{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,21]],"date-time":"2026-03-21T19:19:02Z","timestamp":1774120742366,"version":"3.50.1"},"reference-count":51,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[2013,3,4]],"date-time":"2013-03-04T00:00:00Z","timestamp":1362355200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/2.0\/"},{"start":{"date-parts":[[2013,3,4]],"date-time":"2013-03-04T00:00:00Z","timestamp":1362355200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/2.0\/"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Stem Cell Res Ther"],"abstract":"<jats:title>Abstract<\/jats:title><jats:sec>\n                        <jats:title>Introduction<\/jats:title>\n                        <jats:p>The acute respiratory distress syndrome (ARDS), affects up to 150,000 patients per year in the United States. We and other groups have demonstrated that bone marrow derived mesenchymal stromal stem cells prevent ARDS induced by systemic and local administration of endotoxin (lipopolysaccharide (LPS)) in mice.<\/jats:p>\n                     <\/jats:sec><jats:sec>\n                        <jats:title>Methods<\/jats:title>\n                        <jats:p>A study was undertaken to determine the effects of the diverse populations of bone marrow derived cells on the pathophysiology of ARDS, using a unique <jats:italic>ex-vivo<\/jats:italic> swine preparation, in which only the ventilated lung and the liver are perfused with autologous blood. Six experimental groups were designated as: 1) endotoxin alone, 2) endotoxin + total fresh whole bone marrow nuclear cells (BMC), 3) endotoxin + non-hematopoietic bone marrow cells (CD45 neg), 4) endotoxin + hematopoietic bone marrow cells (CD45 positive), 5) endotoxin + buffy coat and 6) endotoxin + <jats:italic>in vitro<\/jats:italic> expanded swine CD45 negative adherent allogeneic bone marrow cells (cultured CD45neg). We measured at different levels the biological consequences of the infusion of the different subsets of cells. The measured parameters were: pulmonary vascular resistance (PVR), gas exchange (PO<jats:sub>2<\/jats:sub>), lung edema (lung wet\/dry weight), gene expression and serum concentrations of the pro-inflammatory cytokines IL-1\u03b2, TNF-\u03b1 and IL-6.<\/jats:p>\n                     <\/jats:sec><jats:sec>\n                        <jats:title>Results<\/jats:title>\n                        <jats:p>Infusion of freshly purified autologous total BMCs, as well as non-hematopoietic CD45(-) bone marrow cells significantly reduced endotoxin-induced pulmonary hypertension and hypoxemia and reduced the lung edema. Also, in the groups that received BMCs and cultured CD45neg we observed a decrease in the levels of IL-1\u03b2 and TNF-\u03b1 in plasma. Infusion of hematopoietic CD45(+) bone marrow cells or peripheral blood buffy coat cells did not protect against LPS-induced lung injury.<\/jats:p>\n                     <\/jats:sec><jats:sec>\n                        <jats:title>Conclusions<\/jats:title>\n                        <jats:p>We conclude that infusion of freshly isolated autologous whole bone marrow cells and the subset of non-hematopoietic cells can suppress the acute humoral and physiologic responses induced by endotoxemia by modulating the inflammatory response, mechanisms that do not involve engraftment or trans-differentiation of the cells. These observations may have important implications for the design of future cell therapies for ARDS.<\/jats:p>\n                     <\/jats:sec>","DOI":"10.1186\/scrt174","type":"journal-article","created":{"date-parts":[[2013,3,5]],"date-time":"2013-03-05T00:38:58Z","timestamp":1362443938000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":31,"title":["Infusion of freshly isolated autologous bone marrow derived mononuclear cells prevents endotoxin-induced lung injury in an ex-vivo perfused swine model"],"prefix":"10.1186","volume":"4","author":[{"given":"Mauricio","family":"Rojas","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Richard E","family":"Parker","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Natalie","family":"Thorn","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Claudia","family":"Corredor","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Smita S","family":"Iyer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marta","family":"Bueno","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lyle","family":"Mroz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nayra","family":"Cardenes","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ana L","family":"Mora","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Arlene A","family":"Stecenko","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kenneth L","family":"Brigham","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2013,3,4]]},"reference":[{"key":"175_CR1","volume-title":"Breathing in America: Diseases, Progress, and Hope","author":"DE Schraufnagel","year":"2010","unstructured":"Schraufnagel DE: Breathing in America: Diseases, Progress, and Hope. 2010, New York: American Thoracic Society"},{"key":"175_CR2","doi-asserted-by":"publisher","first-page":"243","DOI":"10.1089\/jamp.2009.0775","volume":"23","author":"ER Johnson","year":"2010","unstructured":"Johnson ER, Matthay MA: Acute lung injury: epidemiology, pathogenesis, and treatent. J Aerosol Med Pulm Drug Deliv. 2010, 23: 243-252. 10.1089\/jamp.2009.0775.","journal-title":"J Aerosol Med Pulm Drug Deliv"},{"key":"175_CR3","doi-asserted-by":"publisher","first-page":"205","DOI":"10.1186\/cc10570","volume":"16","author":"M Hayes","year":"2012","unstructured":"Hayes M, Curley G, Ansari B, Laffey JG: Clinical review: stem cell therapies for acute lung injury\/acute respiratory distress syndrome - hope or hype?. Crit Care. 2012, 16: 205-10.1186\/cc10570.","journal-title":"Crit Care"},{"key":"175_CR4","doi-asserted-by":"publisher","first-page":"165","DOI":"10.1002\/ar.21244","volume":"294","author":"JS Lee","year":"2011","unstructured":"Lee JS, Su X, Rackley C, Matthay MA, Gupta N: Priming with endotoxin increases acute lung injury in mice by enhancing the severity of lung endothelial injury. Anat Rec (Hoboken). 2011, 294: 165-172. 10.1002\/ar.21244.","journal-title":"Anat Rec (Hoboken)"},{"key":"175_CR5","doi-asserted-by":"publisher","first-page":"147","DOI":"10.1146\/annurev-pathol-011110-130158","volume":"6","author":"MA Matthay","year":"2011","unstructured":"Matthay MA, Zemans RL: The acute respiratory distress syndrome: pathogenesis and treatment. Annu Rev Pathol. 2011, 6: 147-163. 10.1146\/annurev-pathol-011110-130158.","journal-title":"Annu Rev Pathol"},{"key":"175_CR6","doi-asserted-by":"publisher","first-page":"268","DOI":"10.1213\/ANE.0b013e3181e75ced","volume":"111","author":"MA Matthay","year":"2010","unstructured":"Matthay MA, Jayr C: Acute respiratory distress syndrome after surgery: can the risk be decreased?. Anesth Analg. 2010, 111: 268-269. 10.1213\/ANE.0b013e3181e75ced.","journal-title":"Anesth Analg"},{"key":"175_CR7","doi-asserted-by":"publisher","first-page":"1027","DOI":"10.1164\/rccm.201001-0074UP","volume":"181","author":"MA Matthay","year":"2010","unstructured":"Matthay MA, Idell S: Update on acute lung injury and critical care medicine 2009. Am J Respir Crit Care Med. 2010, 181: 1027-1032. 10.1164\/rccm.201001-0074UP.","journal-title":"Am J Respir Crit Care Med"},{"key":"175_CR8","doi-asserted-by":"publisher","first-page":"243","DOI":"10.1089\/jamp.2009.0775","volume":"23","author":"ER Johnson","year":"2010","unstructured":"Johnson ER, Matthay MA: Acute lung injury: epidemiology, pathogenesis, and treatment. J Aerosol Med Pulm Drug Deliv. 2010, 23: 243-252. 10.1089\/jamp.2009.0775.","journal-title":"J Aerosol Med Pulm Drug Deliv"},{"key":"175_CR9","doi-asserted-by":"publisher","first-page":"1121","DOI":"10.1097\/TA.0b013e3181c40728","volume":"68","author":"RD Fremont","year":"2010","unstructured":"Fremont RD, Koyama T, Calfee CS, Wu W, Dossett LA, Bossert FR, Mitchell D, Wickersham N, Bernard GR, Matthay MA, Addison KM, Ware LB: Acute lung injury in patients with traumatic injuries: utility of a panel of biomarkers for diagnosis and pathogenesis. J Trauma. 2010, 68: 1121-1127. 10.1097\/TA.0b013e3181c40728.","journal-title":"J Trauma"},{"key":"175_CR10","first-page":"83","volume":"2","author":"AJ Friedenstein","year":"1974","unstructured":"Friedenstein AJ, Deriglasova UF, Kulagina NN, Panasuk AF, Rudakowa SF, Luria EA, Ruadkow IA: Precursors for fibroblasts in different populations of hematopoietic cells as detected by the in vitro colony assay method. Exp Hematol. 1974, 2: 83-92.","journal-title":"Exp Hematol"},{"key":"175_CR11","doi-asserted-by":"publisher","first-page":"331","DOI":"10.1097\/00007890-197404000-00001","volume":"17","author":"AJ Friedenstein","year":"1974","unstructured":"Friedenstein AJ, Chailakhyan RK, Latsinik NV, Panasyuk AF, Keiliss-Borok IV: Stromal cells responsible for transferring the microenvironment of the hemopoietic tissues. Cloning in vitro and retransplantation in vivo. Transplantation. 1974, 17: 331-340. 10.1097\/00007890-197404000-00001.","journal-title":"Transplantation"},{"key":"175_CR12","first-page":"393","volume":"3","author":"AJ Friedenstein","year":"1970","unstructured":"Friedenstein AJ, Chailakhjan RK, Lalykina KS: The development of fibroblast colonies in monolayer cultures of guinea-pig bone marrow and spleen cells. Cell Tissue Kinet. 1970, 3: 393-403.","journal-title":"Cell Tissue Kinet"},{"key":"175_CR13","doi-asserted-by":"publisher","first-page":"99","DOI":"10.1097\/00007890-197108000-00001","volume":"12","author":"A Friedenstein","year":"1971","unstructured":"Friedenstein A, Kuralesova AI: Osteogenic precursor cells of bone marrow in radiation chimeras. Transplantation. 1971, 12: 99-108. 10.1097\/00007890-197108000-00001.","journal-title":"Transplantation"},{"key":"175_CR14","doi-asserted-by":"publisher","first-page":"457","DOI":"10.1146\/annurev-pathol-011110-130230","volume":"6","author":"NG Singer","year":"2011","unstructured":"Singer NG, Caplan AI: Mesenchymal stem cells: mechanisms of inflammation. Annu Rev Pathol. 2011, 6: 457-478. 10.1146\/annurev-pathol-011110-130230.","journal-title":"Annu Rev Pathol"},{"key":"175_CR15","doi-asserted-by":"publisher","first-page":"315","DOI":"10.1080\/14653240600855905","volume":"8","author":"M Dominici","year":"2006","unstructured":"Dominici M, Le Blanc K, Mueller I, Slaper-Cortenbach I, Marini F, Krause D, Deans R, Keating A, Prockop D, Horwitz E: Minimal criteria for defining multipotent mesenchymal stromal cells. The International Society for Cellular Therapy position statement. Cytotherapy. 2006, 8: 315-317. 10.1080\/14653240600855905.","journal-title":"Cytotherapy"},{"key":"175_CR16","doi-asserted-by":"publisher","first-page":"L131","DOI":"10.1152\/ajplung.00431.2006","volume":"293","author":"J Xu","year":"2007","unstructured":"Xu J, Woods CR, Mora AL, Joodi R, Brigham KL, Iyer S, Rojas M: Prevention of endotoxin-induced systemic response by bone marrow-derived mesenchymal stem cells in mice. Am J Physiol Lung Cell Mol Physiol. 2007, 293: L131-141. 10.1152\/ajplung.00431.2006.","journal-title":"Am J Physiol Lung Cell Mol Physiol"},{"key":"175_CR17","doi-asserted-by":"publisher","first-page":"1855","DOI":"10.4049\/jimmunol.179.3.1855","volume":"179","author":"N Gupta","year":"2007","unstructured":"Gupta N, Su X, Popov B, Lee JW, Serikov V, Matthay MA: Intrapulmonary delivery of bone marrow-derived mesenchymal stem cells improves survival and attenuates endotoxin-induced acute lung injury in mice. J Immunol. 2007, 179: 1855-1863.","journal-title":"J Immunol"},{"key":"175_CR18","doi-asserted-by":"publisher","first-page":"2379","DOI":"10.1097\/CCM.0b013e3181f96f5f","volume":"38","author":"SK Cribbs","year":"2010","unstructured":"Cribbs SK, Matthay MA, Martin GS: Stem cells in sepsis and acute lung injury. Crit Care Med. 2010, 38: 2379-2385. 10.1097\/CCM.0b013e3181f96f5f.","journal-title":"Crit Care Med"},{"key":"175_CR19","doi-asserted-by":"publisher","first-page":"26211","DOI":"10.1074\/jbc.M110.119917","volume":"285","author":"X Fang","year":"2010","unstructured":"Fang X, Neyrinck AP, Matthay MA, Lee JW: Allogeneic human mesenchymal stem cells restore epithelial protein permeability in cultured human alveolar type II cells by secretion of angiopoietin-1. J Biol Chem. 2010, 285: 26211-26222. 10.1074\/jbc.M110.119917.","journal-title":"J Biol Chem"},{"key":"175_CR20","doi-asserted-by":"publisher","first-page":"16357","DOI":"10.1073\/pnas.0907996106","volume":"106","author":"JW Lee","year":"2009","unstructured":"Lee JW, Fang X, Gupta N, Serikov V, Matthay MA: Allogeneic human mesenchymal stem cells for treatment of E. coli endotoxin-induced acute lung injury in the ex vivo perfused human lung. Proc Natl Acad Sci USA. 2009, 106: 16357-16362. 10.1073\/pnas.0907996106.","journal-title":"Proc Natl Acad Sci USA"},{"key":"175_CR21","doi-asserted-by":"publisher","first-page":"S569","DOI":"10.1097\/CCM.0b013e3181f1ff1d","volume":"38","author":"MA Matthay","year":"2010","unstructured":"Matthay MA, Goolaerts A, Howard JP, Lee JW: Mesenchymal stem cells for acute lung injury: preclinical evidence. Crit Care Med. 2010, 38: S569-573.","journal-title":"Crit Care Med"},{"key":"175_CR22","doi-asserted-by":"publisher","first-page":"179","DOI":"10.1007\/s00408-008-9078-6","volume":"186","author":"VB Serikov","year":"2008","unstructured":"Serikov VB, Mikhaylov VM, Krasnodembskay AD, Matthay MA: Bone marrow-derived cells participate in stromal remodeling of the lung following acute bacterial pneumonia in mice. Lung. 2008, 186: 179-190. 10.1007\/s00408-008-9078-6.","journal-title":"Lung"},{"key":"175_CR23","doi-asserted-by":"publisher","first-page":"1317","DOI":"10.1007\/BF02257804","volume":"37","author":"Z Fireman","year":"1994","unstructured":"Fireman Z, Shabtai F, Lurie B: Chromosome sensitivity to bleomycin-induced mutagenesis in lymphocytes from colorectal cancer patients under 40 years of age. Dis Colon Rectum. 1994, 37: 1317-1320. 10.1007\/BF02257804.","journal-title":"Dis Colon Rectum"},{"key":"175_CR24","doi-asserted-by":"publisher","first-page":"L333","DOI":"10.1152\/ajplung.00334.2004","volume":"288","author":"M Rojas","year":"2005","unstructured":"Rojas M, Woods CR, Mora AL, Xu J, Brigham KL: Endotoxin-induced lung injury in mice: structural, functional, and biochemical responses. Am J Physiol Lung Cell Mol Physiol. 2005, 288: L333-341.","journal-title":"Am J Physiol Lung Cell Mol Physiol"},{"key":"175_CR25","first-page":"35","volume":"9","author":"S Ohkawa","year":"1986","unstructured":"Ohkawa S, Inoue J, Sugiura M: [A clinicopathologic study of dilated cardiomyopathy in the aged]. J Cardiogr Suppl. 1986, 35-47. 9","journal-title":"J Cardiogr Suppl"},{"key":"175_CR26","doi-asserted-by":"publisher","first-page":"34","DOI":"10.1164\/arrd.1983.128.1.34","volume":"128","author":"PB Davis","year":"1983","unstructured":"Davis PB, Del Rio S, Muntz JA, Dieckman L: Sweat chloride concentration in adults with pulmonary diseases. Am Rev Respir Dis. 1983, 128: 34-37.","journal-title":"Am Rev Respir Dis"},{"key":"175_CR27","doi-asserted-by":"publisher","first-page":"96","DOI":"10.1111\/j.1749-6632.1982.tb31236.x","volume":"393","author":"PM Farrell","year":"1982","unstructured":"Farrell PM, Mischler EH, Gutcher GR: Evaluation of vitamin E deficiency in children with lung disease. Ann NY Acad Sci. 1982, 393: 96-108. 10.1111\/j.1749-6632.1982.tb31236.x.","journal-title":"Ann NY Acad Sci"},{"key":"175_CR28","doi-asserted-by":"publisher","first-page":"143","DOI":"10.1016\/0007-0971(76)90027-9","volume":"70","author":"GJ Gibson","year":"1976","unstructured":"Gibson GJ, Pride NB: Lung distensibility. The static pressure-volume curve of the lungs and its use in clinical assessment. Br J Dis Chest. 1976, 70: 143-184.","journal-title":"Br J Dis Chest"},{"key":"175_CR29","doi-asserted-by":"publisher","first-page":"332","DOI":"10.1016\/j.ijrobp.2011.06.1963","volume":"83","author":"ZQ Jiang","year":"2012","unstructured":"Jiang ZQ, Yang K, Komaki R, Wei X, Tucker SL, Zhuang Y, Martel MK, Vedam S, Balter P, Zhu G, Gomez D, Lu C, Mohan R, Cox JD, Liao Z: Long-term clinical outcome of intensity-modulated radiotherapy for inoperable non-small-cell lung cancer: the MD Anderson Experience. Int J Radiat Oncol Biol Phys. 2012, 83: 332-329. 10.1016\/j.ijrobp.2011.06.1963.","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"175_CR30","doi-asserted-by":"publisher","first-page":"1368","DOI":"10.1183\/09031936.00187410","volume":"38","author":"A Nardi","year":"2011","unstructured":"Nardi A, Brillet PY, Letoumelin P, Girard F, Brauner M, Uzunhan Y, Naccache JM, Valeyre D, Nunes H: Stage IV sarcoidosis comparison of survival with the general population and causes of death. Eur Respir J. 2011, 38: 1368-1373. 10.1183\/09031936.00187410.","journal-title":"Eur Respir J"},{"key":"175_CR31","doi-asserted-by":"publisher","first-page":"1301","DOI":"10.1056\/NEJM200005043421801","volume":"342","author":"Ventilation with lower tidal volumes as compared with traditional tidal volumes for acute lung injury and the acute respiratory distress syndrome","year":"2000","unstructured":"Ventilation with lower tidal volumes as compared with traditional tidal volumes for acute lung injury and the acute respiratory distress syndrome. The Acute Respiratory Distress Syndrome Network. N Engl J Med. 2000, 342: 1301-1308.","journal-title":"N Engl J Med"},{"key":"175_CR32","doi-asserted-by":"publisher","first-page":"L23","DOI":"10.1152\/ajplung.00010.2010","volume":"301","author":"G Berger","year":"2011","unstructured":"Berger G, Guetta J, Klorin G, Badarneh R, Braun E, Brod V, Saleh NA, Katz A, Bitterman H, Azzam ZS: Sepsis impairs alveolar epithelial function by downregulating Na-K-ATPase pump. Am J Physiol Lung Cell Mol Physiol. 2011, 301: L23-30. 10.1152\/ajplung.00010.2010.","journal-title":"Am J Physiol Lung Cell Mol Physiol"},{"key":"175_CR33","doi-asserted-by":"publisher","first-page":"763","DOI":"10.1378\/chest.11-1660","volume":"141","author":"I Vadasz","year":"2012","unstructured":"Vadasz I, Weiss CH, Sznajder JI: Ubiquitination and proteolysis in acute lung injury. Chest. 2012, 141: 763-771. 10.1378\/chest.11-1660.","journal-title":"Chest"},{"key":"175_CR34","doi-asserted-by":"publisher","first-page":"460","DOI":"10.7326\/0003-4819-141-6-200409210-00012","volume":"141","author":"CA Piantadosi","year":"2004","unstructured":"Piantadosi CA, Schwartz DA: The acute respiratory distress syndrome. Ann Intern Med. 2004, 141: 460-470.","journal-title":"Ann Intern Med"},{"key":"175_CR35","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1517\/14728214.2012.667800","volume":"17","author":"CM Yamashita","year":"2012","unstructured":"Yamashita CM, Lewis JF: Emerging therapies for treatment of acute lung injury and acute respiratory distress syndrome. Expert Opin Emerg Drugs. 2012, 17: 1-4.","journal-title":"Expert Opin Emerg Drugs"},{"key":"175_CR36","doi-asserted-by":"publisher","first-page":"913","DOI":"10.1002\/stem.643","volume":"29","author":"JW Lee","year":"2011","unstructured":"Lee JW, Fang X, Krasnodembskaya A, Howard JP, Matthay MA: Concise review: mesenchymal stem cells for acute lung injury: role of paracrine soluble factors. Stem Cells. 2011, 29: 913-919. 10.1002\/stem.643.","journal-title":"Stem Cells"},{"key":"175_CR37","doi-asserted-by":"publisher","first-page":"719","DOI":"10.1016\/j.ccc.2011.04.004","volume":"27","author":"JE Gotts","year":"2011","unstructured":"Gotts JE, Matthay MA: Mesenchymal stem cells and acute lung injury. Crit Care Clin. 2011, 27: 719-733. 10.1016\/j.ccc.2011.04.004.","journal-title":"Crit Care Clin"},{"key":"175_CR38","doi-asserted-by":"publisher","first-page":"1564","DOI":"10.1016\/j.jvs.2010.02.020","volume":"51","author":"RW Sprengers","year":"2010","unstructured":"Sprengers RW, Moll FL, Teraa M, Verhaar MC: Rationale and design of the JUVENTAS trial for repeated intra-arterial infusion of autologous bone marrow-derived mononuclear cells in patients with critical limb ischemia. J Vasc Surg. 2010, 51: 1564-1568. 10.1016\/j.jvs.2010.02.020.","journal-title":"J Vasc Surg"},{"key":"175_CR39","volume-title":"Am J Hosp Palliat Care","author":"RF Johnson Jr","year":"2012","unstructured":"Johnson RF, Gustin J: Acute lung injury and acute respiratory distress syndrome requiring tracheal intubation and mechanical ventilation in the intensive care unit: impact on managing uncertainty for patient-centered communication. Am J Hosp Palliat Care. 2012"},{"key":"175_CR40","doi-asserted-by":"publisher","first-page":"984","DOI":"10.1016\/j.burns.2012.05.026","volume":"38","author":"M Starnes-Roubaud","year":"2012","unstructured":"Starnes-Roubaud M, Bales EA, Williams-Resnick A, Lumb PD, Escudero JA, Chan LS, Garner WL: High frequency percussive ventilation and low FiO(2). Burns. 2012, 38: 984-991. 10.1016\/j.burns.2012.05.026.","journal-title":"Burns"},{"key":"175_CR41","doi-asserted-by":"publisher","first-page":"63","DOI":"10.2147\/COPD.S15292","volume":"6","author":"JT Ribeiro-Paes","year":"2011","unstructured":"Ribeiro-Paes JT, Bilaqui A, Greco OT, Ruiz MA, Marcelino MY, Stessuk T, de Faria CA, Lago MR: Unicentric study of cell therapy in chronic obstructive pulmonary disease\/pulmonary emphysema. Int J Chron Obstruct Pulmon Dis. 2011, 6: 63-71.","journal-title":"Int J Chron Obstruct Pulmon Dis"},{"key":"175_CR42","doi-asserted-by":"publisher","first-page":"4995","DOI":"10.4049\/jimmunol.176.8.4995","volume":"176","author":"MB Everhart","year":"2006","unstructured":"Everhart MB, Han W, Sherrill TP, Arutiunov M, Polosukhin VV, Burke JR, Sadikot RT, Christman JW, Yull FE, Blackwell TS: Duration and intensity of NF-kappaB activity determine the severity of endotoxin-induced acute lung injury. J Immunol. 2006, 176: 4995-5005.","journal-title":"J Immunol"},{"key":"175_CR43","doi-asserted-by":"publisher","first-page":"227","DOI":"10.1165\/rcmb.2005-0241OC","volume":"35","author":"UA Maus","year":"2006","unstructured":"Maus UA, Janzen S, Wall G, Srivastava M, Blackwell TS, Christman JW, Seeger W, Welte T, Lohmeyer J: Resident alveolar macrophages are replaced by recruited monocytes in response to endotoxin-induced lung inflammation. Am J Respir Cell Mol Biol. 2006, 35: 227-235. 10.1165\/rcmb.2005-0241OC.","journal-title":"Am J Respir Cell Mol Biol"},{"key":"175_CR44","doi-asserted-by":"publisher","first-page":"4070","DOI":"10.1128\/JCM.01096-07","volume":"45","author":"D Garcia-Yoldi","year":"2007","unstructured":"Garcia-Yoldi D, Le Fleche P, De Miguel MJ, Munoz PM, Blasco JM, Cvetnic Z, Marin CM, Vergnaud G, Lopez-Goni I: Comparison of multiple-locus variable-number tandem-repeat analysis with other PCR-based methods for typing Brucella suis isolates. J Clin Microbiol. 2007, 45: 4070-4072. 10.1128\/JCM.01096-07.","journal-title":"J Clin Microbiol"},{"key":"175_CR45","doi-asserted-by":"publisher","first-page":"321","DOI":"10.1006\/clin.1996.0130","volume":"80","author":"MJ Thomassen","year":"1996","unstructured":"Thomassen MJ, Divis LT, Fisher CJ: Regulation of human alveolar macrophage inflammatory cytokine production by interleukin-10. Clin Immunol Immunopathol. 1996, 80: 321-324. 10.1006\/clin.1996.0130.","journal-title":"Clin Immunol Immunopathol"},{"key":"175_CR46","first-page":"75","volume":"53","author":"K Kondoh","year":"2006","unstructured":"Kondoh K, Usui Y, Ohtani Y, Inase N, Miyake S, Yoshizawa Y: Proinflammatory and anti-inflammatory cytokine gene polymorphisms in hypersensitivity pneumonitis. J Med Dent Sci. 2006, 53: 75-83.","journal-title":"J Med Dent Sci"},{"key":"175_CR47","doi-asserted-by":"publisher","first-page":"11002","DOI":"10.1073\/pnas.0704421104","volume":"104","author":"LA Ortiz","year":"2007","unstructured":"Ortiz LA, Dutreil M, Fattman C, Pandey AC, Torres G, Go K, Phinney DG: Interleukin 1 receptor antagonist mediates the antiinflammatory and antifibrotic effect of mesenchymal stem cells during lung injury. Proc Natl Acad Sci USA. 2007, 104: 11002-11007. 10.1073\/pnas.0704421104.","journal-title":"Proc Natl Acad Sci USA"},{"key":"175_CR48","doi-asserted-by":"publisher","first-page":"1436","DOI":"10.1038\/ncb1664","volume":"9","author":"L Liu","year":"2007","unstructured":"Liu L, Bailey SM, Okuka M, Mu\u00f1oz P, Li C, Zhou L, Wu C, Czerwiec E, Sandler L, Seyfang A, Blasco MA, Keefe DL: Telomere lengthening early in development. Nat Cell Biol. 2007, 9: 1436-1441. 10.1038\/ncb1664.","journal-title":"Nat Cell Biol"},{"key":"175_CR49","doi-asserted-by":"crossref","unstructured":"Verdejo B, Blasco S, Garcia-Espana E, Lloret F, Gavina P, Soriano C, Tatay S, Jimenez HR, Domenech A, Latorre J: Imidazolate bridged Cu(II)-Cu(II) and Cu(II)-Zn(II) complexes of a terpyridinophane azamacrocycle: a solution and solid state study. Dalton Trans. 2007, 4726-4737. 41","DOI":"10.1039\/b708186c"},{"key":"175_CR50","doi-asserted-by":"publisher","first-page":"1101","DOI":"10.1083\/jcb.200704140","volume":"178","author":"M Murga","year":"2007","unstructured":"Murga M, Jaco I, Fan Y, Soria R, Martinez-Pastor B, Cuadrado M, Yang SM, Blasco MA, Skoultchi AI, Fernandez-Capetillo O: Global chromatin compaction limits the strength of the DNA damage response. J Cell Biol. 2007, 178: 1101-1108. 10.1083\/jcb.200704140.","journal-title":"J Cell Biol"},{"key":"175_CR51","doi-asserted-by":"publisher","first-page":"e15404","DOI":"10.1371\/journal.pone.0015404","volume":"5","author":"F Liu","year":"2010","unstructured":"Liu F, Liu J, Weng D, Chen Y, Song L, He Q, Chen J: CD4+CD25+Foxp3+ regulatory T cells depletion may attenuate the development of silica-induced lung fibrosis in mice. PloS One. 2010, 5: e15404-10.1371\/journal.pone.0015404.","journal-title":"PloS One"}],"container-title":["Stem Cell Research &amp; Therapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/scrt174.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1186\/scrt174\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/scrt174.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,10,8]],"date-time":"2024-10-08T11:04:20Z","timestamp":1728385460000},"score":1,"resource":{"primary":{"URL":"https:\/\/stemcellres.biomedcentral.com\/articles\/10.1186\/scrt174"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,3,4]]},"references-count":51,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2013,6]]}},"alternative-id":["175"],"URL":"https:\/\/doi.org\/10.1186\/scrt174","relation":{},"ISSN":["1757-6512"],"issn-type":[{"value":"1757-6512","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,3,4]]},"assertion":[{"value":"14 August 2012","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"3 January 2013","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"4 March 2013","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"4 March 2013","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}}],"article-number":"26"}}