{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,11]],"date-time":"2025-11-11T16:24:55Z","timestamp":1762878295084,"version":"3.45.0"},"reference-count":14,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2025,11,11]],"date-time":"2025-11-11T00:00:00Z","timestamp":1762819200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2025,11,11]],"date-time":"2025-11-11T00:00:00Z","timestamp":1762819200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Gen Thorac Cardiovasc Surg Cases"],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>In patients with uterine leiomyosarcoma and multiple pulmonary metastases complicated by pneumothorax during chemotherapy, repeated metastasectomy may contribute to long-term survival.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Case presentation<\/jats:title>\n                    <jats:p>A 45-year-old woman underwent total hysterectomy for uterine leiomyosarcoma. She subsequently developed multiple pulmonary metastases and was treated with gemcitabine plus docetaxel (GD) chemotherapy. During the course of chemotherapy, she developed a pneumothorax, possibly as a consequence of tumor necrosis induced by treatment. Due to a rapidly declining in the performance status (PS), right lower lobectomy was performed to manage the pneumothorax and reduce the tumor burden. GD chemotherapy was resumed postoperatively but discontinued after a total of 14 cycles due to adverse events. As anticipated, the pulmonary metastases regrew. However, no evidence of extrathoracic disease was identified, and her respiratory function was deemed sufficient for surgery. She subsequently underwent one-stage partial bilateral lung resections, during which a total of 12 metastatic nodules were removed. Two years later, two additional metastatic lesions were resected. Since that time, 5\u00a0years and 8\u00a0months have passed without any recurrence or additional treatment. At the time of reporting, the patient had remained disease-free, 16\u00a0years after the initial hysterectomy, with PS of 0.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Uterine leiomyosarcoma is an aggressive tumor; however, in selected cases, long-term survival may be achieved through multimodal treatment approaches, including surgical resection of metastatic lesions.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1186\/s44215-025-00231-4","type":"journal-article","created":{"date-parts":[[2025,11,11]],"date-time":"2025-11-11T15:42:01Z","timestamp":1762875721000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Long-term survival following serial pulmonary metastasectomies for uterine leiomyosarcoma: a case report"],"prefix":"10.1186","volume":"4","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2508-9449","authenticated-orcid":false,"given":"Ken","family":"Kodama","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Toru","family":"Momozane","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroshi","family":"Takehara","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kazuaki","family":"Sato","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2025,11,11]]},"reference":[{"issue":"1","key":"231_CR1","doi-asserted-by":"publisher","first-page":"70","DOI":"10.6004\/jadpro.2022.13.1.6","volume":"13","author":"KL Byar","year":"2022","unstructured":"Byar KL, Fredericks T. Uterine leiomyosarcoma. J Adv Pract Oncol. 2022;13(1):70\u20136. https:\/\/doi.org\/10.6004\/jadpro.2022.13.1.6.","journal-title":"J Adv Pract Oncol"},{"key":"231_CR2","doi-asserted-by":"publisher","DOI":"10.1016\/j.gore.2023.101308","volume":"51","author":"AC Istl","year":"2024","unstructured":"Istl AC, Desravines N, Nudotor R, et al. Treatment pattern and outcomes for primary uterine leiomyosarcoma with synchronous isolated lung metastases: A National Cancer Databese study of primary resection and metastasectomy. Gynecology Oncology Reports. 2024;51:101308. https:\/\/doi.org\/10.1016\/j.gore.2023.101308.","journal-title":"Gynecology Oncology Reports"},{"key":"231_CR3","doi-asserted-by":"publisher","first-page":"1202","DOI":"10.1016\/j.athoracsur.2011.05.052","volume":"92","author":"BM Burt","year":"2011","unstructured":"Burt BM, Ocejo S, Mery CM, et al. Repeated and aggressive pulmonary resections for leiomyosarcoma metastases extends survival. Ann Thorac Surg. 2011;92:1202\u20137. https:\/\/doi.org\/10.1016\/j.athoracsur.2011.05.052.","journal-title":"Ann Thorac Surg"},{"issue":"2","key":"231_CR4","doi-asserted-by":"publisher","DOI":"10.7759\/cureus.79484","volume":"17","author":"ALE Choo","year":"2025","unstructured":"Choo ALE, Chia CML. Lung metastasis from uterine leiomyosarcoma: a case report and literature review on pulmonary metastasis presenting as both solid and cystic lesions. Cureus. 2025;17(2):e79484. https:\/\/doi.org\/10.7759\/cureus.79484.","journal-title":"Cureus"},{"issue":"6","key":"231_CR5","doi-asserted-by":"publisher","first-page":"1425","DOI":"10.1002\/(SICI)1097-0142(20000315)88:6<1425::AID-CNCR21>3.0.CO;2-3","volume":"88","author":"P Pautier","year":"2000","unstructured":"Pautier P, Genestie C, Rey A, et al. Analysis of clinicopathologic prognostic factors for 157 uterine sarcomas and evaluation of a grading score validated for soft tissue sarcoma. Cancer. 2000;88(6):1425\u201331.","journal-title":"Cancer"},{"key":"231_CR6","doi-asserted-by":"crossref","unstructured":"Carla B, Mariana A, Ana PL, et al. Distant metastases in uterine leiomyosarcomas: The wide variety of body sites and time interval to metastatic relapse. Int J Gynecol Pathol 2017;36(1):31\u201341. https:\/\/doi.org\/10.1097\/PGP.0000000000000284.","DOI":"10.1097\/PGP.0000000000000284"},{"key":"231_CR7","doi-asserted-by":"publisher","first-page":"202","DOI":"10.4103\/0976-7800.145175","volume":"5","author":"K Kaur","year":"2014","unstructured":"Kaur K, Kaur P, Kaur A, Singla A. Uterine leiomyosarcoma: a case report. J Mid-life Health. 2014;5:202\u20134. https:\/\/doi.org\/10.4103\/0976-7800.145175.","journal-title":"J Mid-life Health"},{"key":"231_CR8","doi-asserted-by":"publisher","first-page":"101","DOI":"10.1067\/mtc.2003.92","volume":"125","author":"M Higashiyama","year":"2003","unstructured":"Higashiyama M, Kodama K, Takami K, Higaki N, Nakayama T, Yokouchi H. Intraoperative lavage cytology analysis of surgical margins in patients undergoing limited surgery for lung cancer. J Thorac Cardiovasc Surg. 2003;125:101\u20137.","journal-title":"J Thorac Cardiovasc Surg"},{"issue":"3","key":"231_CR9","doi-asserted-by":"publisher","first-page":"510","DOI":"10.1378\/chest.09-2292","volume":"138","author":"JB Hoag","year":"2010","unstructured":"Hoag JB, Sherman M, Fasihuddin Q, Lund ME. A comprehensive review of spontaneous pneumothorax complicating sarcoma. Chest. 2010;138(3):510\u20138. https:\/\/doi.org\/10.1378\/chest.09-2292.","journal-title":"Chest"},{"key":"231_CR10","doi-asserted-by":"publisher","DOI":"10.1183\/13993003.00797-2023","volume":"63","author":"S Walker","year":"2024","unstructured":"Walker S, Hallifax R, Ricciardi S, et al. Joint ERS\/EACTS\/ESTS clinical practice guidelines on adults with spontaneous pneumothorax. 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We obtained written informed consent from the patient for the publication of this article.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"The authors declare no conflicts of interest.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"46"}}