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Irradiated control animals received only saline infusion.<\/jats:p>\n                     <\/jats:sec><jats:sec>\n                        <jats:title>Results<\/jats:title>\n                        <jats:p>The mobilized CD34<jats:sup>+<\/jats:sup> HSCs significantly ameliorated radiation-induced liver damage. In the liver of recipient mice killed 21 days after irradiation, human albumin<jats:sup>+<\/jats:sup> Y-chromosome<jats:sup>+<\/jats:sup> hepatocyte-like cells, or human cytokeratin<jats:sup>+<\/jats:sup> Y-chromosome<jats:sup>+<\/jats:sup> hepatocyte-like cells formed cords of hepatocytes, occupied ~30% of the 4-\u03bcm section surrounding portal tracts. Furthermore, human-specific albumin mRNA expressed in the liver and human albumin was detected in the serum only in the CD34<jats:sup>+<\/jats:sup> HSC-treated mice.<\/jats:p>\n                     <\/jats:sec><jats:sec>\n                        <jats:title>Conclusions<\/jats:title>\n                        <jats:p>Treatment with G-CSF-mobilized CD34<jats:sup>+<\/jats:sup> HSCs from bone marrow into peripheral blood could significantly promote tissue reparation after acute liver injury by radiation in mice, possibly by the ability of CD34<jats:sup>+<\/jats:sup> HSCs to generate hepatocytes. So mobilization of CD34<jats:sup>+<\/jats:sup> HSCs might offer a novel therapeutic approach for the treatment of radiation-induced complications after radiotherapy or other acute liver diseases in humans.<\/jats:p>\n                     <\/jats:sec>","DOI":"10.1186\/scrt22","type":"journal-article","created":{"date-parts":[[2010,7,16]],"date-time":"2010-07-16T06:14:36Z","timestamp":1279260876000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Human CD34+ cells mobilized by granulocyte colony-stimulating factor ameliorate radiation-induced liver damage in mice"],"prefix":"10.1186","volume":"1","author":[{"given":"Ning","family":"Li","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huixiang","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Baijun","family":"Fang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2010,7,15]]},"reference":[{"key":"22_CR1","doi-asserted-by":"publisher","first-page":"240","DOI":"10.1053\/srao.2001.23485","volume":"11","author":"LA Dawson","year":"2001","unstructured":"Dawson LA, Ten Haken RK, Lawrence TS: Partial irradiation of the liver. 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