doi.org\/10.1186\/s10020-026-01637-8.","journal-title":"Mol Med"},{"issue":"1","key":"637_CR234","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1038\/nrdp.2016.3","volume":"2","author":"FA Yafi","year":"2016","unstructured":"Yafi FA, Jenkins L, Albersen M, Corona G, Isidori AM, Goldfarb S, et al. Erectile dysfunction. Nat Rev Dis Primers. 2016;2(1):1\u201320. https:\/\/doi.org\/10.1038\/nrdp.2016.3.","journal-title":"Nat Rev Dis Primers"},{"issue":"4","key":"637_CR235","doi-asserted-by":"publisher","first-page":"587","DOI":"10.1111\/bju.14813","volume":"124","author":"A Kessler","year":"2019","unstructured":"Kessler A, Sollie S, Challacombe B, Briggs K, Van Hemelrijck M. The global prevalence of erectile dysfunction: a review. BJU Int. 2019;124(4):587\u201399. https:\/\/doi.org\/10.1111\/bju.14813.","journal-title":"BJU Int"},{"key":"637_CR236","unstructured":"Sooriyamoorthy T, Leslie SW. Erectile dysfunction. Treasure Island (FL): StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2024."},{"issue":"2","key":"637_CR237","doi-asserted-by":"publisher","first-page":"332","DOI":"10.1111\/andr.13291","volume":"11","author":"W Xu","year":"2023","unstructured":"Xu W, Sun T, Wang J, Wang T, Wang S, Liu J, et al. Ferroptosis is involved in corpus cavernosum smooth muscle cells impairment in diabetes mellitus-induced erectile dysfunction. Andrology. 2023;11(2):332\u201343. https:\/\/doi.org\/10.1111\/andr.13291.","journal-title":"Andrology"},{"issue":"Suppl 5","key":"637_CR238","doi-asserted-by":"publisher","first-page":"e621","DOI":"10.1097\/JU.0000000000002592.08","volume":"207","author":"H Feng","year":"2022","unstructured":"Feng H, Wang T, Liu J. MP38-08 Human umbilical cord mesenchymal stem cells ameliorate erectile dysfunction in type I and type II diabetes mellitus rats through the attenuation of ferroptosis by SLC7A11\/GPX4\/ACSL4 pathway. J Urol. 2022;207(Suppl 5):e621. https:\/\/doi.org\/10.1097\/JU.0000000000002592.08.","journal-title":"J Urol"},{"issue":"4","key":"637_CR239","doi-asserted-by":"publisher","first-page":"qfad043","DOI":"10.1093\/sexmed\/qfad043","volume":"11","author":"HX Shi","year":"2023","unstructured":"Shi HX, Zhao X, Yang H, Cheng Y, Jiang J, Jiang R. Low androgen levels induce ferroptosis of rat penile cavernous endothelial cells. Sex Med. 2023;11(4):qfad043. https:\/\/doi.org\/10.1093\/sexmed\/qfad043.","journal-title":"Sex Med"},{"key":"637_CR240","doi-asserted-by":"publisher","first-page":"4952857","DOI":"10.1155\/2023\/4952857","volume":"2023","author":"P Chen","year":"2023","unstructured":"Chen P, Chen Z, Zhai J, Yang W, Wei H. Overexpression of PRDX2 in adipose-derived mesenchymal stem cells enhances the therapeutic effect in a neurogenic erectile dysfunction rat model by inhibiting ferroptosis. Oxid Med Cell Longev. 2023;2023:4952857. https:\/\/doi.org\/10.1155\/2023\/4952857.","journal-title":"Oxid Med Cell Longev"},{"issue":"1","key":"637_CR241","doi-asserted-by":"publisher","first-page":"qfac008","DOI":"10.1093\/sexmed\/qfac008","volume":"11","author":"XH Tan","year":"2023","unstructured":"Tan XH, Gu YY, Song WP, Nan TG, Song WD, Fang D, et al. Transcriptome analysis highlights the role of ferroptosis in palmitic acid\u2013induced endothelial dysfunction. Sex Med. 2023;11(1):qfac008. https:\/\/doi.org\/10.1093\/sexmed\/qfac008.","journal-title":"Sex Med"},{"issue":"2","key":"637_CR242","doi-asserted-by":"publisher","first-page":"316","DOI":"10.1111\/andr.13265","volume":"11","author":"Y Wang","year":"2023","unstructured":"Wang Y, Zhang X, Chen Y, Zhu B, Xing Q. Identification of hub biomarkers and exploring the roles of immunity, m6A, ferroptosis, or cuproptosis in rats with diabetic erectile dysfunction. Andrology. 2023;11(2):316\u201331. https:\/\/doi.org\/10.1111\/andr.13265.","journal-title":"Andrology"},{"key":"637_CR243","doi-asserted-by":"publisher","unstructured":"Tiwari P, Yadav A, Kaushik M, Dada R. Cancer risk and male infertility: unravelling predictive biomarkers and prognostic indicators. Clin Chim Acta. 2024:119670. https:\/\/doi.org\/10.1016\/j.cca.2024.119670.","DOI":"10.1016\/j.cca.2024.119670"},{"issue":"4","key":"637_CR244","doi-asserted-by":"publisher","first-page":"957","DOI":"10.3390\/ijms20040957","volume":"20","author":"N Qu","year":"2019","unstructured":"Qu N, Itoh M, Sakabe K. Effects of chemotherapy and radiotherapy on spermatogenesis: the role of testicular immunology. Int J Mol Sci. 2019;20(4):957. https:\/\/doi.org\/10.3390\/ijms20040957.","journal-title":"Int J Mol Sci"},{"issue":"Suppl 1","key":"637_CR245","doi-asserted-by":"publisher","first-page":"dead093-378","DOI":"10.1093\/humrep\/dead093.378","volume":"38","author":"R Akhigbe","year":"2023","unstructured":"Akhigbe R, Adeyemi D, Hamed M, Akhigbe T. P-008 Acetate ameliorates doxorubicin-induced testicular toxicity by modulating Nrf2\/NF\u03baB pathway and apoptotic signaling. Hum Reprod. 2023;38(Suppl 1):dead093-378. https:\/\/doi.org\/10.1093\/humrep\/dead093.378.","journal-title":"Hum Reprod"},{"issue":"Suppl 1","key":"637_CR246","doi-asserted-by":"publisher","first-page":"deae108-382","DOI":"10.1093\/humrep\/deae108.382","volume":"39","author":"R Akhigbe","year":"2024","unstructured":"Akhigbe R, Adeyemi D, Hamed M, Akhigbe T. P-002 Acetate attenuates cyclophosphamide-induced testicular toxicity by modulating steroidogenic and apoptotic signaling via an oxidative stress-dependent pathway. Hum Reprod. 2024;39(Suppl 1):deae108-382. https:\/\/doi.org\/10.1093\/humrep\/deae108.382.","journal-title":"Hum Reprod"},{"key":"637_CR247","doi-asserted-by":"publisher","first-page":"127489","DOI":"10.1016\/j.jtemb.2024.127489","volume":"85","author":"RE Akhigbe","year":"2024","unstructured":"Akhigbe RE, Adelowo OE, Ajani EO, Oyesetan RI, Oladapo DD, Akhigbe TM. Testicular toxicity in cisplatin-treated Wistar rats is mitigated by Daflon and associated with modulation of Nrf2\/HO-1 and TLR4\/NF-\u03baB signaling. J Trace Elem Med Biol. 2024;85:127489. https:\/\/doi.org\/10.1016\/j.jtemb.2024.127489.","journal-title":"J Trace Elem Med Biol"},{"issue":"2","key":"637_CR248","doi-asserted-by":"publisher","first-page":"129","DOI":"10.1016\/S0306-9877(98)90106-2","volume":"51","author":"RD Crawford","year":"1998","unstructured":"Crawford RD. The case for iron repletion as a promoter in testicular cancer. Med Hypotheses. 1998;51(2):129\u201332. https:\/\/doi.org\/10.1016\/S0306-9877(98)90106-2.","journal-title":"Med Hypotheses"},{"issue":"4","key":"637_CR249","doi-asserted-by":"publisher","first-page":"1143","DOI":"10.3892\/ijo.2019.4720","volume":"54","author":"Y Chen","year":"2019","unstructured":"Chen Y, Fan Z, Yang Y, Gu C. Iron metabolism and its contribution to cancer. Int J Oncol. 2019;54(4):1143\u201354. https:\/\/doi.org\/10.3892\/ijo.2019.4720.","journal-title":"Int J Oncol"},{"issue":"8","key":"637_CR250","doi-asserted-by":"publisher","first-page":"1893","DOI":"10.1016\/j.bbagen.2017.05.019","volume":"1861","author":"GO Latunde-Dada","year":"2017","unstructured":"Latunde-Dada GO. Ferroptosis: role of lipid peroxidation, iron and ferritinophagy. Biochim Biophys Acta Gen Subj. 2017;1861(8):1893\u2013900. https:\/\/doi.org\/10.1016\/j.bbagen.2017.05.019.","journal-title":"Biochim Biophys Acta Gen Subj"},{"key":"637_CR251","doi-asserted-by":"publisher","first-page":"175","DOI":"10.1016\/j.freeradbiomed.2020.02.027","volume":"152","author":"F Ursini","year":"2020","unstructured":"Ursini F, Maiorino M. Lipid peroxidation and ferroptosis: the role of GSH and GPx4. Free Radic Biol Med. 2020;152:175\u201385. https:\/\/doi.org\/10.1016\/j.freeradbiomed.2020.02.027.","journal-title":"Free Radic Biol Med"},{"issue":"1","key":"637_CR252","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1159\/000496967","volume":"142","author":"GM Rodgers","year":"2019","unstructured":"Rodgers GM, Gilreath JA. The role of intravenous iron in the treatment of anemia associated with cancer and chemotherapy. Acta Haematol. 2019;142(1):13\u201320. https:\/\/doi.org\/10.1159\/000496967.","journal-title":"Acta Haematol"},{"key":"637_CR253","doi-asserted-by":"publisher","first-page":"116465","DOI":"10.1016\/j.ecoenv.2024.116465","volume":"278","author":"W Yuan","year":"2024","unstructured":"Yuan W, Ji G, Shi X, Sun Z, Liu C, Yu Y, et al. The male reproductive toxicity after 5-fluorouracil exposure: DNA damage, oxidative stress, and mitochondrial dysfunction in vitro and in vivo. Ecotoxicol Environ Saf. 2024;278:116465. https:\/\/doi.org\/10.1016\/j.ecoenv.2024.116465.","journal-title":"Ecotoxicol Environ Saf"},{"issue":"3","key":"637_CR254","doi-asserted-by":"publisher","first-page":"556","DOI":"10.1084\/jem.20181776","volume":"216","author":"EP Amaral","year":"2019","unstructured":"Amaral EP, Costa DL, Namasivayam S, Riteau N, Kamenyeva O, Mittereder L, et al. A major role for ferroptosis in Mycobacterium tuberculosis-induced cell death and tissue necrosis. J Exp Med. 2019;216(3):556\u201370. https:\/\/doi.org\/10.1084\/jem.20181776.","journal-title":"J Exp Med"},{"issue":"18","key":"637_CR255","doi-asserted-by":"publisher","first-page":"2881","DOI":"10.1080\/15384101.2015.1068479","volume":"14","author":"L Jiang","year":"2015","unstructured":"Jiang L, Hickman JH, Wang SJ, Gu W. Dynamic roles of p53-mediated metabolic activities in ROS-induced stress responses. Cell Cycle. 2015;14(18):2881\u20135. https:\/\/doi.org\/10.1080\/15384101.2015.1068479.","journal-title":"Cell Cycle"},{"issue":"12","key":"637_CR256","doi-asserted-by":"publisher","first-page":"1180","DOI":"10.1038\/ncb3064","volume":"16","author":"JP Friedmann Angeli","year":"2014","unstructured":"Friedmann Angeli JP, Schneider M, Proneth B, Tyurina YY, Tyurin VA, Hammond VJ, et al. Inactivation of the ferroptosis regulator Gpx4 triggers acute renal failure in mice. Nat Cell Biol. 2014;16(12):1180\u201391. https:\/\/doi.org\/10.1038\/ncb3064.","journal-title":"Nat Cell Biol"},{"issue":"7146","key":"637_CR257","doi-asserted-by":"publisher","first-page":"865","DOI":"10.1038\/nature05859","volume":"447","author":"N Yagoda","year":"2007","unstructured":"Yagoda N, Von Rechenberg M, Zaganjor E, Bauer AJ, Yang WS, Fridman DJ, et al. RAS\u2013RAF\u2013MEK-dependent oxidative cell death involving voltage-dependent anion channels. Nature. 2007;447(7146):865\u20139. https:\/\/doi.org\/10.1038\/nature05859.","journal-title":"Nature"},{"issue":"4","key":"637_CR258","doi-asserted-by":"publisher","first-page":"e1013060","DOI":"10.1371\/journal.ppat.1013060","volume":"21","author":"W Chen","year":"2025","unstructured":"Chen W, Su X, Pan Y, Zhou H, Gao Y, Wang X, et al. Chlamydial protease-like activity factor targets SLC7A11 for degradation to induce ferroptosis and facilitate progeny releases. PLoS Pathog. 2025;21(4):e1013060. https:\/\/doi.org\/10.1371\/journal.ppat.1013060.","journal-title":"PLoS Pathog"},{"key":"637_CR259","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1002\/aro2.70041","volume":"00","author":"Y Wang","year":"2025","unstructured":"Wang Y, Jin T, Chen Z, Gong Y, Liu Q, Wu Z, et al. Ursolic acid alleviates orchitis via modulating ferroptosis in peritubular myoid cells of testis. An Res One Health. 2025;00:1\u201316. https:\/\/doi.org\/10.1002\/aro2.70041.","journal-title":"An Res One Health"},{"issue":"1","key":"637_CR260","doi-asserted-by":"publisher","first-page":"6833867","DOI":"10.1155\/2022\/6833867","volume":"2022","author":"D Lin","year":"2022","unstructured":"Lin D, Zhang M, Luo C, Wei P, Cui K, Chen Z. Targeting ferroptosis attenuates inflammation, fibrosis, and mast cell activation in chronic prostatitis. J Immunol Res. 2022;2022(1):6833867. https:\/\/doi.org\/10.1155\/2022\/6833867.","journal-title":"J Immunol Res"},{"issue":"4","key":"637_CR261","doi-asserted-by":"publisher","first-page":"105505","DOI":"10.1016\/j.micinf.2025.105505","volume":"27","author":"X Wang","year":"2025","unstructured":"Wang X, Tang C, Wu H, Zhang J, Chen L, Li Z. Chlamydia trachomatis regulates ferroptosis through the p53\/SLC7A11 pathway to promote reproduction. Microbes Infect. 2025;27(4):105505. https:\/\/doi.org\/10.1016\/j.micinf.2025.105505.","journal-title":"Microbes Infect"},{"key":"637_CR262","doi-asserted-by":"publisher","first-page":"159","DOI":"10.1016\/j.fsi.2020.09.036","volume":"112","author":"M Yang","year":"2021","unstructured":"Yang M, Lu Z, Li F, Shi F, Zhan F, Zhao L, et al. Escherichia coli induced ferroptosis in red blood cells of grass carp (Ctenopharyngodon idella). Fish Shellfish Immunol. 2021;112:159\u201367. https:\/\/doi.org\/10.1016\/j.fsi.2020.09.036.","journal-title":"Fish Shellfish Immunol"},{"key":"637_CR263","doi-asserted-by":"publisher","first-page":"1017348","DOI":"10.3389\/fcimb.2022.1017348","volume":"12","author":"JL Stoudenmire","year":"2022","unstructured":"Stoudenmire JL, Greenawalt AN, Cornelissen CN. Stealthy microbes: How Neisseria gonorrhoeae hijacks bulwarked iron during infection. Front Cell Infect Microbiol. 2022;12:1017348. https:\/\/doi.org\/10.3389\/fcimb.2022.1017348.","journal-title":"Front Cell Infect Microbiol"},{"issue":"4","key":"637_CR264","doi-asserted-by":"publisher","first-page":"391","DOI":"10.1093\/humupd\/dmi012","volume":"11","author":"D Goswami","year":"2005","unstructured":"Goswami D, Conway GS. Premature ovarian failure. Hum Reprod Update. 2005;11(4):391\u2013410. https:\/\/doi.org\/10.1093\/humupd\/dmi012.","journal-title":"Hum Reprod Update"},{"issue":"6","key":"637_CR265","doi-asserted-by":"publisher","first-page":"606","DOI":"10.1056\/NEJMcp0808697","volume":"360","author":"LM Nelson","year":"2009","unstructured":"Nelson LM. Clinical practice. Primary ovarian insufficiency. N Engl J Med. 2009;360(6):606\u201314. https:\/\/doi.org\/10.1056\/NEJMcp0808697.","journal-title":"N Engl J Med"},{"issue":"5","key":"637_CR266","doi-asserted-by":"publisher","first-page":"603","DOI":"10.1016\/j.jadohealth.2019.11.315","volume":"66","author":"N Gruber","year":"2020","unstructured":"Gruber N, Kugler S, de Vries L, Brener A, Zung A, Eyal O, et al. Primary ovarian insufficiency nationwide incidence rate and etiology among Israeli adolescents. J Adolesc Health. 2020;66(5):603\u20139. https:\/\/doi.org\/10.1016\/j.jadohealth.2019.11.315.","journal-title":"J Adolesc Health"},{"issue":"2","key":"637_CR267","doi-asserted-by":"publisher","first-page":"154","DOI":"10.1056\/NEJMcp2116488","volume":"388","author":"CA Stuenkel","year":"2023","unstructured":"Stuenkel CA, Gompel A. Primary ovarian insufficiency. N Engl J Med. 2023;388(2):154\u201363. https:\/\/doi.org\/10.1056\/NEJMcp2116488.","journal-title":"N Engl J Med"},{"key":"637_CR268","doi-asserted-by":"publisher","first-page":"123200","DOI":"10.1016\/j.lfs.2024.123200","volume":"359","author":"X Zhang","year":"2024","unstructured":"Zhang X, Man X, Zhang Q, Zhu L, Chen L, Zhu C, et al. Melatonin protects against particulate matter-induced ovarian dysfunction by activating the Nrf2 signaling pathway to alleviate ferroptosis. Life Sci. 2024;359:123200. https:\/\/doi.org\/10.1016\/j.lfs.2024.123200.","journal-title":"Life Sci"},{"issue":"1","key":"637_CR269","doi-asserted-by":"publisher","first-page":"5871","DOI":"10.1038\/s41467-022-33323-8","volume":"13","author":"F Wang","year":"2022","unstructured":"Wang F, Liu Y, Ni F, Jin J, Wu Y, Huang Y, et al. BNC1 deficiency-triggered ferroptosis through the NF2-YAP pathway induces primary ovarian insufficiency. Nat Commun. 2022;13(1):5871. https:\/\/doi.org\/10.1038\/s41467-022-33323-8.","journal-title":"Nat Commun"},{"issue":"1","key":"637_CR270","doi-asserted-by":"publisher","first-page":"168","DOI":"10.1007\/s00018-026-06128-x","volume":"83","author":"Z Chen","year":"2026","unstructured":"Chen Z, Guo J, Gao M, Wang H, Cai H, Yang Q, et al. HDAC3 Preserves the primordial follicle reserve by epigenetically suppressing ferroptosis in pregranulosa cells. Cell Mol Life Sci. 2026;83(1):168. https:\/\/doi.org\/10.1007\/s00018-026-06128-x.","journal-title":"Cell Mol Life Sci"},{"issue":"6","key":"637_CR271","doi-asserted-by":"publisher","first-page":"2745","DOI":"10.1210\/jc.2003-032046","volume":"89","author":"R Azziz","year":"2004","unstructured":"Azziz R, Woods KS, Reyna R, Key TJ, Knochenhauer ES, Yildiz BO. The prevalence and features of the polycystic ovary syndrome in an unselected population. J Clin Endocrinol Metab. 2004;89(6):2745\u20139. https:\/\/doi.org\/10.1210\/jc.2003-032046.","journal-title":"J Clin Endocrinol Metab"},{"issue":"5","key":"637_CR272","doi-asserted-by":"publisher","first-page":"270","DOI":"10.1038\/nrendo.2018.24","volume":"14","author":"HF Escobar-Morreale","year":"2018","unstructured":"Escobar-Morreale HF. Polycystic ovary syndrome: definition, aetiology, diagnosis and treatment. Nat Rev Endocrinol. 2018;14(5):270\u201384. https:\/\/doi.org\/10.1038\/nrendo.2018.24.","journal-title":"Nat Rev Endocrinol"},{"issue":"6","key":"637_CR273","doi-asserted-by":"publisher","first-page":"927","DOI":"10.1210\/endrev\/bnac001","volume":"43","author":"M Dapas","year":"2022","unstructured":"Dapas M, Dunaif A. Deconstructing a syndrome: genomic insights into PCOS causal mechanisms and classification. Endocr Rev. 2022;43(6):927\u201365. https:\/\/doi.org\/10.1210\/endrev\/bnac001.","journal-title":"Endocr Rev"},{"issue":"1","key":"637_CR274","doi-asserted-by":"publisher","first-page":"4983","DOI":"10.1080\/21655979.2021.1956403","volume":"12","author":"L Zhang","year":"2021","unstructured":"Zhang L, Wang F, Li D, Yan Y, Wang H. Transferrin receptor-mediated reactive oxygen species promotes ferroptosis of KGN cells via regulating NADPH oxidase 1\/PTEN induced kinase 1\/acyl-CoA synthetase long chain family member 4 signaling. Bioengineered. 2021;12(1):4983\u201394. https:\/\/doi.org\/10.1080\/21655979.2021.1956403.","journal-title":"Bioengineered"},{"issue":"4","key":"637_CR275","doi-asserted-by":"publisher","first-page":"403","DOI":"10.1016\/j.tjog.2014.06.005","volume":"54","author":"PC Ko","year":"2015","unstructured":"Ko PC, Huang SY, Hsieh CH, Hsu MI, Hsu CS. Serum ferritin levels and polycystic ovary syndrome in obese and nonobese women. Taiwan J Obstet Gynecol. 2015;54(4):403\u20137. https:\/\/doi.org\/10.1016\/j.tjog.2014.06.005.","journal-title":"Taiwan J Obstet Gynecol"},{"issue":"8","key":"637_CR276","doi-asserted-by":"publisher","first-page":"1525","DOI":"10.2337\/dc09-0420","volume":"32","author":"MA Martinez-Garcia","year":"2009","unstructured":"Martinez-Garcia MA, Luque-Ramirez M, San-Millan JL, Escobar-Morreale HF. Body iron stores and glucose intolerance in premenopausal women: role of hyperandrogenism, insulin resistance, and genomic variants related to inflammation, oxidative stress, and iron metabolism. Diabetes Care. 2009;32(8):1525\u201330. https:\/\/doi.org\/10.2337\/dc09-0420.","journal-title":"Diabetes Care"},{"issue":"5","key":"637_CR277","doi-asserted-by":"publisher","first-page":"1730","DOI":"10.1016\/j.fertnstert.2011.01.038","volume":"95","author":"HF Escobar-Morreale","year":"2011","unstructured":"Escobar-Morreale HF, Luque-Ram\u00edrez M. Role of androgen-mediated enhancement of erythropoiesis in the increased body iron stores of patients with polycystic ovary syndrome. Fertil Steril. 2011;95(5):1730-5.e1. https:\/\/doi.org\/10.1016\/j.fertnstert.2011.01.038.","journal-title":"Fertil Steril"},{"issue":"8","key":"637_CR278","doi-asserted-by":"publisher","first-page":"2348","DOI":"10.2337\/diabetes.51.8.2348","volume":"51","author":"JM Fern\u00e1ndez-Real","year":"2002","unstructured":"Fern\u00e1ndez-Real JM, L\u00f3pez-Bermejo A, Ricart W. Cross-talk between iron metabolism and diabetes. Diabetes. 2002;51(8):2348\u201354. https:\/\/doi.org\/10.2337\/diabetes.51.8.2348.","journal-title":"Diabetes"},{"issue":"3","key":"637_CR279","doi-asserted-by":"publisher","first-page":"846","DOI":"10.1210\/jc.2010-2211","volume":"96","author":"M Luque-Ram\u00edrez","year":"2011","unstructured":"Luque-Ram\u00edrez M, \u00c1lvarez-Blasco F, Alpa\u00f1\u00e9s M, Escobar-Morreale HF. Role of decreased circulating hepcidin concentrations in the iron excess of women with the polycystic ovary syndrome. J Clin Endocrinol Metab. 2011;96(3):846\u201352. https:\/\/doi.org\/10.1210\/jc.2010-2211.","journal-title":"J Clin Endocrinol Metab"},{"issue":"12","key":"637_CR280","doi-asserted-by":"publisher","first-page":"118535","DOI":"10.1016\/j.bbamcr.2019.118535","volume":"1866","author":"D Galaris","year":"2019","unstructured":"Galaris D, Barbouti A, Pantopoulos K. Iron homeostasis and oxidative stress: An intimate relationship. Biochim Biophys Acta Mol Cell Res. 2019;1866(12):118535. https:\/\/doi.org\/10.1016\/j.bbamcr.2019.118535.","journal-title":"Biochim Biophys Acta Mol Cell Res"},{"issue":"10","key":"637_CR281","doi-asserted-by":"publisher","first-page":"509","DOI":"10.1016\/j.tem.2012.04.003","volume":"23","author":"HF Escobar-Morreale","year":"2012","unstructured":"Escobar-Morreale HF. Iron metabolism and the polycystic ovary syndrome. Trends Endocrinol Metab. 2012;23(10):509\u201315. https:\/\/doi.org\/10.1016\/j.tem.2012.04.003.","journal-title":"Trends Endocrinol Metab"},{"key":"637_CR282","doi-asserted-by":"publisher","first-page":"967151","DOI":"10.3389\/fimmu.2022.967151","volume":"13","author":"W Tan","year":"2022","unstructured":"Tan W, Dai F, Yang D, Deng Z, Gu R, Zhao X, et al. MiR-93-5p promotes granulosa cell apoptosis and ferroptosis by the NF-kB signaling pathway in polycystic ovary syndrome. Front Immu. 2022;13:967151. https:\/\/doi.org\/10.3389\/fimmu.2022.967151.","journal-title":"Front Immu"},{"issue":"3","key":"637_CR283","doi-asserted-by":"publisher","first-page":"247","DOI":"10.1530\/JOE-20-0155","volume":"246","author":"Y Zhang","year":"2020","unstructured":"Zhang Y, Hu M, Jia W, Liu G, Zhang J, Wang B, et al. Hyperandrogenism and insulin resistance modulate gravid uterine and placental ferroptosis in PCOS-like rats. J Endocrinol. 2020;246(3):247\u201363. https:\/\/doi.org\/10.1530\/JOE-20-0155.","journal-title":"J Endocrinol"},{"issue":"6","key":"637_CR284","doi-asserted-by":"publisher","first-page":"806","DOI":"10.1002\/1873-3468.14289","volume":"596","author":"M Hu","year":"2022","unstructured":"Hu M, Zhang Y, Lu L, Zhou Y, Wu D, Br\u00e4nnstr\u00f6m M, et al. Overactivation of the androgen receptor exacerbates gravid uterine ferroptosis via interaction with and suppression of the NRF2 defense signaling pathway. FEBS Lett. 2022;596(6):806\u201325. https:\/\/doi.org\/10.1002\/1873-3468.14289.","journal-title":"FEBS Lett"},{"issue":"3","key":"637_CR285","doi-asserted-by":"publisher","first-page":"511","DOI":"10.1016\/j.fertnstert.2012.06.029","volume":"98","author":"RO Burney","year":"2012","unstructured":"Burney RO, Giudice LC. Pathogenesis and pathophysiology of endometriosis. Fertil Steril. 2012;98(3):511\u20139. https:\/\/doi.org\/10.1016\/j.fertnstert.2012.06.029.","journal-title":"Fertil Steril"},{"issue":"2","key":"637_CR286","doi-asserted-by":"publisher","first-page":"235","DOI":"10.1016\/S0889-8545(05)70302-8","volume":"24","author":"B Eskenazi","year":"1997","unstructured":"Eskenazi B, Warner ML. Epidemiology of endometriosis. Obstet Gynecol Clin North Am. 1997;24(2):235\u201358. https:\/\/doi.org\/10.1016\/S0889-8545(05)70302-8.","journal-title":"Obstet Gynecol Clin North Am"},{"issue":"4","key":"637_CR287","doi-asserted-by":"publisher","first-page":"395","DOI":"10.1093\/humupd\/dmm010OUCISCIRP","volume":"13","author":"S Simoens","year":"2007","unstructured":"Simoens S, Hummelshoj L, D\u2019Hooghe T. Endometriosis: cost estimates and methodological perspective. Hum Reprod Update. 2007;13(4):395\u2013404. https:\/\/doi.org\/10.1093\/humupd\/dmm010OUCISCIRP.","journal-title":"Hum Reprod Update"},{"issue":"6","key":"637_CR288","doi-asserted-by":"publisher","first-page":"1552","DOI":"10.1093\/humrep\/det050","volume":"28","author":"NP Johnson","year":"2013","unstructured":"Johnson NP, Hummelshoj L, World Endometriosis Society Montpellier Consortium, Abrao MS, Adamson GD, Allaire C, et al. Consensus on current management of endometriosis. Hum Reprod. 2013;28(6):1552\u201368. https:\/\/doi.org\/10.1093\/humrep\/det050.","journal-title":"Hum Reprod"},{"issue":"9","key":"637_CR289","doi-asserted-by":"publisher","first-page":"5927","DOI":"10.1097\/JS9.0000000000002647","volume":"111","author":"S Xu","year":"2025","unstructured":"Xu S, Zhang Y, Ye P, Huang Q, Wang Y, Zhang Y, et al. Global, regional, and national burden of endometriosis among women of childbearing age from 1990 to 2021: a cross-sectional analysis from the 2021 global burden of disease study. Int J Surg (London, England). 2025;111(9):5927. https:\/\/doi.org\/10.1097\/JS9.0000000000002647.","journal-title":"Int J Surg (London, England)"},{"issue":"3","key":"637_CR290","doi-asserted-by":"publisher","first-page":"hoad033","DOI":"10.1093\/hropen\/hoad033","volume":"2023","author":"J Wyatt","year":"2023","unstructured":"Wyatt J, Fernando SM, Powell SG, Hill CJ, Arshad I, Probert C, et al. The role of iron in the pathogenesis of endometriosis: a systematic review. Hum Reprod Open. 2023;2023(3):hoad033. https:\/\/doi.org\/10.1093\/hropen\/hoad033.","journal-title":"Hum Reprod Open"},{"issue":"7","key":"637_CR291","doi-asserted-by":"publisher","first-page":"1383","DOI":"10.1007\/s43032-020-00164-z","volume":"27","author":"SW Ng","year":"2020","unstructured":"Ng SW, Norwitz SG, Taylor HS, Norwitz ER. Endometriosis: the role of iron overload and ferroptosis. Reprod Sci. 2020;27(7):1383\u201390. https:\/\/doi.org\/10.1007\/s43032-020-00164-z.","journal-title":"Reprod Sci"},{"issue":"1","key":"637_CR292","doi-asserted-by":"publisher","first-page":"306","DOI":"10.1038\/s41420-023-01606-8","volume":"9","author":"Y Li","year":"2023","unstructured":"Li Y, He Y, Cheng W, Zhou Z, Ni Z, Yu C. Double-edged roles of ferroptosis in endometriosis and endometriosis-related infertility. Cell death discovery. 2023;9(1):306. https:\/\/doi.org\/10.1038\/s41420-023-01606-8.","journal-title":"Cell death discovery"},{"issue":"2","key":"637_CR293","doi-asserted-by":"publisher","first-page":"107","DOI":"10.1038\/s41422-020-00441-1","volume":"31","author":"D Tang","year":"2021","unstructured":"Tang D, Chen X, Kang R, Kroemer G. Ferroptosis: molecular mechanisms and health implications. Cell Res. 2021;31(2):107\u201325. https:\/\/doi.org\/10.1038\/s41422-020-00441-1.","journal-title":"Cell Res"},{"issue":"2","key":"637_CR294","doi-asserted-by":"publisher","first-page":"112","DOI":"10.5301\/je.5000274","volume":"9","author":"SG Vitale","year":"2017","unstructured":"Vitale SG, La Rosa VL, Rapisarda AM, Lagan\u00e0 AS. Endometriosis and infertility: the impact on quality of life and mental health. J Endometriosis Pelvic Pain Disord. 2017;9(2):112\u20135. https:\/\/doi.org\/10.5301\/je.5000274.","journal-title":"J Endometriosis Pelvic Pain Disord"},{"issue":"2","key":"637_CR295","doi-asserted-by":"publisher","first-page":"159","DOI":"10.1016\/j.critrevonc.2006.03.004","volume":"60","author":"N Colombo","year":"2006","unstructured":"Colombo N, Van Gorp T, Parma G, Amant F, Gatta G, Sessa C, et al. Ovarian cancer. Crit Rev Oncol Hematol. 2006;60(2):159\u201379. https:\/\/doi.org\/10.1016\/j.critrevonc.2006.03.004.","journal-title":"Crit Rev Oncol Hematol"},{"issue":"9951","key":"637_CR296","doi-asserted-by":"publisher","first-page":"1376","DOI":"10.1016\/S0140-6736(13)62146-7","volume":"384","author":"GC Jayson","year":"2014","unstructured":"Jayson GC, Kohn EC, Kitchener HC, Ledermann JA. Ovarian cancer. Lancet. 2014;384(9951):1376\u201388. https:\/\/doi.org\/10.1016\/S0140-6736(13)62146-7.","journal-title":"Lancet"},{"issue":"2","key":"637_CR297","doi-asserted-by":"publisher","first-page":"151","DOI":"10.1016\/j.soncn.2019.02.001","volume":"35","author":"C Stewart","year":"2019","unstructured":"Stewart C, Ralyea C, Lockwood S. Ovarian cancer: an integrated review. Semin Oncol Nurs. 2019;35(2):151\u20136. https:\/\/doi.org\/10.1016\/j.soncn.2019.02.001.","journal-title":"Semin Oncol Nurs"},{"key":"637_CR298","doi-asserted-by":"publisher","DOI":"10.1007\/s12672-026-04785-9","author":"VJ Ashonibare","year":"2026","unstructured":"Ashonibare VJ, Hezekiel OS, Kukoyi OS, Hassan SA, Afolabi OA, Akhigbe TM, et al. Current evidence and emerging approaches in immunotherapy for gynecological cancers. Discover Oncology. 2026. https:\/\/doi.org\/10.1007\/s12672-026-04785-9.","journal-title":"Discover Oncology"},{"issue":"29","key":"637_CR299","doi-asserted-by":"publisher","first-page":"4089","DOI":"10.1038\/onc.2017.11","volume":"36","author":"D Basuli","year":"2017","unstructured":"Basuli D, Tesfay L, Deng Z, Paul B, Yamamoto Y, Ning G, et al. Iron addiction: a novel therapeutic target in ovarian cancer. Oncogene. 2017;36(29):4089\u201399. https:\/\/doi.org\/10.1038\/onc.2017.11.","journal-title":"Oncogene"},{"issue":"20","key":"637_CR300","doi-asserted-by":"publisher","first-page":"12689","DOI":"10.3390\/ijms232012689","volume":"23","author":"SC Sze","year":"2022","unstructured":"Sze SC, Zhang L, Zhang S, Lin K, Ng TB, Ng ML, et al. Aberrant transferrin and ferritin upregulation elicits iron accumulation and oxidative inflammaging causing ferroptosis and undermines estradiol biosynthesis in aging rat ovaries by upregulating NF-\u039ab-Activated inducible nitric oxide synthase: first demonstration of an intricate mechanism. Int J Mol Sci. 2022;23(20):12689. https:\/\/doi.org\/10.3390\/ijms232012689.","journal-title":"Int J Mol Sci"},{"issue":"9","key":"637_CR301","doi-asserted-by":"publisher","first-page":"2262","DOI":"10.1093\/humrep\/der211","volume":"26","author":"P Vercellini","year":"2011","unstructured":"Vercellini P, Crosignani P, Somigliana E, Vigano P, Buggio L, Bolis G, et al. The \u2018incessant menstruation\u2019 hypothesis: a mechanistic ovarian cancer model with implications for prevention. Hum Reprod. 2011;26(9):2262\u201373. https:\/\/doi.org\/10.1093\/humrep\/der211.","journal-title":"Hum Reprod"},{"issue":"9","key":"637_CR302","doi-asserted-by":"publisher","first-page":"995","DOI":"10.1515\/hsz-2017-0074","volume":"398","author":"S Rockfield","year":"2017","unstructured":"Rockfield S, Raffel J, Mehta R, Rehman N, Nanjundan M. Iron overload and altered iron metabolism in ovarian cancer. Biol Chem. 2017;398(9):995\u20131007. https:\/\/doi.org\/10.1515\/hsz-2017-0074.","journal-title":"Biol Chem"},{"issue":"4","key":"637_CR303","doi-asserted-by":"publisher","first-page":"653","DOI":"10.1111\/j.1349-7006.2008.00747.x","volume":"99","author":"H Itamochi","year":"2008","unstructured":"Itamochi H, Kigawa J, Terakawa N. Mechanisms of chemoresistance and poor prognosis in ovarian clear cell carcinoma. Cancer Sci. 2008;99(4):653\u20138. https:\/\/doi.org\/10.1111\/j.1349-7006.2008.00747.x.","journal-title":"Cancer Sci"},{"issue":"5","key":"637_CR304","doi-asserted-by":"publisher","first-page":"296","DOI":"10.1038\/nnano.2011.36","volume":"6","author":"T Yamada","year":"2011","unstructured":"Yamada T, Hayamizu Y, Yamamoto Y, Yomogida Y, Izadi-Najafabadi A, Futaba DN, et al. A stretchable carbon nanotube strain sensor for human-motion detection. Nat Nanotechnol. 2011;6(5):296\u2013301. https:\/\/doi.org\/10.1038\/nnano.2011.36.","journal-title":"Nat Nanotechnol"},{"issue":"1","key":"637_CR305","doi-asserted-by":"publisher","first-page":"86","DOI":"10.4103\/0300-1652.128180","volume":"55","author":"RE Akhigbe","year":"2014","unstructured":"Akhigbe RE. The role of low-dose aspirin in the prevention of pre-eclampsia. Niger Med J. 2014;55(1):86. https:\/\/doi.org\/10.4103\/0300-1652.128180.","journal-title":"Niger Med J"},{"key":"637_CR306","doi-asserted-by":"publisher","first-page":"l5119","DOI":"10.1136\/bmj.l5119","volume":"366","author":"K Webster","year":"2019","unstructured":"Webster K, Fishburn S, Maresh M, Findlay SC, Chappell LC. Diagnosis and management of hypertension in pregnancy: summary of updated NICE guidance. BMJ. 2019;366:l5119. https:\/\/doi.org\/10.1136\/bmj.l5119.","journal-title":"BMJ"},{"issue":"24","key":"637_CR307","doi-asserted-by":"publisher","first-page":"8855","DOI":"10.3390\/molecules27248855","volume":"27","author":"W Yang","year":"2022","unstructured":"Yang W, Liang Z, Wen C, Jiang X, Wang L. Silymarin protects against acute liver injury induced by acetaminophen by downregulating the expression and activity of the CYP2E1 enzyme. Molecules. 2022;27(24):8855. https:\/\/doi.org\/10.3390\/molecules27248855.","journal-title":"Molecules"},{"key":"637_CR308","doi-asserted-by":"publisher","first-page":"416","DOI":"10.1016\/j.freeradbiomed.2019.07.015","volume":"141","author":"P Guerby","year":"2019","unstructured":"Guerby P, Swiader A, Tasta O, Pont F, Rodriguez F, Parant O, et al. Modification of endothelial nitric oxide synthase by 4-oxo-2(E)-nonenal (ONE) in preeclamptic placentas. Free Radic Biol Med. 2019;141:416\u201325. https:\/\/doi.org\/10.1016\/j.freeradbiomed.2019.07.015.","journal-title":"Free Radic Biol Med"},{"issue":"7","key":"637_CR309","doi-asserted-by":"publisher","first-page":"1282","DOI":"10.3390\/antiox11071282","volume":"11","author":"Z Chen","year":"2022","unstructured":"Chen Z, Gan J, Zhang M, Du Y, Zhao H. Ferroptosis and its emerging role in pre-eclampsia. Antioxidants (Basel). 2022;11(7):1282. https:\/\/doi.org\/10.3390\/antiox11071282.","journal-title":"Antioxidants (Basel)"},{"issue":"6","key":"637_CR310","doi-asserted-by":"publisher","first-page":"890","DOI":"10.1093\/humupd\/dmac027","volume":"28","author":"F Louwen","year":"2022","unstructured":"Louwen F, Kreis NN, Ritter A, Friemel A, Solbach C, Yuan J. BCL6, a key oncogene, in the placenta, pre-eclampsia and endometriosis. Hum Reprod Update. 2022;28(6):890\u2013909. https:\/\/doi.org\/10.1093\/humupd\/dmac027.","journal-title":"Hum Reprod Update"},{"issue":"5","key":"637_CR311","doi-asserted-by":"publisher","first-page":"1115","DOI":"10.1007\/s10815-022-02443-x","volume":"39","author":"SR El-Khalik","year":"2022","unstructured":"El-Khalik SR, Ibrahim RR, Ghafar MT, Shatat D, El-Deeb OS. Novel insights into the SLC7A11-mediated ferroptosis signaling pathways in preeclampsia patients: identifying pannexin 1 and toll-like receptor 4 as innovative prospective diagnostic biomarkers. J Assist Reprod Genet. 2022;39(5):1115\u201324. https:\/\/doi.org\/10.1007\/s10815-022-02443-x.","journal-title":"J Assist Reprod Genet"},{"key":"637_CR312","doi-asserted-by":"publisher","first-page":"807583","DOI":"10.3389\/fphys.2022.807583","volume":"13","author":"L Zhang","year":"2022","unstructured":"Zhang L, Bi S, Liang Y, Huang L, Li Y, Huang M, et al. Integrated metabolomic and lipidomic analysis in the placenta of preeclampsia. Front Physiol. 2022;13:807583. https:\/\/doi.org\/10.3389\/fphys.2022.807583.","journal-title":"Front Physiol"},{"issue":"10022","key":"637_CR313","doi-asserted-by":"publisher","first-page":"999","DOI":"10.1016\/S0140-6736(15)00070-7","volume":"387","author":"BW Mol","year":"2016","unstructured":"Mol BW, Roberts CT, Thangaratinam S, Magee LA, De Groot CJ, Hofmeyr GJ. Pre-eclampsia Lancet. 2016;387(10022):999\u20131011. https:\/\/doi.org\/10.1016\/S0140-6736(15)00070-7.","journal-title":"Pre-eclampsia Lancet"},{"key":"637_CR314","doi-asserted-by":"publisher","first-page":"32","DOI":"10.1016\/j.placenta.2021.03.007","volume":"108","author":"O Beharier","year":"2021","unstructured":"Beharier O, Kajiwara K, Sadovsky Y. Ferroptosis, trophoblast lipotoxic damage, and adverse pregnancy outcome. Placenta. 2021;108:32\u20138. https:\/\/doi.org\/10.1016\/j.placenta.2021.03.007.","journal-title":"Placenta"},{"issue":"13","key":"637_CR315","doi-asserted-by":"publisher","first-page":"3283","DOI":"10.3390\/ijms20133283","volume":"20","author":"SW Ng","year":"2019","unstructured":"Ng SW, Norwitz SG, Norwitz ER. The impact of iron overload and ferroptosis on reproductive disorders in humans: implications for preeclampsia. Int J Mol Sci. 2019;20(13):3283. https:\/\/doi.org\/10.3390\/ijms20133283.","journal-title":"Int J Mol Sci"},{"key":"637_CR316","doi-asserted-by":"publisher","first-page":"389042","DOI":"10.3389\/fmed.2018.00181","volume":"5","author":"E Amabebe","year":"2018","unstructured":"Amabebe E, Anumba DO. The vaginal microenvironment: the physiologic role of lactobacilli. Front Med. 2018;5:389042. https:\/\/doi.org\/10.3389\/fmed.2018.00181.","journal-title":"Front Med"},{"key":"637_CR317","doi-asserted-by":"publisher","first-page":"110080","DOI":"10.1016\/j.intimp.2023.110080","volume":"118","author":"L Cao","year":"2023","unstructured":"Cao L, Qin R, Liu J. Farnesoid X receptor protects against lipopolysaccharide-induced endometritis by inhibiting ferroptosis and inflammatory response. Int Immunopharmacol. 2023;118:110080. https:\/\/doi.org\/10.1016\/j.intimp.2023.110080.","journal-title":"Int Immunopharmacol"},{"issue":"20","key":"637_CR318","doi-asserted-by":"publisher","first-page":"e70175","DOI":"10.1111\/jcmm.70175","volume":"28","author":"L Cao","year":"2024","unstructured":"Cao L, Liu J, Ye C, Hu Y, Qin R. Caffeic acid inhibits Staphylococcus aureus-induced endometritis through regulating AMPK\u03b1\/mTOR\/HIF-1\u03b1 signalling pathway. J Cell Mol Med. 2024;28(20):e70175. https:\/\/doi.org\/10.1111\/jcmm.70175.","journal-title":"J Cell Mol Med"},{"key":"637_CR319","doi-asserted-by":"publisher","first-page":"1649801","DOI":"10.3389\/fcimb.2025.1649801","volume":"15","author":"F Chen","year":"2025","unstructured":"Chen F, Cheng R, Chen X, Guo Z. Indole-3-carboxamide alleviates LPS-induced endometritis through suppressing ferroptosis and inflammation via regulating Aryl hydrocarbon receptor. Front Cell Infect Microbiol. 2025;15:1649801. https:\/\/doi.org\/10.3389\/fcimb.2025.1649801.","journal-title":"Front Cell Infect Microbiol"},{"issue":"1","key":"637_CR320","doi-asserted-by":"publisher","first-page":"201","DOI":"10.1038\/s41420-022-01013-5","volume":"8","author":"T Wang","year":"2022","unstructured":"Wang T, Gong M, Cao Y, Zhao C, Lu Y, Zhou Y, et al. Persistent ferroptosis promotes cervical squamous intraepithelial lesion development and oncogenesis by regulating KRAS expression in patients with high risk-HPV infection. Cell death discovery. 2022;8(1):201. https:\/\/doi.org\/10.1038\/s41420-022-01013-5.","journal-title":"Cell death discovery"},{"issue":"1","key":"637_CR321","doi-asserted-by":"publisher","first-page":"129","DOI":"10.1186\/s13578-024-01309-2","volume":"14","author":"XJ Chen","year":"2024","unstructured":"Chen XJ, Guo CH, Yang Y, Wang ZC, Liang YY, Cai YQ, et al. HPV16 integration regulates ferroptosis resistance via the c-Myc\/miR-142-5p\/HOXA5\/SLC7A11 axis during cervical carcinogenesis. Cell Biosci. 2024;14(1):129. https:\/\/doi.org\/10.1186\/s13578-024-01309-2.","journal-title":"Cell Biosci"},{"issue":"4","key":"637_CR322","doi-asserted-by":"publisher","first-page":"407","DOI":"10.3390\/antiox15040407","volume":"15","author":"YM Hou","year":"2026","unstructured":"Hou YM, Yu H, Feng F, Yao HY, Yao JM, An RF. Ferroptosis in Recurrent Vulvovaginal Candidiasis Through Integrated Bioinformatics and Experimental Validation. Antioxidants. 2026;15(4):407. https:\/\/doi.org\/10.3390\/antiox15040407.","journal-title":"Antioxidants"},{"key":"637_CR323","doi-asserted-by":"publisher","first-page":"127704","DOI":"10.1016\/j.micres.2024.127704","volume":"283","author":"H Mo","year":"2024","unstructured":"Mo H, Zhang T, Zhang J, Peng S, Xiang F, Li H, et al. Ferrous sulphate triggers ferroptosis in Candida albicans and cures vulvovaginal candidiasis in a mouse model. Microbiol Res. 2024;283:127704. https:\/\/doi.org\/10.1016\/j.micres.2024.127704.","journal-title":"Microbiol Res"},{"issue":"1","key":"637_CR324","doi-asserted-by":"publisher","first-page":"3644","DOI":"10.1038\/s41467-021-23902-6","volume":"12","author":"D Chen","year":"2021","unstructured":"Chen D, Chu B, Yang X, Liu Z, Jin Y, Kon N, et al. iPLA2\u03b2-mediated lipid detoxification controls p53-driven ferroptosis independent of GPX4. Nat Commun. 2021;12(1):3644. https:\/\/doi.org\/10.1038\/s41467-021-23902-6.","journal-title":"Nat Commun"},{"issue":"4","key":"637_CR325","doi-asserted-by":"publisher","first-page":"161","DOI":"10.2183\/pjab.97.010","volume":"97","author":"T Miyazawa","year":"2021","unstructured":"Miyazawa T. Lipid hydroperoxides in nutrition, health, and diseases. Proceed Japan Acad Series B. 2021;97(4):161\u201396. https:\/\/doi.org\/10.2183\/pjab.97.010.","journal-title":"Proceed Japan Acad Series B"},{"issue":"3","key":"637_CR326","doi-asserted-by":"publisher","first-page":"489","DOI":"10.1080\/01480545.2025.2592930","volume":"49","author":"WA Saka","year":"2026","unstructured":"Saka WA, Ashonibare VJ, Aderoju RA, Lawal AT, Kajola PO, Adegbola CA, et al. Silymarin ameliorates post-weaning bisphenol A exposure-induced cardiotoxicity via suppression of TLR4\/VCAM signaling in male Wistar rats. Drug Chem Toxicol. 2026;49(3):489\u2013502. https:\/\/doi.org\/10.1080\/01480545.2025.2592930.","journal-title":"Drug Chem Toxicol"},{"key":"637_CR327","doi-asserted-by":"publisher","first-page":"151668","DOI":"10.1016\/j.bbrc.2025.151668","volume":"758","author":"RE Akhigbe","year":"2025","unstructured":"Akhigbe RE, Adekunle AO, Ajao MD, Sunmola TA, Aboyeji DO, Adegbola CA, et al. Silymarin attenuates post-weaning bisphenol A-induced renal injury by suppressing ferroptosis and amyloidosis through Kim-1\/Nrf2\/HO-1 signaling modulation in male Wistar rats. Biochem Biophys Res Commun. 2025;758:151668. https:\/\/doi.org\/10.1016\/j.bbrc.2025.151668.","journal-title":"Biochem Biophys Res Commun"},{"issue":"1","key":"637_CR328","doi-asserted-by":"publisher","first-page":"158","DOI":"10.1186\/s12915-025-02268-x","volume":"23","author":"W Zhou","year":"2025","unstructured":"Zhou W, Thiery JP. Ferroptosis-related LncRNAs in diseases. BMC Biol. 2025;23(1):158. https:\/\/doi.org\/10.1186\/s12915-025-02268-x.","journal-title":"BMC Biol"},{"issue":"1","key":"637_CR329","doi-asserted-by":"publisher","first-page":"300","DOI":"10.1186\/s40001-025-02559-7","volume":"30","author":"Y Jiang","year":"2025","unstructured":"Jiang Y, Saeed TN, Alfarttoosi KH, Bishoyi AK, Rekha MM, Kundlas M, et al. The intersection of ferroptosis and non-coding RNAs: a novel approach to ovarian cancer. Eur J Med Res. 2025;30(1):300. https:\/\/doi.org\/10.1186\/s40001-025-02559-7.","journal-title":"Eur J Med Res"},{"key":"637_CR330","doi-asserted-by":"publisher","unstructured":"Hsu CY, Al-Hasnaawei S, Kumar A, Ballal S, Mahmood AA, Kalia R, et al. Exosomal non-coding RNA as a key mediator of ferroptosis in lung cancer. Cellular Signalling. 2025;112135. https:\/\/doi.org\/10.1016\/j.cellsig.2025.112135.","DOI":"10.1016\/j.cellsig.2025.112135"},{"key":"637_CR331","doi-asserted-by":"publisher","unstructured":"Li M, Zheng H, Fu Z, Yan X, Mao D, Yu G. Prognostic Relevance of ACSL4 as a serological marker and its mediating roles in acute supratentorial intracerebral hemorrhage: an observational analytical study. International Journal of General Medicine. 2026:580561. https:\/\/doi.org\/10.2147\/IJGM.S580561","DOI":"10.2147\/IJGM.S580561"},{"issue":"1","key":"637_CR332","doi-asserted-by":"publisher","first-page":"91","DOI":"10.1038\/nchembio.2239","volume":"13","author":"S Doll","year":"2017","unstructured":"Doll S, Proneth B, Tyurina YY, Panzilius E, Kobayashi S, Ingold I, et al. ACSL4 dictates ferroptosis sensitivity by shaping cellular lipid composition. Nat Chem Biol. 2017;13(1):91\u20138. https:\/\/doi.org\/10.1038\/nchembio.2239.","journal-title":"Nat Chem Biol"},{"issue":"7","key":"637_CR333","doi-asserted-by":"publisher","first-page":"402","DOI":"10.1691\/ph.2017.7449","volume":"72","author":"J Yuan","year":"2017","unstructured":"Yuan J, Liu Z, Song R. Antisense lncRNA As-SLC7A11 suppresses epithelial ovarian cancer progression mainly by targeting SLC7A11. Die Pharmazie-An International J Pharmaceutical Sci. 2017;72(7):402\u20137. https:\/\/doi.org\/10.1691\/ph.2017.7449.","journal-title":"Die Pharmazie-An International J Pharmaceutical Sci"},{"issue":"10","key":"637_CR334","doi-asserted-by":"publisher","first-page":"1181","DOI":"10.1038\/s41556-018-0178-0","volume":"20","author":"Y Zhang","year":"2018","unstructured":"Zhang Y, Shi J, Liu X, Feng L, Gong Z, Koppula P, et al. BAP1 links metabolic regulation of ferroptosis to tumour suppression. Nat Cell Biol. 2018;20(10):1181\u201392. https:\/\/doi.org\/10.1038\/s41556-018-0178-0.","journal-title":"Nat Cell Biol"},{"key":"637_CR335","doi-asserted-by":"publisher","first-page":"115415","DOI":"10.1016\/j.biopha.2023.115415","volume":"166","author":"M Liu","year":"2023","unstructured":"Liu M, Wu K, Wu Y. The emerging role of ferroptosis in female reproductive disorders. Biomed Pharmacother. 2023;166:115415. https:\/\/doi.org\/10.1016\/j.biopha.2023.115415.","journal-title":"Biomed Pharmacother"},{"issue":"7","key":"637_CR336","doi-asserted-by":"publisher","first-page":"1692","DOI":"10.1016\/j.celrep.2017.07.055","volume":"20","author":"Y Xie","year":"2017","unstructured":"Xie Y, Zhu S, Song X, Sun X, Fan Y, Liu J, et al. The tumor suppressor p53 limits ferroptosis by blocking DPP4 activity. Cell Rep. 2017;20(7):1692\u2013704. https:\/\/doi.org\/10.1016\/j.celrep.2017.07.055.","journal-title":"Cell Rep"},{"issue":"3","key":"637_CR337","doi-asserted-by":"publisher","first-page":"443","DOI":"10.1016\/j.bbrc.2016.10.068","volume":"480","author":"X Song","year":"2016","unstructured":"Song X, Xie Y, Kang R, Hou W, Sun X, Epperly MW, et al. FANCD2 protects against bone marrow injury from ferroptosis. Biochem Biophys Res Commun. 2016;480(3):443\u20139. https:\/\/doi.org\/10.1016\/j.bbrc.2016.10.068.","journal-title":"Biochem Biophys Res Commun"},{"issue":"27","key":"637_CR338","doi-asserted-by":"publisher","first-page":"24393","DOI":"10.18632\/oncotarget.5162","volume":"6","author":"MY Kwon","year":"2015","unstructured":"Kwon MY, Park E, Lee SJ, Chung SW. Heme oxygenase-1 accelerates erastin-induced ferroptotic cell death. Oncotarget. 2015;6(27):24393. https:\/\/doi.org\/10.18632\/oncotarget.5162.","journal-title":"Oncotarget"},{"key":"637_CR339","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/s12943-020-01157-x","volume":"19","author":"Y Wu","year":"2020","unstructured":"Wu Y, Zhang S, Gong X, Tam S, Xiao D, Liu S, et al. The epigenetic regulators and metabolic changes in ferroptosis-associated cancer progression. Mol Cancer. 2020;19:1\u20137. https:\/\/doi.org\/10.1186\/s12943-020-01157-x.","journal-title":"Mol Cancer"},{"issue":"25","key":"637_CR340","doi-asserted-by":"publisher","first-page":"21148","DOI":"10.18632\/oncotarget.4125","volume":"6","author":"P Wang","year":"2015","unstructured":"Wang P, Zhu CF, Ma MZ, Chen G, Song M, Zeng ZL, et al. Micro-RNA-155 is induced by K-Ras oncogenic signal and promotes ROS stress in pancreatic cancer. Oncotarget. 2015;6(25):21148. https:\/\/doi.org\/10.18632\/oncotarget.4125.","journal-title":"Oncotarget"},{"issue":"3","key":"637_CR341","doi-asserted-by":"publisher","first-page":"e0122674","DOI":"10.1371\/journal.pone.0122674","volume":"10","author":"Y Zhang","year":"2015","unstructured":"Zhang Y, Zheng S, Geng Y, Xue J, Wang Z, Xie X, et al. MicroRNA profiling of atrial fibrillation in canines: miR-206 modulates intrinsic cardiac autonomic nerve remodeling by regulating SOD1. PLoS ONE. 2015;10(3):e0122674. https:\/\/doi.org\/10.1371\/journal.pone.0122674.","journal-title":"PLoS ONE"},{"issue":"1","key":"637_CR342","doi-asserted-by":"publisher","first-page":"25","DOI":"10.1038\/nrclinonc.2010.174","volume":"8","author":"CF Cheok","year":"2011","unstructured":"Cheok CF, Verma CS, Baselga J, Lane DP. Translating p53 into the clinic. Nat Rev Clin Oncol. 2011;8(1):25\u201337. https:\/\/doi.org\/10.1038\/nrclinonc.2010.174.","journal-title":"Nat Rev Clin Oncol"},{"issue":"13","key":"637_CR343","doi-asserted-by":"publisher","first-page":"3484","DOI":"10.1158\/0008-5472.CAN-17-3454","volume":"78","author":"C Mao","year":"2018","unstructured":"Mao C, Wang X, Liu Y, Wang M, Yan B, Jiang Y, et al. A G3BP1-interacting lncRNA promotes ferroptosis and apoptosis in cancer via nuclear sequestration of p53. Can Res. 2018;78(13):3484\u201396. https:\/\/doi.org\/10.1158\/0008-5472.CAN-17-3454.","journal-title":"Can Res"},{"issue":"44","key":"637_CR344","doi-asserted-by":"publisher","first-page":"E6806","DOI":"10.1073\/pnas.1607152113","volume":"113","author":"Y Ou","year":"2016","unstructured":"Ou Y, Wang SJ, Li D, Chu B, Gu W. Activation of SAT1 engages polyamine metabolism with p53-mediated ferroptotic responses. Proc Natl Acad Sci. 2016;113(44):E6806\u201312. https:\/\/doi.org\/10.1073\/pnas.1607152113.","journal-title":"Proc Natl Acad Sci"},{"issue":"8","key":"637_CR345","doi-asserted-by":"publisher","first-page":"1457","DOI":"10.1038\/s41418-017-0053-8","volume":"25","author":"M Luo","year":"2018","unstructured":"Luo M, Wu L, Zhang K, Wang H, Zhang T, Gutierrez L, et al. miR-137 regulates ferroptosis by targeting glutamine transporter SLC1A5 in melanoma. Cell Death Differ. 2018;25(8):1457\u201372. https:\/\/doi.org\/10.1038\/s41418-017-0053-8.","journal-title":"Cell Death Differ"},{"key":"637_CR346","doi-asserted-by":"publisher","first-page":"111","DOI":"10.1016\/j.yjmcc.2013.05.009","volume":"62","author":"ZV Varga","year":"2013","unstructured":"Varga ZV, Kupai K, Sz\u0171cs G, G\u00e1sp\u00e1r R, P\u00e1l\u00f3czi J, Farag\u00f3 N, et al. MicroRNA-25-dependent up-regulation of NADPH oxidase 4 (NOX4) mediates hypercholesterolemia-induced oxidative\/nitrative stress and subsequent dysfunction in the heart. J Mol Cell Cardiol. 2013;62:111\u201321. https:\/\/doi.org\/10.1016\/j.yjmcc.2013.05.009.","journal-title":"J Mol Cell Cardiol"},{"issue":"3","key":"637_CR347","doi-asserted-by":"publisher","first-page":"324","DOI":"10.1093\/cvr\/cvv238","volume":"108","author":"S Kyrychenko","year":"2015","unstructured":"Kyrychenko S, Kyrychenko V, Badr MA, Ikeda Y, Sadoshima J, Shirokova N. Pivotal role of miR-448 in the development of ROS-induced cardiomyopathy. Cardiovasc Res. 2015;108(3):324\u201334. https:\/\/doi.org\/10.1093\/cvr\/cvv238.","journal-title":"Cardiovasc Res"},{"issue":"1","key":"637_CR348","doi-asserted-by":"publisher","first-page":"104","DOI":"10.1038\/cdd.2017.169","volume":"25","author":"BJ Aubrey","year":"2018","unstructured":"Aubrey BJ, Kelly GL, Janic A, Herold MJ, Strasser A. How does p53 induce apoptosis and how does this relate to p53-mediated tumour suppression? Cell Death Differ. 2018;25(1):104\u201313. https:\/\/doi.org\/10.1038\/cdd.2017.169.","journal-title":"Cell Death Differ"},{"issue":"4","key":"637_CR349","doi-asserted-by":"publisher","first-page":"1243","DOI":"10.1182\/bloodadvances.2021004938","volume":"6","author":"JL Kwiatkowski","year":"2022","unstructured":"Kwiatkowski JL, Hamdy M, El-Beshlawy A, Ebeid FS, Badr M, Alshehri A, et al. Deferiprone vs deferoxamine for transfusional iron overload in SCD and other anemias: a randomized, open-label noninferiority study. Blood Adv. 2022;6(4):1243\u201354. https:\/\/doi.org\/10.1182\/bloodadvances.2021004938.","journal-title":"Blood Adv"},{"issue":"5","key":"637_CR350","doi-asserted-by":"publisher","first-page":"517","DOI":"10.18632\/oncoscience.160","volume":"2","author":"N Eling","year":"2015","unstructured":"Eling N, Reuter S, Hazin J, Hamacher-Brady A, Brady NR. Identification of artesunate as a specific activator of ferroptosis in pancreatic cancer cells. Oncoscience. 2015;2(5):517\u201332. https:\/\/doi.org\/10.18632\/oncoscience.160.","journal-title":"Oncoscience"},{"issue":"9","key":"637_CR351","doi-asserted-by":"publisher","first-page":"1104","DOI":"10.1038\/s41418-024-01350-1","volume":"31","author":"F Maremonti","year":"2024","unstructured":"Maremonti F, Tonnus W, Gavali S, Bornstein S, Shah A, Giacca M, et al. Ferroptosis-based advanced therapies as treatment approaches for metabolic and cardiovascular diseases. Cell Death Differ. 2024;31(9):1104\u201312. https:\/\/doi.org\/10.1038\/s41418-024-01350-1.","journal-title":"Cell Death Differ"},{"issue":"8","key":"637_CR352","doi-asserted-by":"publisher","first-page":"5053","DOI":"10.1007\/s12010-023-04457-2","volume":"195","author":"GM Ezzat","year":"2023","unstructured":"Ezzat GM, Nassar AY, Bakr MH, Mohamed S, Nassar GA, Kamel AA. Acetylated oligopeptide and N-acetyl cysteine protected against oxidative stress, inflammation, testicular-blood barrier damage, and testicular cell death in iron-overload rat model. Appl Biochem Biotechnol. 2023;195(8):5053\u201371. https:\/\/doi.org\/10.1007\/s12010-023-04457-2.","journal-title":"Appl Biochem Biotechnol"},{"key":"637_CR353","doi-asserted-by":"publisher","unstructured":"Famurewa AC, Akhigbe RE, George MY, Adekunle YA, Oyedokun PA, Akhigbe TM, et al. Mechanisms of ferroptotic and non-ferroptotic organ toxicity of chemotherapy: protective and therapeutic effects of ginger, 6-gingerol and zingerone in preclinical studies. Naunyn-Schmiedeberg's Archives of Pharmacology. 2024:1\u201332. https:\/\/doi.org\/10.1007\/s00210-024-03623-5.","DOI":"10.1007\/s00210-024-03623-5"},{"issue":"21","key":"637_CR354","doi-asserted-by":"publisher","first-page":"10869","DOI":"10.1021\/cr400532z","volume":"114","author":"L Cheng","year":"2014","unstructured":"Cheng L, Wang C, Feng L, Yang K, Liu Z. Functional nanomaterials for phototherapies of cancer. Chem Rev. 2014;114(21):10869\u2013939. https:\/\/doi.org\/10.1021\/cr400532z.","journal-title":"Chem Rev"},{"key":"637_CR355","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/s13045-021-01096-0","volume":"14","author":"Z Cheng","year":"2021","unstructured":"Cheng Z, Li M, Dey R, Chen Y. Nanomaterials for cancer therapy: current progress and perspectives. J Hematol Oncol. 2021;14:1\u201327. https:\/\/doi.org\/10.1186\/s13045-021-01096-0.","journal-title":"J Hematol Oncol"},{"key":"637_CR356","doi-asserted-by":"publisher","first-page":"735965","DOI":"10.3389\/fphar.2021.735965","volume":"12","author":"Y Wang","year":"2021","unstructured":"Wang Y, Liu T, Li X, Sheng H, Ma X, Hao L. Ferroptosis-inducing nanomedicine for cancer therapy. Front Pharmacol. 2021;12:735965. https:\/\/doi.org\/10.3389\/fphar.2021.735965.","journal-title":"Front Pharmacol"},{"issue":"40","key":"637_CR357","doi-asserted-by":"publisher","first-page":"2312141","DOI":"10.1002\/smll.202312141","volume":"20","author":"X Chu","year":"2024","unstructured":"Chu X, Hou HY, Duan MD, Zhang YJ, Zhu YY, Liu Y, et al. Tumor microenvironment specific regulation Ca-Fe-nanospheres for ferroptosis-promoted domino synergistic therapy and tumor immune response. Small. 2024;20(40):2312141. https:\/\/doi.org\/10.1002\/smll.202312141.","journal-title":"Small"},{"issue":"1","key":"637_CR358","doi-asserted-by":"publisher","first-page":"19","DOI":"10.1186\/s13046-023-02925-5","volume":"43","author":"Y Hua","year":"2024","unstructured":"Hua Y, Yang S, Zhang Y, Li J, Wang M, Yeerkenbieke P, et al. Modulating ferroptosis sensitivity: environmental and cellular targets within the tumor microenvironment. J Exp Clin Cancer Res. 2024;43(1):19. https:\/\/doi.org\/10.1186\/s13046-023-02925-5.","journal-title":"J Exp Clin Cancer Res"},{"issue":"7","key":"637_CR359","doi-asserted-by":"publisher","first-page":"405","DOI":"10.1038\/s41568-019-0149-1","volume":"19","author":"JP Friedmann Angeli","year":"2019","unstructured":"Friedmann Angeli JP, Krysko DV, Conrad M. Ferroptosis at the crossroads of cancer-acquired drug resistance and immune evasion. Nat Rev Cancer. 2019;19(7):405\u201314. https:\/\/doi.org\/10.1038\/s41568-019-0149-1.","journal-title":"Nat Rev Cancer"},{"issue":"3","key":"637_CR360","doi-asserted-by":"publisher","first-page":"369","DOI":"10.1038\/cdd.2015.158","volume":"23","author":"Y Xie","year":"2016","unstructured":"Xie Y, Hou W, Song X, Yu Y, Huang J, Sun X, et al. Ferroptosis: process and function. Cell Death Differ. 2016;23(3):369\u201379. https:\/\/doi.org\/10.1038\/cdd.2015.158.","journal-title":"Cell Death Differ"},{"issue":"22","key":"637_CR361","doi-asserted-by":"publisher","first-page":"e2502876122","DOI":"10.1073\/pnas.2502876122","volume":"122","author":"SM Lamperis","year":"2025","unstructured":"Lamperis SM, McMahon KM, Calvert AE, Rink JS, Vasan K, Pandkar MR, et al. CRISPR screen reveals a simultaneous targeted mechanism to reduce cancer cell selenium and increase lipid oxidation to induce ferroptosis. Proc Natl Acad Sci. 2025;122(22):e2502876122. https:\/\/doi.org\/10.1073\/pnas.2502876122.","journal-title":"Proc Natl Acad Sci"},{"issue":"1","key":"637_CR362","doi-asserted-by":"publisher","first-page":"501","DOI":"10.1038\/s41420-022-01297-7","volume":"8","author":"Y Du","year":"2022","unstructured":"Du Y, Guo Z. Recent progress in ferroptosis: inducers and inhibitors. Cell Death Discovery. 2022;8(1):501. https:\/\/doi.org\/10.1038\/s41420-022-01297-7.","journal-title":"Cell Death Discovery"},{"key":"637_CR363","doi-asserted-by":"publisher","first-page":"115000","DOI":"10.1016\/j.ejmech.2022.115000","volume":"247","author":"ZW Zeng","year":"2023","unstructured":"Zeng ZW, Chen D, Chen L, He B, Li Y. A comprehensive overview of Artemisinin and its derivatives as anticancer agents. Eur J Med Chem. 2023;247:115000. https:\/\/doi.org\/10.1016\/j.ejmech.2022.115000.","journal-title":"Eur J Med Chem"},{"key":"637_CR364","doi-asserted-by":"publisher","unstructured":"Dhas N, Kudarha R, Tiwari R, Tiwari G, Garg N, Kumar P, Tiwari S, Mutalik S. Recent advancements in nanomaterial-mediated ferroptosis-induced cancer therapy: importance of molecular dynamics and novel strategies. Life Sciences. 2024;122629. https:\/\/doi.org\/10.1016\/j.lfs.2024.122629","DOI":"10.1016\/j.lfs.2024.122629"},{"key":"637_CR365","doi-asserted-by":"publisher","first-page":"1119369","DOI":"10.3389\/fonc.2023.1119369","volume":"13","author":"H Cai","year":"2023","unstructured":"Cai H, Ren Y, Chen S, Wang Y, Chu L. Ferroptosis and tumor immunotherapy: A promising combination therapy for tumors. Front Oncol. 2023;13:1119369. https:\/\/doi.org\/10.3389\/fonc.2023.1119369.","journal-title":"Front Oncol"},{"key":"637_CR366","doi-asserted-by":"publisher","first-page":"1228968","DOI":"10.3389\/fncel.2023.1228968","volume":"17","author":"W Dong","year":"2023","unstructured":"Dong W, Gong F, Zhao Y, Bai H, Yang R. Ferroptosis and mitochondrial dysfunction in acute central nervous system injury. Front Cell Neurosci. 2023;17:1228968. https:\/\/doi.org\/10.3389\/fncel.2023.1228968.","journal-title":"Front Cell Neurosci"},{"issue":"11","key":"637_CR367","doi-asserted-by":"publisher","first-page":"e48276","DOI":"10.7759\/cureus.48276","volume":"15","author":"A Salem","year":"2023","unstructured":"Salem A, Desai P, Elgebaly A. Efficacy and safety of combined deferiprone and deferasirox in iron-overloaded patients: a systematic review. Cureus. 2023;15(11):e48276. https:\/\/doi.org\/10.7759\/cureus.48276.","journal-title":"Cureus"},{"issue":"1","key":"637_CR368","doi-asserted-by":"publisher","first-page":"136","DOI":"10.1186\/s12943-025-02305-x","volume":"24","author":"M Zhang","year":"2025","unstructured":"Zhang M, Liu C, Tu J, Tang M, Ashrafizadeh M, Nabavi N, et al. Advances in cancer immunotherapy: historical perspectives, current developments, and future directions. Mol Cancer. 2025;24(1):136. https:\/\/doi.org\/10.1186\/s12943-025-02305-x.","journal-title":"Mol Cancer"},{"key":"637_CR369","doi-asserted-by":"publisher","first-page":"1598279","DOI":"10.3389\/fphar.2025.1598279","volume":"16","author":"J Zhang","year":"2025","unstructured":"Zhang J, Ouyang D, Liu M, Xiang Y, Li Z. Research progress on ferroptosis and PARP inhibitors in ovarian cancer: action mechanisms and resistance mechanisms. Front Pharmacol. 2025;16:1598279. https:\/\/doi.org\/10.3389\/fphar.2025.1598279.","journal-title":"Front Pharmacol"},{"issue":"1","key":"637_CR370","doi-asserted-by":"publisher","first-page":"89","DOI":"10.1186\/s12943-024-01999-9","volume":"23","author":"J Diao","year":"2024","unstructured":"Diao J, Jia Y, Dai E, Liu J, Kang R, Tang D, et al. Ferroptotic therapy in cancer: benefits, side effects, and risks. Mol Cancer. 2024;23(1):89. https:\/\/doi.org\/10.1186\/s12943-024-01999-9.","journal-title":"Mol Cancer"},{"issue":"1","key":"637_CR371","doi-asserted-by":"publisher","first-page":"155","DOI":"10.1002\/hep.30989","volume":"72","author":"CON Leung","year":"2020","unstructured":"Leung CON, Tong M, Chung KPS, Zhou L, Che N, Tang KH, et al. Overriding adaptive resistance to sorafenib through combination therapy with src homology 2 domain-containing phosphatase 2 blockade in hepatocellular carcinoma. Hepatology. 2020;72(1):155\u201368. https:\/\/doi.org\/10.1002\/hep.30989.","journal-title":"Hepatology"},{"key":"637_CR372","doi-asserted-by":"publisher","first-page":"103255","DOI":"10.1016\/j.redox.2024.103255","volume":"75","author":"F Feng Meng","year":"2024","unstructured":"Feng Meng F, Huo F, Zhu Y, Qin Y, Gui Y, Zhang H, et al. Inhibition of ferroptosis rescues M2 macrophages and alleviates arthritis by suppressing the HMGB1\/TLR4\/STAT3 axis in M1 macrophages. Redox Biol. 2024;75:103255. https:\/\/doi.org\/10.1016\/j.redox.2024.103255.","journal-title":"Redox Biol"},{"key":"637_CR373","doi-asserted-by":"publisher","first-page":"1489877","DOI":"10.3389\/fphar.2024.1489877","volume":"15","author":"XD Hao","year":"2024","unstructured":"Hao XD, Xu WH, Zhang X, Xue J. Targeting ferroptosis: a novel therapeutic strategy for the treatment of retinal diseases. Front Pharmacol. 2024;15:1489877. https:\/\/doi.org\/10.3389\/fphar.2024.1489877.","journal-title":"Front Pharmacol"},{"key":"637_CR374","doi-asserted-by":"publisher","first-page":"155082","DOI":"10.1016\/j.prp.2024.155082","volume":"254","author":"AM Shbeer","year":"2024","unstructured":"Shbeer AM, Robadi IA. Liquid biopsy holds a promising approach for the early detection of cancer: Current information and future perspectives. Pathology - Research and Practice. 2024;254:155082. https:\/\/doi.org\/10.1016\/j.prp.2024.155082.","journal-title":"Pathology - Research and Practice"},{"key":"637_CR375","doi-asserted-by":"publisher","first-page":"1327","DOI":"10.3389\/fimmu.2017.01327","volume":"8","author":"F Huang","year":"2017","unstructured":"Huang F, Zhao JL, Wang L, Gao CC, Liang SQ, An DJ, et al. MiR-148a-3p mediates notch signaling to promote the differentiation and M1 activation of macrophages. Front Immunol. 2017;8:1327. https:\/\/doi.org\/10.3389\/fimmu.2017.01327.","journal-title":"Front Immunol"}],"container-title":["Molecular Biomedicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s43556-026-00637-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s43556-026-00637-8","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s43556-026-00637-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T23:03:38Z","timestamp":1792796618000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s43556-026-00637-8"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,10,24]]},"references-count":375,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2026,12]]}},"alternative-id":["637"],"URL":"https:\/\/doi.org\/10.1186\/s43556-026-00637-8","relation":{},"ISSN":["2662-8651"],"issn-type":[{"value":"2662-8651","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,10,24]]},"assertion":[{"value":"15 September 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"1 October 2026","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"12 October 2026","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"24 October 2026","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"N\/A.","order":1,"name":"Ethics","label":"Ethics approval and consent to participate","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"N\/A.","order":2,"name":"Ethics","label":"Consent for publication","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors have no conflicts of interest.","order":3,"name":"Ethics","label":"Competing interests","group":{"name":"EthicsHeading","label":"Declarations"}}],"article-number":"228"}}