{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,23]],"date-time":"2026-08-23T23:20:08Z","timestamp":1787527208365,"version":"build-2736575974"},"reference-count":10,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2026,8,24]],"date-time":"2026-08-24T00:00:00Z","timestamp":1787529600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2026,8,24]],"date-time":"2026-08-24T00:00:00Z","timestamp":1787529600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Echo Res Pract"],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Methamphetamine-associated heart failure (MAHF) is a growing cause of healthcare burden, yet the echocardiographic phenotype at the time of initial diagnosis is poorly characterized. We tested the hypothesis that new-onset MAHF exhibits a distinct echocardiographic phenotype that could aid in early disease identification.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      We conducted a retrospective cohort study comparing echocardiographic parameters in patients with new-onset MAHF versus controls with non-ischemic cardiomyopathy unrelated to methamphetamine use. Patients with MAHF (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200975) were identified by positive urine drug screen, ICD-10 codes for incident heart failure, and confirmed active methamphetamine use at index hospitalization. Controls were matched 1:1 by age, sex, and race. Pre-specified echocardiographic endpoints included left and right ventricular size and function, left ventricular thrombi, valvular dysfunction, and pulmonary artery systolic pressure.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The two groups showed no significant differences in echocardiographic parameters. Left ventricular ejection fraction (28%, 20\u201336% vs. 25%, 19\u201335%), left ventricular indexed end-diastolic volume (103\u00a0ml\/m2, 79-130\u00a0ml\/m2 vs. 94\u00a0ml\/m2, 73-118\u00a0ml\/m2), left atrial size, right ventricular size and function, diastolic parameters, pulmonary artery pressures, and prevalence of ventricular thrombi were all similar between groups.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>At the time of initial heart failure diagnosis, MAHF is indistinguishable by traditional echocardiographic parameters from other non-ischemic cardiomyopathies. The findings of this study differ from prior research into the echocardiographic phenotype of MAHF by focusing on the time of initial heart failure diagnosis, presumably when less adverse remodeling has occurred. These negative findings underscore that MAHF is a diagnosis of exclusion and a full work-up to assess for alternative etiologies of cardiomyopathy is paramount.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1186\/s44156-026-00133-3","type":"journal-article","created":{"date-parts":[[2026,8,23]],"date-time":"2026-08-23T23:02:47Z","timestamp":1787526167000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Echocardiographic characteristics of new-onset methamphetamine-associated heart failure: a retrospective cohort study"],"prefix":"10.1186","volume":"13","author":[{"given":"Joey","family":"Chiang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Danelle","family":"Hidano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heather","family":"Herren","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher T.","family":"Longenecker","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mrinal","family":"Yadava","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8180-1886","authenticated-orcid":false,"given":"Cooper B.","family":"Kersey","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,8,24]]},"reference":[{"issue":"6","key":"133_CR1","doi-asserted-by":"publisher","first-page":"435","DOI":"10.1016\/j.jchf.2017.02.017","volume":"5","author":"S Sch\u00fcrer","year":"2017","unstructured":"Sch\u00fcrer S, Klingel K, Sandri M, Majunke N, Besler C, Kandolf R, et al. Clinical Characteristics, Histopathological Features, and Clinical Outcome of Methamphetamine-Associated Cardiomyopathy. JACC Heart Fail. 2017;5(6):435\u201345. https:\/\/doi.org\/10.1016\/j.jchf.2017.02.017.","journal-title":"JACC Heart Fail"},{"issue":"7Part2","key":"133_CR2","doi-asserted-by":"publisher","first-page":"100840","DOI":"10.1016\/j.jacadv.2024.100840","volume":"3","author":"Z Al-Yafeai","year":"2024","unstructured":"Al-Yafeai Z, Ali S, Brown J, Venkataraj M, Bhuiyan MS, Mosa Faisal AS, et al. Cardiomyopathy-Associated Hospital Admissions Among Methamphetamine Users. JACC Adv. 2024;3(7Part2):100840. https:\/\/doi.org\/10.1016\/j.jacadv.2024.100840.","journal-title":"JACC Adv"},{"key":"133_CR3","doi-asserted-by":"crossref","unstructured":"Chiang J, Pechan J, Smith K et al. Community-based outreach for people living with methamphetamine-associated cardiomyopathy. J Am Coll Cardiol Case Rep, 2024.","DOI":"10.1016\/j.jaccas.2024.102598"},{"issue":"6","key":"133_CR4","doi-asserted-by":"publisher","first-page":"E18","DOI":"10.1002\/clc.20367","volume":"32","author":"H Ito","year":"2009","unstructured":"Ito H, Yeo KK, Wijetunga M, Seto TB, Tay K, Schatz IJ. A Comparison of Echocardiographic Findings in Young Adults With Cardiomyopathy: With and Without a History of Methamphetamine Abuse. Clin Cardiol. 2009;32(6):E18\u201322. https:\/\/doi.org\/10.1002\/clc.20367.","journal-title":"Clin Cardiol"},{"key":"133_CR5","doi-asserted-by":"publisher","unstructured":"Jariwal R, Narang V, Raza N, Mann B, Bhandohal J, Valdez M et al. Echocardiographic findings in heart failure patients with methamphetamine use: a case-control study. Cureus 13(7):e16170. https:\/\/doi.org\/10.7759\/cureus.16170. PubMed PMID: 34268059; PubMed Central PMCID: PMC8262112.","DOI":"10.7759\/cureus.16170"},{"key":"133_CR6","doi-asserted-by":"publisher","first-page":"1329","DOI":"10.1001\/jamapsychiatry.2021.2588","volume":"78","author":"B Han","year":"2021","unstructured":"Han B, Compton WM, Jones CM, Einstein EB, Volkow ND. Methamphetamine Use, Methamphetamine Use Disorder, and Associated Overdose Deaths Among US Adults. JAMA Psychiatry. 2021;78:1329\u201342.","journal-title":"JAMA Psychiatry"},{"issue":"22","key":"133_CR7","doi-asserted-by":"publisher","first-page":"e037339","DOI":"10.1161\/JAHA.124.037339","volume":"13","author":"CB Kersey","year":"2024","unstructured":"Kersey CB, Hidano D, Chiang J, Doshi S, Longenecker CT. Ischemic Evaluation in New-Onset Methamphetamine\u2010Associated Heart Failure. J Am Heart Assoc. 2024;13(22):e037339. https:\/\/doi.org\/10.1161\/JAHA.124.037339.","journal-title":"J Am Heart Assoc"},{"issue":"5","key":"133_CR8","doi-asserted-by":"publisher","first-page":"e041888","DOI":"10.1161\/JAHA.125.041888","volume":"15","author":"ED Riley","year":"2026","unstructured":"Riley ED, Ma Y, Wu KC, Shitole SG, Neilands TB, Martinez C, et al. Associations Between Sustained Methamphetamine\/Amphetamine Use and Left Ventricular Dysfunction in a Cohort of Women Living With and Without HIV. J Am Heart Assoc. 2026;15(5):e041888. https:\/\/doi.org\/10.1161\/JAHA.125.041888 . PubMed PMID: 41744114; PubMed Central PMCID: PMC13055775.","journal-title":"J Am Heart Assoc"},{"issue":"10","key":"133_CR9","doi-asserted-by":"publisher","first-page":"1589","DOI":"10.1007\/s10554-018-1381-6","volume":"34","author":"LJ Zhang","year":"2018","unstructured":"Zhang LJ, Chen KQ, Shi YY, Qiao XL, Wang LY, Zheng XZ. Findings on 3D speckle tracking echocardiography in asymptomatic methamphetamine abusers. Int J Cardiovasc Imaging. 2018;34(10):1589\u201393. https:\/\/doi.org\/10.1007\/s10554-018-1381-6.","journal-title":"Int J Cardiovasc Imaging"},{"issue":"11","key":"133_CR10","doi-asserted-by":"publisher","first-page":"985","DOI":"10.1016\/j.echo.2025.07.007","volume":"38","author":"JD Thomas","year":"2025","unstructured":"Thomas JD, Edvardsen T, Abraham T, Appadurai V, Badano L, Banchs J, et al. Clinical Applications of Strain Echocardiography: A Clinical Consensus Statement From the American Society of Echocardiography Developed in Collaboration With the European Association of Cardiovascular Imaging of the European Society of Cardiology. J Am Soc Echocardiogr. 2025;38(11):985\u20131020. https:\/\/doi.org\/10.1016\/j.echo.2025.07.007 . PubMed PMID: 40864001.","journal-title":"J Am Soc Echocardiogr"}],"container-title":["Echo Research &amp; Practice"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s44156-026-00133-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s44156-026-00133-3","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s44156-026-00133-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,23]],"date-time":"2026-08-23T23:02:48Z","timestamp":1787526168000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1186\/s44156-026-00133-3"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8,24]]},"references-count":10,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2026,12]]}},"alternative-id":["133"],"URL":"https:\/\/doi.org\/10.1186\/s44156-026-00133-3","relation":{},"ISSN":["2055-0464"],"issn-type":[{"value":"2055-0464","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,8,24]]},"assertion":[{"value":"27 April 2026","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"25 July 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"24 August 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"Not applicable.","order":1,"name":"Ethics","label":"Human ethics and consent to participate","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"This study was conducted using IRB protocol 00014632. Informed consent was waived for this retrospective study as it involved review of the existing medical records, posing no more than minimal risk to participants.","order":2,"name":"Ethics","label":"Consent to participate","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":3,"name":"Ethics","label":"Competing interests","group":{"name":"EthicsHeading","label":"Declarations"}}],"article-number":"31"}}