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While single component movement behaviors have been related to its development, comprehensive assessments of their joint associations are scarce.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Objective<\/jats:title>\n                <jats:p>To investigate the single-component and multi-component associations of moderate and vigorous physical activity (MVPA), light physical activity (LPA), sedentary behavior (SB), and sleep with prevalent SLD in Brazilian adults.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Methods<\/jats:title>\n                <jats:p>A cross-sectional analysis using data from the third wave of the ELSA-Brasil cohort (2017\u20132019). Participants wore an ActiGraph wGT3X-BT in the waist for seven days and completed a sleep diary. SLD was defined by a Fatty Liver Index\u2009\u2265\u200960. To investigate single-component and multi-component associations, we used three exposure modeling approaches based on Poisson models: multivariable-adjusted regression, restricted cubic splines, and compositional data analysis.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>Among 8569 participants (55.7% women, mean age 59.2\u2009\u00b1\u20098.60), 43.9% had SLD. Total activity volume adjusted for covariates was inversely associated with prevalent SLD. Every 1\u00a0mg\/day increase in total activity volume was associated with a PR of 0.95 in individuals sleeping\u2009&lt;\u20097\u00a0h\/day (95% CI\u20090.94\u20130.97) and 0.95 (95% CI\u20090.93\u20130.96) in those sleeping\u2009\u2265\u20097\u00a0h\/day. Increasing 30\u00a0min\/day of MVPA was associated with decreasing prevalence of SLD (sleep\u2009\u2265\u20097\u00a0h\/day [PR 0.83; 95% CI\u20090.77\u20130.89]; sleep\u2009\u2265\u20097\u00a0h\/day [PR 0.78; 95% CI\u20090.74\u20130.83]). Sleep, SB, and LPA were not associated with SLD. Associations of total activity volume and MVPA were more pronounced among females. Adjustment with adiposity markers attenuated the associations.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusions<\/jats:title>\n                <jats:p>In adults, total activity volume and MVPA were inversely associated with SLD in a dose\u2013response fashion. Substituting lower-intensity behaviors with MVPA was associated with a lower prevalence of SLD independent of sleep\u00a0duration, sex, and age.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1186\/s44167-024-00055-7","type":"journal-article","created":{"date-parts":[[2024,7,3]],"date-time":"2024-07-03T04:38:37Z","timestamp":1719981517000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Associations of activity, sedentary and sleep behaviors with prevalent steatotic liver disease in middle-aged and older adults: the ELSA-Brasil study"],"prefix":"10.1186","volume":"3","author":[{"given":"Danilo","family":"de Paula","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Natan","family":"Feter","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rodrigo Citton Padilha","family":"dos Reis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rosane Harter","family":"Griep","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bruce Bartholow","family":"Duncan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria In\u00eas","family":"Schmidt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,7,3]]},"reference":[{"key":"55_CR1","doi-asserted-by":"publisher","first-page":"1999","DOI":"10.1053\/j.gastro.2019.11.312","volume":"158","author":"M Eslam","year":"2020","unstructured":"Eslam M, Sanyal AJ, George J, et al. 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