{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,27]],"date-time":"2025-11-27T11:25:45Z","timestamp":1764242745815,"version":"3.46.0"},"reference-count":15,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2025,11,27]],"date-time":"2025-11-27T00:00:00Z","timestamp":1764201600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2025,11,27]],"date-time":"2025-11-27T00:00:00Z","timestamp":1764201600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"name":"Hochschule Bremerhaven"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Gen Thorac Cardiovasc Surg Cases"],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Surgical site infections following median sternotomy are common and can lead to extended hospital stays, prolonged courses of intravenous antibiotics, increased healthcare costs, and, in many cases, the need for repeated debridement or additional surgical interventions. Recognizing this significant unmet clinical need, we adopted an alternative approach in the present case report to address and resolve the problem.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Case presentation<\/jats:title>\n                    <jats:p>We herein report a case of a 52-year-old female patient, that developed a deep incisional infection with localized dehiscence after a median sternotomy performed for left atrial myxoma removal. Klebsiella aerogenes was cultured from the wound swabs and, despite prolonged intravenous antibiotic therapy and regular debridement we were unable to obtain culture negativity or wound healing over the course of several weeks. A commercially available Taurolidine 2% solution was employed every other day to irrigate the wound, which led to culture negativity within five days. Complete reepithelization was reached after a total of five weeks.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Reports of various taurolidine solutions promoting healing in complex wound lesions are scarcely available. In our case it proved to be an effective therapeutic option, preventing the need for additional surgical intervention and facilitating healing by secondary intention.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1186\/s44215-025-00237-y","type":"journal-article","created":{"date-parts":[[2025,11,27]],"date-time":"2025-11-27T05:05:43Z","timestamp":1764219943000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Efficacy of topical application of taurolidine 2% in promoting second intention healing of poststernotomy deep incisional wound infection"],"prefix":"10.1186","volume":"4","author":[{"given":"Roberto","family":"Cemin","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michela","family":"Coronet","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrea","family":"Azzolini","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cinzia","family":"Viola","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carmen","family":"Ladurner","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrea","family":"Comunello","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7082-533X","authenticated-orcid":false,"given":"Benito","family":"Baldauf","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2025,11,27]]},"reference":[{"issue":"5","key":"237_CR1","doi-asserted-by":"publisher","first-page":"831","DOI":"10.1016\/S1010-7940(02)00124-0","volume":"21","author":"JE Losanoff","year":"2002","unstructured":"Losanoff JE, Richman BW, Jones JW. Disruption and infection of median sternotomy: a comprehensive review. Eur J Cardiothorac Surg. 2002;21(5):831\u20139.","journal-title":"Eur J Cardiothorac Surg"},{"issue":"6","key":"237_CR2","doi-asserted-by":"publisher","first-page":"835","DOI":"10.1016\/j.hlc.2019.01.008","volume":"28","author":"M Sharif","year":"2019","unstructured":"Sharif M, Wong CHM, Harky A. Sternal wound infections, risk factors and management \u2013 how far are we? A literature review. Heart Lung Circ. 2019;28(6):835\u201343.","journal-title":"Heart Lung Circ"},{"issue":"11","key":"237_CR3","doi-asserted-by":"publisher","first-page":"907","DOI":"10.1007\/s11748-019-01204-5","volume":"67","author":"A Nenna","year":"2019","unstructured":"Nenna A, et al. Sternal wound closure in the current era: the need of a tailored approach. Gen Thorac Cardiovasc Surg. 2019;67(11):907\u201316.","journal-title":"Gen Thorac Cardiovasc Surg"},{"issue":"1","key":"237_CR4","doi-asserted-by":"publisher","first-page":"184","DOI":"10.1186\/s13019-023-02228-y","volume":"18","author":"Y Song","year":"2023","unstructured":"Song Y, et al. Review on risk factors, classification, and treatment of sternal wound infection. J Cardiothorac Surg. 2023;18(1):184.","journal-title":"J Cardiothorac Surg"},{"issue":"4","key":"237_CR5","doi-asserted-by":"publisher","first-page":"291","DOI":"10.5999\/aps.2018.01151","volume":"46","author":"L Schiraldi","year":"2019","unstructured":"Schiraldi L, et al. Deep sternal wound infections: evidence for prevention, treatment, and reconstructive surgery. Arch Plast Surg. 2019;46(4):291\u2013302.","journal-title":"Arch Plast Surg"},{"key":"237_CR6","doi-asserted-by":"publisher","first-page":"3051","DOI":"10.2147\/JMDH.S512254","volume":"18","author":"TAF Alharbi","year":"2025","unstructured":"Alharbi TAF, et al. Diagnostic challenges and patient safety: the critical role of Accuracy - A systematic review. J Multidiscip Healthc. 2025;18:3051\u201364.","journal-title":"J Multidiscip Healthc"},{"issue":"6","key":"237_CR7","doi-asserted-by":"publisher","first-page":"1720","DOI":"10.1128\/AAC.44.6.1720-1724.2000","volume":"44","author":"C Torres-Viera","year":"2000","unstructured":"Torres-Viera C, et al. Activities of taurolidine in vitro and in experimental enterococcal endocarditis. Antimicrob Agents Chemother. 2000;44(6):1720\u20134.","journal-title":"Antimicrob Agents Chemother"},{"issue":"5","key":"237_CR8","doi-asserted-by":"publisher","first-page":"2031","DOI":"10.1007\/s00784-017-2297-6","volume":"22","author":"L Pirracchio","year":"2018","unstructured":"Pirracchio L, et al. Activity of taurolidine gels on ex vivo periodontal biofilm. Clin Oral Invest. 2018;22(5):2031\u20137.","journal-title":"Clin Oral Invest"},{"issue":"12","key":"237_CR9","doi-asserted-by":"publisher","first-page":"1010","DOI":"10.21037\/atm-21-2739","volume":"9","author":"L Wu","year":"2021","unstructured":"Wu L, et al. Collagen sponge prolongs taurine release for improved wound healing through inflammation inhibition and proliferation stimulation. Ann Transl Med. 2021;9(12):1010.","journal-title":"Ann Transl Med"},{"issue":"5","key":"237_CR10","doi-asserted-by":"publisher","first-page":"2210","DOI":"10.1016\/j.clnu.2018.09.020","volume":"38","author":"Y Wouters","year":"2019","unstructured":"Wouters Y, et al. Clinical outcomes of home parenteral nutrition patients using taurolidine as catheter lock: A long-term cohort study. Clin Nutr. 2019;38(5):2210\u20138.","journal-title":"Clin Nutr"},{"key":"237_CR11","doi-asserted-by":"publisher","DOI":"10.3390\/jcdd9010018","author":"J Weichsel","year":"2022","unstructured":"Weichsel J, et al. Eradication of ventricular assist device driveline infection in paediatric patients with Taurolidine. J Cardiovasc Dev Dis. 2022. https:\/\/doi.org\/10.3390\/jcdd9010018.","journal-title":"J Cardiovasc Dev Dis"},{"key":"237_CR12","doi-asserted-by":"publisher","DOI":"10.3390\/antibiotics13090841","author":"SY Dakhode","year":"2024","unstructured":"Dakhode SY, et al. Is taurolidine irrigation effective in preventing surgical site infection during fracture surgery? Antibiotics. 2024. https:\/\/doi.org\/10.3390\/antibiotics13090841.","journal-title":"Antibiotics"},{"key":"237_CR13","first-page":"101835","volume-title":"Use of taurolidine in a patient with a cardiac implantable electronic device protrusion","author":"M Giudice","year":"2023","unstructured":"Giudice M, et al. Use of taurolidine in a patient with a cardiac implantable electronic device protrusion. Volume 14. JACC: Case Reports; 2023. p. 101835."},{"issue":"1","key":"237_CR14","doi-asserted-by":"publisher","first-page":"592","DOI":"10.1186\/s13019-024-03059-1","volume":"19","author":"R Vonthein","year":"2024","unstructured":"Vonthein R, et al. Taurolidine-containing solution for reducing cardiac implantable electronic device infection-early report from the European TauroPace\u2122 registry. J Cardiothorac Surg. 2024;19(1):592.","journal-title":"J Cardiothorac Surg"},{"key":"237_CR15","doi-asserted-by":"publisher","DOI":"10.1093\/europace\/euad306","author":"S Borov","year":"2023","unstructured":"Borov S, et al. Use of a taurolidine containing antimicrobial wash to reduce cardiac implantable electronic device infection. Europace. 2023. https:\/\/doi.org\/10.1093\/europace\/euad306.","journal-title":"Europace"}],"container-title":["General Thoracic and Cardiovascular Surgery Cases"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s44215-025-00237-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s44215-025-00237-y\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s44215-025-00237-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,11,27]],"date-time":"2025-11-27T11:21:40Z","timestamp":1764242500000},"score":1,"resource":{"primary":{"URL":"https:\/\/gtcscases.biomedcentral.com\/articles\/10.1186\/s44215-025-00237-y"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,11,27]]},"references-count":15,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2025,12]]}},"alternative-id":["237"],"URL":"https:\/\/doi.org\/10.1186\/s44215-025-00237-y","relation":{},"ISSN":["2731-6203"],"issn-type":[{"type":"electronic","value":"2731-6203"}],"subject":[],"published":{"date-parts":[[2025,11,27]]},"assertion":[{"value":"21 September 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"21 November 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"27 November 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The patient provided written informed consent for the publication of this case report and any accompanying images. All procedures described were conducted in accordance with the ethical standards of the institutional and national research committee and with the principles outlined in the Declaration of Helsinki.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"BB currently holds or held the following positions during the last three years - medical consultant\/part of the advisory board of: Abbott, BiolineSupply, Biotronik, Boston Scientific, CRM Microport, CrosstecGmbH, DrugsalesLtd., DSE Holding T\u00fcrkiye, Implicity, Kappamed, KimalPLC, M3 Medical\/EcclipseMedical, Medival SRL, Medtronic, Philips\/Spectranetics, SintecSRL, Tauro-ImplantGmbH, Tauropharm GmbH, Transcutan, Transaxis, 4G.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}],"article-number":"50"}}