{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T05:30:24Z","timestamp":1787808624920,"version":"build-2784847793"},"reference-count":19,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2025,1,6]],"date-time":"2025-01-06T00:00:00Z","timestamp":1736121600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2025,1,6]],"date-time":"2025-01-06T00:00:00Z","timestamp":1736121600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/501100001809","name":"The National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["No. U21A20523"],"award-info":[{"award-number":["No. U21A20523"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Echo Res Pract"],"abstract":"<jats:title>Abstract<\/jats:title><jats:sec>\n                <jats:title>Objective<\/jats:title>\n                <jats:p>To explore the diagnostic value of crucial parameters of echocardiography for fetal bicuspid aortic valve (BAV) and improve diagnostic accuracy.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Methods<\/jats:title>\n                <jats:p>Fetuses with a prenatal suspected diagnosis of BAV were followed, and confirmed and misdiagnosed cases were obtained. Prenatal echocardiography was reviewed and analyzed. ROC curves were plotted to evaluate the diagnostic capabilities of different echo signs.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>14 cases were confirmed, and 7 patients were misdiagnosed. Some abnormal ultrasound signs were observed in both groups, including direct ultrasound signs of the aortic valve: Two commissures and a \u201cfish-mouth\u201d opening; Thickening, hyperechogenicity, or the presence of a raphe; Restricted motion or opening; Eccentric or a-linear valve leaflet closure line and indirect ultrasound signs: Increased supra-aortic valve velocity; Post-stenotic widening of the ascending aorta. The combination of \u201cIncreased supra-aortic valve velocity\u201d and \u201cTwo commissures and a \u2018fish-mouth\u2019 opening\u201d had the highest AUC (AUC: 0.893, 95%CI: 0.752-1.000, Sensitivity: 0.786, Specificity: 1.000).<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusions<\/jats:title>\n                <jats:p>We first found that the combination of \u201cIncreased supra-aortic valve velocity\u201d and \u201cTwo commissures and a \u2018fish-mouth\u2019 opening\u201d had the best diagnostic capability and could reduce the rate of misdiagnosis. Fetuses with BAV should be followed up prenatally for the aortic valve and ascending aorta as they progressively deteriorate with gestational age.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1186\/s44156-024-00065-w","type":"journal-article","created":{"date-parts":[[2025,1,6]],"date-time":"2025-01-06T04:18:15Z","timestamp":1736137095000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Diagnostic value of selected fetal echocardiographic parameters in the prenatally suspected bicuspid aortic valve"],"prefix":"10.1186","volume":"12","author":[{"given":"Min","family":"Zheng","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanping","family":"Ruan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lin","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaowei","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiancheng","family":"Han","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yihua","family":"He","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,1,6]]},"reference":[{"key":"65_CR1","doi-asserted-by":"publisher","first-page":"615175","DOI":"10.3389\/fphys.2021.615175","volume":"12","author":"J Wang","year":"2021","unstructured":"Wang J, Deng W, Lv Q, et al. Aortic dilatation in patients with bicuspid aortic valve. Front Physiol. 2021;12:615175.","journal-title":"Front Physiol"},{"issue":"6","key":"65_CR2","doi-asserted-by":"publisher","first-page":"830","DOI":"10.1016\/S0022-5223(19)33931-5","volume":"102","author":"AP Kappetein","year":"1991","unstructured":"Kappetein AP, Gittenberger-de Groot AC, Zwinderman AH, et al. The neural crest as a possible pathogenetic factor in coarctation of the aorta and bicuspid aortic valve. J Thorac Cardiovasc Surg. 1991;102(6):830\u20136.","journal-title":"J Thorac Cardiovasc Surg"},{"issue":"1","key":"65_CR3","doi-asserted-by":"publisher","first-page":"30","DOI":"10.1046\/j.1469-0705.2002.00723.x","volume":"20","author":"D Paladini","year":"2002","unstructured":"Paladini D, Russo MG, Vassallo M, et al. Ultrasound evaluation of aortic valve anatomy in the fetus. 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