{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T04:38:24Z","timestamp":1792730304217,"version":"4.5.0"},"reference-count":292,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T00:00:00Z","timestamp":1792713600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T00:00:00Z","timestamp":1792713600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82201594"],"award-info":[{"award-number":["82201594"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81502582"],"award-info":[{"award-number":["81502582"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Mol Biomed"],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Circadian rhythms, serving as a crucial temporal bridge linking neural activity and pathological biology, are regulated by central pacemaker neurons to maintain cellular homeostasis and coordinate diverse biological processes. Circadian rhythm disruption is closely associated with various diseases, including neurodegenerative disorders, metabolic disorders, and cancer. Circadian rhythms are controlled by core clock genes, such as BMAL1 and CLOCK, modulating numerous physiological processes, encompassing metabolism, immune responses, neural activity, and hormone regulation. Circadian rhythms disruptions arising from shift work, jet lag, or inconsistent sleep schedules are implicated in both the onset and progression of numerous diseases, notably Alzheimer's disease, Parkinson's disease, diabetes, and cardiovascular disease. The article highlights how circadian dysregulation alters cellular processes to potentially accelerate disease progression. Circadian disruption results in impaired immune function, further promoting disease development and resistance to treatment. Potential therapeutic applications based on circadian biology, such as chronotherapy and personalized medicine, are also discussed. Recent technological advances, embodied in wearable devices and omics approaches, are increasingly providing deeper insights into circadian biology. Further unveiling the role of circadian in health and disease opens new avenues for tailoring treatment timing to patients' biological rhythms, thereby enhancing therapeutic outcomes across various diseases. By bridging fundamental circadian mechanisms with clinical pathology, this review provides a roadmap for future chronotherapeutic interventions in precision medicine.<\/jats:p>","DOI":"10.1186\/s43556-026-00646-7","type":"journal-article","created":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T04:05:52Z","timestamp":1792728352000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Circadian rhythms in health and disease"],"prefix":"10.1186","volume":"7","author":[{"given":"Xiaoyan","family":"Liu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuguang","family":"Du","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shihong","family":"Qi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lin","family":"Yuan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liyu","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kaiyu","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liqin","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wanlu","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qian","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Min","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9083-250X","authenticated-orcid":false,"given":"Yongye","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,10,23]]},"reference":[{"issue":"32","key":"646_CR1","doi-asserted-by":"publisher","first-page":"eabo2389","DOI":"10.1126\/sciadv.abo2389","volume":"8","author":"SK Chun","year":"2022","unstructured":"Chun SK, Fortin BM, Fellows RC, Habowski AN, Verlande A, Song WA, et al. Disruption of the circadian clock drives Apc loss of heterozygosity to accelerate colorectal cancer. Sci Adv. 2022;8(32):eabo2389. https:\/\/doi.org\/10.1126\/sciadv.abo2389.","journal-title":"Sci Adv"},{"issue":"1","key":"646_CR2","doi-asserted-by":"publisher","first-page":"8","DOI":"10.1186\/s40035-023-00340-6","volume":"12","author":"Y Shen","year":"2023","unstructured":"Shen Y, Lv QK, Xie WY, Gong SY, Zhuang S, Liu JY, et al. Circadian disruption and sleep disorders in neurodegeneration. Transl Neurodegener. 2023;12(1):8. https:\/\/doi.org\/10.1186\/s40035-023-00340-6.","journal-title":"Transl Neurodegener"},{"issue":"4","key":"646_CR3","doi-asserted-by":"publisher","first-page":"e12956","DOI":"10.1111\/jpi.12956","volume":"76","author":"EM Speksnijder","year":"2024","unstructured":"Speksnijder EM, Bisschop PH, Siegelaar SE, Stenvers DJ, Kalsbeek A. Circadian desynchrony and glucose metabolism. J Pineal Res. 2024;76(4):e12956. https:\/\/doi.org\/10.1111\/jpi.12956.","journal-title":"J Pineal Res"},{"key":"646_CR4","doi-asserted-by":"publisher","unstructured":"Smyllie NJ, Bagnall J, Koch AA, Niranjan D, Polidarova L, Chesham JE et al. Cryptochrome proteins regulate the circadian intracellular behavior and localization of PER2 in mouse suprachiasmatic nucleus neurons. Proc Natl Acad Sci U S A. 2022;119(4). https:\/\/doi.org\/10.1073\/pnas.2113845119.","DOI":"10.1073\/pnas.2113845119"},{"issue":"1","key":"646_CR5","doi-asserted-by":"publisher","first-page":"31","DOI":"10.1111\/jnc.15012","volume":"157","author":"D Ono","year":"2021","unstructured":"Ono D, Honma KI, Honma S. GABAergic mechanisms in the suprachiasmatic nucleus that influence circadian rhythm. J Neurochem. 2021;157(1):31\u201341. https:\/\/doi.org\/10.1111\/jnc.15012.","journal-title":"J Neurochem"},{"key":"646_CR6","doi-asserted-by":"publisher","first-page":"377","DOI":"10.1016\/j.lfs.2019.02.006","volume":"221","author":"K Singh","year":"2019","unstructured":"Singh K, Jha NK, Thakur A. Spatiotemporal chromatin dynamics - A telltale of circadian epigenetic gene regulation. Life Sci. 2019;221:377\u201391. https:\/\/doi.org\/10.1016\/j.lfs.2019.02.006.","journal-title":"Life Sci"},{"issue":"3","key":"646_CR7","doi-asserted-by":"publisher","first-page":"196","DOI":"10.1016\/j.trecan.2023.11.002","volume":"10","author":"X Zhu","year":"2024","unstructured":"Zhu X, Maier G, Panda S. Learning from circadian rhythm to transform cancer prevention, prognosis, and survivorship care. Trends Cancer. 2024;10(3):196\u2013207. https:\/\/doi.org\/10.1016\/j.trecan.2023.11.002.","journal-title":"Trends Cancer"},{"key":"646_CR8","doi-asserted-by":"publisher","first-page":"0612","DOI":"10.34133\/research.0612","volume":"8","author":"J Wang","year":"2025","unstructured":"Wang J, Shao F, Yu QX, Ye L, Wusiman D, Wu R, et al. The Common Hallmarks and Interconnected Pathways of Aging, Circadian Rhythms, and Cancer: Implications for Therapeutic Strategies. Research (Wash D C). 2025;8:0612. https:\/\/doi.org\/10.34133\/research.0612.","journal-title":"Research (Wash D C)"},{"issue":"7","key":"646_CR9","doi-asserted-by":"publisher","first-page":"1598","DOI":"10.1016\/j.cmet.2024.04.018","volume":"36","author":"F Peng","year":"2024","unstructured":"Peng F, Lu J, Su K, Liu X, Luo H, He B, et al. Oncogenic fatty acid oxidation senses circadian disruption in sleep-deficiency-enhanced tumorigenesis. Cell Metab. 2024;36(7):1598\u2013618.e11. https:\/\/doi.org\/10.1016\/j.cmet.2024.04.018.","journal-title":"Cell Metab"},{"issue":"1","key":"646_CR10","doi-asserted-by":"publisher","first-page":"28","DOI":"10.1038\/s41398-020-0694-0","volume":"10","author":"WH Walker 2nd","year":"2020","unstructured":"Walker WH 2nd, Walton JC, DeVries AC, Nelson RJ. Circadian rhythm disruption and mental health. Transl Psychiatry. 2020;10(1):28. https:\/\/doi.org\/10.1038\/s41398-020-0694-0.","journal-title":"Transl Psychiatry"},{"issue":"2","key":"646_CR11","doi-asserted-by":"publisher","first-page":"e21231","DOI":"10.1096\/fj.202001753R","volume":"35","author":"PM Wagner","year":"2021","unstructured":"Wagner PM, Prucca CG, Velazquez FN, Sosa Alderete LG, Caputto BL, Guido ME. Temporal regulation of tumor growth in nocturnal mammals: In vivo studies and chemotherapeutical potential. Faseb j. 2021;35(2):e21231. https:\/\/doi.org\/10.1096\/fj.202001753R.","journal-title":"Faseb j"},{"key":"646_CR12","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-025-08735-3","author":"V Thiel","year":"2025","unstructured":"Thiel V, Renders S, Panten J, Dross N, Bauer K, Azorin D, et al. Characterization of single neurons reprogrammed by pancreatic cancer. Nature. 2025. https:\/\/doi.org\/10.1038\/s41586-025-08735-3.","journal-title":"Nature"},{"key":"646_CR13","doi-asserted-by":"publisher","first-page":"199","DOI":"10.1146\/annurev-neuro-111020-092702","volume":"45","author":"MB Keough","year":"2022","unstructured":"Keough MB, Monje M. Neural Signaling in Cancer. Annu Rev Neurosci. 2022;45:199\u2013221. https:\/\/doi.org\/10.1146\/annurev-neuro-111020-092702.","journal-title":"Annu Rev Neurosci"},{"key":"646_CR14","doi-asserted-by":"publisher","DOI":"10.1038\/s41593-025-01925-2","author":"M Monje","year":"2025","unstructured":"Monje M, Winkler F. Cancer research needs neuroscience and neuroscientists. Nat Neurosci. 2025. https:\/\/doi.org\/10.1038\/s41593-025-01925-2.","journal-title":"Nat Neurosci"},{"issue":"2","key":"646_CR15","doi-asserted-by":"publisher","first-page":"100839","DOI":"10.1016\/j.isci.2020.100839","volume":"23","author":"CA Ramos","year":"2020","unstructured":"Ramos CA, Ouyang C, Qi Y, Chung Y, Cheng CT, LaBarge MA, et al. A non-canonical function of BMAL1 metabolically limits obesity-promoted triple-negative breast cancer. iScience. 2020;23(2):100839. https:\/\/doi.org\/10.1016\/j.isci.2020.100839.","journal-title":"iScience"},{"issue":"4","key":"646_CR16","doi-asserted-by":"publisher","first-page":"546","DOI":"10.1038\/s43018-024-00759-4","volume":"5","author":"Y Wang","year":"2024","unstructured":"Wang Y, Narasimamurthy R, Qu M, Shi N, Guo H, Xue Y, et al. Circadian regulation of cancer stem cells and the tumor microenvironment during metastasis. Nat Cancer. 2024;5(4):546\u201356. https:\/\/doi.org\/10.1038\/s43018-024-00759-4.","journal-title":"Nat Cancer"},{"key":"646_CR17","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-025-08797-3","author":"M Liao","year":"2025","unstructured":"Liao M, Liu Y, Xu Z, Fang M, Yu Z, Cui Y, et al. The P-loop NTPase RUVBL2 is a conserved clock component across eukaryotes. Nature. 2025. https:\/\/doi.org\/10.1038\/s41586-025-08797-3.","journal-title":"Nature"},{"issue":"1","key":"646_CR18","doi-asserted-by":"publisher","first-page":"25","DOI":"10.1016\/j.neuron.2023.09.023","volume":"112","author":"HK Dollish","year":"2024","unstructured":"Dollish HK, Tsyglakova M, McClung CA. Circadian rhythms and mood disorders: time to see the light. Neuron. 2024;112(1):25\u201340. https:\/\/doi.org\/10.1016\/j.neuron.2023.09.023.","journal-title":"Neuron"},{"issue":"4","key":"646_CR19","doi-asserted-by":"publisher","first-page":"268","DOI":"10.1111\/imm.13167","volume":"161","author":"P Downton","year":"2020","unstructured":"Downton P, Early JO, Gibbs JE. Circadian rhythms in adaptive immunity. Immunology. 2020;161(4):268\u201377. https:\/\/doi.org\/10.1111\/imm.13167.","journal-title":"Immunology"},{"key":"646_CR20","doi-asserted-by":"publisher","first-page":"101928","DOI":"10.1016\/j.arr.2023.101928","volume":"87","author":"A Salminen","year":"2023","unstructured":"Salminen A. Aryl hydrocarbon receptor (AhR) impairs circadian regulation: Impact on the aging process. Ageing Res Rev. 2023;87:101928. https:\/\/doi.org\/10.1016\/j.arr.2023.101928.","journal-title":"Ageing Res Rev"},{"issue":"14","key":"646_CR21","doi-asserted-by":"publisher","first-page":"2201","DOI":"10.1016\/j.neuron.2023.04.016","volume":"111","author":"L Xie","year":"2023","unstructured":"Xie L, Xiong Y, Ma D, Shi K, Chen J, Yang Q, et al. Cholecystokinin neurons in mouse suprachiasmatic nucleus regulate the robustness of circadian clock. Neuron. 2023;111(14):2201\u201317.e4. https:\/\/doi.org\/10.1016\/j.neuron.2023.04.016.","journal-title":"Neuron"},{"issue":"15","key":"646_CR22","doi-asserted-by":"publisher","first-page":"3245","DOI":"10.1016\/j.cell.2023.05.045","volume":"186","author":"Y Zhuang","year":"2023","unstructured":"Zhuang Y, Li Z, Xiong S, Sun C, Li B, Wu SA, et al. Circadian clocks are modulated by compartmentalized oscillating translation. Cell. 2023;186(15):3245\u201360.e23. https:\/\/doi.org\/10.1016\/j.cell.2023.05.045.","journal-title":"Cell"},{"key":"646_CR23","doi-asserted-by":"publisher","unstructured":"Saad L, Zwiller J, Kalsbeek A, Anglard P. Epigenetic regulation of circadian clocks and its involvement in drug addiction. Genes (Basel). 2021;12(8). https:\/\/doi.org\/10.3390\/genes12081263.","DOI":"10.3390\/genes12081263"},{"issue":"8047","key":"646_CR24","doi-asserted-by":"publisher","first-page":"974","DOI":"10.1038\/s41586-024-08371-3","volume":"637","author":"Q Zheng","year":"2025","unstructured":"Zheng Q, Weekley BH, Vinson DA, Zhao S, Bastle RM, Thompson RE, et al. Bidirectional histone monoaminylation dynamics regulate neural rhythmicity. Nature. 2025;637(8047):974\u201382. https:\/\/doi.org\/10.1038\/s41586-024-08371-3.","journal-title":"Nature"},{"key":"646_CR25","doi-asserted-by":"publisher","unstructured":"Samoilova EM, Belopasov VV, Ekusheva EV, Zhang C, Troitskiy AV, Baklaushev VP. Epigenetic clock and circadian rhythms in stem cell aging and rejuvenation. J Pers Med. 2021;11(11). https:\/\/doi.org\/10.3390\/jpm11111050.","DOI":"10.3390\/jpm11111050"},{"issue":"10","key":"646_CR26","doi-asserted-by":"publisher","first-page":"1406","DOI":"10.1016\/j.febslet.2011.04.047","volume":"585","author":"JA Ripperger","year":"2011","unstructured":"Ripperger JA, Merrow M. Perfect timing: epigenetic regulation of the circadian clock. FEBS Lett. 2011;585(10):1406\u201311. https:\/\/doi.org\/10.1016\/j.febslet.2011.04.047.","journal-title":"FEBS Lett"},{"issue":"8","key":"646_CR27","doi-asserted-by":"publisher","first-page":"102866","DOI":"10.1016\/j.autrev.2021.102866","volume":"20","author":"K Xiang","year":"2021","unstructured":"Xiang K, Xu Z, Hu YQ, He YS, Wu GC, Li TY, et al. Circadian clock genes as promising therapeutic targets for autoimmune diseases. Autoimmun Rev. 2021;20(8):102866. https:\/\/doi.org\/10.1016\/j.autrev.2021.102866.","journal-title":"Autoimmun Rev"},{"issue":"3","key":"646_CR28","doi-asserted-by":"publisher","first-page":"e12758","DOI":"10.1111\/jpi.12758","volume":"71","author":"J Zhang","year":"2021","unstructured":"Zhang J, Jiang H, Du K, Xie T, Wang B, Chen C, et al. Pan-cancer analyses reveal genomics and clinical characteristics of the melatonergic regulators in cancer. J Pineal Res. 2021;71(3):e12758. https:\/\/doi.org\/10.1111\/jpi.12758.","journal-title":"J Pineal Res"},{"key":"646_CR29","doi-asserted-by":"publisher","unstructured":"Bukowska B, Sici\u0144ska P. Influence of Benzo(a)pyrene on different epigenetic processes. Int J Mol Sci. 2021;22(24). https:\/\/doi.org\/10.3390\/ijms222413453.","DOI":"10.3390\/ijms222413453"},{"key":"646_CR30","doi-asserted-by":"publisher","unstructured":"Song H, Chu JW, Park SC, Im H, Park IG, Kim H et al. Isoform-specific lysine methylation of ROR\u03b12 by SETD7 Is required for association of the TIP60 coactivator complex in prostate cancer progression. Int J Mol Sci. 2020;21(5). https:\/\/doi.org\/10.3390\/ijms21051622.","DOI":"10.3390\/ijms21051622"},{"issue":"4","key":"646_CR31","doi-asserted-by":"publisher","first-page":"312","DOI":"10.1038\/nsmb.2990","volume":"22","author":"L Aguilar-Arnal","year":"2015","unstructured":"Aguilar-Arnal L, Katada S, Orozco-Solis R, Sassone-Corsi P. NAD(+)-SIRT1 control of H3K4 trimethylation through circadian deacetylation of MLL1. Nat Struct Mol Biol. 2015;22(4):312\u20138. https:\/\/doi.org\/10.1038\/nsmb.2990.","journal-title":"Nat Struct Mol Biol"},{"issue":"5964","key":"646_CR32","doi-asserted-by":"publisher","first-page":"463","DOI":"10.1126\/science.1180067","volume":"327","author":"MS Robles","year":"2010","unstructured":"Robles MS, Boyault C, Knutti D, Padmanabhan K, Weitz CJ. Identification of RACK1 and protein kinase Calpha as integral components of the mammalian circadian clock. Science. 2010;327(5964):463\u20136. https:\/\/doi.org\/10.1126\/science.1180067.","journal-title":"Science"},{"issue":"3","key":"646_CR33","doi-asserted-by":"publisher","first-page":"658","DOI":"10.1016\/j.immuni.2020.08.005","volume":"53","author":"N Acharya","year":"2020","unstructured":"Acharya N, Madi A, Zhang H, Klapholz M, Escobar G, Dulberg S, et al. Endogenous Glucocorticoid Signaling Regulates CD8(+) T cell differentiation and development of dysfunction in the tumor microenvironment. Immunity. 2020;53(3):658\u201371.e6. https:\/\/doi.org\/10.1016\/j.immuni.2020.08.005.","journal-title":"Immunity"},{"issue":"8","key":"646_CR34","doi-asserted-by":"publisher","first-page":"107668","DOI":"10.1016\/j.celrep.2020.107668","volume":"31","author":"KA DiTacchio","year":"2020","unstructured":"DiTacchio KA, Kalinowska D, Saran AR, Byrne A, Vollmers C, DiTacchio L. JARID1a Ablation in the Liver Alters Systemic Metabolism and Adaptation to Feeding. Cell Rep. 2020;31(8):107668. https:\/\/doi.org\/10.1016\/j.celrep.2020.107668.","journal-title":"Cell Rep"},{"issue":"15","key":"646_CR35","doi-asserted-by":"publisher","first-page":"10849","DOI":"10.1021\/acs.jmedchem.3c01114","volume":"66","author":"L Brewitz","year":"2023","unstructured":"Brewitz L, Nakashima Y, Piasecka SK, Salah E, Fletcher SC, Tumber A, et al. 5-Substituted Pyridine-2,4-dicarboxylate derivatives have potential for selective inhibition of human Jumonji-C domain-containing protein 5. J Med Chem. 2023;66(15):10849\u201365. https:\/\/doi.org\/10.1021\/acs.jmedchem.3c01114.","journal-title":"J Med Chem"},{"issue":"1","key":"646_CR36","doi-asserted-by":"publisher","first-page":"62","DOI":"10.1038\/npp.2012.86","volume":"38","author":"L Peixoto","year":"2013","unstructured":"Peixoto L, Abel T. The role of histone acetylation in memory formation and cognitive impairments. Neuropsychopharmacology. 2013;38(1):62\u201376. https:\/\/doi.org\/10.1038\/npp.2012.86.","journal-title":"Neuropsychopharmacology"},{"key":"646_CR37","doi-asserted-by":"publisher","first-page":"865","DOI":"10.1016\/j.omtn.2019.12.020","volume":"19","author":"Z Tang","year":"2020","unstructured":"Tang Z, Xu T, Li Y, Fei W, Yang G, Hong Y. Inhibition of CRY2 by STAT3\/miRNA-7-5p Promotes Osteoblast Differentiation through Upregulation of CLOCK\/BMAL1\/P300 Expression. Mol Ther Nucleic Acids. 2020;19:865\u201376. https:\/\/doi.org\/10.1016\/j.omtn.2019.12.020.","journal-title":"Mol Ther Nucleic Acids"},{"key":"646_CR38","doi-asserted-by":"publisher","first-page":"8","DOI":"10.1016\/j.gde.2017.10.004","volume":"48","author":"X Hu","year":"2018","unstructured":"Hu X, Sood AK, Dang CV, Zhang L. The role of long noncoding RNAs in cancer: the dark matter matters. Curr Opin Genet Dev. 2018;48:8\u201315. https:\/\/doi.org\/10.1016\/j.gde.2017.10.004.","journal-title":"Curr Opin Genet Dev"},{"issue":"12","key":"646_CR39","doi-asserted-by":"publisher","first-page":"2252","DOI":"10.1016\/j.molcel.2022.05.027","volume":"82","author":"AB Herman","year":"2022","unstructured":"Herman AB, Tsitsipatis D, Gorospe M. Integrated lncRNA function upon genomic and epigenomic regulation. Mol Cell. 2022;82(12):2252\u201366. https:\/\/doi.org\/10.1016\/j.molcel.2022.05.027.","journal-title":"Mol Cell"},{"issue":"2","key":"646_CR40","doi-asserted-by":"publisher","first-page":"350","DOI":"10.1016\/j.cell.2018.05.022","volume":"174","author":"B Kleaveland","year":"2018","unstructured":"Kleaveland B, Shi CY, Stefano J, Bartel DP. A network of noncoding regulatory rnas acts in the mammalian brain. Cell. 2018;174(2):350\u201362.e17. https:\/\/doi.org\/10.1016\/j.cell.2018.05.022.","journal-title":"Cell"},{"issue":"11\u201312","key":"646_CR41","doi-asserted-by":"publisher","first-page":"899","DOI":"10.1101\/gad.343541.120","volume":"35","author":"RA Mosig","year":"2021","unstructured":"Mosig RA, Castaneda AN, Deslauriers JC, Frazier LP, He KL, Maghzian N, et al. Natural antisense transcript of Period2, Per2AS, regulates the amplitude of the mouse circadian clock. Genes Dev. 2021;35(11\u201312):899\u2013913. https:\/\/doi.org\/10.1101\/gad.343541.120.","journal-title":"Genes Dev"},{"issue":"3","key":"646_CR42","doi-asserted-by":"publisher","first-page":"111514","DOI":"10.1016\/j.celrep.2022.111514","volume":"41","author":"R Brooks","year":"2022","unstructured":"Brooks R, Monzy J, Aaron B, Zhang X, Kossenkov A, Hayden J, et al. Circadian lncRNA ADIRF-AS1 binds PBAF and regulates renal clear cell tumorigenesis. Cell Rep. 2022;41(3):111514. https:\/\/doi.org\/10.1016\/j.celrep.2022.111514.","journal-title":"Cell Rep"},{"key":"646_CR43","doi-asserted-by":"publisher","unstructured":"Wang S, Lin Y, Li F, Qin Z, Zhou Z, Gao L et al. An NF-\u03baB-driven lncRNA orchestrates colitis and circadian clock. Sci Adv. 2020;6(42). https:\/\/doi.org\/10.1126\/sciadv.abb5202.","DOI":"10.1126\/sciadv.abb5202"},{"issue":"2","key":"646_CR44","doi-asserted-by":"publisher","first-page":"598","DOI":"10.1093\/bib\/bby021","volume":"20","author":"M Zhou","year":"2019","unstructured":"Zhou M, Zhao H, Wang X, Sun J, Su J. Analysis of long noncoding RNAs highlights region-specific altered expression patterns and diagnostic roles in Alzheimer\u2019s disease. Brief Bioinform. 2019;20(2):598\u2013608. https:\/\/doi.org\/10.1093\/bib\/bby021.","journal-title":"Brief Bioinform"},{"issue":"3","key":"646_CR45","doi-asserted-by":"publisher","first-page":"2897","DOI":"10.18632\/aging.102785","volume":"12","author":"N Ma","year":"2020","unstructured":"Ma N, Tie C, Yu B, Zhang W, Wan J. Identifying lncRNA-miRNA-mRNA networks to investigate Alzheimer\u2019s disease pathogenesis and therapy strategy. Aging (Albany NY). 2020;12(3):2897\u2013920. https:\/\/doi.org\/10.18632\/aging.102785.","journal-title":"Aging (Albany NY)"},{"issue":"9","key":"646_CR46","doi-asserted-by":"publisher","first-page":"e12887","DOI":"10.1111\/cpr.12887","volume":"53","author":"C Tu","year":"2020","unstructured":"Tu C, Yang K, Wan L, He J, Qi L, Wang W, et al. The crosstalk between lncRNAs and the Hippo signalling pathway in cancer progression. Cell Prolif. 2020;53(9):e12887. https:\/\/doi.org\/10.1111\/cpr.12887.","journal-title":"Cell Prolif"},{"issue":"1","key":"646_CR47","doi-asserted-by":"publisher","first-page":"33","DOI":"10.1016\/j.tibs.2018.09.012","volume":"44","author":"X Qian","year":"2019","unstructured":"Qian X, Zhao J, Yeung PY, Zhang QC, Kwok CK. Revealing lncRNA Structures and Interactions by Sequencing-Based Approaches. Trends Biochem Sci. 2019;44(1):33\u201352. https:\/\/doi.org\/10.1016\/j.tibs.2018.09.012.","journal-title":"Trends Biochem Sci"},{"key":"646_CR48","doi-asserted-by":"publisher","unstructured":"Wang L, Cho KB, Li Y, Tao G, Xie Z, Guo B. Long noncoding RNA (lncRNA)-mediated competing endogenous rna networks provide novel potential biomarkers and therapeutic targets for colorectal cancer. Int J Mol Sci. 2019;20(22). https:\/\/doi.org\/10.3390\/ijms20225758.","DOI":"10.3390\/ijms20225758"},{"issue":"5","key":"646_CR49","doi-asserted-by":"publisher","first-page":"1258","DOI":"10.1016\/j.gendis.2021.07.004","volume":"9","author":"A Zaki","year":"2022","unstructured":"Zaki A, Ali MS, Hadda V, Ali SM, Chopra A, Fatma T. Long non-coding RNA (lncRNA): A potential therapeutic target in acute lung injury. Genes Dis. 2022;9(5):1258\u201368. https:\/\/doi.org\/10.1016\/j.gendis.2021.07.004.","journal-title":"Genes Dis"},{"issue":"2","key":"646_CR50","doi-asserted-by":"publisher","first-page":"215","DOI":"10.1016\/j.cell.2009.01.002","volume":"136","author":"DP Bartel","year":"2009","unstructured":"Bartel DP. MicroRNAs: target recognition and regulatory functions. Cell. 2009;136(2):215\u201333. https:\/\/doi.org\/10.1016\/j.cell.2009.01.002.","journal-title":"Cell"},{"issue":"1","key":"646_CR51","doi-asserted-by":"publisher","first-page":"21","DOI":"10.1038\/s41580-018-0045-7","volume":"20","author":"LFR Gebert","year":"2019","unstructured":"Gebert LFR, MacRae IJ. Regulation of microRNA function in animals. Nat Rev Mol Cell Biol. 2019;20(1):21\u201337. https:\/\/doi.org\/10.1038\/s41580-018-0045-7.","journal-title":"Nat Rev Mol Cell Biol"},{"issue":"13","key":"646_CR52","doi-asserted-by":"publisher","first-page":"1059","DOI":"10.1161\/circulationaha.120.051614","volume":"144","author":"A Schober","year":"2021","unstructured":"Schober A, Blay RM, Saboor Maleki S, Zahedi F, Winklmaier AE, Kakar MY, et al. MicroRNA-21 controls circadian regulation of apoptosis in atherosclerotic lesions. Circulation. 2021;144(13):1059\u201373. https:\/\/doi.org\/10.1161\/circulationaha.120.051614.","journal-title":"Circulation"},{"issue":"21","key":"646_CR53","doi-asserted-by":"publisher","first-page":"E4271","DOI":"10.1073\/pnas.1619442114","volume":"114","author":"J Fan","year":"2017","unstructured":"Fan J, Jia L, Li Y, Ebrahim S, May-Simera H, Wood A, et al. Maturation arrest in early postnatal sensory receptors by deletion of the miR-183\/96\/182 cluster in mouse. Proc Natl Acad Sci U S A. 2017;114(21):E4271\u201380. https:\/\/doi.org\/10.1073\/pnas.1619442114.","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"34","key":"646_CR54","doi-asserted-by":"publisher","first-page":"25053","DOI":"10.1074\/jbc.M700501200","volume":"282","author":"S Xu","year":"2007","unstructured":"Xu S, Witmer PD, Lumayag S, Kovacs B, Valle D. MicroRNA (miRNA) transcriptome of mouse retina and identification of a sensory organ-specific miRNA cluster. J Biol Chem. 2007;282(34):25053\u201366. https:\/\/doi.org\/10.1074\/jbc.M700501200.","journal-title":"J Biol Chem"},{"key":"646_CR55","doi-asserted-by":"publisher","unstructured":"Zhou L, Miller C, Miraglia LJ, Romero A, Mure LS, Panda S et al. A genome-wide microRNA screen identifies the microRNA-183\/96\/182 cluster as a modulator of circadian rhythms. Proc Natl Acad Sci U S A. 2021;118(1). https:\/\/doi.org\/10.1073\/pnas.2020454118.","DOI":"10.1073\/pnas.2020454118"},{"issue":"5","key":"646_CR56","doi-asserted-by":"publisher","first-page":"813","DOI":"10.1016\/j.neuron.2007.05.017","volume":"54","author":"HY Cheng","year":"2007","unstructured":"Cheng HY, Papp JW, Varlamova O, Dziema H, Russell B, Curfman JP, et al. microRNA modulation of circadian-clock period and entrainment. Neuron. 2007;54(5):813\u201329. https:\/\/doi.org\/10.1016\/j.neuron.2007.05.017.","journal-title":"Neuron"},{"issue":"10","key":"646_CR57","doi-asserted-by":"publisher","first-page":"2071","DOI":"10.4103\/1673-5374.308101","volume":"16","author":"N Sha","year":"2021","unstructured":"Sha N, Wang HW, Sun B, Gong M, Miao P, Jiang XL, et al. The role of pineal microRNA-325 in regulating circadian rhythms after neonatal hypoxic-ischemic brain damage. Neural Regen Res. 2021;16(10):2071\u20137. https:\/\/doi.org\/10.4103\/1673-5374.308101.","journal-title":"Neural Regen Res"},{"key":"646_CR58","doi-asserted-by":"publisher","first-page":"106537","DOI":"10.1016\/j.phrs.2022.106537","volume":"186","author":"L Mei","year":"2022","unstructured":"Mei L, Zheng Y, Gao X, Ma T, Xia B, Hao Y, et al. Hsa-let-7f-1-3p targeting the circadian gene Bmal1 mediates intervertebral disc degeneration by regulating autophagy. Pharmacol Res. 2022;186:106537. https:\/\/doi.org\/10.1016\/j.phrs.2022.106537.","journal-title":"Pharmacol Res"},{"issue":"9","key":"646_CR59","doi-asserted-by":"publisher","first-page":"1614","DOI":"10.1038\/s12276-020-00496-5","volume":"52","author":"I Park","year":"2020","unstructured":"Park I, Kim D, Kim J, Jang S, Choi M, Choe HK, et al. microRNA-25 as a novel modulator of circadian Period2 gene oscillation. Exp Mol Med. 2020;52(9):1614\u201326. https:\/\/doi.org\/10.1038\/s12276-020-00496-5.","journal-title":"Exp Mol Med"},{"issue":"5","key":"646_CR60","doi-asserted-by":"publisher","first-page":"1836","DOI":"10.1093\/bib\/bby054","volume":"20","author":"L Chen","year":"2019","unstructured":"Chen L, Heikkinen L, Wang C, Yang Y, Sun H, Wong G. Trends in the development of miRNA bioinformatics tools. Brief Bioinform. 2019;20(5):1836\u201352. https:\/\/doi.org\/10.1093\/bib\/bby054.","journal-title":"Brief Bioinform"},{"key":"646_CR61","doi-asserted-by":"publisher","unstructured":"Correction for Zhou et al., A genome-wide microRNA screen identifies the microRNA-183\/96\/182 cluster as a modulator of circadian rhythms. Proc Natl Acad Sci U S A. 2025;122(1):e2424179121. https:\/\/doi.org\/10.1073\/pnas.2424179121.","DOI":"10.1073\/pnas.2424179121"},{"issue":"11","key":"646_CR62","doi-asserted-by":"publisher","first-page":"4575","DOI":"10.1038\/s41380-022-01711-7","volume":"27","author":"M Du","year":"2022","unstructured":"Du M, Wu C, Yu R, Cheng Y, Tang Z, Wu B, et al. A novel circular RNA, circIgfbp2, links neural plasticity and anxiety through targeting mitochondrial dysfunction and oxidative stress-induced synapse dysfunction after traumatic brain injury. Mol Psychiatry. 2022;27(11):4575\u201389. https:\/\/doi.org\/10.1038\/s41380-022-01711-7.","journal-title":"Mol Psychiatry"},{"issue":"11","key":"646_CR63","doi-asserted-by":"publisher","first-page":"675","DOI":"10.1038\/s41576-019-0158-7","volume":"20","author":"LS Kristensen","year":"2019","unstructured":"Kristensen LS, Andersen MS, Stagsted LVW, Ebbesen KK, Hansen TB, Kjems J. The biogenesis, biology and characterization of circular RNAs. Nat Rev Genet. 2019;20(11):675\u201391. https:\/\/doi.org\/10.1038\/s41576-019-0158-7.","journal-title":"Nat Rev Genet"},{"issue":"12","key":"646_CR64","doi-asserted-by":"publisher","first-page":"4455","DOI":"10.1016\/j.bioactmat.2021.04.031","volume":"6","author":"SC Tao","year":"2021","unstructured":"Tao SC, Huang JY, Gao Y, Li ZX, Wei ZY, Dawes H, et al. Small extracellular vesicles in combination with sleep-related circRNA3503: a targeted therapeutic agent with injectable thermosensitive hydrogel to prevent osteoarthritis. Bioact Mater. 2021;6(12):4455\u201369. https:\/\/doi.org\/10.1016\/j.bioactmat.2021.04.031.","journal-title":"Bioact Mater"},{"issue":"14","key":"646_CR65","doi-asserted-by":"publisher","first-page":"2265","DOI":"10.1158\/0008-5472.Can-23-3942","volume":"84","author":"D Liu","year":"2024","unstructured":"Liu D, Wei B, Liang L, Sheng Y, Sun S, Sun X, et al. The circadian clock component RORA increases immunosurveillance in melanoma by inhibiting PD-L1 expression. Cancer Res. 2024;84(14):2265\u201381. https:\/\/doi.org\/10.1158\/0008-5472.Can-23-3942.","journal-title":"Cancer Res"},{"issue":"22","key":"646_CR66","doi-asserted-by":"publisher","first-page":"7177","DOI":"10.1111\/febs.16125","volume":"289","author":"M Rangel","year":"2022","unstructured":"Rangel M, Kong J, Bhatt V, Khayati K, Guo JY. Autophagy and tumorigenesis. Febs j. 2022;289(22):7177\u201398. https:\/\/doi.org\/10.1111\/febs.16125.","journal-title":"Febs j"},{"issue":"8","key":"646_CR67","doi-asserted-by":"publisher","first-page":"475","DOI":"10.1016\/j.trecan.2019.07.002","volume":"5","author":"G Sulli","year":"2019","unstructured":"Sulli G, Lam MTY, Panda S. Interplay between circadian clock and cancer: new frontiers for cancer treatment. Trends Cancer. 2019;5(8):475\u201394. https:\/\/doi.org\/10.1016\/j.trecan.2019.07.002.","journal-title":"Trends Cancer"},{"issue":"1","key":"646_CR68","doi-asserted-by":"publisher","first-page":"37","DOI":"10.1186\/s12964-021-00721-2","volume":"19","author":"Z Zhang","year":"2021","unstructured":"Zhang Z, Zeng P, Gao W, Zhou Q, Feng T, Tian X. Circadian clock: a regulator of the immunity in cancer. Cell Commun Signal. 2021;19(1):37. https:\/\/doi.org\/10.1186\/s12964-021-00721-2.","journal-title":"Cell Commun Signal"},{"issue":"9","key":"646_CR69","doi-asserted-by":"publisher","first-page":"812","DOI":"10.1016\/j.tips.2018.07.003","volume":"39","author":"G Sulli","year":"2018","unstructured":"Sulli G, Manoogian ENC, Taub PR, Panda S. Training the circadian clock, clocking the drugs, and drugging the clock to prevent, manage, and treat chronic diseases. Trends Pharmacol Sci. 2018;39(9):812\u201327. https:\/\/doi.org\/10.1016\/j.tips.2018.07.003.","journal-title":"Trends Pharmacol Sci"},{"issue":"3","key":"646_CR70","doi-asserted-by":"publisher","first-page":"314","DOI":"10.1016\/j.cels.2018.01.013","volume":"6","author":"Y Ye","year":"2018","unstructured":"Ye Y, Xiang Y, Ozguc FM, Kim Y, Liu CJ, Park PK, et al. The genomic landscape and pharmacogenomic interactions of clock genes in cancer chronotherapy. Cell Syst. 2018;6(3):314\u201328.e2. https:\/\/doi.org\/10.1016\/j.cels.2018.01.013.","journal-title":"Cell Syst"},{"issue":"11","key":"646_CR71","doi-asserted-by":"publisher","first-page":"2690","DOI":"10.1016\/j.cell.2024.04.015","volume":"187","author":"C Wang","year":"2024","unstructured":"Wang C, Zeng Q, G\u00fcl ZM, Wang S, Pick R, Cheng P, et al. Circadian tumor infiltration and function of CD8(+) T cells dictate immunotherapy efficacy. Cell. 2024;187(11):2690\u2013702.e17. https:\/\/doi.org\/10.1016\/j.cell.2024.04.015.","journal-title":"Cell"},{"issue":"21","key":"646_CR72","first-page":"7277","volume":"63","author":"S Koyanagi","year":"2003","unstructured":"Koyanagi S, Kuramoto Y, Nakagawa H, Aramaki H, Ohdo S, Soeda S, et al. A molecular mechanism regulating circadian expression of vascular endothelial growth factor in tumor cells. Cancer Res. 2003;63(21):7277\u201383.","journal-title":"Cancer Res"},{"issue":"8","key":"646_CR73","doi-asserted-by":"publisher","first-page":"1633","DOI":"10.1016\/j.bbagen.2014.10.025","volume":"1850","author":"LD Jensen","year":"2015","unstructured":"Jensen LD. The circadian clock and hypoxia in tumor cell de-differentiation and metastasis. Biochim Biophys Acta. 2015;1850(8):1633\u201341. https:\/\/doi.org\/10.1016\/j.bbagen.2014.10.025.","journal-title":"Biochim Biophys Acta"},{"issue":"3","key":"646_CR74","doi-asserted-by":"publisher","first-page":"e12988","DOI":"10.1111\/cpr.12988","volume":"54","author":"Z Wang","year":"2021","unstructured":"Wang Z, Su G, Dai Z, Meng M, Zhang H, Fan F, et al. Circadian clock genes promote glioma progression by affecting tumour immune infiltration and tumour cell proliferation. Cell Prolif. 2021;54(3):e12988. https:\/\/doi.org\/10.1111\/cpr.12988.","journal-title":"Cell Prolif"},{"issue":"4","key":"646_CR75","doi-asserted-by":"publisher","first-page":"774","DOI":"10.1016\/j.molcel.2016.10.012","volume":"64","author":"AL Huber","year":"2016","unstructured":"Huber AL, Papp SJ, Chan AB, Henriksson E, Jordan SD, Kriebs A, et al. CRY2 and FBXL3 Cooperatively Degrade c-MYC. Mol Cell. 2016;64(4):774\u201389. https:\/\/doi.org\/10.1016\/j.molcel.2016.10.012.","journal-title":"Mol Cell"},{"issue":"8","key":"646_CR76","doi-asserted-by":"publisher","first-page":"2841","DOI":"10.1073\/pnas.0813028106","volume":"106","author":"N Ozturk","year":"2009","unstructured":"Ozturk N, Lee JH, Gaddameedhi S, Sancar A. Loss of cryptochrome reduces cancer risk in p53 mutant mice. Proc Natl Acad Sci U S A. 2009;106(8):2841\u20136. https:\/\/doi.org\/10.1073\/pnas.0813028106.","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"24","key":"646_CR77","doi-asserted-by":"publisher","first-page":"9315","DOI":"10.1158\/0008-5472.Can-09-0648","volume":"69","author":"Y Zhu","year":"2009","unstructured":"Zhu Y, Stevens RG, Hoffman AE, Fitzgerald LM, Kwon EM, Ostrander EA, et al. Testing the circadian gene hypothesis in prostate cancer: a population-based case-control study. Cancer Res. 2009;69(24):9315\u201322. https:\/\/doi.org\/10.1158\/0008-5472.Can-09-0648.","journal-title":"Cancer Res"},{"issue":"9","key":"646_CR78","doi-asserted-by":"publisher","first-page":"1794","DOI":"10.1002\/ijc.30883","volume":"141","author":"F Gu","year":"2017","unstructured":"Gu F, Zhang H, Hyland PL, Berndt S, Gapstur SM, Wheeler W, et al. Inherited variation in circadian rhythm genes and risks of prostate cancer and three other cancer sites in combined cancer consortia. Int J Cancer. 2017;141(9):1794\u2013802. https:\/\/doi.org\/10.1002\/ijc.30883.","journal-title":"Int J Cancer"},{"key":"646_CR79","doi-asserted-by":"publisher","first-page":"99","DOI":"10.1016\/j.semcancer.2023.03.003","volume":"91","author":"C Miro","year":"2023","unstructured":"Miro C, Docimo A, Barrea L, Verde L, Cernea S, Sojat AS, et al. \u201cTime\u201d for obesity-related cancer: The role of the circadian rhythm in cancer pathogenesis and treatment. Semin Cancer Biol. 2023;91:99\u2013109. https:\/\/doi.org\/10.1016\/j.semcancer.2023.03.003.","journal-title":"Semin Cancer Biol"},{"key":"646_CR80","doi-asserted-by":"publisher","first-page":"1444426","DOI":"10.3389\/fimmu.2024.1444426","volume":"15","author":"Y Yan","year":"2024","unstructured":"Yan Y, Su L, Huang S, He Q, Lu J, Luo H, et al. Circadian rhythms and breast cancer: unraveling the biological clock\u2019s role in tumor microenvironment and ageing. Front Immunol. 2024;15:1444426. https:\/\/doi.org\/10.3389\/fimmu.2024.1444426.","journal-title":"Front Immunol"},{"issue":"1","key":"646_CR81","doi-asserted-by":"publisher","first-page":"41","DOI":"10.1016\/s0092-8674(02)00961-3","volume":"111","author":"L Fu","year":"2002","unstructured":"Fu L, Pelicano H, Liu J, Huang P, Lee C. The circadian gene Period2 plays an important role in tumor suppression and DNA damage response in vivo. Cell. 2002;111(1):41\u201350. https:\/\/doi.org\/10.1016\/s0092-8674(02)00961-3.","journal-title":"Cell"},{"issue":"1","key":"646_CR82","doi-asserted-by":"publisher","first-page":"335","DOI":"10.1038\/s41420-021-00704-9","volume":"7","author":"S Kubra","year":"2021","unstructured":"Kubra S, Zhang H, Si Y, Gao X, Wang T, Pan L, et al. REG\u03b3 regulates circadian clock by modulating BMAL1 protein stability. Cell Death Discov. 2021;7(1):335. https:\/\/doi.org\/10.1038\/s41420-021-00704-9.","journal-title":"Cell Death Discov"},{"issue":"35","key":"646_CR83","doi-asserted-by":"publisher","first-page":"21609","DOI":"10.1073\/pnas.2011225117","volume":"117","author":"Z Liu","year":"2020","unstructured":"Liu Z, Selby CP, Yang Y, Lindsey-Boltz LA, Cao X, Eynullazada K, et al. Circadian regulation of c-MYC in mice. Proc Natl Acad Sci U S A. 2020;117(35):21609\u201317. https:\/\/doi.org\/10.1073\/pnas.2011225117.","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"1","key":"646_CR84","doi-asserted-by":"publisher","first-page":"50","DOI":"10.1097\/cco.0000000000000153","volume":"27","author":"S Masri","year":"2015","unstructured":"Masri S, Kinouchi K, Sassone-Corsi P. Circadian clocks, epigenetics, and cancer. Curr Opin Oncol. 2015;27(1):50\u20136. https:\/\/doi.org\/10.1097\/cco.0000000000000153.","journal-title":"Curr Opin Oncol"},{"issue":"11","key":"646_CR85","doi-asserted-by":"publisher","first-page":"671","DOI":"10.1038\/s41579-024-01068-4","volume":"22","author":"FC Ross","year":"2024","unstructured":"Ross FC, Patangia D, Grimaud G, Lavelle A, Dempsey EM, Ross RP, et al. The interplay between diet and the gut microbiome: implications for health and disease. Nat Rev Microbiol. 2024;22(11):671\u201386. https:\/\/doi.org\/10.1038\/s41579-024-01068-4.","journal-title":"Nat Rev Microbiol"},{"issue":"6","key":"646_CR86","doi-asserted-by":"publisher","first-page":"1320","DOI":"10.1016\/j.cmet.2024.04.019","volume":"36","author":"JL Liu","year":"2024","unstructured":"Liu JL, Xu X, Rixiati Y, Wang CY, Ni HL, Chen WS, et al. Dysfunctional circadian clock accelerates cancer metastasis by intestinal microbiota triggering accumulation of myeloid-derived suppressor cells. Cell Metab. 2024;36(6):1320\u201334.e9. https:\/\/doi.org\/10.1016\/j.cmet.2024.04.019.","journal-title":"Cell Metab"},{"issue":"1","key":"646_CR87","doi-asserted-by":"publisher","first-page":"37","DOI":"10.1038\/s41392-024-01743-1","volume":"9","author":"JS Loh","year":"2024","unstructured":"Loh JS, Mak WQ, Tan LKS, Ng CX, Chan HH, Yeow SH, et al. Microbiota-gut-brain axis and its therapeutic applications in neurodegenerative diseases. Signal Transduct Target Ther. 2024;9(1):37. https:\/\/doi.org\/10.1038\/s41392-024-01743-1.","journal-title":"Signal Transduct Target Ther"},{"key":"646_CR88","doi-asserted-by":"publisher","first-page":"643420","DOI":"10.3389\/fimmu.2021.643420","volume":"12","author":"W Zhao","year":"2021","unstructured":"Zhao W, Peng C, Sakandar HA, Kwok LY, Zhang W. Meta-analysis: randomized trials of lactobacillus plantarum on immune regulation over the last decades. Front Immunol. 2021;12:643420. https:\/\/doi.org\/10.3389\/fimmu.2021.643420.","journal-title":"Front Immunol"},{"issue":"15","key":"646_CR89","doi-asserted-by":"publisher","first-page":"3884","DOI":"10.1016\/j.cell.2021.05.030","volume":"184","author":"BM Henrick","year":"2021","unstructured":"Henrick BM, Rodriguez L, Lakshmikanth T, Pou C, Henckel E, Arzoomand A, et al. Bifidobacteria-mediated immune system imprinting early in life. Cell. 2021;184(15):3884\u201398.e11. https:\/\/doi.org\/10.1016\/j.cell.2021.05.030.","journal-title":"Cell"},{"issue":"3","key":"646_CR90","doi-asserted-by":"publisher","first-page":"1491","DOI":"10.1080\/09546634.2020.1836310","volume":"33","author":"CRS Prakoeswa","year":"2022","unstructured":"Prakoeswa CRS, Bonita L, Karim A, Herwanto N, Umborowati MA, Setyaningrum T, et al. Beneficial effect of Lactobacillus plantarum IS-10506 supplementation in adults with atopic dermatitis: a randomized controlled trial. J Dermatolog Treat. 2022;33(3):1491\u20138. https:\/\/doi.org\/10.1080\/09546634.2020.1836310.","journal-title":"J Dermatolog Treat"},{"issue":"5","key":"646_CR91","doi-asserted-by":"publisher","first-page":"833","DOI":"10.3920\/bm2017.0011","volume":"8","author":"CRS Prakoeswa","year":"2017","unstructured":"Prakoeswa CRS, Herwanto N, Prameswari R, Astari L, Sawitri S, Hidayati AN, et al. Lactobacillus plantarum IS-10506 supplementation reduced SCORAD in children with atopic dermatitis. Benef Microbes. 2017;8(5):833\u201340. https:\/\/doi.org\/10.3920\/bm2017.0011.","journal-title":"Benef Microbes"},{"issue":"10","key":"646_CR92","doi-asserted-by":"publisher","first-page":"701","DOI":"10.1038\/nrn3346","volume":"13","author":"JF Cryan","year":"2012","unstructured":"Cryan JF, Dinan TG. Mind-altering microorganisms: the impact of the gut microbiota on brain and behaviour. Nat Rev Neurosci. 2012;13(10):701\u201312. https:\/\/doi.org\/10.1038\/nrn3346.","journal-title":"Nat Rev Neurosci"},{"issue":"3","key":"646_CR93","doi-asserted-by":"publisher","first-page":"397","DOI":"10.1016\/j.bbi.2010.10.023","volume":"25","author":"MT Bailey","year":"2011","unstructured":"Bailey MT, Dowd SE, Galley JD, Hufnagle AR, Allen RG, Lyte M. Exposure to a social stressor alters the structure of the intestinal microbiota: implications for stressor-induced immunomodulation. Brain Behav Immun. 2011;25(3):397\u2013407. https:\/\/doi.org\/10.1016\/j.bbi.2010.10.023.","journal-title":"Brain Behav Immun"},{"issue":"3","key":"646_CR94","doi-asserted-by":"publisher","first-page":"263","DOI":"10.1016\/j.biopsych.2008.06.026","volume":"65","author":"SM O'Mahony","year":"2009","unstructured":"O\u2019Mahony SM, Marchesi JR, Scully P, Codling C, Ceolho AM, Quigley EM, et al. Early life stress alters behavior, immunity, and microbiota in rats: implications for irritable bowel syndrome and psychiatric illnesses. Biol Psychiatry. 2009;65(3):263\u20137. https:\/\/doi.org\/10.1016\/j.biopsych.2008.06.026.","journal-title":"Biol Psychiatry"},{"key":"646_CR95","doi-asserted-by":"publisher","first-page":"119","DOI":"10.1146\/annurev-neuro-091819-094557","volume":"43","author":"G Artiushin","year":"2020","unstructured":"Artiushin G, Sehgal A. The glial perspective on sleep and circadian rhythms. Annu Rev Neurosci. 2020;43:119\u201340. https:\/\/doi.org\/10.1146\/annurev-neuro-091819-094557.","journal-title":"Annu Rev Neurosci"},{"issue":"2\u20133","key":"646_CR96","doi-asserted-by":"publisher","first-page":"77","DOI":"10.1016\/j.neuchi.2015.03.002","volume":"61","author":"B Claustrat","year":"2015","unstructured":"Claustrat B, Leston J. Melatonin: Physiological effects in humans. Neurochirurgie. 2015;61(2\u20133):77\u201384. https:\/\/doi.org\/10.1016\/j.neuchi.2015.03.002.","journal-title":"Neurochirurgie"},{"issue":"6","key":"646_CR97","doi-asserted-by":"publisher","first-page":"1022","DOI":"10.2174\/1570159x19666210907122933","volume":"20","author":"SY Sun","year":"2022","unstructured":"Sun SY, Chen GH. Treatment of circadian rhythm sleep-wake disorders. Curr Neuropharmacol. 2022;20(6):1022\u201334. https:\/\/doi.org\/10.2174\/1570159x19666210907122933.","journal-title":"Curr Neuropharmacol"},{"key":"646_CR98","doi-asserted-by":"publisher","first-page":"345","DOI":"10.1016\/b978-0-12-819975-6.00022-4","volume":"179","author":"A Oishi","year":"2021","unstructured":"Oishi A, Gbahou F, Jockers R. Melatonin receptors, brain functions, and therapies. Handb Clin Neurol. 2021;179:345\u201356. https:\/\/doi.org\/10.1016\/b978-0-12-819975-6.00022-4.","journal-title":"Handb Clin Neurol"},{"issue":"7800","key":"646_CR99","doi-asserted-by":"publisher","first-page":"609","DOI":"10.1038\/s41586-020-2027-0","volume":"579","author":"RM Stein","year":"2020","unstructured":"Stein RM, Kang HJ, McCorvy JD, Glatfelter GC, Jones AJ, Che T, et al. Virtual discovery of melatonin receptor ligands to modulate circadian rhythms. Nature. 2020;579(7800):609\u201314. https:\/\/doi.org\/10.1038\/s41586-020-2027-0.","journal-title":"Nature"},{"key":"646_CR100","doi-asserted-by":"publisher","first-page":"10","DOI":"10.1016\/j.smrv.2016.06.005","volume":"34","author":"F Auld","year":"2017","unstructured":"Auld F, Maschauer EL, Morrison I, Skene DJ, Riha RL. Evidence for the efficacy of melatonin in the treatment of primary adult sleep disorders. Sleep Med Rev. 2017;34:10\u201322. https:\/\/doi.org\/10.1016\/j.smrv.2016.06.005.","journal-title":"Sleep Med Rev"},{"issue":"15","key":"646_CR101","doi-asserted-by":"publisher","first-page":"1070","DOI":"10.1056\/nejm200010123431503","volume":"343","author":"RL Sack","year":"2000","unstructured":"Sack RL, Brandes RW, Kendall AR, Lewy AJ. Entrainment of free-running circadian rhythms by melatonin in blind people. N Engl J Med. 2000;343(15):1070\u20137. https:\/\/doi.org\/10.1056\/nejm200010123431503.","journal-title":"N Engl J Med"},{"issue":"1","key":"646_CR102","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1034\/j.1600-079x.2002.10808.x","volume":"32","author":"A Wirz-Justice","year":"2002","unstructured":"Wirz-Justice A, Werth E, Renz C, M\u00fcller S, Kr\u00e4uchi K. No evidence for a phase delay in human circadian rhythms after a single morning melatonin administration. J Pineal Res. 2002;32(1):1\u20135. https:\/\/doi.org\/10.1034\/j.1600-079x.2002.10808.x.","journal-title":"J Pineal Res"},{"key":"646_CR103","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-025-08731-7","author":"EF Harkin","year":"2025","unstructured":"Harkin EF, Grossman CD, Cohen JY, B\u00e9\u00efque JC, Naud R. A prospective code for value in the serotonin system. Nature. 2025. https:\/\/doi.org\/10.1038\/s41586-025-08731-7.","journal-title":"Nature"},{"key":"646_CR104","doi-asserted-by":"publisher","first-page":"100746","DOI":"10.1016\/j.yfrne.2019.04.003","volume":"54","author":"RA Daut","year":"2019","unstructured":"Daut RA, Fonken LK. Circadian regulation of depression: A role for serotonin. Front Neuroendocrinol. 2019;54:100746. https:\/\/doi.org\/10.1016\/j.yfrne.2019.04.003.","journal-title":"Front Neuroendocrinol"},{"issue":"5","key":"646_CR105","doi-asserted-by":"publisher","first-page":"1758","DOI":"10.1523\/jneurosci.3798-15.2016","volume":"36","author":"SC Wyler","year":"2016","unstructured":"Wyler SC, Spencer WC, Green NH, Rood BD, Crawford L, Craige C, et al. Pet-1 switches transcriptional targets postnatally to regulate maturation of serotonin neuron excitability. J Neurosci. 2016;36(5):1758\u201374. https:\/\/doi.org\/10.1523\/jneurosci.3798-15.2016.","journal-title":"J Neurosci"},{"issue":"8","key":"646_CR106","doi-asserted-by":"publisher","first-page":"1175","DOI":"10.1080\/07420528.2018.1458316","volume":"35","author":"EM McGlashan","year":"2018","unstructured":"McGlashan EM, Drummond SPA, Cain SW. Evening types demonstrate reduced SSRI treatment efficacy. Chronobiol Int. 2018;35(8):1175\u20138. https:\/\/doi.org\/10.1080\/07420528.2018.1458316.","journal-title":"Chronobiol Int"},{"issue":"6","key":"646_CR107","doi-asserted-by":"publisher","first-page":"429","DOI":"10.1016\/j.smrv.2007.07.005","volume":"11","author":"T Roenneberg","year":"2007","unstructured":"Roenneberg T, Kuehnle T, Juda M, Kantermann T, Allebrandt K, Gordijn M, et al. Epidemiology of the human circadian clock. Sleep Med Rev. 2007;11(6):429\u201338. https:\/\/doi.org\/10.1016\/j.smrv.2007.07.005.","journal-title":"Sleep Med Rev"},{"issue":"5","key":"646_CR108","doi-asserted-by":"publisher","first-page":"843","DOI":"10.1016\/s0893-133x(02)00358-5","volume":"27","author":"I Arnulf","year":"2002","unstructured":"Arnulf I, Quintin P, Alvarez JC, Vigil L, Touitou Y, L\u00e8bre AS, et al. Mid-morning tryptophan depletion delays REM sleep onset in healthy subjects. Neuropsychopharmacology. 2002;27(5):843\u201351. https:\/\/doi.org\/10.1016\/s0893-133x(02)00358-5.","journal-title":"Neuropsychopharmacology"},{"key":"646_CR109","doi-asserted-by":"publisher","unstructured":"Rodriguez P, Laskowski LJ, Pallais JP, Bock HA, Cavalco NG, Anderson EI, et al. Functional profiling of the G protein-coupled receptor C3aR1 reveals ligand-mediated biased agonism. J Biol Chem. 2023:105549. https:\/\/doi.org\/10.1016\/j.jbc.2023.105549.","DOI":"10.1016\/j.jbc.2023.105549"},{"issue":"11","key":"646_CR110","doi-asserted-by":"publisher","first-page":"5296","DOI":"10.7150\/thno.55986","volume":"11","author":"S Karmakar","year":"2021","unstructured":"Karmakar S, Lal G. Role of serotonin receptor signaling in cancer cells and anti-tumor immunity. Theranostics. 2021;11(11):5296\u2013312. https:\/\/doi.org\/10.7150\/thno.55986.","journal-title":"Theranostics"},{"key":"646_CR111","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2024.12.038","author":"R Dong","year":"2025","unstructured":"Dong R, Wang T, Dong W, Zhang H, Li Y, Tao R, et al. TGM2-mediated histone serotonylation promotes HCC progression via MYC signalling pathway. J Hepatol. 2025. https:\/\/doi.org\/10.1016\/j.jhep.2024.12.038.","journal-title":"J Hepatol"},{"key":"646_CR112","doi-asserted-by":"publisher","first-page":"107255","DOI":"10.1016\/j.phrs.2024.107255","volume":"205","author":"Y Zhang","year":"2024","unstructured":"Zhang Y, Wang Y. The dual roles of serotonin in antitumor immunity. Pharmacol Res. 2024;205:107255. https:\/\/doi.org\/10.1016\/j.phrs.2024.107255.","journal-title":"Pharmacol Res"},{"issue":"6","key":"646_CR113","doi-asserted-by":"publisher","first-page":"e2204006","DOI":"10.1002\/advs.202204006","volume":"10","author":"D Liu","year":"2023","unstructured":"Liu D, Liang CH, Huang B, Zhuang X, Cui W, Yang L, et al. Tryptophan metabolism acts as a new anti-ferroptotic pathway to mediate tumor growth. Adv Sci (Weinh). 2023;10(6):e2204006. https:\/\/doi.org\/10.1002\/advs.202204006.","journal-title":"Adv Sci (Weinh)"},{"issue":"1","key":"646_CR114","doi-asserted-by":"publisher","first-page":"102","DOI":"10.1002\/path.5285","volume":"249","author":"JY Sakita","year":"2019","unstructured":"Sakita JY, Bader M, Santos ES, Garcia SB, Minto SB, Alenina N, et al. Serotonin synthesis protects the mouse colonic crypt from DNA damage and colorectal tumorigenesis. J Pathol. 2019;249(1):102\u201313. https:\/\/doi.org\/10.1002\/path.5285.","journal-title":"J Pathol"},{"issue":"33","key":"646_CR115","doi-asserted-by":"publisher","first-page":"53137","DOI":"10.18632\/oncotarget.10614","volume":"7","author":"RM Hallett","year":"2016","unstructured":"Hallett RM, Girgis-Gabardo A, Gwynne WD, Giacomelli AO, Bisson JN, Jensen JE, et al. Serotonin transporter antagonists target tumor-initiating cells in a transgenic mouse model of breast cancer. Oncotarget. 2016;7(33):53137\u201352. https:\/\/doi.org\/10.18632\/oncotarget.10614.","journal-title":"Oncotarget"},{"issue":"1","key":"646_CR116","doi-asserted-by":"publisher","first-page":"91","DOI":"10.1111\/j.1440-1681.1978.tb00657.x","volume":"5","author":"PJ Tutton","year":"1978","unstructured":"Tutton PJ, Barkla DH. The influence of serotonin on the mitotic rate in the colonic crypt epithelium and in colonic adenocarcinoma in rats. Clin Exp Pharmacol Physiol. 1978;5(1):91\u20134. https:\/\/doi.org\/10.1111\/j.1440-1681.1978.tb00657.x.","journal-title":"Clin Exp Pharmacol Physiol"},{"issue":"11","key":"646_CR117","doi-asserted-by":"publisher","first-page":"2154","DOI":"10.1182\/blood-2012-07-443903","volume":"121","author":"L Qin","year":"2013","unstructured":"Qin L, Zhao D, Xu J, Ren X, Terwilliger EF, Parangi S, et al. The vascular permeabilizing factors histamine and serotonin induce angiogenesis through TR3\/Nur77 and subsequently truncate it through thrombospondin-1. Blood. 2013;121(11):2154\u201364. https:\/\/doi.org\/10.1182\/blood-2012-07-443903.","journal-title":"Blood"},{"issue":"10","key":"646_CR118","doi-asserted-by":"publisher","first-page":"1574","DOI":"10.1111\/j.1440-1746.2008.05560.x","volume":"23","author":"M Gulubova","year":"2008","unstructured":"Gulubova M, Vlaykova T. Chromogranin A-, serotonin-, synaptophysin- and vascular endothelial growth factor-positive endocrine cells and the prognosis of colorectal cancer: an immunohistochemical and ultrastructural study. J Gastroenterol Hepatol. 2008;23(10):1574\u201385. https:\/\/doi.org\/10.1111\/j.1440-1746.2008.05560.x.","journal-title":"J Gastroenterol Hepatol"},{"issue":"13","key":"646_CR119","doi-asserted-by":"publisher","first-page":"5152","DOI":"10.1158\/0008-5472.Can-08-0202","volume":"68","author":"A Nocito","year":"2008","unstructured":"Nocito A, Dahm F, Jochum W, Jang JH, Georgiev P, Bader M, et al. Serotonin regulates macrophage-mediated angiogenesis in a mouse model of colon cancer allografts. Cancer Res. 2008;68(13):5152\u20138. https:\/\/doi.org\/10.1158\/0008-5472.Can-08-0202.","journal-title":"Cancer Res"},{"issue":"12","key":"646_CR120","doi-asserted-by":"publisher","first-page":"6845","DOI":"10.4049\/jimmunol.161.12.6845","volume":"161","author":"LA Cornelius","year":"1998","unstructured":"Cornelius LA, Nehring LC, Harding E, Bolanowski M, Welgus HG, Kobayashi DK, et al. Matrix metalloproteinases generate angiostatin: effects on neovascularization. J Immunol. 1998;161(12):6845\u201352.","journal-title":"J Immunol"},{"issue":"4","key":"646_CR121","doi-asserted-by":"publisher","first-page":"760","DOI":"10.1016\/j.molcel.2023.12.015","volume":"84","author":"X Wang","year":"2024","unstructured":"Wang X, Fu SQ, Yuan X, Yu F, Ji Q, Tang HW, et al. A GAPDH serotonylation system couples CD8(+) T cell glycolytic metabolism to antitumor immunity. Mol Cell. 2024;84(4):760\u201375.e7. https:\/\/doi.org\/10.1016\/j.molcel.2023.12.015.","journal-title":"Mol Cell"},{"key":"646_CR122","doi-asserted-by":"publisher","unstructured":"Schneider MA, Heeb L, Beffinger MM, Pantelyushin S, Linecker M, Roth L et al. Attenuation of peripheral serotonin inhibits tumor growth and enhances immune checkpoint blockade therapy in murine tumor models. Sci Transl Med. 2021;13(611):eabc8188. https:\/\/doi.org\/10.1126\/scitranslmed.abc8188.","DOI":"10.1126\/scitranslmed.abc8188"},{"issue":"4","key":"646_CR123","doi-asserted-by":"publisher","first-page":"1395","DOI":"10.1096\/fj.14-259598","volume":"29","author":"CS Reigstad","year":"2015","unstructured":"Reigstad CS, Salmonson CE, Rainey JF 3rd, Szurszewski JH, Linden DR, Sonnenburg JL, et al. Gut microbes promote colonic serotonin production through an effect of short-chain fatty acids on enterochromaffin cells. Faseb j. 2015;29(4):1395\u2013403. https:\/\/doi.org\/10.1096\/fj.14-259598.","journal-title":"Faseb j"},{"issue":"5","key":"646_CR124","doi-asserted-by":"publisher","first-page":"1486","DOI":"10.1053\/j.gastro.2020.10.066","volume":"160","author":"KG Margolis","year":"2021","unstructured":"Margolis KG, Cryan JF, Mayer EA. The microbiota-gut-brain axis: from motility to mood. Gastroenterology. 2021;160(5):1486\u2013501. https:\/\/doi.org\/10.1053\/j.gastro.2020.10.066.","journal-title":"Gastroenterology"},{"key":"646_CR125","doi-asserted-by":"publisher","first-page":"439","DOI":"10.1146\/annurev-med-042320-014032","volume":"73","author":"EA Mayer","year":"2022","unstructured":"Mayer EA, Nance K, Chen S. The Gut-Brain Axis. Annu Rev Med. 2022;73:439\u201353. https:\/\/doi.org\/10.1146\/annurev-med-042320-014032.","journal-title":"Annu Rev Med"},{"issue":"7917","key":"646_CR126","doi-asserted-by":"publisher","first-page":"156","DOI":"10.1038\/s41586-022-04875-y","volume":"607","author":"Z Diamantopoulou","year":"2022","unstructured":"Diamantopoulou Z, Castro-Giner F, Schwab FD, Foerster C, Saini M, Budinjas S, et al. The metastatic spread of breast cancer accelerates during sleep. Nature. 2022;607(7917):156\u201362. https:\/\/doi.org\/10.1038\/s41586-022-04875-y.","journal-title":"Nature"},{"key":"646_CR127","doi-asserted-by":"publisher","first-page":"1161768","DOI":"10.3389\/fendo.2023.1161768","volume":"14","author":"S Khadka","year":"2023","unstructured":"Khadka S, Druffner SR, Duncan BC, Busada JT. Glucocorticoid regulation of cancer development and progression. Front Endocrinol (Lausanne). 2023;14:1161768. https:\/\/doi.org\/10.3389\/fendo.2023.1161768.","journal-title":"Front Endocrinol (Lausanne)"},{"key":"646_CR128","doi-asserted-by":"publisher","first-page":"307","DOI":"10.1196\/annals.1366.027","volume":"1088","author":"SR Bornstein","year":"2006","unstructured":"Bornstein SR, Ziegler CG, Krug AW, Kanczkowski W, Rettori V, McCann SM, et al. The role of toll-like receptors in the immune-adrenal crosstalk. Ann N Y Acad Sci. 2006;1088:307\u201318. https:\/\/doi.org\/10.1196\/annals.1366.027.","journal-title":"Ann N Y Acad Sci"},{"issue":"69","key":"646_CR129","doi-asserted-by":"publisher","first-page":"eabm0631","DOI":"10.1126\/sciimmunol.abm0631","volume":"7","author":"R Tang","year":"2022","unstructured":"Tang R, Acharya N, Subramanian A, Purohit V, Tabaka M, Hou Y, et al. Tim-3 adapter protein Bat3 acts as an endogenous regulator of tolerogenic dendritic cell function. Sci Immunol. 2022;7(69):eabm0631. https:\/\/doi.org\/10.1126\/sciimmunol.abm0631.","journal-title":"Sci Immunol"},{"issue":"7749","key":"646_CR130","doi-asserted-by":"publisher","first-page":"540","DOI":"10.1038\/s41586-019-1019-4","volume":"567","author":"MMS Obradovi\u0107","year":"2019","unstructured":"Obradovi\u0107 MMS, Hamelin B, Manevski N, Couto JP, Sethi A, Coissieux MM, et al. Glucocorticoids promote breast cancer metastasis. Nature. 2019;567(7749):540\u20134. https:\/\/doi.org\/10.1038\/s41586-019-1019-4.","journal-title":"Nature"},{"issue":"2","key":"646_CR131","doi-asserted-by":"publisher","first-page":"224","DOI":"10.1016\/j.cell.2011.03.027","volume":"145","author":"M Surjit","year":"2011","unstructured":"Surjit M, Ganti KP, Mukherji A, Ye T, Hua G, Metzger D, et al. Widespread negative response elements mediate direct repression by agonist-liganded glucocorticoid receptor. Cell. 2011;145(2):224\u201341. https:\/\/doi.org\/10.1016\/j.cell.2011.03.027.","journal-title":"Cell"},{"issue":"7203","key":"646_CR132","doi-asserted-by":"publisher","first-page":"436","DOI":"10.1038\/nature07205","volume":"454","author":"A Mantovani","year":"2008","unstructured":"Mantovani A, Allavena P, Sica A, Balkwill F. Cancer-related inflammation. Nature. 2008;454(7203):436\u201344. https:\/\/doi.org\/10.1038\/nature07205.","journal-title":"Nature"},{"issue":"3","key":"646_CR133","doi-asserted-by":"publisher","first-page":"1490","DOI":"10.4049\/jimmunol.163.3.1490","volume":"163","author":"KA Roth","year":"1999","unstructured":"Roth KA, Kapadia SB, Martin SM, Lorenz RG. Cellular immune responses are essential for the development of Helicobacter felis-associated gastric pathology. J Immunol. 1999;163(3):1490\u20137.","journal-title":"J Immunol"},{"issue":"62","key":"646_CR134","doi-asserted-by":"publisher","first-page":"105312","DOI":"10.18632\/oncotarget.22172","volume":"8","author":"Y Gu","year":"2017","unstructured":"Gu Y, Deng B, Kong J, Yan C, Huang T, Yang J, et al. Functional polymorphisms in NR3C1 are associated with gastric cancer risk in Chinese population. Oncotarget. 2017;8(62):105312\u20139. https:\/\/doi.org\/10.18632\/oncotarget.22172.","journal-title":"Oncotarget"},{"issue":"47","key":"646_CR135","doi-asserted-by":"publisher","first-page":"18514","DOI":"10.1073\/pnas.0705316104","volume":"104","author":"GT Stathopoulos","year":"2007","unstructured":"Stathopoulos GT, Sherrill TP, Cheng DS, Scoggins RM, Han W, Polosukhin VV, et al. Epithelial NF-kappaB activation promotes urethane-induced lung carcinogenesis. Proc Natl Acad Sci U S A. 2007;104(47):18514\u20139. https:\/\/doi.org\/10.1073\/pnas.0705316104.","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"5","key":"646_CR136","doi-asserted-by":"publisher","first-page":"1047","DOI":"10.1002\/ijc.24942","volume":"126","author":"R Balansky","year":"2010","unstructured":"Balansky R, Ganchev G, Iltcheva M, Steele VE, De Flora S. Prevention of cigarette smoke-induced lung tumors in mice by budesonide, phenethyl isothiocyanate, and N-acetylcysteine. Int J Cancer. 2010;126(5):1047\u201354. https:\/\/doi.org\/10.1002\/ijc.24942.","journal-title":"Int J Cancer"},{"issue":"9","key":"646_CR137","doi-asserted-by":"publisher","first-page":"1428","DOI":"10.1038\/s41591-019-0566-4","volume":"25","author":"H Yang","year":"2019","unstructured":"Yang H, Xia L, Chen J, Zhang S, Martin V, Li Q, et al. Stress-glucocorticoid-TSC22D3 axis compromises therapy-induced antitumor immunity. Nat Med. 2019;25(9):1428\u201341. https:\/\/doi.org\/10.1038\/s41591-019-0566-4.","journal-title":"Nat Med"},{"issue":"2","key":"646_CR138","doi-asserted-by":"publisher","first-page":"e12496","DOI":"10.1111\/jpi.12496","volume":"65","author":"H Lee","year":"2018","unstructured":"Lee H, Lee HJ, Jung JH, Shin EA, Kim SH. Melatonin disturbs SUMOylation-mediated crosstalk between c-Myc and nestin via MT1 activation and promotes the sensitivity of paclitaxel in brain cancer stem cells. J Pineal Res. 2018;65(2):e12496. https:\/\/doi.org\/10.1111\/jpi.12496.","journal-title":"J Pineal Res"},{"issue":"4","key":"646_CR139","doi-asserted-by":"publisher","first-page":"e70064","DOI":"10.1111\/jpi.70064","volume":"77","author":"S Cardenas-Romero","year":"2025","unstructured":"Cardenas-Romero S, Saderi N, Ramirez-Plascencia OD, Baez-Ruiz A, Flores-Sandoval O, Briones CE, et al. Melatonin prevents tumor growth: the role of genes controlling the circadian clock, the cell cycle, and angiogenesis. J Pineal Res. 2025;77(4):e70064. https:\/\/doi.org\/10.1111\/jpi.70064.","journal-title":"J Pineal Res"},{"key":"646_CR140","doi-asserted-by":"publisher","unstructured":"Liu J, Guan Q, Li S, Qi Q, Pan X. Melatonin Alleviates MBP-Induced Oxidative Stress and Apoptosis in TM3 Cells via the SIRT1\/PGC-1\u03b1 Signaling Pathway. Int J Mol Sci. 2025;26(12). https:\/\/doi.org\/10.3390\/ijms26125910.","DOI":"10.3390\/ijms26125910"},{"issue":"1","key":"646_CR141","doi-asserted-by":"publisher","first-page":"137","DOI":"10.1093\/neuonc\/noad148","volume":"26","author":"B Xing","year":"2024","unstructured":"Xing B, Lei Z, Wang Z, Wang Q, Jiang Q, Zhang Z, et al. A disintegrin and metalloproteinase 22 activates integrin \u03b21 through its disintegrin domain to promote the progression of pituitary adenoma. Neuro Oncol. 2024;26(1):137\u201352. https:\/\/doi.org\/10.1093\/neuonc\/noad148.","journal-title":"Neuro Oncol"},{"issue":"7063","key":"646_CR142","doi-asserted-by":"publisher","first-page":"1257","DOI":"10.1038\/nature04284","volume":"437","author":"CB Saper","year":"2005","unstructured":"Saper CB, Scammell TE, Lu J. Hypothalamic regulation of sleep and circadian rhythms. Nature. 2005;437(7063):1257\u201363. https:\/\/doi.org\/10.1038\/nature04284.","journal-title":"Nature"},{"key":"646_CR143","doi-asserted-by":"publisher","first-page":"361","DOI":"10.1146\/annurev-pharmtox-010814-124742","volume":"56","author":"J Liu","year":"2016","unstructured":"Liu J, Clough SJ, Hutchinson AJ, Adamah-Biassi EB, Popovska-Gorevski M, Dubocovich ML. MT1 and MT2 melatonin receptors: a therapeutic perspective. Annu Rev Pharmacol Toxicol. 2016;56:361\u201383. https:\/\/doi.org\/10.1146\/annurev-pharmtox-010814-124742.","journal-title":"Annu Rev Pharmacol Toxicol"},{"issue":"7755","key":"646_CR144","doi-asserted-by":"publisher","first-page":"284","DOI":"10.1038\/s41586-019-1141-3","volume":"569","author":"B Stauch","year":"2019","unstructured":"Stauch B, Johansson LC, McCorvy JD, Patel N, Han GW, Huang XP, et al. Structural basis of ligand recognition at the human MT(1) melatonin receptor. Nature. 2019;569(7755):284\u20138. https:\/\/doi.org\/10.1038\/s41586-019-1141-3.","journal-title":"Nature"},{"key":"646_CR145","doi-asserted-by":"publisher","unstructured":"Vasey C, McBride J, Penta K. Circadian Rhythm Dysregulation and Restoration: The Role of Melatonin. Nutrients. 2021;13(10). https:\/\/doi.org\/10.3390\/nu13103480.","DOI":"10.3390\/nu13103480"},{"issue":"24","key":"646_CR146","doi-asserted-by":"publisher","first-page":"12019","DOI":"10.1073\/pnas.1901824116","volume":"116","author":"AJK Phillips","year":"2019","unstructured":"Phillips AJK, Vidafar P, Burns AC, McGlashan EM, Anderson C, Rajaratnam SMW, et al. High sensitivity and interindividual variability in the response of the human circadian system to evening light. Proc Natl Acad Sci U S A. 2019;116(24):12019\u201324. https:\/\/doi.org\/10.1073\/pnas.1901824116.","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"25","key":"646_CR147","doi-asserted-by":"publisher","first-page":"7222","DOI":"10.1016\/j.cell.2025.10.022","volume":"188","author":"C Wang","year":"2025","unstructured":"Wang C, Zhang N, Shao Y, Li T, Zhang M, Gao M, et al. Pathway-selective 5-HT(1A)R agonist as a rapid antidepressant strategy. Cell. 2025;188(25):7222\u201337.e24. https:\/\/doi.org\/10.1016\/j.cell.2025.10.022.","journal-title":"Cell"},{"issue":"6","key":"646_CR148","doi-asserted-by":"publisher","first-page":"448","DOI":"10.1161\/circulationaha.121.056076","volume":"145","author":"S Song","year":"2022","unstructured":"Song S, Tien CL, Cui H, Basil P, Zhu N, Gong Y, et al. Myocardial rev-erb-mediated diurnal metabolic rhythm and obesity paradox. Circulation. 2022;145(6):448\u201364. https:\/\/doi.org\/10.1161\/circulationaha.121.056076.","journal-title":"Circulation"},{"issue":"6509","key":"646_CR149","doi-asserted-by":"publisher","first-page":"1388","DOI":"10.1126\/science.aba8984","volume":"369","author":"D Guan","year":"2020","unstructured":"Guan D, Xiong Y, Trinh TM, Xiao Y, Hu W, Jiang C, et al. The hepatocyte clock and feeding control chronophysiology of multiple liver cell types. Science. 2020;369(6509):1388\u201394. https:\/\/doi.org\/10.1126\/science.aba8984.","journal-title":"Science"},{"issue":"72","key":"646_CR150","doi-asserted-by":"publisher","first-page":"eabm2465","DOI":"10.1126\/sciimmunol.abm2465","volume":"7","author":"C Wang","year":"2022","unstructured":"Wang C, Lutes LK, Barnoud C, Scheiermann C. The circadian immune system. Sci Immunol. 2022;7(72):eabm2465. https:\/\/doi.org\/10.1126\/sciimmunol.abm2465.","journal-title":"Sci Immunol"},{"issue":"11","key":"646_CR151","doi-asserted-by":"publisher","first-page":"5761","DOI":"10.1073\/pnas.1915773117","volume":"117","author":"EN Greenberg","year":"2020","unstructured":"Greenberg EN, Marshall ME, Jin S, Venkatesh S, Dragan M, Tsoi LC, et al. Circadian control of interferon-sensitive gene expression in murine skin. Proc Natl Acad Sci U S A. 2020;117(11):5761\u201371. https:\/\/doi.org\/10.1073\/pnas.1915773117.","journal-title":"Proc Natl Acad Sci U S A"},{"key":"646_CR152","doi-asserted-by":"publisher","first-page":"107753","DOI":"10.1016\/j.pharmthera.2020.107753","volume":"221","author":"Y Xiao","year":"2021","unstructured":"Xiao Y, Yu D. Tumor microenvironment as a therapeutic target in cancer. Pharmacol Ther. 2021;221:107753. https:\/\/doi.org\/10.1016\/j.pharmthera.2020.107753.","journal-title":"Pharmacol Ther"},{"key":"646_CR153","doi-asserted-by":"publisher","unstructured":"Arneth B. Tumor Microenvironment. Medicina (Kaunas). 2019;56(1). https:\/\/doi.org\/10.3390\/medicina56010015.","DOI":"10.3390\/medicina56010015"},{"issue":"11","key":"646_CR154","doi-asserted-by":"publisher","first-page":"940","DOI":"10.1016\/j.tcb.2021.06.008","volume":"31","author":"W Xuan","year":"2021","unstructured":"Xuan W, Khan F, James CD, Heimberger AB, Lesniak MS, Chen P. Circadian regulation of cancer cell and tumor microenvironment crosstalk. Trends Cell Biol. 2021;31(11):940\u201350. https:\/\/doi.org\/10.1016\/j.tcb.2021.06.008.","journal-title":"Trends Cell Biol"},{"issue":"2","key":"646_CR155","doi-asserted-by":"publisher","first-page":"112127","DOI":"10.1016\/j.celrep.2023.112127","volume":"42","author":"L Pang","year":"2023","unstructured":"Pang L, Dunterman M, Xuan W, Gonzalez A, Lin Y, Hsu WH, et al. Circadian regulator CLOCK promotes tumor angiogenesis in glioblastoma. Cell Rep. 2023;42(2):112127. https:\/\/doi.org\/10.1016\/j.celrep.2023.112127.","journal-title":"Cell Rep"},{"issue":"7297","key":"646_CR156","doi-asserted-by":"publisher","first-page":"483","DOI":"10.1038\/nature09002","volume":"465","author":"Y Wang","year":"2010","unstructured":"Wang Y, Nakayama M, Pitulescu ME, Schmidt TS, Bochenek ML, Sakakibara A, et al. Ephrin-B2 controls VEGF-induced angiogenesis and lymphangiogenesis. Nature. 2010;465(7297):483\u20136. https:\/\/doi.org\/10.1038\/nature09002.","journal-title":"Nature"},{"issue":"11","key":"646_CR157","doi-asserted-by":"publisher","first-page":"825","DOI":"10.1093\/jnci\/95.11.825","volume":"95","author":"ES Schernhammer","year":"2003","unstructured":"Schernhammer ES, Laden F, Speizer FE, Willett WC, Hunter DJ, Kawachi I, et al. Night-shift work and risk of colorectal cancer in the nurses\u2019 health study. J Natl Cancer Inst. 2003;95(11):825\u20138. https:\/\/doi.org\/10.1093\/jnci\/95.11.825.","journal-title":"J Natl Cancer Inst"},{"issue":"4","key":"646_CR158","doi-asserted-by":"publisher","first-page":"187","DOI":"10.1016\/j.it.2004.02.001","volume":"25","author":"RJ Nelson","year":"2004","unstructured":"Nelson RJ. Seasonal immune function and sickness responses. Trends Immunol. 2004;25(4):187\u201392. https:\/\/doi.org\/10.1016\/j.it.2004.02.001.","journal-title":"Trends Immunol"},{"issue":"6","key":"646_CR159","doi-asserted-by":"publisher","first-page":"770","DOI":"10.1158\/2326-6066.Cir-21-0559","volume":"10","author":"W Xuan","year":"2022","unstructured":"Xuan W, Hsu WH, Khan F, Dunterman M, Pang L, Wainwright DA, et al. Circadian regulator CLOCK drives Immunosuppression in Glioblastoma. Cancer Immunol Res. 2022;10(6):770\u201384. https:\/\/doi.org\/10.1158\/2326-6066.Cir-21-0559.","journal-title":"Cancer Immunol Res"},{"issue":"2","key":"646_CR160","doi-asserted-by":"publisher","first-page":"239","DOI":"10.1038\/s43018-025-00909-2","volume":"6","author":"R Jin","year":"2025","unstructured":"Jin R, Neufeld L, McGaha TL. Linking macrophage metabolism to function in the tumor microenvironment. Nat Cancer. 2025;6(2):239\u201352. https:\/\/doi.org\/10.1038\/s43018-025-00909-2.","journal-title":"Nat Cancer"},{"issue":"18","key":"646_CR161","doi-asserted-by":"publisher","first-page":"4557","DOI":"10.1158\/0008-5472.Can-18-3962","volume":"79","author":"DC Hinshaw","year":"2019","unstructured":"Hinshaw DC, Shevde LA. The tumor microenvironment innately modulates cancer progression. Cancer Res. 2019;79(18):4557\u201366. https:\/\/doi.org\/10.1158\/0008-5472.Can-18-3962.","journal-title":"Cancer Res"},{"issue":"2","key":"646_CR162","doi-asserted-by":"publisher","first-page":"R67","DOI":"10.1530\/erc-20-0390","volume":"28","author":"E Hadadi","year":"2021","unstructured":"Hadadi E, Acloque H. Role of circadian rhythm disorders on EMT and tumour-immune interactions in endocrine-related cancers. Endocr Relat Cancer. 2021;28(2):R67\u2013r80. https:\/\/doi.org\/10.1530\/erc-20-0390.","journal-title":"Endocr Relat Cancer"},{"key":"646_CR163","doi-asserted-by":"publisher","first-page":"1091218","DOI":"10.3389\/fimmu.2023.1091218","volume":"14","author":"H Chi","year":"2023","unstructured":"Chi H, Yang J, Peng G, Zhang J, Song G, Xie X, et al. Circadian rhythm-related genes index: A predictor for HNSCC prognosis, immunotherapy efficacy, and chemosensitivity. Front Immunol. 2023;14:1091218. https:\/\/doi.org\/10.3389\/fimmu.2023.1091218.","journal-title":"Front Immunol"},{"issue":"1","key":"646_CR164","doi-asserted-by":"publisher","first-page":"7217","DOI":"10.1038\/s41467-022-34897-z","volume":"13","author":"MP Cervantes-Silva","year":"2022","unstructured":"Cervantes-Silva MP, Carroll RG, Wilk MM, Moreira D, Payet CA, O\u2019Siorain JR, et al. The circadian clock influences T cell responses to vaccination by regulating dendritic cell antigen processing. Nat Commun. 2022;13(1):7217. https:\/\/doi.org\/10.1038\/s41467-022-34897-z.","journal-title":"Nat Commun"},{"key":"646_CR165","doi-asserted-by":"publisher","first-page":"2451","DOI":"10.3389\/fimmu.2019.02451","volume":"10","author":"Y Wu","year":"2019","unstructured":"Wu Y, Tao B, Zhang T, Fan Y, Mao R. Pan-cancer analysis reveals disrupted circadian clock associates with t cell exhaustion. Front Immunol. 2019;10:2451. https:\/\/doi.org\/10.3389\/fimmu.2019.02451.","journal-title":"Front Immunol"},{"issue":"1","key":"646_CR166","doi-asserted-by":"publisher","first-page":"41","DOI":"10.1038\/s41392-022-00899-y","volume":"7","author":"F Fagiani","year":"2022","unstructured":"Fagiani F, Di Marino D, Romagnoli A, Travelli C, Voltan D, Di Cesare ML, et al. Molecular regulations of circadian rhythm and implications for physiology and diseases. Signal Transduct Target Ther. 2022;7(1):41. https:\/\/doi.org\/10.1038\/s41392-022-00899-y.","journal-title":"Signal Transduct Target Ther"},{"issue":"12","key":"646_CR167","doi-asserted-by":"publisher","first-page":"5278","DOI":"10.1158\/0008-5472.Can-04-1853","volume":"65","author":"S Goswami","year":"2005","unstructured":"Goswami S, Sahai E, Wyckoff JB, Cammer M, Cox D, Pixley FJ, et al. Macrophages promote the invasion of breast carcinoma cells via a colony-stimulating factor-1\/epidermal growth factor paracrine loop. Cancer Res. 2005;65(12):5278\u201383. https:\/\/doi.org\/10.1158\/0008-5472.Can-04-1853.","journal-title":"Cancer Res"},{"issue":"19","key":"646_CR168","doi-asserted-by":"publisher","first-page":"7022","DOI":"10.1158\/0008-5472.Can-04-1449","volume":"64","author":"J Wyckoff","year":"2004","unstructured":"Wyckoff J, Wang W, Lin EY, Wang Y, Pixley F, Stanley ER, et al. A paracrine loop between tumor cells and macrophages is required for tumor cell migration in mammary tumors. Cancer Res. 2004;64(19):7022\u20139. https:\/\/doi.org\/10.1158\/0008-5472.Can-04-1449.","journal-title":"Cancer Res"},{"issue":"1","key":"646_CR169","doi-asserted-by":"publisher","first-page":"91","DOI":"10.1186\/s13045-021-01105-2","volume":"14","author":"Y Lei","year":"2021","unstructured":"Lei Y, Tang R, Xu J, Wang W, Zhang B, Liu J, et al. Applications of single-cell sequencing in cancer research: progress and perspectives. J Hematol Oncol. 2021;14(1):91. https:\/\/doi.org\/10.1186\/s13045-021-01105-2.","journal-title":"J Hematol Oncol"},{"issue":"10","key":"646_CR170","doi-asserted-by":"publisher","first-page":"935","DOI":"10.1631\/jzus.B2500455","volume":"26","author":"Y Shen","year":"2025","unstructured":"Shen Y, Zhao Y, Sun X, Ji G, Xu D, Wang Z. Circadian genes CLOCK and BMAL1 in cancer: mechanistic insights and therapeutic strategies. J Zhejiang Univ Sci B. 2025;26(10):935\u201348. https:\/\/doi.org\/10.1631\/jzus.B2500455.","journal-title":"J Zhejiang Univ Sci B"},{"key":"646_CR171","doi-asserted-by":"publisher","first-page":"517","DOI":"10.1146\/annurev-physiol-021909-135821","volume":"72","author":"C Dibner","year":"2010","unstructured":"Dibner C, Schibler U, Albrecht U. The mammalian circadian timing system: organization and coordination of central and peripheral clocks. Annu Rev Physiol. 2010;72:517\u201349. https:\/\/doi.org\/10.1146\/annurev-physiol-021909-135821.","journal-title":"Annu Rev Physiol"},{"key":"646_CR172","doi-asserted-by":"publisher","first-page":"142","DOI":"10.3181\/00379727-103-25439","volume":"103","author":"F Halberg","year":"1960","unstructured":"Halberg F, Johnson EA, Brown BW, Bittner JJ. Susceptibility rhythm to E. coli endotoxin and bioassay. Proc Soc Exp Biol Med. 1960;103:142\u20134. https:\/\/doi.org\/10.3181\/00379727-103-25439.","journal-title":"Proc Soc Exp Biol Med"},{"key":"646_CR173","doi-asserted-by":"publisher","DOI":"10.14336\/ad.2024.0533","author":"Y Zhu","year":"2024","unstructured":"Zhu Y, Zheng Y, Dai R, Gu X. Crosstalk between circadian rhythm dysregulation and tumorigenesis, tumor metabolism and tumor immune response. Aging Dis. 2024. https:\/\/doi.org\/10.14336\/ad.2024.0533.","journal-title":"Aging Dis"},{"issue":"9","key":"646_CR174","doi-asserted-by":"publisher","first-page":"4168","DOI":"10.7150\/thno.43834","volume":"10","author":"S Wang","year":"2020","unstructured":"Wang S, Li F, Lin Y, Wu B. Targeting REV-ERB\u03b1 for therapeutic purposes: promises and challenges. Theranostics. 2020;10(9):4168\u201382. https:\/\/doi.org\/10.7150\/thno.43834.","journal-title":"Theranostics"},{"issue":"1","key":"646_CR175","doi-asserted-by":"publisher","first-page":"115","DOI":"10.1146\/annurev-psych-022824-043825","volume":"76","author":"C Cajochen","year":"2025","unstructured":"Cajochen C, Schmidt C. The circadian brain and cognition. Annu Rev Psychol. 2025;76(1):115\u201341. https:\/\/doi.org\/10.1146\/annurev-psych-022824-043825.","journal-title":"Annu Rev Psychol"},{"key":"646_CR176","doi-asserted-by":"publisher","first-page":"139","DOI":"10.1146\/annurev.psych.56.091103.070307","volume":"57","author":"MP Walker","year":"2006","unstructured":"Walker MP, Stickgold R. Sleep, memory, and plasticity. Annu Rev Psychol. 2006;57:139\u201366. https:\/\/doi.org\/10.1146\/annurev.psych.56.091103.070307.","journal-title":"Annu Rev Psychol"},{"issue":"2","key":"646_CR177","doi-asserted-by":"publisher","first-page":"170","DOI":"10.1016\/j.ceb.2013.01.003","volume":"25","author":"L Aguilar-Arnal","year":"2013","unstructured":"Aguilar-Arnal L, Sassone-Corsi P. The circadian epigenome: how metabolism talks to chromatin remodeling. Curr Opin Cell Biol. 2013;25(2):170\u20136. https:\/\/doi.org\/10.1016\/j.ceb.2013.01.003.","journal-title":"Curr Opin Cell Biol"},{"key":"646_CR178","doi-asserted-by":"publisher","unstructured":"Munteanu C, Turti S, Achim L, Muresan R, Souca M, Prifti E et al. The Relationship between Circadian Rhythm and Cancer Disease. Int J Mol Sci. 2024;25(11). https:\/\/doi.org\/10.3390\/ijms25115846.","DOI":"10.3390\/ijms25115846"},{"issue":"6695","key":"646_CR179","doi-asserted-by":"publisher","first-page":"563","DOI":"10.1126\/science.adj8533","volume":"384","author":"A Kumar","year":"2024","unstructured":"Kumar A, Vaca-Dempere M, Mortimer T, Deryagin O, Smith JG, Petrus P, et al. Brain-muscle communication prevents muscle aging by maintaining daily physiology. Science. 2024;384(6695):563\u201372. https:\/\/doi.org\/10.1126\/science.adj8533.","journal-title":"Science"},{"key":"646_CR180","doi-asserted-by":"publisher","unstructured":"Liao J, Wang Y, Li J, Li P, Liu Y, Wu J et al. Circadian disruption induces cognitive impairment through tryptophan-5-HT metabolic pathway dysregulation. Sleep. 2026;49(2). https:\/\/doi.org\/10.1093\/sleep\/zsaf258.","DOI":"10.1093\/sleep\/zsaf258"},{"issue":"12","key":"646_CR181","doi-asserted-by":"publisher","first-page":"2233","DOI":"10.1021\/acschemneuro.1c00238","volume":"12","author":"A Sharma","year":"2021","unstructured":"Sharma A, Mohammad A, Saini AK, Goyal R. Neuroprotective effects of fluoxetine on molecular markers of circadian rhythm, cognitive deficits, oxidative damage, and biomarkers of Alzheimer\u2019s disease-like pathology induced under chronic constant light regime in wistar rats. ACS Chem Neurosci. 2021;12(12):2233\u201346. https:\/\/doi.org\/10.1021\/acschemneuro.1c00238.","journal-title":"ACS Chem Neurosci"},{"key":"646_CR182","doi-asserted-by":"publisher","first-page":"12","DOI":"10.1016\/j.neuroscience.2024.08.008","volume":"557","author":"J Chen","year":"2024","unstructured":"Chen J, Peng G, Sun B. Alzheimer\u2019s disease and sleep disorders: A bidirectional relationship. Neuroscience. 2024;557:12\u201323. https:\/\/doi.org\/10.1016\/j.neuroscience.2024.08.008.","journal-title":"Neuroscience"},{"issue":"1","key":"646_CR183","doi-asserted-by":"publisher","first-page":"159","DOI":"10.1016\/j.jsmc.2023.10.003","volume":"19","author":"AS Eiser","year":"2024","unstructured":"Eiser AS. Sleep-related dissociative disorders. Sleep Med Clin. 2024;19(1):159\u201367. https:\/\/doi.org\/10.1016\/j.jsmc.2023.10.003.","journal-title":"Sleep Med Clin"},{"issue":"12","key":"646_CR184","doi-asserted-by":"publisher","first-page":"2233","DOI":"10.2174\/1570159x19666210517115706","volume":"19","author":"R Taximaimaiti","year":"2021","unstructured":"Taximaimaiti R, Luo X, Wang XP. Pharmacological and non-pharmacological treatments of sleep disorders in Parkinson\u2019s disease. Curr Neuropharmacol. 2021;19(12):2233\u201349. https:\/\/doi.org\/10.2174\/1570159x19666210517115706.","journal-title":"Curr Neuropharmacol"},{"issue":"3-4","key":"646_CR185","doi-asserted-by":"publisher","first-page":"161","DOI":"10.1080\/21678421.2020.1844755","volume":"22","author":"D Lucia","year":"2021","unstructured":"Lucia D, McCombe PA, Henderson RD, Ngo ST. Disorders of sleep and wakefulness in amyotrophic lateral sclerosis (ALS): a systematic review. Amyotroph Lateral Scler Frontotemporal Degener. 2021;22(3\u20134):161\u20139. https:\/\/doi.org\/10.1080\/21678421.2020.1844755.","journal-title":"Amyotroph Lateral Scler Frontotemporal Degener"},{"key":"646_CR186","doi-asserted-by":"publisher","first-page":"151","DOI":"10.2147\/nss.S134864","volume":"9","author":"G Medic","year":"2017","unstructured":"Medic G, Wille M, Hemels ME. Short- and long-term health consequences of sleep disruption. Nat Sci Sleep. 2017;9:151\u201361. https:\/\/doi.org\/10.2147\/nss.S134864.","journal-title":"Nat Sci Sleep"},{"issue":"7","key":"646_CR187","doi-asserted-by":"publisher","first-page":"860","DOI":"10.1016\/j.cjca.2015.01.015","volume":"31","author":"FJ Alibhai","year":"2015","unstructured":"Alibhai FJ, Tsimakouridze EV, Reitz CJ, Pyle WG, Martino TA. Consequences of circadian and sleep disturbances for the cardiovascular system. Can J Cardiol. 2015;31(7):860\u201372. https:\/\/doi.org\/10.1016\/j.cjca.2015.01.015.","journal-title":"Can J Cardiol"},{"key":"646_CR188","doi-asserted-by":"publisher","first-page":"1175483","DOI":"10.3389\/fmed.2023.1175483","volume":"10","author":"H Alqaderi","year":"2023","unstructured":"Alqaderi H, Abdullah A, Finkelman M, Abufarha M, Devarajan S, Abubaker J, et al. The relationship between sleep and salivary and serum inflammatory biomarkers in adolescents. Front Med (Lausanne). 2023;10:1175483. https:\/\/doi.org\/10.3389\/fmed.2023.1175483.","journal-title":"Front Med (Lausanne)"},{"key":"646_CR189","doi-asserted-by":"publisher","unstructured":"Palomino-Segura M, Hidalgo A. Circadian immune circuits. J Exp Med. 2021;218(2). https:\/\/doi.org\/10.1084\/jem.20200798.","DOI":"10.1084\/jem.20200798"},{"issue":"5","key":"646_CR190","doi-asserted-by":"publisher","first-page":"744","DOI":"10.1111\/iej.14201","volume":"58","author":"L Ye","year":"2025","unstructured":"Ye L, Mei G, Liu H, Zhong R, Tang Q, Yuan Z. Circadian rhythm disruption aggravates alveolar bone loss in rat apical periodontitis. Int Endod J. 2025;58(5):744\u201356. https:\/\/doi.org\/10.1111\/iej.14201.","journal-title":"Int Endod J"},{"key":"646_CR191","doi-asserted-by":"publisher","first-page":"103516","DOI":"10.1016\/j.jaut.2025.103516","volume":"158","author":"T Tian","year":"2026","unstructured":"Tian T, Rao L, Wei M, Du J, Gu Y, Wu X, et al. Circadian clock genes: Potential therapeutic targets for autoimmune diseases. J Autoimmun. 2026;158:103516. https:\/\/doi.org\/10.1016\/j.jaut.2025.103516.","journal-title":"J Autoimmun"},{"issue":"8","key":"646_CR192","doi-asserted-by":"publisher","first-page":"1689","DOI":"10.1016\/j.cell.2023.02.002","volume":"186","author":"F Winkler","year":"2023","unstructured":"Winkler F, Venkatesh HS, Amit M, Batchelor T, Demir IE, Deneen B, et al. Cancer neuroscience: State of the field, emerging directions. Cell. 2023;186(8):1689\u2013707. https:\/\/doi.org\/10.1016\/j.cell.2023.02.002.","journal-title":"Cell"},{"issue":"1","key":"646_CR193","doi-asserted-by":"publisher","first-page":"93","DOI":"10.1007\/s12264-024-01238-7","volume":"41","author":"X Li","year":"2025","unstructured":"Li X, Ye C, Wang M, Kwan P, Tian X, Zhang Y. Crosstalk between the nervous system and colorectal cancer. Neurosci Bull. 2025;41(1):93\u2013106. https:\/\/doi.org\/10.1007\/s12264-024-01238-7.","journal-title":"Neurosci Bull"},{"key":"646_CR194","doi-asserted-by":"publisher","first-page":"217492","DOI":"10.1016\/j.canlet.2025.217492","volume":"612","author":"Y Huang","year":"2025","unstructured":"Huang Y, Zhou X, Liu J, Cao Y, Fu W, Yang J. Emerging neuroimmune mechanisms in cancer neuroscience. Cancer Lett. 2025;612:217492. https:\/\/doi.org\/10.1016\/j.canlet.2025.217492.","journal-title":"Cancer Lett"},{"key":"646_CR195","doi-asserted-by":"publisher","unstructured":"Zhang S, Yuan L, Lin P, Yang G, Zhou X, Xu J et al. Cancer neuroscience: signaling pathways and new therapeutic strategies for cancer. Signal Transduct Target Ther. 2026;11(1). https:\/\/doi.org\/10.1038\/s41392-025-02364-y.","DOI":"10.1038\/s41392-025-02364-y"},{"issue":"1","key":"646_CR196","doi-asserted-by":"publisher","first-page":"101","DOI":"10.1186\/s12943-025-02299-6","volume":"24","author":"H Wang","year":"2025","unstructured":"Wang H, Song X, Shen H, Liu W, Wang Y, Zhang M, et al. Cancer neuroscience in head and neck: interactions, modulation, and therapeutic strategies. Mol Cancer. 2025;24(1):101. https:\/\/doi.org\/10.1186\/s12943-025-02299-6.","journal-title":"Mol Cancer"},{"issue":"2","key":"646_CR197","doi-asserted-by":"publisher","first-page":"219","DOI":"10.1016\/j.cell.2020.03.034","volume":"181","author":"M Monje","year":"2020","unstructured":"Monje M, Borniger JC, D\u2019Silva NJ, Deneen B, Dirks PB, Fattahi F, et al. Roadmap for the Emerging Field of Cancer Neuroscience. Cell. 2020;181(2):219\u201322. https:\/\/doi.org\/10.1016\/j.cell.2020.03.034.","journal-title":"Cell"},{"issue":"7971","key":"646_CR198","doi-asserted-by":"publisher","first-page":"844","DOI":"10.1038\/s41586-023-06267-2","volume":"619","author":"E Huang-Hobbs","year":"2023","unstructured":"Huang-Hobbs E, Cheng YT, Ko Y, Luna-Figueroa E, Lozzi B, Taylor KR, et al. Remote neuronal activity drives glioma progression through SEMA4F. Nature. 2023;619(7971):844\u201350. https:\/\/doi.org\/10.1038\/s41586-023-06267-2.","journal-title":"Nature"},{"issue":"4","key":"646_CR199","doi-asserted-by":"publisher","first-page":"117","DOI":"10.1007\/s12032-025-02641-4","volume":"42","author":"DD Shah","year":"2025","unstructured":"Shah DD, Chorawala MR, Raghani NR, Patel R, Fareed M, Kashid VA, et al. Tumor microenvironment: recent advances in understanding and its role in modulating cancer therapies. Med Oncol. 2025;42(4):117. https:\/\/doi.org\/10.1007\/s12032-025-02641-4.","journal-title":"Med Oncol"},{"issue":"1","key":"646_CR200","doi-asserted-by":"publisher","first-page":"2785","DOI":"10.1038\/s41467-022-30466-6","volume":"13","author":"C Anastasaki","year":"2022","unstructured":"Anastasaki C, Mo J, Chen JK, Chatterjee J, Pan Y, Scheaffer SM, et al. Neuronal hyperexcitability drives central and peripheral nervous system tumor progression in models of neurofibromatosis-1. Nat Commun. 2022;13(1):2785. https:\/\/doi.org\/10.1038\/s41467-022-30466-6.","journal-title":"Nat Commun"},{"key":"646_CR201","doi-asserted-by":"publisher","first-page":"106555","DOI":"10.1016\/j.phrs.2022.106555","volume":"187","author":"F Li","year":"2023","unstructured":"Li F, He C, Yao H, Zhao Y, Ye X, Zhou S, et al. Glutamate from nerve cells promotes perineural invasion in pancreatic cancer by regulating tumor glycolysis through HK2 mRNA-m6A modification. Pharmacol Res. 2023;187:106555. https:\/\/doi.org\/10.1016\/j.phrs.2022.106555.","journal-title":"Pharmacol Res"},{"issue":"2","key":"646_CR202","doi-asserted-by":"publisher","first-page":"e62","DOI":"10.1016\/s1470-2045(21)00596-9","volume":"23","author":"DD Shi","year":"2022","unstructured":"Shi DD, Guo JA, Hoffman HI, Su J, Mino-Kenudson M, Barth JL, et al. Therapeutic avenues for cancer neuroscience: translational frontiers and clinical opportunities. Lancet Oncol. 2022;23(2):e62\u201374. https:\/\/doi.org\/10.1016\/s1470-2045(21)00596-9.","journal-title":"Lancet Oncol"},{"issue":"7775","key":"646_CR203","doi-asserted-by":"publisher","first-page":"526","DOI":"10.1038\/s41586-019-1576-6","volume":"573","author":"Q Zeng","year":"2019","unstructured":"Zeng Q, Michael IP, Zhang P, Saghafinia S, Knott G, Jiao W, et al. Synaptic proximity enables NMDAR signalling to promote brain metastasis. Nature. 2019;573(7775):526\u201331. https:\/\/doi.org\/10.1038\/s41586-019-1576-6.","journal-title":"Nature"},{"issue":"7965","key":"646_CR204","doi-asserted-by":"publisher","first-page":"467","DOI":"10.1038\/s41586-023-05968-y","volume":"618","author":"R Mancusi","year":"2023","unstructured":"Mancusi R, Monje M. The neuroscience of cancer. Nature. 2023;618(7965):467\u201379. https:\/\/doi.org\/10.1038\/s41586-023-05968-y.","journal-title":"Nature"},{"key":"646_CR205","doi-asserted-by":"publisher","first-page":"1077","DOI":"10.3389\/fonc.2019.01077","volume":"9","author":"CB Colon-Echevarria","year":"2019","unstructured":"Colon-Echevarria CB, Lamboy-Caraballo R, Aquino-Acevedo AN, Armaiz-Pena GN. Neuroendocrine regulation of tumor-associated immune cells. Front Oncol. 2019;9:1077. https:\/\/doi.org\/10.3389\/fonc.2019.01077.","journal-title":"Front Oncol"},{"key":"646_CR206","doi-asserted-by":"publisher","first-page":"368","DOI":"10.1016\/j.bbi.2020.11.005","volume":"93","author":"B Cui","year":"2021","unstructured":"Cui B, Peng F, Lu J, He B, Su Q, Luo H, et al. Cancer and stress: NextGen strategies. Brain Behav Immun. 2021;93:368\u201383. https:\/\/doi.org\/10.1016\/j.bbi.2020.11.005.","journal-title":"Brain Behav Immun"},{"key":"646_CR207","doi-asserted-by":"publisher","first-page":"101409","DOI":"10.1016\/j.smrv.2020.101409","volume":"56","author":"MP Mogavero","year":"2021","unstructured":"Mogavero MP, DelRosso LM, Fanfulla F, Bruni O, Ferri R. Sleep disorders and cancer: State of the art and future perspectives. Sleep Med Rev. 2021;56:101409. https:\/\/doi.org\/10.1016\/j.smrv.2020.101409.","journal-title":"Sleep Med Rev"},{"issue":"1","key":"646_CR208","doi-asserted-by":"publisher","first-page":"178","DOI":"10.2741\/s533","volume":"11","author":"P Rida","year":"2019","unstructured":"Rida P, Syed MI, Aneja R. Time will tell: Circadian clock dysregulation in triple negative breast cancer. Front Biosci (Schol Ed). 2019;11(1):178\u201392. https:\/\/doi.org\/10.2741\/s533.","journal-title":"Front Biosci (Schol Ed)"},{"issue":"9","key":"646_CR209","doi-asserted-by":"publisher","first-page":"1816","DOI":"10.7150\/ijbs.35520","volume":"15","author":"S Khan","year":"2019","unstructured":"Khan S, Liu Y, Siddique R, Nabi G, Xue M, Hou H. Impact of chronically alternating light-dark cycles on circadian clock mediated expression of cancer (glioma)-related genes in the brain. Int J Biol Sci. 2019;15(9):1816\u201334. https:\/\/doi.org\/10.7150\/ijbs.35520.","journal-title":"Int J Biol Sci"},{"key":"646_CR210","doi-asserted-by":"publisher","first-page":"17","DOI":"10.1016\/j.freeradbiomed.2017.11.023","volume":"119","author":"C Kinoshita","year":"2018","unstructured":"Kinoshita C, Aoyama K, Nakaki T. Neuroprotection afforded by circadian regulation of intracellular glutathione levels: a key role for miRNAs. Free Radic Biol Med. 2018;119:17\u201333. https:\/\/doi.org\/10.1016\/j.freeradbiomed.2017.11.023.","journal-title":"Free Radic Biol Med"},{"key":"646_CR211","doi-asserted-by":"publisher","unstructured":"Lim JC, Suzuki-Kerr H, Nguyen TX, Lim CJJ, Poulsen RC. Redox homeostasis in ocular tissues: circadian regulation of glutathione in the lens? Antioxidants (Basel). 2022;11(8). https:\/\/doi.org\/10.3390\/antiox11081516.","DOI":"10.3390\/antiox11081516"},{"issue":"6","key":"646_CR212","doi-asserted-by":"publisher","first-page":"548","DOI":"10.1101\/gad.237081.113","volume":"28","author":"V Pekovic-Vaughan","year":"2014","unstructured":"Pekovic-Vaughan V, Gibbs J, Yoshitane H, Yang N, Pathiranage D, Guo B, et al. The circadian clock regulates rhythmic activation of the NRF2\/glutathione-mediated antioxidant defense pathway to modulate pulmonary fibrosis. Genes Dev. 2014;28(6):548\u201360. https:\/\/doi.org\/10.1101\/gad.237081.113.","journal-title":"Genes Dev"},{"issue":"1","key":"646_CR213","doi-asserted-by":"publisher","first-page":"16960","DOI":"10.1038\/s41598-024-67559-9","volume":"14","author":"W Hou","year":"2024","unstructured":"Hou W, Hou W, Zhao X. Exploring transcriptomic databases: unraveling circadian gene disruptions in lower grade glioma. Sci Rep. 2024;14(1):16960. https:\/\/doi.org\/10.1038\/s41598-024-67559-9.","journal-title":"Sci Rep"},{"key":"646_CR214","doi-asserted-by":"publisher","first-page":"864","DOI":"10.3389\/fphys.2017.00864","volume":"8","author":"JM Duhart","year":"2017","unstructured":"Duhart JM, Brocardo L, Caldart CS, Marpegan L, Golombek DA. Circadian alterations in a murine model of hypothalamic glioma. Front Physiol. 2017;8:864. https:\/\/doi.org\/10.3389\/fphys.2017.00864.","journal-title":"Front Physiol"},{"issue":"1","key":"646_CR215","doi-asserted-by":"publisher","first-page":"82","DOI":"10.1186\/s13073-019-0704-0","volume":"11","author":"F Rijo-Ferreira","year":"2019","unstructured":"Rijo-Ferreira F, Takahashi JS. Genomics of circadian rhythms in health and disease. Genome Med. 2019;11(1):82. https:\/\/doi.org\/10.1186\/s13073-019-0704-0.","journal-title":"Genome Med"},{"issue":"9","key":"646_CR216","doi-asserted-by":"publisher","first-page":"e2416757122","DOI":"10.1073\/pnas.2416757122","volume":"122","author":"Y Gao","year":"2025","unstructured":"Gao Y, Sun M, Fu T, Wang Z, Jiang X, Yang L, et al. NOTCH, ERK, and SHH signaling respectively control the fate determination of cortical glia and olfactory bulb interneurons. Proc Natl Acad Sci U S A. 2025;122(9):e2416757122. https:\/\/doi.org\/10.1073\/pnas.2416757122.","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"1","key":"646_CR217","doi-asserted-by":"publisher","first-page":"122","DOI":"10.1016\/j.ccell.2024.12.006","volume":"43","author":"J Gao","year":"2025","unstructured":"Gao J, Gu D, Yang K, Zhang J, Lin Q, Yuan W, et al. Infiltrating plasma cells maintain glioblastoma stem cells through IgG-Tumor binding. Cancer Cell. 2025;43(1):122\u201343.e8. https:\/\/doi.org\/10.1016\/j.ccell.2024.12.006.","journal-title":"Cancer Cell"},{"issue":"6","key":"646_CR218","doi-asserted-by":"publisher","first-page":"2133","DOI":"10.1172\/jci46043","volume":"121","author":"W Huang","year":"2011","unstructured":"Huang W, Ramsey KM, Marcheva B, Bass J. Circadian rhythms, sleep, and metabolism. J Clin Invest. 2011;121(6):2133\u201341. https:\/\/doi.org\/10.1172\/jci46043.","journal-title":"J Clin Invest"},{"issue":"12","key":"646_CR219","doi-asserted-by":"publisher","first-page":"1930","DOI":"10.1111\/cns.13966","volume":"28","author":"Z Wang","year":"2022","unstructured":"Wang Z, Chen G. Insights about circadian clock in glioma: From molecular pathways to therapeutic drugs. CNS Neurosci Ther. 2022;28(12):1930\u201341. https:\/\/doi.org\/10.1111\/cns.13966.","journal-title":"CNS Neurosci Ther"},{"key":"646_CR220","doi-asserted-by":"publisher","first-page":"123","DOI":"10.1146\/annurev-neuro-100322-112249","volume":"46","author":"MH Hastings","year":"2023","unstructured":"Hastings MH, Brancaccio M, Gonzalez-Aponte MF, Herzog ED. Circadian rhythms and astrocytes: the good, the bad, and the ugly. Annu Rev Neurosci. 2023;46:123\u201343. https:\/\/doi.org\/10.1146\/annurev-neuro-100322-112249.","journal-title":"Annu Rev Neurosci"},{"issue":"7775","key":"646_CR221","doi-asserted-by":"publisher","first-page":"539","DOI":"10.1038\/s41586-019-1563-y","volume":"573","author":"HS Venkatesh","year":"2019","unstructured":"Venkatesh HS, Morishita W, Geraghty AC, Silverbush D, Gillespie SM, Arzt M, et al. Electrical and synaptic integration of glioma into neural circuits. Nature. 2019;573(7775):539\u201345. https:\/\/doi.org\/10.1038\/s41586-019-1563-y.","journal-title":"Nature"},{"issue":"7775","key":"646_CR222","doi-asserted-by":"publisher","first-page":"532","DOI":"10.1038\/s41586-019-1564-x","volume":"573","author":"V Venkataramani","year":"2019","unstructured":"Venkataramani V, Tanev DI, Strahle C, Studier-Fischer A, Fankhauser L, Kessler T, et al. Glutamatergic synaptic input to glioma cells drives brain tumour progression. Nature. 2019;573(7775):532\u20138. https:\/\/doi.org\/10.1038\/s41586-019-1564-x.","journal-title":"Nature"},{"issue":"1","key":"646_CR223","doi-asserted-by":"publisher","first-page":"86","DOI":"10.1016\/j.cell.2013.02.051","volume":"153","author":"L Li","year":"2013","unstructured":"Li L, Hanahan D. Hijacking the neuronal NMDAR signaling circuit to promote tumor growth and invasion. Cell. 2013;153(1):86\u2013100. https:\/\/doi.org\/10.1016\/j.cell.2013.02.051.","journal-title":"Cell"},{"issue":"7","key":"646_CR224","doi-asserted-by":"publisher","first-page":"2291","DOI":"10.1083\/jcb.201804161","volume":"217","author":"A Bansal","year":"2018","unstructured":"Bansal A, Simon MC. Glutathione metabolism in cancer progression and treatment resistance. J Cell Biol. 2018;217(7):2291\u20138. https:\/\/doi.org\/10.1083\/jcb.201804161.","journal-title":"J Cell Biol"},{"issue":"1","key":"646_CR225","doi-asserted-by":"publisher","first-page":"19","DOI":"10.1096\/fj.00-0445fje","volume":"15","author":"ZZ Huang","year":"2001","unstructured":"Huang ZZ, Chen C, Zeng Z, Yang H, Oh J, Chen L, et al. Mechanism and significance of increased glutathione level in human hepatocellular carcinoma and liver regeneration. Faseb j. 2001;15(1):19\u201321. https:\/\/doi.org\/10.1096\/fj.00-0445fje.","journal-title":"Faseb j"},{"issue":"40","key":"646_CR226","doi-asserted-by":"publisher","first-page":"e2203936119","DOI":"10.1073\/pnas.2203936119","volume":"119","author":"S Miller","year":"2022","unstructured":"Miller S, Kesherwani M, Chan P, Nagai Y, Yagi M, Cope J, et al. CRY2 isoform selectivity of a circadian clock modulator with antiglioblastoma efficacy. Proc Natl Acad Sci U S A. 2022;119(40):e2203936119. https:\/\/doi.org\/10.1073\/pnas.2203936119.","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"45","key":"646_CR227","doi-asserted-by":"publisher","first-page":"16219","DOI":"10.1073\/pnas.1408886111","volume":"111","author":"R Zhang","year":"2014","unstructured":"Zhang R, Lahens NF, Ballance HI, Hughes ME, Hogenesch JB. A circadian gene expression atlas in mammals: implications for biology and medicine. Proc Natl Acad Sci U S A. 2014;111(45):16219\u201324. https:\/\/doi.org\/10.1073\/pnas.1408886111.","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"6","key":"646_CR228","doi-asserted-by":"publisher","first-page":"840","DOI":"10.1038\/s41588-021-00852-9","volume":"53","author":"J Chen","year":"2021","unstructured":"Chen J, Spracklen CN, Marenne G, Varshney A, Corbin LJ, Luan J, et al. The trans-ancestral genomic architecture of glycemic traits. Nat Genet. 2021;53(6):840\u201360. https:\/\/doi.org\/10.1038\/s41588-021-00852-9.","journal-title":"Nat Genet"},{"issue":"6787","key":"646_CR229","doi-asserted-by":"publisher","first-page":"eaea3381","DOI":"10.1126\/science.aea3381","volume":"391","author":"K Yamashita","year":"2026","unstructured":"Yamashita K, Kinoshita FL, Yoshida SY, Matsumoto K, Mitani TT, Fujishima H, et al. A whole-brain single-cell atlas of circadian neural activity in mice. Science. 2026;391(6787):eaea3381. https:\/\/doi.org\/10.1126\/science.aea3381.","journal-title":"Science"},{"issue":"4","key":"646_CR230","doi-asserted-by":"publisher","first-page":"775","DOI":"10.1016\/j.cell.2018.11.043","volume":"176","author":"H Li","year":"2019","unstructured":"Li H, van der Leun AM, Yofe I, Lubling Y, Gelbard-Solodkin D, van Akkooi ACJ, et al. Dysfunctional CD8 T cells form a proliferative, dynamically regulated compartment within human melanoma. Cell. 2019;176(4):775\u201389.e18. https:\/\/doi.org\/10.1016\/j.cell.2018.11.043.","journal-title":"Cell"},{"key":"646_CR231","doi-asserted-by":"publisher","first-page":"53","DOI":"10.1007\/978-981-15-6082-8_5","volume":"1276","author":"X Pan","year":"2020","unstructured":"Pan X, Mota S, Zhang B. Circadian clock regulation on lipid metabolism and metabolic diseases. Adv Exp Med Biol. 2020;1276:53\u201366. https:\/\/doi.org\/10.1007\/978-981-15-6082-8_5.","journal-title":"Adv Exp Med Biol"},{"key":"646_CR232","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1016\/j.metabol.2017.11.017","volume":"84","author":"E Poggiogalle","year":"2018","unstructured":"Poggiogalle E, Jamshed H, Peterson CM. Circadian regulation of glucose, lipid, and energy metabolism in humans. Metabolism. 2018;84:11\u201327. https:\/\/doi.org\/10.1016\/j.metabol.2017.11.017.","journal-title":"Metabolism"},{"issue":"1","key":"646_CR233","doi-asserted-by":"publisher","first-page":"147","DOI":"10.1158\/1078-0432.Ccr-19-1834","volume":"26","author":"R Juthani","year":"2020","unstructured":"Juthani R, Madajewski B, Yoo B, Zhang L, Chen PM, Chen F, et al. Ultrasmall core-shell silica nanoparticles for precision drug delivery in a high-grade malignant brain tumor model. Clin Cancer Res. 2020;26(1):147\u201358. https:\/\/doi.org\/10.1158\/1078-0432.Ccr-19-1834.","journal-title":"Clin Cancer Res"},{"key":"646_CR234","doi-asserted-by":"publisher","first-page":"475","DOI":"10.2147\/itt.S499806","volume":"14","author":"Y Tao","year":"2025","unstructured":"Tao Y, Li J, Pan J, Wang Q, Ke RW, Yuan D, et al. Integration of scRNA-Seq and Bulk RNA-Seq identifies circadian rhythm disruption-related genes associated with prognosis and drug resistance in colorectal cancer patients. Immunotargets Ther. 2025;14:475\u201389. https:\/\/doi.org\/10.2147\/itt.S499806.","journal-title":"Immunotargets Ther"},{"issue":"1","key":"646_CR235","doi-asserted-by":"publisher","first-page":"138","DOI":"10.1186\/s40364-025-00852-5","volume":"13","author":"ZH Shang","year":"2025","unstructured":"Shang ZH, Zhang QC, Xi SY, Chen K, Guo SB, Zhou Z, et al. NONO links circadian rhythm disruption and enhanced tumor-fibroblast crosstalk in right-sided colorectal cancer. Biomark Res. 2025;13(1):138. https:\/\/doi.org\/10.1186\/s40364-025-00852-5.","journal-title":"Biomark Res"},{"issue":"1","key":"646_CR236","doi-asserted-by":"publisher","first-page":"3840","DOI":"10.1038\/s41467-024-48041-6","volume":"15","author":"J Duan","year":"2024","unstructured":"Duan J, Ngo MN, Karri SS, Tsoi LC, Gudjonsson JE, Shahbaba B, et al. tauFisher predicts circadian time from a single sample of bulk and single-cell pseudobulk transcriptomic data. Nat Commun. 2024;15(1):3840. https:\/\/doi.org\/10.1038\/s41467-024-48041-6.","journal-title":"Nat Commun"},{"key":"646_CR237","doi-asserted-by":"publisher","first-page":"369","DOI":"10.3389\/fnins.2017.00369","volume":"11","author":"KA Dyar","year":"2017","unstructured":"Dyar KA, Eckel-Mahan KL. Circadian Metabolomics in Time and Space. Front Neurosci. 2017;11:369. https:\/\/doi.org\/10.3389\/fnins.2017.00369.","journal-title":"Front Neurosci"},{"issue":"17","key":"646_CR238","doi-asserted-by":"publisher","first-page":"4549","DOI":"10.1016\/j.cell.2025.06.039","volume":"188","author":"D Kaltenecker","year":"2025","unstructured":"Kaltenecker D, Fisker Schmidt S, Weber P, Loft A, Morigny P, Machado J, et al. Functional liver genomics identifies hepatokines promoting wasting in cancer cachexia. Cell. 2025;188(17):4549\u201366.e22. https:\/\/doi.org\/10.1016\/j.cell.2025.06.039.","journal-title":"Cell"},{"issue":"1","key":"646_CR239","doi-asserted-by":"publisher","first-page":"108","DOI":"10.1080\/07420528.2024.2446622","volume":"42","author":"A Natarajan","year":"2025","unstructured":"Natarajan A, Gleichauf K, Khalid M, Heneghan C, Schneider LD. Circadian rhythm of heart rate and activity: a cross-sectional study. Chronobiol Int. 2025;42(1):108\u201321. https:\/\/doi.org\/10.1080\/07420528.2024.2446622.","journal-title":"Chronobiol Int"},{"key":"646_CR240","doi-asserted-by":"publisher","first-page":"214","DOI":"10.1109\/icc51166.2024.10622995","volume":"2024","author":"Y Song","year":"2024","unstructured":"Song Y, Li B, Luo D, Brewster Glasgow GS, Phillips BG, Ke Y, et al. Real-time continuous blood pressure estimation with contact-free bedseismogram. IEEE Int Conf Commun. 2024;2024:214\u20139. https:\/\/doi.org\/10.1109\/icc51166.2024.10622995.","journal-title":"IEEE Int Conf Commun"},{"issue":"1","key":"646_CR241","doi-asserted-by":"publisher","first-page":"197","DOI":"10.1038\/s41386-020-00830-5","volume":"46","author":"GP Dunster","year":"2021","unstructured":"Dunster GP, Swendsen J, Merikangas KR. Real-time mobile monitoring of bipolar disorder: a review of evidence and future directions. Neuropsychopharmacology. 2021;46(1):197\u2013208. https:\/\/doi.org\/10.1038\/s41386-020-00830-5.","journal-title":"Neuropsychopharmacology"},{"issue":"11","key":"646_CR242","doi-asserted-by":"publisher","first-page":"1216","DOI":"10.1017\/s0007114519003428","volume":"123","author":"F Zeb","year":"2020","unstructured":"Zeb F, Wu X, Chen L, Fatima S, Haq IU, Chen A, et al. Effect of time-restricted feeding on metabolic risk and circadian rhythm associated with gut microbiome in healthy males. Br J Nutr. 2020;123(11):1216\u201326. https:\/\/doi.org\/10.1017\/s0007114519003428.","journal-title":"Br J Nutr"},{"key":"646_CR243","doi-asserted-by":"publisher","unstructured":"Martinelli J, Dulong S, Li XM, Teboul M, Soliman S, L\u00e9vi F et al. Model learning to identify systemic regulators of the peripheral circadian clock. Bioinformatics. 2021;37(Suppl_1):i401\u2013i9. https:\/\/doi.org\/10.1093\/bioinformatics\/btab297.","DOI":"10.1093\/bioinformatics\/btab297"},{"issue":"2","key":"646_CR244","doi-asserted-by":"publisher","first-page":"161","DOI":"10.1124\/pr.116.013441","volume":"69","author":"A Ballesta","year":"2017","unstructured":"Ballesta A, Innominato PF, Dallmann R, Rand DA, L\u00e9vi FA. Systems Chronotherapeutics. Pharmacol Rev. 2017;69(2):161\u201399. https:\/\/doi.org\/10.1124\/pr.116.013441.","journal-title":"Pharmacol Rev"},{"key":"646_CR245","doi-asserted-by":"publisher","first-page":"114045","DOI":"10.1016\/j.bcp.2020.114045","volume":"178","author":"D Dong","year":"2020","unstructured":"Dong D, Yang D, Lin L, Wang S, Wu B. Circadian rhythm in pharmacokinetics and its relevance to chronotherapy. Biochem Pharmacol. 2020;178:114045. https:\/\/doi.org\/10.1016\/j.bcp.2020.114045.","journal-title":"Biochem Pharmacol"},{"issue":"5","key":"646_CR246","doi-asserted-by":"publisher","first-page":"430","DOI":"10.1016\/j.molmed.2016.03.004","volume":"22","author":"R Dallmann","year":"2016","unstructured":"Dallmann R, Okyar A, L\u00e9vi F. Dosing-time makes the poison: circadian regulation and pharmacotherapy. Trends Mol Med. 2016;22(5):430\u201345. https:\/\/doi.org\/10.1016\/j.molmed.2016.03.004.","journal-title":"Trends Mol Med"},{"issue":"19","key":"646_CR247","doi-asserted-by":"publisher","first-page":"2413","DOI":"10.1002\/1873-3468.14192","volume":"595","author":"J Duan","year":"2021","unstructured":"Duan J, Greenberg EN, Karri SS, Andersen B. The circadian clock and diseases of the skin. FEBS Lett. 2021;595(19):2413\u201336. https:\/\/doi.org\/10.1002\/1873-3468.14192.","journal-title":"FEBS Lett"},{"issue":"13","key":"646_CR248","doi-asserted-by":"publisher","first-page":"2023","DOI":"10.1016\/j.ejca.2005.05.010","volume":"41","author":"SP Megdal","year":"2005","unstructured":"Megdal SP, Kroenke CH, Laden F, Pukkala E, Schernhammer ES. Night work and breast cancer risk: a systematic review and meta-analysis. Eur J Cancer. 2005;41(13):2023\u201332. https:\/\/doi.org\/10.1016\/j.ejca.2005.05.010.","journal-title":"Eur J Cancer"},{"key":"646_CR249","doi-asserted-by":"publisher","first-page":"1006","DOI":"10.3389\/fonc.2020.01006","volume":"10","author":"A Dun","year":"2020","unstructured":"Dun A, Zhao X, Jin X, Wei T, Gao X, Wang Y, et al. Association between night-shift work and cancer risk: updated systematic review and meta-analysis. Front Oncol. 2020;10:1006. https:\/\/doi.org\/10.3389\/fonc.2020.01006.","journal-title":"Front Oncol"},{"issue":"1","key":"646_CR250","doi-asserted-by":"publisher","first-page":"185","DOI":"10.1186\/s12967-023-04013-w","volume":"21","author":"Y Liu","year":"2023","unstructured":"Liu Y, Guo S, Sun Y, Zhang C, Gan J, Ning S, et al. CRS: a circadian rhythm score model for predicting prognosis and treatment response in cancer patients. J Transl Med. 2023;21(1):185. https:\/\/doi.org\/10.1186\/s12967-023-04013-w.","journal-title":"J Transl Med"},{"issue":"1","key":"646_CR251","doi-asserted-by":"publisher","first-page":"e12803","DOI":"10.1111\/jpi.12803","volume":"73","author":"L He","year":"2022","unstructured":"He L, Fan Y, Zhang Y, Tu T, Zhang Q, Yuan F, et al. Single-cell transcriptomic analysis reveals circadian rhythm disruption associated with poor prognosis and drug-resistance in lung adenocarcinoma. J Pineal Res. 2022;73(1):e12803. https:\/\/doi.org\/10.1111\/jpi.12803.","journal-title":"J Pineal Res"},{"issue":"8","key":"646_CR252","doi-asserted-by":"publisher","first-page":"1503","DOI":"10.1158\/0008-5472.Can-21-1820","volume":"82","author":"J Wang","year":"2022","unstructured":"Wang J, Huang Q, Hu X, Zhang S, Jiang Y, Yao G, et al. Disrupting circadian rhythm via the PER1-HK2 axis reverses trastuzumab resistance in gastric cancer. Cancer Res. 2022;82(8):1503\u201317. https:\/\/doi.org\/10.1158\/0008-5472.Can-21-1820.","journal-title":"Cancer Res"},{"issue":"11","key":"646_CR253","doi-asserted-by":"publisher","first-page":"1556","DOI":"10.1158\/2159-8290.Cd-19-0215","volume":"9","author":"Z Dong","year":"2019","unstructured":"Dong Z, Zhang G, Qu M, Gimple RC, Wu Q, Qiu Z, et al. Targeting glioblastoma stem cells through disruption of the circadian clock. Cancer Discov. 2019;9(11):1556\u201373. https:\/\/doi.org\/10.1158\/2159-8290.Cd-19-0215.","journal-title":"Cancer Discov"},{"key":"646_CR254","doi-asserted-by":"publisher","first-page":"593","DOI":"10.1146\/annurev.pharmtox.47.120505.105208","volume":"47","author":"F Levi","year":"2007","unstructured":"Levi F, Schibler U. Circadian rhythms: mechanisms and therapeutic implications. Annu Rev Pharmacol Toxicol. 2007;47:593\u2013628. https:\/\/doi.org\/10.1146\/annurev.pharmtox.47.120505.105208.","journal-title":"Annu Rev Pharmacol Toxicol"},{"issue":"3","key":"646_CR255","doi-asserted-by":"publisher","first-page":"101068","DOI":"10.1016\/j.jbc.2021.101068","volume":"297","author":"Y Yang","year":"2021","unstructured":"Yang Y, Lindsey-Boltz LA, Vaughn CM, Selby CP, Cao X, Liu Z, et al. Circadian clock, carcinogenesis, chronochemotherapy connections. J Biol Chem. 2021;297(3):101068. https:\/\/doi.org\/10.1016\/j.jbc.2021.101068.","journal-title":"J Biol Chem"},{"key":"646_CR256","doi-asserted-by":"publisher","first-page":"357","DOI":"10.1016\/b978-0-12-819975-6.00023-6","volume":"179","author":"DP Cardinali","year":"2021","unstructured":"Cardinali DP, Brown GM, Pandi-Perumal SR. Chronotherapy. Handb Clin Neurol. 2021;179:357\u201370. https:\/\/doi.org\/10.1016\/b978-0-12-819975-6.00023-6.","journal-title":"Handb Clin Neurol"},{"key":"646_CR257","doi-asserted-by":"publisher","unstructured":"Ozturk N, Ozturk D, Kavakli IH, Okyar A. Molecular Aspects of Circadian Pharmacology and Relevance for Cancer Chronotherapy. Int J Mol Sci. 2017;18(10). https:\/\/doi.org\/10.3390\/ijms18102168.","DOI":"10.3390\/ijms18102168"},{"issue":"5","key":"646_CR258","doi-asserted-by":"publisher","first-page":"395","DOI":"10.1124\/dmd.120.090472","volume":"48","author":"D Lu","year":"2020","unstructured":"Lu D, Zhao M, Chen M, Wu B. Circadian clock-controlled drug metabolism: implications for chronotherapeutics. Drug Metab Dispos. 2020;48(5):395\u2013406. https:\/\/doi.org\/10.1124\/dmd.120.090472.","journal-title":"Drug Metab Dispos"},{"key":"646_CR259","doi-asserted-by":"publisher","DOI":"10.3390\/cancers14205071","author":"A Amiama-Roig","year":"2022","unstructured":"Amiama-Roig A, Verdugo-Sivianes EM, Carnero A, Blanco JR. Chronotherapy: circadian rhythms and their influence in cancer therapy. Cancers (Basel). 2022;14(20). https:\/\/doi.org\/10.3390\/cancers14205071.","journal-title":"Cancers (Basel)"},{"key":"646_CR260","doi-asserted-by":"publisher","first-page":"378","DOI":"10.1038\/s42003-019-0607-z","volume":"2","author":"Y Lin","year":"2019","unstructured":"Lin Y, Wang S, Zhou Z, Guo L, Yu F, Wu B. Bmal1 regulates circadian expression of cytochrome P450 3a11 and drug metabolism in mice. Commun Biol. 2019;2:378. https:\/\/doi.org\/10.1038\/s42003-019-0607-z.","journal-title":"Commun Biol"},{"issue":"1","key":"646_CR261","doi-asserted-by":"publisher","first-page":"vdab041","DOI":"10.1093\/noajnl\/vdab041","volume":"3","author":"AR Damato","year":"2021","unstructured":"Damato AR, Luo J, Katumba RGN, Talcott GR, Rubin JB, Herzog ED, et al. Temozolomide chronotherapy in patients with glioblastoma: a retrospective single-institute study. Neurooncol Adv. 2021;3(1):vdab041. https:\/\/doi.org\/10.1093\/noajnl\/vdab041.","journal-title":"Neurooncol Adv"},{"key":"646_CR262","doi-asserted-by":"publisher","first-page":"104470","DOI":"10.1016\/j.ebiom.2023.104470","volume":"89","author":"M Petkovi\u0107","year":"2023","unstructured":"Petkovi\u0107 M, Henis M, Heese O, Rel\u00f3gio A. Chronotherapy in Glioblastoma: state of the art and future perspectives. EBioMedicine. 2023;89:104470. https:\/\/doi.org\/10.1016\/j.ebiom.2023.104470.","journal-title":"EBioMedicine"},{"issue":"9","key":"646_CR263","doi-asserted-by":"publisher","first-page":"1882","DOI":"10.7150\/ijbs.31999","volume":"15","author":"X Zheng","year":"2019","unstructured":"Zheng X, Lu G, Yao Y, Gu W. An autocrine IL-6\/IGF-1R Loop mediates EMT and promotes tumor growth in non-small cell lung cancer. Int J Biol Sci. 2019;15(9):1882\u201391. https:\/\/doi.org\/10.7150\/ijbs.31999.","journal-title":"Int J Biol Sci"},{"key":"646_CR264","doi-asserted-by":"publisher","first-page":"856235","DOI":"10.3389\/fnins.2022.856235","volume":"16","author":"A Berisha","year":"2022","unstructured":"Berisha A, Shutkind K, Borniger JC. Sleep disruption and cancer: chicken or the egg? Front Neurosci. 2022;16:856235. https:\/\/doi.org\/10.3389\/fnins.2022.856235.","journal-title":"Front Neurosci"},{"key":"646_CR265","doi-asserted-by":"publisher","unstructured":"Borniger JC, Walker Ii WH, Surbhi, Emmer KM, Zhang N, Zalenski AA et al. A Role for Hypocretin\/Orexin in Metabolic and Sleep Abnormalities in a Mouse Model of Non-metastatic Breast Cancer. Cell Metab. 2018;28(1):118\u201329.e5. https:\/\/doi.org\/10.1016\/j.cmet.2018.04.021.","DOI":"10.1016\/j.cmet.2018.04.021"},{"issue":"5","key":"646_CR266","doi-asserted-by":"publisher","first-page":"355","DOI":"10.1016\/j.clml.2012.05.004","volume":"12","author":"K Vu","year":"2012","unstructured":"Vu K, Busaidy N, Cabanillas ME, Konopleva M, Faderl S, Thomas DA, et al. A randomized controlled trial of an intensive insulin regimen in patients with hyperglycemic acute lymphoblastic leukemia. Clin Lymphoma Myeloma Leuk. 2012;12(5):355\u201362. https:\/\/doi.org\/10.1016\/j.clml.2012.05.004.","journal-title":"Clin Lymphoma Myeloma Leuk"},{"issue":"19","key":"646_CR267","doi-asserted-by":"publisher","first-page":"3977","DOI":"10.1111\/bph.15571","volume":"178","author":"M Mampay","year":"2021","unstructured":"Mampay M, Flint MS, Sheridan GK. Tumour brain: pretreatment cognitive and affective disorders caused by peripheral cancers. Br J Pharmacol. 2021;178(19):3977\u201396. https:\/\/doi.org\/10.1111\/bph.15571.","journal-title":"Br J Pharmacol"},{"issue":"33","key":"646_CR268","doi-asserted-by":"publisher","first-page":"e2203958","DOI":"10.1002\/adma.202203958","volume":"34","author":"Y Zou","year":"2022","unstructured":"Zou Y, Wang Y, Xu S, Liu Y, Yin J, Lovejoy DB, et al. Brain co-delivery of temozolomide and cisplatin for combinatorial glioblastoma chemotherapy. Adv Mater. 2022;34(33):e2203958. https:\/\/doi.org\/10.1002\/adma.202203958.","journal-title":"Adv Mater"},{"key":"646_CR269","doi-asserted-by":"publisher","unstructured":"Chuang HY, Hsu LY, Pan CM, Pikatan NW, Yadav VK, Fong IH et al. The E3 Ubiquitin Ligase NEDD4-1 mediates temozolomide-resistant glioblastoma through PTEN attenuation and redox imbalance in Nrf2-HO-1 Axis. Int J Mol Sci. 2021;22(19). https:\/\/doi.org\/10.3390\/ijms221910247.","DOI":"10.3390\/ijms221910247"},{"issue":"10","key":"646_CR270","doi-asserted-by":"publisher","first-page":"792","DOI":"10.1016\/j.tcb.2021.04.001","volume":"31","author":"G Torcal Garcia","year":"2021","unstructured":"Torcal Garcia G, Graf T. The transcription factor code: a beacon for histone methyltransferase docking. Trends Cell Biol. 2021;31(10):792\u2013800. https:\/\/doi.org\/10.1016\/j.tcb.2021.04.001.","journal-title":"Trends Cell Biol"},{"issue":"24","key":"646_CR271","doi-asserted-by":"publisher","first-page":"e108684","DOI":"10.15252\/embj.2021108684","volume":"40","author":"J Yan","year":"2021","unstructured":"Yan J, Li S, Kim YJ, Zeng Q, Radziejwoski A, Wang L, et al. TOC1 clock protein phosphorylation controls complex formation with NF-YB\/C to repress hypocotyl growth. Embo j. 2021;40(24):e108684. https:\/\/doi.org\/10.15252\/embj.2021108684.","journal-title":"Embo j"},{"issue":"6","key":"646_CR272","doi-asserted-by":"publisher","first-page":"584","DOI":"10.1210\/er.2016-1083","volume":"37","author":"GD Potter","year":"2016","unstructured":"Potter GD, Skene DJ, Arendt J, Cade JE, Grant PJ, Hardie LJ. Circadian rhythm and sleep disruption: causes, metabolic consequences, and countermeasures. Endocr Rev. 2016;37(6):584\u2013608. https:\/\/doi.org\/10.1210\/er.2016-1083.","journal-title":"Endocr Rev"},{"issue":"2","key":"646_CR273","doi-asserted-by":"publisher","first-page":"151","DOI":"10.1080\/07420528.2018.1527773","volume":"36","author":"L T\u00e4hk\u00e4m\u00f6","year":"2019","unstructured":"T\u00e4hk\u00e4m\u00f6 L, Partonen T, Pesonen AK. Systematic review of light exposure impact on human circadian rhythm. Chronobiol Int. 2019;36(2):151\u201370. https:\/\/doi.org\/10.1080\/07420528.2018.1527773.","journal-title":"Chronobiol Int"},{"key":"646_CR274","doi-asserted-by":"publisher","first-page":"27","DOI":"10.1007\/978-3-031-63657-8_2","volume":"1460","author":"A Engin","year":"2024","unstructured":"Engin A. Misalignment of circadian rhythms in diet-induced obesity. Adv Exp Med Biol. 2024;1460:27\u201371. https:\/\/doi.org\/10.1007\/978-3-031-63657-8_2.","journal-title":"Adv Exp Med Biol"},{"issue":"2","key":"646_CR275","doi-asserted-by":"publisher","first-page":"75","DOI":"10.1038\/s41574-018-0122-1","volume":"15","author":"DJ Stenvers","year":"2019","unstructured":"Stenvers DJ, Scheer F, Schrauwen P, la Fleur SE, Kalsbeek A. Circadian clocks and insulin resistance. Nat Rev Endocrinol. 2019;15(2):75\u201389. https:\/\/doi.org\/10.1038\/s41574-018-0122-1.","journal-title":"Nat Rev Endocrinol"},{"issue":"4","key":"646_CR276","doi-asserted-by":"publisher","first-page":"525","DOI":"10.1111\/imm.13747","volume":"171","author":"J Ding","year":"2024","unstructured":"Ding J, Chen P, Qi C. Circadian rhythm regulation in the immune system. Immunology. 2024;171(4):525\u201333. https:\/\/doi.org\/10.1111\/imm.13747.","journal-title":"Immunology"},{"key":"646_CR277","doi-asserted-by":"publisher","first-page":"107","DOI":"10.1016\/j.trsl.2018.12.001","volume":"206","author":"M Gombert","year":"2019","unstructured":"Gombert M, Carrasco-Luna J, Pin-Arboledas G, Codo\u00f1er-Franch P. The connection of circadian rhythm to inflammatory bowel disease. Transl Res. 2019;206:107\u201318. https:\/\/doi.org\/10.1016\/j.trsl.2018.12.001.","journal-title":"Transl Res"},{"issue":"1","key":"646_CR278","doi-asserted-by":"publisher","first-page":"57","DOI":"10.1186\/s13063-024-07903-6","volume":"25","author":"M Kragh","year":"2024","unstructured":"Kragh M, Dyrberg H, Speed M, Pedersen P, Kristiansen ST, Martiny K. The efficacy of a transdiagnostic sleep intervention for outpatients with sleep problems and depression, bipolar disorder, or attention deficit disorder: study protocol for a randomized controlled trial. Trials. 2024;25(1):57. https:\/\/doi.org\/10.1186\/s13063-024-07903-6.","journal-title":"Trials"},{"issue":"1","key":"646_CR279","doi-asserted-by":"publisher","first-page":"7205","DOI":"10.1038\/s41467-024-51611-3","volume":"15","author":"C Ector","year":"2024","unstructured":"Ector C, Schmal C, Didier J, De Landtsheer S, Finger AM, M\u00fcller-Marquardt F, et al. Time-of-day effects of cancer drugs revealed by high-throughput deep phenotyping. Nat Commun. 2024;15(1):7205. https:\/\/doi.org\/10.1038\/s41467-024-51611-3.","journal-title":"Nat Commun"},{"issue":"4","key":"646_CR280","doi-asserted-by":"publisher","first-page":"259","DOI":"10.1111\/imm.13284","volume":"161","author":"S Milling","year":"2020","unstructured":"Milling S. It\u2019s time to think about circadian rhythms. Immunology. 2020;161(4):259\u201360. https:\/\/doi.org\/10.1111\/imm.13284.","journal-title":"Immunology"},{"key":"646_CR281","doi-asserted-by":"publisher","first-page":"218155","DOI":"10.1016\/j.canlet.2025.218155","volume":"638","author":"G Li","year":"2026","unstructured":"Li G, Wan Y, Cui G, Jiang K, Su J, Duan S, et al. Cancer metastasis mediated by circadian rhythm disruption: Molecular mechanisms to clinical significance and implications. Cancer Lett. 2026;638:218155. https:\/\/doi.org\/10.1016\/j.canlet.2025.218155.","journal-title":"Cancer Lett"},{"key":"646_CR282","doi-asserted-by":"publisher","unstructured":"Zhang Z, Sun D, Tang H, Ren J, Yin S, Yang K. PER2 binding to HSP90 enhances immune response against oral squamous cell carcinoma by inhibiting IKK\/NF-\u03baB pathway and PD-L1 expression. J Immunother Cancer. 2023;11(11). https:\/\/doi.org\/10.1136\/jitc-2023-007627.","DOI":"10.1136\/jitc-2023-007627"},{"issue":"1","key":"646_CR283","doi-asserted-by":"publisher","first-page":"5834","DOI":"10.1038\/s41467-025-60904-0","volume":"16","author":"RM Mello","year":"2025","unstructured":"Mello RM, Gomez Ceballos D, Sandate CR, Wang S, Jouffe C, Agudelo D, et al. BMAL1 and ARNT enable circadian HIF2\u03b1 responses in clear cell renal cell carcinoma. Nat Commun. 2025;16(1):5834. https:\/\/doi.org\/10.1038\/s41467-025-60904-0.","journal-title":"Nat Commun"},{"issue":"7856","key":"646_CR284","doi-asserted-by":"publisher","first-page":"763","DOI":"10.1038\/s41586-021-03358-w","volume":"592","author":"G Ding","year":"2021","unstructured":"Ding G, Li X, Hou X, Zhou W, Gong Y, Liu F, et al. REV-ERB in GABAergic neurons controls diurnal hepatic insulin sensitivity. Nature. 2021;592(7856):763\u20137. https:\/\/doi.org\/10.1038\/s41586-021-03358-w.","journal-title":"Nature"},{"issue":"1","key":"646_CR285","doi-asserted-by":"publisher","first-page":"7","DOI":"10.1038\/s41582-021-00577-7","volume":"18","author":"M Nassan","year":"2022","unstructured":"Nassan M, Videnovic A. Circadian rhythms in neurodegenerative disorders. Nat Rev Neurol. 2022;18(1):7\u201324. https:\/\/doi.org\/10.1038\/s41582-021-00577-7.","journal-title":"Nat Rev Neurol"},{"issue":"2","key":"646_CR286","doi-asserted-by":"publisher","first-page":"118","DOI":"10.1159\/000450945","volume":"63","author":"G Cornelissen","year":"2017","unstructured":"Cornelissen G, Otsuka K. Chronobiology of aging: a mini-review. Gerontology. 2017;63(2):118\u201328. https:\/\/doi.org\/10.1159\/000450945.","journal-title":"Gerontology"},{"key":"646_CR287","doi-asserted-by":"publisher","first-page":"103803","DOI":"10.1016\/j.critrevonc.2022.103803","volume":"179","author":"LG Marcu","year":"2022","unstructured":"Marcu LG. Developments on tumour site-specific chrono-oncology towards personalised treatment. Crit Rev Oncol Hematol. 2022;179:103803. https:\/\/doi.org\/10.1016\/j.critrevonc.2022.103803.","journal-title":"Crit Rev Oncol Hematol"},{"issue":"1","key":"646_CR288","doi-asserted-by":"publisher","first-page":"14922","DOI":"10.1038\/s41598-022-17420-8","volume":"12","author":"S Komatsu","year":"2022","unstructured":"Komatsu S, Konishi T, Matsubara D, Soga K, Shimomura K, Ikeda J, et al. Night home enteral nutrition as a novel enforced and physiologically effective nutrition therapy following total gastrectomy for gastric cancer. Sci Rep. 2022;12(1):14922. https:\/\/doi.org\/10.1038\/s41598-022-17420-8.","journal-title":"Sci Rep"},{"issue":"2","key":"646_CR289","doi-asserted-by":"publisher","first-page":"532","DOI":"10.1158\/0008-5472.Can-16-1322","volume":"77","author":"Q Tang","year":"2017","unstructured":"Tang Q, Cheng B, Xie M, Chen Y, Zhao J, Zhou X, et al. Circadian clock gene bmal1 inhibits tumorigenesis and increases paclitaxel sensitivity in tongue squamous cell carcinoma. Cancer Res. 2017;77(2):532\u201344. https:\/\/doi.org\/10.1158\/0008-5472.Can-16-1322.","journal-title":"Cancer Res"},{"key":"646_CR290","doi-asserted-by":"publisher","first-page":"139","DOI":"10.1016\/j.ebiom.2019.07.004","volume":"45","author":"E Burgermeister","year":"2019","unstructured":"Burgermeister E, Battaglin F, Eladly F, Wu W, Herweck F, Schulte N, et al. Aryl hydrocarbon receptor nuclear translocator-like (ARNTL\/BMAL1) is associated with bevacizumab resistance in colorectal cancer via regulation of vascular endothelial growth factor A. EBioMedicine. 2019;45:139\u201354. https:\/\/doi.org\/10.1016\/j.ebiom.2019.07.004.","journal-title":"EBioMedicine"},{"issue":"2","key":"646_CR291","doi-asserted-by":"publisher","first-page":"67","DOI":"10.1038\/s41580-019-0179-2","volume":"21","author":"A Patke","year":"2020","unstructured":"Patke A, Young MW, Axelrod S. Molecular mechanisms and physiological importance of circadian rhythms. Nat Rev Mol Cell Biol. 2020;21(2):67\u201384. https:\/\/doi.org\/10.1038\/s41580-019-0179-2.","journal-title":"Nat Rev Mol Cell Biol"},{"issue":"21","key":"646_CR292","doi-asserted-by":"publisher","first-page":"e408","DOI":"10.1161\/cir.0000000000001388","volume":"152","author":"KL Knutson","year":"2025","unstructured":"Knutson KL, Dixon DD, Grandner MA, Jackson CL, Kline CE, Maher L, et al. Role of circadian health in cardiometabolic health and disease risk: a scientific statement from the american heart association. Circulation. 2025;152(21):e408\u201319. https:\/\/doi.org\/10.1161\/cir.0000000000001388.","journal-title":"Circulation"}],"container-title":["Molecular Biomedicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s43556-026-00646-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s43556-026-00646-7","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s43556-026-00646-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T04:05:55Z","timestamp":1792728355000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s43556-026-00646-7"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,10,23]]},"references-count":292,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2026,12]]}},"alternative-id":["646"],"URL":"https:\/\/doi.org\/10.1186\/s43556-026-00646-7","relation":{},"ISSN":["2662-8651"],"issn-type":[{"value":"2662-8651","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,10,23]]},"assertion":[{"value":"1 June 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"24 September 2026","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"14 October 2026","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"23 October 2026","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"Not applicable.","order":1,"name":"Ethics","label":"Ethics approval and consent to participate","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Not applicable.","order":2,"name":"Ethics","label":"Consent for publication","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":3,"name":"Ethics","label":"Competing interests","group":{"name":"EthicsHeading","label":"Declarations"}}],"article-number":"224"}}