{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,26]],"date-time":"2026-03-26T16:29:51Z","timestamp":1774542591594,"version":"3.50.1"},"reference-count":30,"publisher":"Springer Science and Business Media LLC","issue":"S1","license":[{"start":{"date-parts":[[2013,12,1]],"date-time":"2013-12-01T00:00:00Z","timestamp":1385856000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2013,12,1]],"date-time":"2013-12-01T00:00:00Z","timestamp":1385856000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Stem Cell Res Ther"],"published-print":{"date-parts":[[2013,12]]},"DOI":"10.1186\/scrt372","type":"journal-article","created":{"date-parts":[[2013,12,20]],"date-time":"2013-12-20T16:04:05Z","timestamp":1387555445000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":24,"title":["All-human microphysical model of metastasis therapy"],"prefix":"10.1186","volume":"4","author":[{"given":"Sarah E","family":"Wheeler","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jeffrey T","family":"Borenstein","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amanda M","family":"Clark","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohammad R","family":"Ebrahimkhani","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ira J","family":"Fox","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Linda","family":"Griffith","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Walker","family":"Inman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Douglas","family":"Lauffenburger","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Transon","family":"Nguyen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Venkateswaran C","family":"Pillai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rachelle","family":"Prantil-Baun","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Donna B","family":"Stolz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Donald","family":"Taylor","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Theresa","family":"Ulrich","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Raman","family":"Venkataramanan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alan","family":"Wells","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carissa","family":"Young","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2013,12,20]]},"reference":[{"key":"286_CR1","first-page":"2541","volume":"60","author":"MD Cameron","year":"2000","unstructured":"Cameron MD, Schmidt EE, Kerkvliet N, Nadkarni KV, Morris VL, Groom AC, Chambers AF, MacDonald IC: Temporal progression of metastasis in lung: cell survival, dormancy, and location dependence of metastatic inefficiency. Cancer Res. 2000, 60: 2541-2546.","journal-title":"Cancer Res"},{"key":"286_CR2","doi-asserted-by":"publisher","first-page":"865","DOI":"10.1016\/S0002-9440(10)65628-3","volume":"153","author":"KJ Luzzi","year":"1998","unstructured":"Luzzi KJ, MacDonald IC, Schmidt EE, Kerkvliet N, Morris VL, Chambers AF, Groom AC: Multistep nature of metastatic inefficiency: dormancy of solitary cells after successful extravasation and limited survival of early micrometastases. Am J Pathol. 1998, 153: 865-873. 10.1016\/S0002-9440(10)65628-3.","journal-title":"Am J Pathol"},{"key":"286_CR3","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1007\/978-0-387-74039-3_1","volume":"608","author":"AM Gonzalez-Angulo","year":"2007","unstructured":"Gonzalez-Angulo AM, Morales-Vasquez F, Hortobagyi GN: Overview of resistance to systemic therapy in patients with breast cancer. Adv Exp Med Biol. 2007, 608: 1-22. 10.1007\/978-0-387-74039-3_1.","journal-title":"Adv Exp Med Biol"},{"key":"286_CR4","doi-asserted-by":"publisher","first-page":"621","DOI":"10.1007\/s10585-008-9167-1","volume":"25","author":"A Wells","year":"2008","unstructured":"Wells A, Yates C, Shepard CR: E-cadherin as an indicator of mesenchymal to epithelial reverting transitions during the metastatic seeding of disseminated carcinomas. Clin Exp Metastasis. 2008, 25: 621-628. 10.1007\/s10585-008-9167-1.","journal-title":"Clin Exp Metastasis"},{"key":"286_CR5","doi-asserted-by":"publisher","first-page":"834","DOI":"10.1038\/nrc2256","volume":"7","author":"JA Aguirre-Ghiso","year":"2007","unstructured":"Aguirre-Ghiso JA: Models, mechanisms and clinical evidence for cancer dormancy. Nat Rev Cancer. 2007, 7: 834-846. 10.1038\/nrc2256.","journal-title":"Nat Rev Cancer"},{"key":"286_CR6","first-page":"2162","volume":"62","author":"GN Naumov","year":"2002","unstructured":"Naumov GN, MacDonald IC, Weinmeister PM, Kerkvliet N, Nadkarni KV, Wilson SM, Morris VL, Groom AC, Chambers AF: Persistence of solitary mammary carcinoma cells in a secondary site: a possible contributor to dormancy. Cancer Res. 2002, 62: 2162-2168.","journal-title":"Cancer Res"},{"key":"286_CR7","doi-asserted-by":"publisher","first-page":"298","DOI":"10.1126\/science.1131000","volume":"314","author":"CM Nelson","year":"2006","unstructured":"Nelson CM, Vanduijn MM, Inman JL, Fletcher DA, Bissell MJ: Tissue geometry determines sites of mammary branching morphogenesis in organotypic cultures. Science. 2006, 314: 298-300. 10.1126\/science.1131000.","journal-title":"Science"},{"key":"286_CR8","doi-asserted-by":"publisher","first-page":"297","DOI":"10.1007\/s10911-004-1402-z","volume":"9","author":"KR Shaw","year":"2004","unstructured":"Shaw KR, Wrobel CN, Brugge JS: Use of three-dimensional basement membrane cultures to model oncogene-induced changes in mammary epithelial morphogenesis. J Mammary Gland Biol Neoplasia. 2004, 9: 297-310. 10.1007\/s10911-004-1402-z.","journal-title":"J Mammary Gland Biol Neoplasia"},{"key":"286_CR9","doi-asserted-by":"publisher","first-page":"1293","DOI":"10.1002\/bit.24399","volume":"109","author":"AY Hsiao","year":"2012","unstructured":"Hsiao AY, Tung YC, Qu X, Patel LR, Pienta KJ, Takayama S: 384 hanging drop arrays give excellent Z-factors and allow versatile formation of co-culture spheroids. Biotechnol Bioeng. 2012, 109: 1293-1304. 10.1002\/bit.24399.","journal-title":"Biotechnol Bioeng"},{"key":"286_CR10","doi-asserted-by":"publisher","first-page":"1450","DOI":"10.1038\/nm.2265","volume":"16","author":"TW Ridky","year":"2010","unstructured":"Ridky TW, Chow JM, Wong DJ, Khavari PA: Invasive three-dimensional organotypic neoplasia from multiple normal human epithelia. Nat Med. 2010, 16: 1450-1455. 10.1038\/nm.2265.","journal-title":"Nat Med"},{"key":"286_CR11","doi-asserted-by":"publisher","first-page":"681","DOI":"10.1016\/j.copbio.2011.05.512","volume":"22","author":"NK Inamdar","year":"2011","unstructured":"Inamdar NK, Borenstein JT: Microfluidic cell culture models for tissue engineering. Curr Opin Biotechnol. 2011, 22: 681-689. 10.1016\/j.copbio.2011.05.512.","journal-title":"Curr Opin Biotechnol"},{"key":"286_CR12","doi-asserted-by":"publisher","first-page":"225","DOI":"10.1016\/S0065-230X(06)97010-9","volume":"97","author":"C Yates","year":"2007","unstructured":"Yates C, Shepard CR, Papworth G, Dash A, Beer Stolz D, Tannenbaum S, Griffith L, Wells A: Novel three-dimensional organotypic liver bioreactor to directly visualize early events in metastatic progression. Adv Cancer Res. 2007, 97: 225-246.","journal-title":"Adv Cancer Res"},{"key":"286_CR13","doi-asserted-by":"publisher","first-page":"1063","DOI":"10.1158\/1078-0432.CCR-12-3180","volume":"19","author":"DP Taylor","year":"2013","unstructured":"Taylor DP, Wells JZ, Savol A, Chennubhotla C, Wells A: Modeling boundary conditions for balanced proliferation in metastatic latency. Clin Cancer Res. 2013, 19: 1063-1070. 10.1158\/1078-0432.CCR-12-3180.","journal-title":"Clin Cancer Res"},{"key":"286_CR14","doi-asserted-by":"publisher","first-page":"39","DOI":"10.1007\/s10585-011-9427-3","volume":"29","author":"Y Chao","year":"2012","unstructured":"Chao Y, Wu Q, Shepard C, Wells A: Hepatocyte induced re-expression of E-cadherin in breast and prostate cancer cells increases chemoresistance. Clin Exp Metastasis. 2012, 29: 39-50. 10.1007\/s10585-011-9427-3.","journal-title":"Clin Exp Metastasis"},{"key":"286_CR15","doi-asserted-by":"publisher","first-page":"582","DOI":"10.1073\/pnas.1106750109","volume":"109","author":"JE Gibbs","year":"2012","unstructured":"Gibbs JE, Blaikley J, Beesley S, Matthews L, Simpson KD, Boyce SH, Farrow SN, Else KJ, Singh D, Ray D, Loudon AS: The nuclear receptor REV-ERBalpha mediates circadian regulation of innate immunity through selective regulation of inflammatory cytokines. Proc Natl Acad Sci USA. 2012, 109: 582-587. 10.1073\/pnas.1106750109.","journal-title":"Proc Natl Acad Sci USA"},{"key":"286_CR16","doi-asserted-by":"publisher","first-page":"191","DOI":"10.1016\/j.tips.2010.01.002","volume":"31","author":"DA Bechtold","year":"2010","unstructured":"Bechtold DA, Gibbs JE, Loudon AS: Circadian dysfunction in disease. Trends Pharmacol Sci. 2010, 31: 191-198. 10.1016\/j.tips.2010.01.002.","journal-title":"Trends Pharmacol Sci"},{"key":"286_CR17","doi-asserted-by":"publisher","first-page":"5796","DOI":"10.4049\/jimmunol.1001026","volume":"185","author":"O Castanon-Cervantes","year":"2010","unstructured":"Castanon-Cervantes O, Wu M, Ehlen JC, Paul K, Gamble KL, Johnson RL, Besing RC, Menaker M, Gewirtz AT, Davidson AJ: Dysregulation of inflammatory responses by chronic circadian disruption. J Immunol. 2010, 185: 5796-5805. 10.4049\/jimmunol.1001026.","journal-title":"J Immunol"},{"key":"286_CR18","doi-asserted-by":"publisher","first-page":"1722","DOI":"10.1016\/j.ejca.2011.07.005","volume":"48","author":"J Hansen","year":"2012","unstructured":"Hansen J, Stevens RG: Case-control study of shift-work and breast cancer risk in Danish nurses: impact of shift systems. Eur J Cancer. 2012, 48: 1722-1729. 10.1016\/j.ejca.2011.07.005.","journal-title":"Eur J Cancer"},{"key":"286_CR19","doi-asserted-by":"publisher","first-page":"124ra127","DOI":"10.1126\/scitranslmed.3003293","volume":"4","author":"C Lee","year":"2012","unstructured":"Lee C, Raffaghello L, Brandhorst S, Safdie FM, Bianchi G, Martin-Montalvo A, Pistoia V, Wei M, Hwang S, Merlino A, Emionite L, de Cabo R, Longo VD: Fasting cycles retard growth of tumors and sensitize a range of cancer cell types to chemotherapy. Sci Transl Med. 2012, 4: 124ra127-","journal-title":"Sci Transl Med"},{"key":"286_CR20","doi-asserted-by":"publisher","first-page":"155","DOI":"10.1254\/jphs.FMJ06003X6","volume":"103","author":"S Ohdo","year":"2007","unstructured":"Ohdo S: Circadian rhythms in the CNS and peripheral clock disorders: chronopharmacological findings on antitumor drugs. J Pharmacol Sci. 2007, 103: 155-158. 10.1254\/jphs.FMJ06003X6.","journal-title":"J Pharmacol Sci"},{"key":"286_CR21","doi-asserted-by":"publisher","first-page":"4642","DOI":"10.1038\/emboj.2011.322","volume":"30","author":"D Ma","year":"2011","unstructured":"Ma D, Panda S, Lin JD: Temporal orchestration of circadian autophagy rhythm by C\/EBPbeta. Embo J. 2011, 30: 4642-4651. 10.1038\/emboj.2011.322.","journal-title":"Embo J"},{"key":"286_CR22","doi-asserted-by":"publisher","first-page":"18560","DOI":"10.1073\/pnas.1115753108","volume":"108","author":"A Atwood","year":"2011","unstructured":"Atwood A, DeConde R, Wang SS, Mockler TC, Sabir JS, Ideker T, Kay SA: Cell-autonomous circadian clock of hepatocytes drives rhythms in transcription and polyamine synthesis. Proc Natl Acad Sci USA. 2011, 108: 18560-18565. 10.1073\/pnas.1115753108.","journal-title":"Proc Natl Acad Sci USA"},{"key":"286_CR23","doi-asserted-by":"publisher","first-page":"437","DOI":"10.1126\/science.1172156","volume":"326","author":"KA Lamia","year":"2009","unstructured":"Lamia KA, Sachdeva UM, DiTacchio L, Williams EC, Alvarez JG, Egan DF, Vasquez DS, Juguilon H, Panda S, Shaw RJ, Thompson CB, Evans RM: AMPK regulates the circadian clock by cryptochrome phosphorylation and degradation. Science. 2009, 326: 437-440. 10.1126\/science.1172156.","journal-title":"Science"},{"key":"286_CR24","doi-asserted-by":"publisher","first-page":"267","DOI":"10.1039\/b823059e","volume":"1","author":"M Domenech","year":"2009","unstructured":"Domenech M, Yu H, Warrick J, Badders NM, Meyvantsson I, Alexander CM, Beebe DJ: Cellular observations enabled by microculture: paracrine signaling and population demographics. Integr Biol (Camb). 2009, 1: 267-274. 10.1039\/b823059e.","journal-title":"Integr Biol (Camb)"},{"key":"286_CR25","doi-asserted-by":"publisher","first-page":"1646","DOI":"10.1126\/science.1116598","volume":"310","author":"KA Janes","year":"2005","unstructured":"Janes KA, Albeck JG, Gaudet S, Sorger PK, Lauffenburger DA, Yaffe MB: A systems model of signaling identifies a molecular basis set for cytokine-induced apoptosis. Science. 2005, 310: 1646-1653. 10.1126\/science.1116598.","journal-title":"Science"},{"key":"286_CR26","doi-asserted-by":"publisher","first-page":"e1000340","DOI":"10.1371\/journal.pcbi.1000340","volume":"5","author":"BB Aldridge","year":"2009","unstructured":"Aldridge BB, Saez-Rodriguez J, Muhlich JL, Sorger PK, Lauffenburger DA: Fuzzy logic analysis of kinase pathway crosstalk in TNF\/EGF\/insulin-induced signaling. PLoS Comput Biol. 2009, 5: e1000340-10.1371\/journal.pcbi.1000340.","journal-title":"PLoS Comput Biol"},{"key":"286_CR27","doi-asserted-by":"publisher","first-page":"2","DOI":"10.1093\/carcin\/bgp261","volume":"31","author":"PK Kreeger","year":"2010","unstructured":"Kreeger PK, Lauffenburger DA: Cancer systems biology: a network modeling perspective. Carcinogenesis. 2010, 31: 2-8. 10.1093\/carcin\/bgp261.","journal-title":"Carcinogenesis"},{"key":"286_CR28","doi-asserted-by":"publisher","first-page":"257","DOI":"10.1007\/s10439-005-9047-7","volume":"34","author":"T Ideker","year":"2006","unstructured":"Ideker T, Winslow LR, Lauffenburger AD: Bioengineering and systems biology. Ann Biomed Eng. 2006, 34: 257-264. 10.1007\/s10439-005-9047-7.","journal-title":"Ann Biomed Eng"},{"key":"286_CR29","doi-asserted-by":"publisher","first-page":"6921","DOI":"10.1158\/0008-5472.CAN-11-1457","volume":"71","author":"F Hirschhaeuser","year":"2011","unstructured":"Hirschhaeuser F, Sattler UG, Mueller-Klieser W: Lactate: a metabolic key player in cancer. Cancer Res. 2011, 71: 6921-6925. 10.1158\/0008-5472.CAN-11-1457.","journal-title":"Cancer Res"},{"key":"286_CR30","doi-asserted-by":"publisher","first-page":"1159","DOI":"10.1517\/17425250903160664","volume":"5","author":"A Dash","year":"2009","unstructured":"Dash A, Inman W, Hoffmaster K, Sevidal S, Kelly J, Obach RS, Griffith LG, Tannenbaum SR: Liver tissue engineering in the evaluation of drug safety. Expert Opin Drug Metab Toxicol. 2009, 5: 1159-1174. 10.1517\/17425250903160664.","journal-title":"Expert Opin Drug Metab Toxicol"}],"container-title":["Stem Cell Research &amp; Therapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/scrt372.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1186\/scrt372\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/scrt372.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,11,16]],"date-time":"2021-11-16T06:11:51Z","timestamp":1637043111000},"score":1,"resource":{"primary":{"URL":"https:\/\/stemcellres.biomedcentral.com\/articles\/10.1186\/scrt372"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,12]]},"references-count":30,"journal-issue":{"issue":"S1","published-print":{"date-parts":[[2013,12]]}},"alternative-id":["286"],"URL":"https:\/\/doi.org\/10.1186\/scrt372","relation":{},"ISSN":["1757-6512"],"issn-type":[{"value":"1757-6512","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,12]]},"assertion":[{"value":"20 December 2013","order":1,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"This content has been made available to all.","name":"free","label":"Free to read"}],"article-number":"S11"}}