{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,22]],"date-time":"2025-02-22T00:44:53Z","timestamp":1740185093920,"version":"3.37.3"},"reference-count":9,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2024,6,11]],"date-time":"2024-06-11T00:00:00Z","timestamp":1718064000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2024,6,11]],"date-time":"2024-06-11T00:00:00Z","timestamp":1718064000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Gen Thorac Cardiovasc Surg Cases"],"abstract":"<jats:title>Abstract<\/jats:title><jats:sec>\n                <jats:title>Background<\/jats:title>\n                <jats:p>Pleural mesothelioma, characterized by a dismal prognosis even with multimodal therapy, has seen emerging interest in immune checkpoint inhibitors (ICIs) due to their demonstrated efficacy. Here, we present a case of epithelioid-type pleural mesothelioma with chest wall invasion treated with definitive ICI therapy, resulting in a remarkable pretreatment effect.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Case presentation<\/jats:title>\n                <jats:p>A 46-year-old man was diagnosed with an abnormal chest shadow on a medical check, and a computed tomography scan showed pleural thickening at the dorsal right upper chest wall. One of the nodules was suspected to have invaded the chest wall. A needle biopsy revealed epithelioid-type pleural mesothelioma. After five cycles of nivolumab plus ipilimumab, he underwent right pleurectomy\/decortication (P\/D). Pathological examination revealed a significant treatment effect, showing numerous lymphocytes infiltrating the tumor nodule and viable tumor cells localized at approximately 6\u00a0mm.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusion<\/jats:title>\n                <jats:p>Although further accumulation of cases is required to evaluate the effectiveness and case selection, P\/D after immunotherapy is a useful curative treatment option for advanced pleural mesothelioma.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1186\/s44215-024-00157-3","type":"journal-article","created":{"date-parts":[[2024,6,11]],"date-time":"2024-06-11T22:01:12Z","timestamp":1718143272000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Epithelioid pleural mesothelioma successfully treated with perioperative immunotherapy: a case report"],"prefix":"10.1186","volume":"3","author":[{"given":"Gaku","family":"Yamazaki","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aki","family":"Fujiwara-Kuroda","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jun","family":"Muto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hideki","family":"Ujiie","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masato","family":"Aragaki","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Megumi","family":"Furuta","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sakurako","family":"Ohno","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kanako C.","family":"Hatanaka","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yutaka","family":"Hatanaka","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoshihiro","family":"Matsuno","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4063-0042","authenticated-orcid":false,"given":"Tatsuya","family":"Kato","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2024,6,11]]},"reference":[{"issue":"10272","key":"157_CR1","doi-asserted-by":"publisher","first-page":"375","DOI":"10.1016\/S0140-6736(20)32714-8","volume":"397","author":"P Baas","year":"2021","unstructured":"Baas P, Scherpereel A, Nowak AK, Fujimoto N, Peters S, Tsao AS, et al. First-line nivolumab plus ipilimumab in unresectable malignant pleural mesothelioma (CheckMate 743): a multicentre, randomised, open-label, phase 3 trial. Lancet. 2021;397(10272):375\u201386. https:\/\/doi.org\/10.1016\/S0140-6736(20)32714-8. (PMID33485464).","journal-title":"Lancet"},{"issue":"21","key":"157_CR2","doi-asserted-by":"publisher","first-page":"1973","DOI":"10.1056\/NEJMoa2202170","volume":"386","author":"PM Forde","year":"2022","unstructured":"Forde PM, Spicer J, Lu S, Provencio M, Mitsudomi T, Awad MM, et al. Neoadjuvant Nivolumab plus chemotherapy in resectable lung cancer. N Engl J Med. 2022;386(21):1973\u201385. https:\/\/doi.org\/10.1056\/NEJMoa2202170. (PMID35403841).","journal-title":"N Engl J Med"},{"issue":"13","key":"157_CR3","doi-asserted-by":"publisher","first-page":"1969","DOI":"10.1002\/cncr.34755","volume":"129","author":"Y Wu","year":"2023","unstructured":"Wu Y, Verma V, Gay CM, Chen Y, Liang F, Lin Q, et al. Neoadjuvant immunotherapy for advanced, resectable non-small cell lung cancer: a systematic review and meta-analysis. Cancer. 2023;129(13):1969\u201385. https:\/\/doi.org\/10.1002\/cncr.34755. (PMID36994945).","journal-title":"Cancer"},{"key":"157_CR4","doi-asserted-by":"publisher","unstructured":"Kitajima K, Maruyama M, Yokoyama H, Minami T, Yokoi T, Nakamura A, et al. Response to immune checkpoint inhibitor therapy in patients with unresectable recurrent malignant pleural mesothelioma shown by FDG-PET and CT. Cancers (Basel). 2021;13(5). https:\/\/doi.org\/10.3390\/cancers13051098. PMID 33806464.","DOI":"10.3390\/cancers13051098"},{"issue":"1","key":"157_CR5","doi-asserted-by":"publisher","first-page":"121","DOI":"10.1016\/j.atssr.2022.07.004","volume":"1","author":"K Kajiyama","year":"2023","unstructured":"Kajiyama K, Taira A, Takenaka M, Kuroda K, Kusano M, Nawata A, et al. Salvage pleurectomy\/decortication after immunotherapy for sarcomatoid malignant pleural mesothelioma. Annals Thorac Surg Short Rep. 2023;1(1):121\u20133. https:\/\/doi.org\/10.1016\/j.atssr.2022.07.004.","journal-title":"Annals Thorac Surg Short Rep"},{"issue":"5","key":"157_CR6","doi-asserted-by":"publisher","first-page":"e357","DOI":"10.1016\/j.athoracsur.2022.01.011","volume":"114","author":"KC Banks","year":"2022","unstructured":"Banks KC, Chaudhary MJ, Hsu DS, Mooney CM, Velotta JB. Salvage resection after immunotherapy in refractory malignant pleural mesothelioma. Ann Thorac Surg. 2022;114(5):e357\u20139. https:\/\/doi.org\/10.1016\/j.athoracsur.2022.01.011. (PMID35104447).","journal-title":"Ann Thorac Surg"},{"issue":"9","key":"157_CR7","doi-asserted-by":"publisher","first-page":"2972","DOI":"10.1080\/21645515.2021.1917933","volume":"17","author":"G Metro","year":"2021","unstructured":"Metro G, Signorelli D, Pizzutilo EG, Giannetta L, Cerea G, Garaffa M, et al. Immune checkpoint inhibitors for unresectable malignant pleural mesothelioma. Hum Vaccin Immunother. 2021;17(9):2972\u201380. https:\/\/doi.org\/10.1080\/21645515.2021.1917933. (PMID34003722).","journal-title":"Hum Vaccin Immunother"},{"issue":"5","key":"157_CR8","doi-asserted-by":"publisher","first-page":"100315","DOI":"10.1016\/j.jtocrr.2022.100315","volume":"3","author":"AS Mansfield","year":"2022","unstructured":"Mansfield AS, Brown RJ, Sammon C, Daumont MJ, McKenna M, Sanzari JK, et al. The predictive and prognostic nature of programmed death-ligand 1 in malignant pleural mesothelioma: a systematic literature review. JTO Clin Res Rep. 2022;3(5):100315. https:\/\/doi.org\/10.1016\/j.jtocrr.2022.100315. (PMID35516726).","journal-title":"JTO Clin Res Rep"},{"issue":"4","key":"157_CR9","doi-asserted-by":"publisher","first-page":"719","DOI":"10.1007\/s10456-021-09792-8","volume":"24","author":"L Blanchard","year":"2021","unstructured":"Blanchard L, Girard JP. High endothelial venules (HEVs) in immunity, inflammation and cancer. Angiogenesis. 2021;24(4):719\u201353. https:\/\/doi.org\/10.1007\/s10456-021-09792-8. (PMID33956259).","journal-title":"Angiogenesis"}],"container-title":["General Thoracic and Cardiovascular Surgery Cases"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s44215-024-00157-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s44215-024-00157-3\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s44215-024-00157-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,6,11]],"date-time":"2024-06-11T22:01:32Z","timestamp":1718143292000},"score":1,"resource":{"primary":{"URL":"https:\/\/gtcscases.biomedcentral.com\/articles\/10.1186\/s44215-024-00157-3"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,6,11]]},"references-count":9,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2024,12]]}},"alternative-id":["157"],"URL":"https:\/\/doi.org\/10.1186\/s44215-024-00157-3","relation":{},"ISSN":["2731-6203"],"issn-type":[{"type":"electronic","value":"2731-6203"}],"subject":[],"published":{"date-parts":[[2024,6,11]]},"assertion":[{"value":"22 February 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"3 June 2024","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"11 June 2024","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Not applicable.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Written informed consent was obtained from the patient for the publication of this case report and accompanying images.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare that they have no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"31"}}