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Public Health"],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Pre-eclampsia is a leading cause of maternal and neonatal mortality; 30,000 pre-eclampsia-related maternal deaths occur annually, with 70% in Sub-Saharan Africa (SSA) and 16% in South Asia. We have shown that early, accurate detection of hypertension combined with planned early delivery in women with late preterm pre-eclampsia significantly reduces stillbirth and severe maternal hypertension. We describe co-development and delivery of policy labs, working with The Policy Institute (King\u2019s College London), and local stakeholders in Sierra Leone and Zambia, to expedite integration of new knowledge into pre-eclampsia care pathways, to improve care for women and babies with the worst outcomes. Policy labs are a unique, user-centric engagement approach, bringing diverse stakeholders together in co-designing strategies for translation of evidence into policy and impact. Both labs were facilitated by local, well-respected female team members, and addressed co-developed questions: \u2018How can we improve timely detection and appropriate action in women with pre-eclampsia?\u2019 (Sierra Leone); \u2018What are enablers and barriers to offering planned early delivery between 34 and 37 weeks?\u2019(Zambia). Participants at both labs identified lack of pre-eclampsia awareness as a key barrier, and recommended local co-design of community-based strategies to increase access to timely pre-eclampsia management. We demonstrated \u00a0policy labs as an effective approach in two low-and middle income settings to facilitate transfer of new knowledge into policy and action.<\/jats:p>","DOI":"10.1186\/s44263-024-00116-8","type":"journal-article","created":{"date-parts":[[2025,1,7]],"date-time":"2025-01-07T10:48:47Z","timestamp":1736246927000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["A novel approach to expedite evidence to impact in pre-eclampsia: co-developed policy labs in Zambia and Sierra Leone"],"prefix":"10.1186","volume":"3","author":[{"given":"Katy","family":"Kuhrt","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chileshe","family":"Mabula-Bwalya","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Harriet","family":"Boulding","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alice","family":"Beardmore-Gray","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexandra","family":"Ridout","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Osman","family":"Koroma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Betty","family":"Sam","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Prince Tommy","family":"Williams","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francis","family":"Smart","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isabel","family":"Meleki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meek","family":"Mwila","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mubanga","family":"Chileshe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Racheal","family":"Mawere","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alice","family":"Hurrell","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christabel","family":"Mbiiza","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cristina","family":"Fernandez-Turienzo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jane","family":"Sandall","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bellington","family":"Vwalika","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew","family":"Shennan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kate","family":"Bramham","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,1,7]]},"reference":[{"issue":"9947","key":"116_CR1","doi-asserted-by":"crossref","first-page":"980","DOI":"10.1016\/S0140-6736(14)60696-6","volume":"384","author":"NJ Kassebaum","year":"2014","unstructured":"Kassebaum NJ, Bertozzi-Villa A, Coggeshall MS, Shackelford KA, Steiner C, Heuton KR, et al. Global, regional, and national levels and causes of maternal mortality during 1990\u20132013: a systematic analysis for the Global Burden of Disease Study 2013. Lancet. 2014;384(9947):980\u20131004.","journal-title":"Lancet"},{"key":"116_CR2","unstructured":"World Health Organisation. Trends in maternal mortality 2000 to 2020: estimates by WHO, UNICEF, UNFPA, World Bank Group and UNDESA\/Population Division 2023 . Available from: https:\/\/www.who.int\/publications\/i\/item\/9789240068759."},{"issue":"3","key":"116_CR3","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1053\/j.semperi.2009.02.010","volume":"33","author":"L Duley","year":"2009","unstructured":"Duley L. The global impact of pre-eclampsia and eclampsia. Semin Perinatol. 2009;33(3):130\u20137.","journal-title":"Semin Perinatol"},{"key":"116_CR4","unstructured":"World Bank. Gender Portal Sierra Leone 2023 [2nd November 2023]. Available from: https:\/\/genderdata.worldbank.org\/countries\/sierra-leone\/#:~:text=The%20maternal%20mortality%20ratio%20in,lower%20than%20its%20regional%20average."},{"issue":"9","key":"116_CR5","doi-asserted-by":"crossref","first-page":"1082","DOI":"10.1111\/1471-0528.16309","volume":"127","author":"N Vousden","year":"2020","unstructured":"Vousden N, Holmes E, Seed P, Gidiri M, Goudar S, Sandall J, et al. Incidence and characteristics of pregnancy-related death across ten low- and middle-income geographical regions: secondary analysis of a cluster randomised controlled trial. BJOG. 2020;127(9):1082\u20139.","journal-title":"BJOG."},{"issue":"1","key":"116_CR6","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1161\/HYPERTENSIONAHA.117.10803","volume":"72","author":"MA Brown","year":"2018","unstructured":"Brown MA, Magee LA, Kenny LC, Karumanchi SA, McCarthy FP, Saito S, et al. 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Rev Policy Res. 2023;40(3):341\u201362.","journal-title":"Rev Policy Res"}],"container-title":["BMC Global and Public Health"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s44263-024-00116-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s44263-024-00116-8\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s44263-024-00116-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,3,21]],"date-time":"2025-03-21T07:16:03Z","timestamp":1742541363000},"score":1,"resource":{"primary":{"URL":"https:\/\/bmcglobalpublichealth.biomedcentral.com\/articles\/10.1186\/s44263-024-00116-8"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,1,7]]},"references-count":28,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2025,12]]}},"alternative-id":["116"],"URL":"https:\/\/doi.org\/10.1186\/s44263-024-00116-8","relation":{"has-preprint":[{"id-type":"doi","id":"10.22541\/au.171894273.32332717\/v1","asserted-by":"object"}]},"ISSN":["2731-913X"],"issn-type":[{"value":"2731-913X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,1,7]]},"assertion":[{"value":"13 June 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"28 November 2024","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"7 January 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Ethical approval was granted from the Office of the Sierra Leone Ethics and Scientific Review Committee on 24th January 2022 and from the King\u2019s College London, UK, Research Ethic Committee on 27 January 2022\u00a0(reference: HR\/DP-21\/22\u201327014) for CRADLE-5 trial, which was carried out in accordance with the declaration of Helsinki, and included policy lab workshops. Participants provided consent to being photographed and voice recorded during the event, including interviews. Ethical approval was granted for the ethnographic observation which took place at the Sierra Leone policy lab only\u00a0(MRSP-22\/23\u201336017).","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Participants provided written consent for the sharing and publication of ethnographic observation and photographs.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"3"}}