{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T02:55:57Z","timestamp":1791168957211,"version":"4.1.0"},"reference-count":34,"publisher":"Springer Science and Business Media LLC","issue":"5","license":[{"start":{"date-parts":[[2013,10,24]],"date-time":"2013-10-24T00:00:00Z","timestamp":1382572800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/2.0\/"},{"start":{"date-parts":[[2013,10,24]],"date-time":"2013-10-24T00:00:00Z","timestamp":1382572800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/2.0\/"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Stem Cell Res Ther"],"abstract":"<jats:title>Abstract<\/jats:title><jats:sec>\n                        <jats:title>Introduction<\/jats:title>\n                        <jats:p>Huntington\u2019s disease (HD) is an autosomal dominant disorder caused by an expanded CAG repeat on the short arm of chromosome 4 resulting in cognitive decline, motor dysfunction, and death, typically occurring 15 to 20\u00a0years after the onset of motor symptoms. Neuropathologically, HD is characterized by a specific loss of medium spiny neurons in the caudate and the putamen, as well as subsequent neuronal loss in the cerebral cortex. The transgenic R6\/2 mouse model of HD carries the N-terminal fragment of the human HD gene (145 to 155 repeats) and rapidly develops some of the behavioral characteristics that are analogous to the human form of the disease. Mesenchymal stem cells (MSCs) have shown the ability to slow the onset of behavioral and neuropathological deficits following intrastriatal transplantation in rodent models of HD. Use of MSCs derived from umbilical cord (UC) offers an attractive strategy for transplantation as these cells are isolated from a noncontroversial and inexhaustible source and can be harvested at a low cost. Because UC MSCs represent an intermediate link between adult and embryonic tissue, they may hold more pluripotent properties than adult stem cells derived from other sources.<\/jats:p>\n                     <\/jats:sec><jats:sec>\n                        <jats:title>Methods<\/jats:title>\n                        <jats:p>Mesenchymal stem cells, isolated from the UC of day 15 gestation pups, were transplanted intrastriatally into 5-week-old R6\/2 mice at either a low-passage (3 to 8) or high-passage (40 to 50). Mice were tested behaviorally for 6\u00a0weeks using the rotarod task, the Morris water maze, and the limb-clasping response. Following behavioral testing, tissue sections were analyzed for UC MSC survival, the immune response to the transplanted cells, and neuropathological changes.<\/jats:p>\n                     <\/jats:sec><jats:sec>\n                        <jats:title>Results<\/jats:title>\n                        <jats:p>Following transplantation of UC MSCs, R6\/2 mice did not display a reduction in motor deficits but there appeared to be transient sparing in a spatial memory task when compared to untreated R6\/2 mice. However, R6\/2 mice receiving either low- or high-passage UC MSCs displayed significantly less neuropathological deficits, relative to untreated R6\/2 mice.<\/jats:p>\n                     <\/jats:sec><jats:sec>\n                        <jats:title>Conclusions<\/jats:title>\n                        <jats:p>The results from this study demonstrate that UC MSCs hold promise for reducing the neuropathological deficits observed in the R6\/2 rodent model of HD.<\/jats:p>\n                     <\/jats:sec>","DOI":"10.1186\/scrt341","type":"journal-article","created":{"date-parts":[[2013,10,24]],"date-time":"2013-10-24T11:08:20Z","timestamp":1382612900000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":51,"title":["Transplantation of umbilical cord-derived mesenchymal stem cells into the striata of R6\/2 mice: behavioral and neuropathological analysis"],"prefix":"10.1186","volume":"4","author":[{"given":"Kyle D","family":"Fink","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julien","family":"Rossignol","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew T","family":"Crane","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kendra K","family":"Davis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew C","family":"Bombard","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angela M","family":"Bavar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steven","family":"Clerc","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steven A","family":"Lowrance","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cheng","family":"Song","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laurent","family":"Lescaudron","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gary L","family":"Dunbar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2013,10,24]]},"reference":[{"key":"478_CR1","doi-asserted-by":"publisher","first-page":"265","DOI":"10.1016\/j.arcmed.2007.11.011","volume":"39","author":"AM Estrada S\u00e1nchez","year":"2008","unstructured":"Estrada S\u00e1nchez AM, Mej\u00eda-Toiber J, Massieu L: Excitotoxic neuronal death and the pathogenesis of Huntington\u2019s disease. Arch Med Res. 2008, 39: 265-276. 10.1016\/j.arcmed.2007.11.011.","journal-title":"Arch Med Res"},{"key":"478_CR2","doi-asserted-by":"publisher","first-page":"13589","DOI":"10.1523\/JNEUROSCI.4286-09.2009","volume":"29","author":"AL Southwell","year":"2009","unstructured":"Southwell AL, Ko J, Patterson PH: Intrabody gene therapy ameliorates motor, cognitive, and neuropathological symptoms in multiple mouse models of Huntington\u2019s disease. J Neurosci. 2009, 29: 13589-13602. 10.1523\/JNEUROSCI.4286-09.2009.","journal-title":"J Neurosci"},{"key":"478_CR3","doi-asserted-by":"crossref","first-page":"5115","DOI":"10.1523\/JNEUROSCI.20-13-05115.2000","volume":"20","author":"KP Murphy","year":"2000","unstructured":"Murphy KP, Carter RJ, Lione LA, Mangiarini L, Mahal A, Bates GP, Dunnett SB, Morton AJ: Abnormal synaptic plasticity and impaired spatial cognition in mice transgenic for exon 1 of the human Huntington\u2019s disease mutation. J Neurosci. 2000, 20: 5115-5123.","journal-title":"J Neurosci"},{"key":"478_CR4","doi-asserted-by":"publisher","first-page":"375","DOI":"10.1016\/j.nbd.2008.02.010","volume":"30","author":"Z DeMarch","year":"2008","unstructured":"DeMarch Z, Giamp\u00e0 C, Patassini S, Bernardi G, Fusco FR: Beneficial effects of rolipram in the R6\/2 mouse model of Huntington\u2019s disease. Neurobiol Dis. 2008, 30: 375-387. 10.1016\/j.nbd.2008.02.010.","journal-title":"Neurobiol Dis"},{"key":"478_CR5","first-page":"231","volume":"32","author":"N Ende","year":"2001","unstructured":"Ende N, Chen R: Human umbilical cord blood cells ameliorate Huntington\u2019s disease in transgenic mice. J Med. 2001, 32: 231-240.","journal-title":"J Med"},{"key":"478_CR6","doi-asserted-by":"publisher","first-page":"671","DOI":"10.1002\/ana.21788","volume":"66","author":"ST Lee","year":"2009","unstructured":"Lee ST, Chu K, Jung KH, Im WS, Park JE, Lim HC, Won CH, Shin SH, Lee SK, Kim M, Roh JK: Slowed progression in models of Huntington disease by adipose stem cell transplantation. Ann Neurol. 2009, 66: 671-681. 10.1002\/ana.21788.","journal-title":"Ann Neurol"},{"key":"478_CR7","doi-asserted-by":"publisher","first-page":"369","DOI":"10.1016\/j.bbr.2010.11.006","volume":"217","author":"J Rossignol","year":"2011","unstructured":"Rossignol J, Boyer C, L\u00e9v\u00e8que X, Fink KD, Thinard R, Blanchard F, Dunbar GL, Lescaudron L: Mesenchymal stem cell transplantation and DMEM administration in a 3NP rat model of Huntington\u2019s disease: morphological and behavioral outcomes. Behav Brain Res. 2011, 217: 369-378. 10.1016\/j.bbr.2010.11.006.","journal-title":"Behav Brain Res"},{"key":"478_CR8","doi-asserted-by":"crossref","unstructured":"Rossignol J, Fink KD, Crane AT, Davis KK, Bombard MC, Clerc S, Bavar AM, Lowrance SA, Song C, Witte SJ, Lescaudron L, Dunbar GL: Behavioral and neurolopathological sparing in the R6\/2 mouse model of Huntington\u2019s disease following transplantation of bone-marrow-derived mesenchymal stem cells is dependent on passage number. Stem Cells Dev. In Review","DOI":"10.1186\/scrt545"},{"key":"478_CR9","doi-asserted-by":"publisher","first-page":"3693","DOI":"10.1007\/s11033-012-2445-7","volume":"40","author":"FJ Adegani","year":"2013","unstructured":"Adegani FJ, Langroudi L, Arefian E, Shafiee A, Dinarvand P, Soleimani M: A comparison of pluripotency and differentiation status of four mesenchymal adult stem cells. Mol Biol Rep. 2013, 40: 3693-3703. 10.1007\/s11033-012-2445-7.","journal-title":"Mol Biol Rep"},{"key":"478_CR10","doi-asserted-by":"publisher","first-page":"155","DOI":"10.1007\/s12015-006-0022-y","volume":"2","author":"ML Weiss","year":"2006","unstructured":"Weiss ML, Troyer DL: Stem cells in the umbilical cord. Stem Cell Rev. 2006, 2: 155-162. 10.1007\/s12015-006-0022-y.","journal-title":"Stem Cell Rev"},{"key":"478_CR11","doi-asserted-by":"publisher","first-page":"319","DOI":"10.1634\/stemcells.2006-0286","volume":"25","author":"S Karahuseyinoglu","year":"2007","unstructured":"Karahuseyinoglu S, Cinar O, Kilic E, Kara F, Akay GG, Demiralp DO, Tukun A, Uckan D, Can A: Biology of stem cells in human umbilical cord stroma: in situ and in vitro surveys. Stem Cells. 2007, 25: 319-331. 10.1634\/stemcells.2006-0286.","journal-title":"Stem Cells"},{"key":"478_CR12","doi-asserted-by":"publisher","first-page":"54","DOI":"10.1080\/14653240701732763","volume":"10","author":"MF Manca","year":"2008","unstructured":"Manca MF, Zwart I, Beo J, Palasingham R, Jen LS, Navarrete R, Girdlestone J, Navarrete CV: Characterization of mesenchymal stromal cells derived from full-term umbilical cord blood. Cytotherapy. 2008, 10: 54-68. 10.1080\/14653240701732763.","journal-title":"Cytotherapy"},{"key":"478_CR13","doi-asserted-by":"publisher","first-page":"2592","DOI":"10.1172\/JCI26690","volume":"115","author":"J Kurtzberg","year":"2005","unstructured":"Kurtzberg J, Lyerly AD, Sugarman J: Untying the Gordian knot: policies, practices, and ethical issues related to banking of umbilical cord blood. J Clin Invest. 2005, 115: 2592-2597. 10.1172\/JCI26690.","journal-title":"J Clin Invest"},{"key":"478_CR14","doi-asserted-by":"publisher","first-page":"1815","DOI":"10.1056\/NEJM200106143442402","volume":"344","author":"MJ Laughlin","year":"2001","unstructured":"Laughlin MJ, Barker J, Bambach B, Koc ON, Rizzieri DA, Wagner JE, Gerson SL, Lazarus HM, Cairo M, Stevens CE, Rubinstein P, Kurtzberg J: Hematopoietic engraftment and survival in adult recipients of umbilical-cord blood from unrelated donors. N Engl J Med. 2001, 344: 1815-1822. 10.1056\/NEJM200106143442402.","journal-title":"N Engl J Med"},{"key":"478_CR15","doi-asserted-by":"publisher","first-page":"8","DOI":"10.1186\/1477-7827-4-8","volume":"4","author":"R Carlin","year":"2006","unstructured":"Carlin R, Davis D, Weiss M, Schultz B, Troyer D: Expression of early transcription factors Oct-4, Sox-2 and Nanog by porcine umbilical cord (PUC) matrix cells. Reprod Biol Endocrinol. 2006, 4: 8-10.1186\/1477-7827-4-8.","journal-title":"Reprod Biol Endocrinol"},{"key":"478_CR16","doi-asserted-by":"publisher","first-page":"226","DOI":"10.1007\/s12015-012-9418-z","volume":"9","author":"A Bongso","year":"2013","unstructured":"Bongso A, Fong CY: The therapeutic potential, challenges and future clinical directions of stem cells from the Wharton\u2019s jelly of the human umbilical cord. Stem Cell Rev. 2013, 9: 226-240. 10.1007\/s12015-012-9418-z.","journal-title":"Stem Cell Rev"},{"key":"478_CR17","doi-asserted-by":"publisher","first-page":"708","DOI":"10.1016\/S1472-6483(10)60539-1","volume":"15","author":"CY Fong","year":"2007","unstructured":"Fong CY, Richards M, Manasi N, Biswas A, Bongso A: Comparative growth behaviour and characterization of stem cells from human Wharton\u2019s jelly. Reprod Biomed Online. 2007, 15: 708-718. 10.1016\/S1472-6483(10)60539-1.","journal-title":"Reprod Biomed Online"},{"key":"478_CR18","doi-asserted-by":"publisher","first-page":"115","DOI":"10.1634\/stemcells.2005-0053","volume":"24","author":"YS Fu","year":"2006","unstructured":"Fu YS, Cheng YC, Lin MY, Cheng H, Chu PM, Chou SC, Shih YH, Ko MH, Sung MS: Conversion of human umbilical cord mesenchymal stem cells in Wharton\u2019s jelly to dopaminergic neurons in vitro: potential therapeutic application for Parkinsonism. Stem Cells. 2006, 24: 115-124. 10.1634\/stemcells.2005-0053.","journal-title":"Stem Cells"},{"key":"478_CR19","doi-asserted-by":"publisher","first-page":"652","DOI":"10.1007\/BF02256131","volume":"11","author":"YS Fu","year":"2004","unstructured":"Fu YS, Shih YT, Cheng YC, Min MY: Transformation of human umbilical mesenchymal cells into neurons in vitro. J Biomed Sci. 2004, 11: 652-660. 10.1007\/BF02256131.","journal-title":"J Biomed Sci"},{"key":"478_CR20","doi-asserted-by":"publisher","first-page":"50","DOI":"10.1634\/stemcells.21-1-50","volume":"21","author":"KE Mitchell","year":"2003","unstructured":"Mitchell KE, Weiss ML, Mitchell BM, Martin P, Davis D, Morales L, Helwig B, Beerenstrauch M, Abou-Easa K, Hildreth T, Troyer D, Medicetty S: Matrix cells from Wharton\u2019s jelly form neurons and glia. Stem Cells. 2003, 21: 50-60. 10.1634\/stemcells.21-1-50.","journal-title":"Stem Cells"},{"key":"478_CR21","doi-asserted-by":"publisher","first-page":"1330","DOI":"10.1634\/stemcells.2004-0013","volume":"22","author":"HS Wang","year":"2004","unstructured":"Wang HS, Hung SC, Peng ST, Huang CC, Wei HM, Guo YJ, Fu YS, Lai MC, Chen CC: Mesenchymal stem cells in the Wharton\u2019s jelly of the human umbilical cord. Stem Cells. 2004, 22: 1330-1337. 10.1634\/stemcells.2004-0013.","journal-title":"Stem Cells"},{"key":"478_CR22","doi-asserted-by":"publisher","first-page":"32","DOI":"10.1016\/j.expneurol.2004.06.023","volume":"190","author":"S Medicetty","year":"2004","unstructured":"Medicetty S, Bledsoe AR, Fahrenholtz CB, Troyer D, Weiss ML: Transplantation of pig stem cells into rat brain: proliferation during the first 8\u00a0weeks. Exp Neurol. 2004, 190: 32-41. 10.1016\/j.expneurol.2004.06.023.","journal-title":"Exp Neurol"},{"key":"478_CR23","doi-asserted-by":"publisher","first-page":"339","DOI":"10.1016\/j.nbd.2007.06.010","volume":"27","author":"DC Ding","year":"2007","unstructured":"Ding DC, Shyu WC, Chiang MF, Lin SZ, Chang YC, Wang HJ, Su CY, Li H: Enhancement of neuroplasticity through upregulation of beta1-integrin in human umbilical cord-derived stromal cell implanted stroke model. Neurobiol Dis. 2007, 27: 339-353. 10.1016\/j.nbd.2007.06.010.","journal-title":"Neurobiol Dis"},{"key":"478_CR24","doi-asserted-by":"publisher","first-page":"233","DOI":"10.1016\/j.brainres.2008.06.087","volume":"1229","author":"SH Koh","year":"2008","unstructured":"Koh SH, Kim KS, Choi MR, Jung KH, Park KS, Chai YG, Roh W, Hwang SJ, Ko HJ, Huh YM, Kim HT, Kim SH: Implantation of human umbilical cord-derived mesenchymal stem cells as a neuroprotective therapy for ischemic stroke in rats. Brain Res. 2008, 1229: 233-248.","journal-title":"Brain Res"},{"key":"478_CR25","doi-asserted-by":"publisher","first-page":"1437","DOI":"10.1161\/STROKEAHA.110.593129","volume":"42","author":"L Zhang","year":"2011","unstructured":"Zhang L, Li Y, Zhang C, Chopp M, Gosiewska A, Hong K: Delayed administration of human umbilical tissue-derived cells improved neurological functional recovery in a rodent model of focal ischemia. Stroke J Cereb Circ. 2011, 42: 1437-1444. 10.1161\/STROKEAHA.110.593129.","journal-title":"Stroke J Cereb Circ"},{"key":"478_CR26","doi-asserted-by":"publisher","first-page":"1337","DOI":"10.1089\/scd.2010.0266","volume":"20","author":"N Ahmadbeigi","year":"2011","unstructured":"Ahmadbeigi N, Soleimani M, Gheisari Y, Vasei M, Amanpour S, Bagherizadeh I, Shariati SAM, Azadmanesh K, Amini S, Shafiee A, Arabkari V, Nardi NB: Dormant phase and multinuclear cells: two key phenomena in early culture of murine bone marrow mesenchymal stem cells. Stem Cells Dev. 2011, 20: 1337-1347. 10.1089\/scd.2010.0266.","journal-title":"Stem Cells Dev"},{"key":"478_CR27","doi-asserted-by":"publisher","first-page":"2547","DOI":"10.1111\/j.1582-4934.2008.00657.x","volume":"13","author":"J Rossignol","year":"2009","unstructured":"Rossignol J, Boyer C, Thinard R, Remy S, Dugast AS, Dubayle D, Dey ND, Boeffard F, Delecrin J, Heymann D, Vanhove B, Anegon I, Naveilhan P, Dunbar GL, Lescaudron L: Mesenchymal stem cells induce a weak immune response in the rat striatum after allo or xenotransplantation. J Cell Mol Med. 2009, 13: 2547-2558.","journal-title":"J Cell Mol Med"},{"key":"478_CR28","doi-asserted-by":"publisher","first-page":"147","DOI":"10.1007\/978-1-61779-815-3_10","volume":"879","author":"L Lescaudron","year":"2012","unstructured":"Lescaudron L, Boyer C, Bonnamain V, Fink KD, L\u00e9v\u00eaque X, Rossignol J, Nerri\u00e8re-Daguin V, Malouet AC, Lelan F, Dey ND, Michel-Monigadon D, Lu M, Neveu I, von H\u00f6rsten S, Naveilhan P, Dunbar GL: Assessing the potential clinical utility of transplantations of neural and mesenchymal stem cells for treating neurodegenerative diseases. Methods Mol Biol. 2012, 879: 147-164. 10.1007\/978-1-61779-815-3_10.","journal-title":"Methods Mol Biol"},{"key":"478_CR29","doi-asserted-by":"publisher","first-page":"193","DOI":"10.1016\/j.bbr.2010.05.023","volume":"214","author":"ND Dey","year":"2010","unstructured":"Dey ND, Bombard MC, Roland BP, Davidson S, Lu M, Rossignol J, Sandstrom MI, Skeel RL, Lescaudron L, Dunbar GL: Genetically engineered mesenchymal stem cells reduce behavioral deficits in the YAC 128 mouse model of Huntington\u2019s disease. Behav Brain Res. 2010, 214: 193-200. 10.1016\/j.bbr.2010.05.023.","journal-title":"Behav Brain Res"},{"key":"478_CR30","doi-asserted-by":"publisher","first-page":"945","DOI":"10.1080\/00207450390207759","volume":"113","author":"L Lescaudron","year":"2003","unstructured":"Lescaudron L, Unni D, Dunbar GL: Autologous adult bone marrow stem cell transplantation in an animal model of huntington\u2019s disease: behavioral and morphological outcomes. Int J Neurosci. 2003, 113: 945-956. 10.1080\/00207450390207759.","journal-title":"Int J Neurosci"},{"key":"478_CR31","doi-asserted-by":"publisher","first-page":"e22966","DOI":"10.1371\/journal.pone.0022966","volume":"6","author":"C Zuccato","year":"2011","unstructured":"Zuccato C, Marullo M, Vitali B, Tarditi A, Mariotti C, Valenza M, Lahiri N, Wild EJ, Sassone J, Ciammola A, Bachoud-L\u00e8vi AC, Tabrizi SJ, Di Donato S, Cattaneo E: Brain-derived neurotrophic factor in patients with Huntington\u2019s disease. PLoS One. 2011, 6: e22966-10.1371\/journal.pone.0022966.","journal-title":"PLoS One"},{"key":"478_CR32","doi-asserted-by":"publisher","first-page":"25","DOI":"10.1186\/scrt66","volume":"2","author":"T Miki","year":"2011","unstructured":"Miki T: Amnion-derived stem cells: in quest of clinical applications. Stem Cell Res Ther. 2011, 2: 25-10.1186\/scrt66.","journal-title":"Stem Cell Res Ther"},{"key":"478_CR33","doi-asserted-by":"publisher","first-page":"32","DOI":"10.1186\/scrt73","volume":"2","author":"J Peng","year":"2011","unstructured":"Peng J, Zeng X: The role of induced pluripotent stem cells in regenerative medicine: neurodegenerative diseases. Stem Cell Res Ther. 2011, 2: 32-10.1186\/scrt73.","journal-title":"Stem Cell Res Ther"},{"key":"478_CR34","unstructured":"Fink KD, Rossignol J, Lu M, Leveque X, Hulse TD, Crane AT, Nerriere-Daguin V, Wyse RD, Starski PA, Schloop MT, Dues DJ, Witte SJ, Song C, Vallier L, Nguyen TH, Naveilhan P, Anegon I, Lescaudron L, Dunbar GL: Survival and differentiation of adenovirus-generated induced pluripotent stem cells transplanted into the rat striatum. Cell Transplant. in press"}],"container-title":["Stem Cell Research &amp; Therapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/scrt341.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1186\/scrt341\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/scrt341.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,10,8]],"date-time":"2024-10-08T10:05:52Z","timestamp":1728381952000},"score":1,"resource":{"primary":{"URL":"https:\/\/stemcellres.biomedcentral.com\/articles\/10.1186\/scrt341"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,10,24]]},"references-count":34,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2013,12]]}},"alternative-id":["478"],"URL":"https:\/\/doi.org\/10.1186\/scrt341","relation":{},"ISSN":["1757-6512"],"issn-type":[{"value":"1757-6512","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,10,24]]},"assertion":[{"value":"20 June 2013","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"15 August 2013","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"9 October 2013","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"24 October 2013","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}}],"article-number":"130"}}