{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T19:47:08Z","timestamp":1790624828138,"version":"4.1.0"},"reference-count":72,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[2014,3,27]],"date-time":"2014-03-27T00:00:00Z","timestamp":1395878400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2014,3,27]],"date-time":"2014-03-27T00:00:00Z","timestamp":1395878400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Stem Cell Res Ther"],"DOI":"10.1186\/scrt433","type":"journal-article","created":{"date-parts":[[2014,3,27]],"date-time":"2014-03-27T08:04:10Z","timestamp":1395907450000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":38,"title":["Cancer stem-like cell: a novel target for nasopharyngeal carcinoma therapy"],"prefix":"10.1186","volume":"5","author":[{"given":"Pingpin","family":"Wei","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Man","family":"Niu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suming","family":"Pan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanhong","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cijun","family":"Shuai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuping","family":"Peng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guiyuan","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2014,3,27]]},"reference":[{"key":"339_CR1","doi-asserted-by":"publisher","first-page":"9385","DOI":"10.1158\/0008-5472.CAN-06-0590","volume":"66","author":"HL Lung","year":"2006","unstructured":"Lung HL, Cheung AK, Xie D, Cheng Y, Kwong FM, Murakami Y, Guan XY, Sham JS, Chua D, Protopopov AI, Zabarovsky ER, Tsao SW, Stanbridge EJ, Lung ML: TSLC1 is a tumor suppressor gene associated with metastasis in nasopharyngeal carcinoma. Cancer Res. 2006, 66: 9385-9392. 10.1158\/0008-5472.CAN-06-0590.","journal-title":"Cancer Res"},{"key":"339_CR2","doi-asserted-by":"publisher","first-page":"551","DOI":"10.5732\/cjc.009.10518","volume":"29","author":"L Kong","year":"2012","unstructured":"Kong L, Zhang YW, Hu CS, Guo Y: Neoadjuvant chemotherapy followed by concurrent chemoradiation for locally advanced nasopharyngeal carcinoma. Chin J Cancer. 2012, 29: 551-555.","journal-title":"Chin J Cancer"},{"key":"339_CR3","doi-asserted-by":"publisher","first-page":"6005","DOI":"10.7314\/APJCP.2012.13.12.6005","volume":"13","author":"NA Nor Hashim","year":"2012","unstructured":"Nor Hashim NA, Ramzi NH, Velapasamy S, Alex L, Chahil JK, Lye SH, Munretnam K, Haron MR, Ler LW: Identification of genetic and non-genetic risk factors for nasopharyngeal carcinoma in a Southeast Asian population. Asian Pac J Cancer Prev. 2012, 13: 6005-6010. 10.7314\/APJCP.2012.13.12.6005.","journal-title":"Asian Pac J Cancer Prev"},{"key":"339_CR4","doi-asserted-by":"publisher","first-page":"74","DOI":"10.1002\/cncr.11485","volume":"98","author":"DT Chua","year":"2003","unstructured":"Chua DT, Sham JS, Kwong DL, Au GK: Treatment outcome after radiotherapy alone for patients with stage I\u2013II nasopharyngeal carcinoma. Cancer. 2003, 98: 74-80. 10.1002\/cncr.11485.","journal-title":"Cancer"},{"key":"339_CR5","doi-asserted-by":"crossref","first-page":"1350","DOI":"10.1200\/JCO.2001.19.5.1350","volume":"19","author":"J Ma","year":"2001","unstructured":"Ma J, Mai HQ, Hong MH, Min HQ, Mao ZD, Cui NJ, Lu TX, Mo HY: Results of a prospective randomized trial comparing neoadjuvant chemotherapy plus radiotherapy with radiotherapy alone in patients with locoregionally advanced nasopharyngeal carcinoma. J Clin Oncol. 2001, 19: 1350-1357.","journal-title":"J Clin Oncol"},{"key":"339_CR6","doi-asserted-by":"publisher","first-page":"e406","DOI":"10.3747\/co.20.1456","volume":"20","author":"T Xu","year":"2013","unstructured":"Xu T, Tang J, Gu M, Liu L, Wei W, Yang H: Recurrent nasopharyngeal carcinoma: a clinical dilemma and challenge. Curr Oncol. 2013, 20: e406-e419. 10.3747\/co.20.1456.","journal-title":"Curr Oncol"},{"key":"339_CR7","first-page":"719754","volume":"2012","author":"JX Li","year":"2012","unstructured":"Li JX, Lu TX, Huang Y, Han F: Clinical characteristics of recurrent nasopharyngeal carcinoma in high-incidence area. Sci World J. 2012, 2012: 719754-","journal-title":"Sci World J"},{"key":"339_CR8","doi-asserted-by":"publisher","first-page":"645","DOI":"10.1038\/367645a0","volume":"367","author":"T Lapidot","year":"1994","unstructured":"Lapidot T, Sirard C, Vormoor J, Murdoch B, Hoang T, Caceres-Cortes J, Minden M, Paterson B, Caligiuri MA, Dick JE: A cell initiating human acute myeloid leukaemia after transplantation into SCID mice. Nature. 1994, 367: 645-648. 10.1038\/367645a0.","journal-title":"Nature"},{"key":"339_CR9","doi-asserted-by":"publisher","first-page":"105","DOI":"10.1038\/35102167","volume":"414","author":"T Reya","year":"2001","unstructured":"Reya T, Morrison SJ, Clarke MF, Weissman IL: Stem cells, cancer, and cancer stem cells. Nature. 2001, 414: 105-111. 10.1038\/35102167.","journal-title":"Nature"},{"key":"339_CR10","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1038\/ncponc1110","volume":"5","author":"A Trumpp","year":"2008","unstructured":"Trumpp A, Wiestler OD: Mechanisms of disease: cancer stem cells \u2013 targeting the evil twin. Nat Clin Pract Oncol. 2008, 5: 337-347.","journal-title":"Nat Clin Pract Oncol"},{"key":"339_CR11","doi-asserted-by":"publisher","first-page":"396","DOI":"10.1038\/nature03128","volume":"432","author":"SK Singh","year":"2004","unstructured":"Singh SK, Hawkins C, Clarke ID, Squire JA, Bayani J, Hide T, Henkelman RM, Cusimano MD, Dirks PB: Identification of human brain tumour initiating cells. Nature. 2004, 432: 396-401. 10.1038\/nature03128.","journal-title":"Nature"},{"key":"339_CR12","doi-asserted-by":"publisher","first-page":"3983","DOI":"10.1073\/pnas.0530291100","volume":"100","author":"M Al-Hajj","year":"2003","unstructured":"Al-Hajj M, Wicha MS, Benito-Hernandez A, Morrison SJ, Clarke MF: Prospective identification of tumorigenic breast cancer cells. Proc Natl Acad Sci U S A. 2003, 100: 3983-3988. 10.1073\/pnas.0530291100.","journal-title":"Proc Natl Acad Sci U S A"},{"key":"339_CR13","doi-asserted-by":"publisher","first-page":"10158","DOI":"10.1073\/pnas.0703478104","volume":"104","author":"P Dalerba","year":"2007","unstructured":"Dalerba P, Dylla SJ, Park IK, Liu R, Wang X, Cho RW, Hoey T, Gurney A, Huang EH, Simeone DM, Shelton AA, Parmiani G, Castelli C, Clarke MF: Phenotypic characterization of human colorectal cancer stem cells. Proc Natl Acad Sci U S A. 2007, 104: 10158-10163. 10.1073\/pnas.0703478104.","journal-title":"Proc Natl Acad Sci U S A"},{"key":"339_CR14","doi-asserted-by":"publisher","first-page":"106","DOI":"10.1038\/nature05372","volume":"445","author":"CA O'Brien","year":"2007","unstructured":"O'Brien CA, Pollett A, Gallinger S, Dick JE: A human colon cancer cell capable of initiating tumour growth in immunodeficient mice. Nature. 2007, 445: 106-110. 10.1038\/nature05372.","journal-title":"Nature"},{"key":"339_CR15","doi-asserted-by":"publisher","first-page":"313","DOI":"10.1016\/j.stem.2007.06.002","volume":"1","author":"PC Hermann","year":"2007","unstructured":"Hermann PC, Huber SL, Herrler T, Aicher A, Ellwart JW, Guba M, Bruns CJ, Heeschen C: Distinct populations of cancer stem cells determine tumor growth and metastatic activity in human pancreatic cancer. Cell Stem Cell. 2007, 1: 313-323. 10.1016\/j.stem.2007.06.002.","journal-title":"Cell Stem Cell"},{"key":"339_CR16","doi-asserted-by":"publisher","first-page":"1030","DOI":"10.1158\/0008-5472.CAN-06-2030","volume":"67","author":"C Li","year":"2007","unstructured":"Li C, Heidt DG, Dalerba P, Burant CF, Zhang L, Adsay V, Wicha M, Clarke MF, Simeone DM: Identification of pancreatic cancer stem cells. Cancer Res. 2007, 67: 1030-1037. 10.1158\/0008-5472.CAN-06-2030.","journal-title":"Cancer Res"},{"key":"339_CR17","doi-asserted-by":"publisher","first-page":"347","DOI":"10.1007\/s00418-006-0251-9","volume":"127","author":"HB Zhang","year":"2007","unstructured":"Zhang HB, Ren CP, Yang XY, Wang L, Li H, Zhao M, Yang H, Yao KT: Identification of label-retaining cells in nasopharyngeal epithelia and nasopharyngeal carcinoma tissues. Histochem Cell Biol. 2007, 127: 347-354. 10.1007\/s00418-006-0251-9.","journal-title":"Histochem Cell Biol"},{"key":"339_CR18","doi-asserted-by":"publisher","first-page":"572","DOI":"10.5732\/cjc.009.10420","volume":"29","author":"QP Jiang","year":"2010","unstructured":"Jiang QP, Yao KT: Isolation and detection of label-retaining cells in a nasopharyngeal carcinoma cell line. Chin J Cancer. 2010, 29: 572-574. 10.5732\/cjc.009.10420.","journal-title":"Chin J Cancer"},{"key":"339_CR19","doi-asserted-by":"publisher","first-page":"1219","DOI":"10.1158\/0008-5472.CAN-12-1408","volume":"73","author":"WJ Wang","year":"2013","unstructured":"Wang WJ, Wu SP, Liu JB, Shi YS, Huang X, Zhang QB, Yao KT: MYC regulation of CHK1 and CHK2 promotes radioresistance in a stem cell-like population of nasopharyngeal carcinoma cells. Cancer Res. 2013, 73: 1219-1231. 10.1158\/0008-5472.CAN-12-1408.","journal-title":"Cancer Res"},{"key":"339_CR20","doi-asserted-by":"publisher","first-page":"180","DOI":"10.1089\/scd.2013.0103","volume":"23","author":"Y Zhao","year":"2014","unstructured":"Zhao Y, Bao Q, Schwarz B, Zhao L, Mysliwietz J, Ellwart J, Renner A, Hirner H, Niess H, Camaj P, Angele M, Gros S, Izbicki J, Jauch KW, Nelson PJ, Bruns CJ: Stem cell-like side populations in esophageal cancer: a source of chemotherapy resistance and metastases. Stem Cells Dev. 2014, 23: 180-192. 10.1089\/scd.2013.0103.","journal-title":"Stem Cells Dev"},{"key":"339_CR21","doi-asserted-by":"publisher","first-page":"2106","DOI":"10.3390\/cancers3022106","volume":"3","author":"KM Britton","year":"2011","unstructured":"Britton KM, Kirby JA, Lennard TW, Meeson AP: Cancer stem cells and side population cells in breast cancer and metastasis. Cancers (Basel). 2011, 3: 2106-2130. 10.3390\/cancers3022106.","journal-title":"Cancers (Basel)"},{"key":"339_CR22","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1007\/s13577-010-0002-z","volume":"24","author":"S Hosonuma","year":"2011","unstructured":"Hosonuma S, Kobayashi Y, Kojo S, Wada H, Seino K, Kiguchi K, Ishizuka B: Clinical significance of side population in ovarian cancer cells. Hum Cell. 2011, 24: 9-12. 10.1007\/s13577-010-0002-z.","journal-title":"Hum Cell"},{"key":"339_CR23","doi-asserted-by":"publisher","first-page":"2771","DOI":"10.1002\/ijc.24349","volume":"124","author":"A Kabashima","year":"2009","unstructured":"Kabashima A, Higuchi H, Takaishi H, Matsuzaki Y, Suzuki S, Izumiya M, Iizuka H, Sakai G, Hozawa S, Azuma T, Hibi T: Side population of pancreatic cancer cells predominates in TGF-beta-mediated epithelial to mesenchymal transition and invasion. Int J Cancer. 2009, 124: 2771-2779. 10.1002\/ijc.24349.","journal-title":"Int J Cancer"},{"key":"339_CR24","doi-asserted-by":"publisher","first-page":"1155","DOI":"10.1007\/s00432-008-0407-1","volume":"134","author":"GM Shi","year":"2008","unstructured":"Shi GM, Xu Y, Fan J, Zhou J, Yang XR, Qiu SJ, Liao Y, Wu WZ, Ji Y, Ke AW, Ding ZB, He YZ, Wu B, Yang GH, Qin WZ, Zhang W, Zhu J, Min ZH, Wu ZQ: Identification of side population cells in human hepatocellular carcinoma cell lines with stepwise metastatic potentials. J Cancer Res Clin Oncol. 2008, 134: 1155-1163. 10.1007\/s00432-008-0407-1.","journal-title":"J Cancer Res Clin Oncol"},{"key":"339_CR25","doi-asserted-by":"publisher","first-page":"3716","DOI":"10.1158\/0008-5472.CAN-06-4343","volume":"67","author":"J Wang","year":"2007","unstructured":"Wang J, Guo LP, Chen LZ, Zeng YX, Lu SH: Identification of cancer stem cell-like side population cells in human nasopharyngeal carcinoma cell line. Cancer Res. 2007, 67: 3716-3724. 10.1158\/0008-5472.CAN-06-4343.","journal-title":"Cancer Res"},{"key":"339_CR26","doi-asserted-by":"crossref","first-page":"1177","DOI":"10.3892\/or.2011.1618","volume":"27","author":"H Zhang","year":"2012","unstructured":"Zhang H, Liu W, Feng X, Wang L, Jiang X, Liu D, Zhang L, Zhu B, Zhou W, Jia W, Li G, Ren C: Identification of ABCG2(+) cells in nasopharyngeal carcinoma cells. Oncol Rep. 2012, 27: 1177-1187.","journal-title":"Oncol Rep"},{"key":"339_CR27","doi-asserted-by":"publisher","first-page":"6207","DOI":"10.1158\/0008-5472.CAN-05-0592","volume":"65","author":"L Patrawala","year":"2005","unstructured":"Patrawala L, Calhoun T, Schneider-Broussard R, Zhou J, Claypool K, Tang DG: Side population is enriched in tumorigenic, stem-like cancer cells, whereas ABCG2+ and ABCG2\u2212 cancer cells are similarly tumorigenic. Cancer Res. 2005, 65: 6207-6219. 10.1158\/0008-5472.CAN-05-0592.","journal-title":"Cancer Res"},{"key":"339_CR28","doi-asserted-by":"crossref","first-page":"1097","DOI":"10.1182\/blood.V87.3.1097.bloodjournal8731097","volume":"87","author":"M Magni","year":"1996","unstructured":"Magni M, Shammah S, Schir\u00f3 R, Mellado W, Dalla-Favera R, Gianni AM: Induction of cyclophosphamide-resistance by aldehyde-dehydrogenase gene transfer. Blood. 1996, 87: 1097-1103.","journal-title":"Blood"},{"key":"339_CR29","doi-asserted-by":"publisher","first-page":"181","DOI":"10.1016\/j.canlet.2012.11.046","volume":"330","author":"A Wu","year":"2013","unstructured":"Wu A, Luo W, Zhang Q, Yang Z, Zhang G, Li S, Yao K: Aldehyde dehydrogenase 1, a functional marker for identifying cancer stem cells in human nasopharyngeal carcinoma. Cancer Lett. 2013, 330: 181-189. 10.1016\/j.canlet.2012.11.046.","journal-title":"Cancer Lett"},{"key":"339_CR30","doi-asserted-by":"publisher","first-page":"1072","DOI":"10.1111\/j.1365-2559.2012.04350.x","volume":"61","author":"WR Luo","year":"2012","unstructured":"Luo WR, Gao F, Li SY, Yao KT: Tumour budding and the expression of cancer stem cell marker aldehyde dehydrogenase 1 in nasopharyngeal carcinoma. Histopathology. 2012, 61: 1072-1081. 10.1111\/j.1365-2559.2012.04350.x.","journal-title":"Histopathology"},{"key":"339_CR31","doi-asserted-by":"publisher","first-page":"1903","DOI":"10.1002\/lary.24003","volume":"123","author":"F Yu","year":"2013","unstructured":"Yu F, Sim AC, Li C, Li Y, Zhao X, Wang DY, Loh KS: Identification of a subpopulation of nasopharyngeal carcinoma cells with cancer stem-like cell properties by high aldehyde dehydrogenase activity. Laryngoscope. 2013, 123: 1903-1911. 10.1002\/lary.24003.","journal-title":"Laryngoscope"},{"key":"339_CR32","first-page":"254","volume":"48","author":"X You","year":"2013","unstructured":"You X, Yang YC:[Research progress of separation screening and oncogenes correlation in nasopharyngeal carcinoma cancer stem cells]. Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2013, 48: 254-257.","journal-title":"Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi"},{"key":"339_CR33","doi-asserted-by":"publisher","first-page":"171","DOI":"10.1007\/s00405-013-2517-x","volume":"271","author":"W Hou","year":"2014","unstructured":"Hou W, He W, Li Y, Ma R, Wang Z, Zhu X, Fu Q, Wen Y, Li H, Wen W: Increased expression of aldehyde dehydrogenase 1 A1 in nasopharyngeal carcinoma is associated with enhanced invasiveness. Eur Arch Otorhinolaryngol. 2014, 271: 171-179. 10.1007\/s00405-013-2517-x.","journal-title":"Eur Arch Otorhinolaryngol"},{"key":"339_CR34","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1038\/sj.cr.7310118","volume":"17","author":"F Li","year":"2007","unstructured":"Li F, Tiede B, Massagu\u00e9 J, Kang Y: Beyond tumorigenesis: cancer stem cells in metastasis. Cell Res. 2007, 17: 3-14. 10.1038\/sj.cr.7310118.","journal-title":"Cell Res"},{"key":"339_CR35","doi-asserted-by":"publisher","first-page":"1696","DOI":"10.1038\/sj.onc.1209327","volume":"25","author":"L Patrawala","year":"2006","unstructured":"Patrawala L, Calhoun T, Schneider-Broussard R, Li H, Bhatia B, Tang S, Reilly JG, Chandra D, Zhou J, Claypool K, Coghlan L, Tang DG: Highly purified CD44+ prostate cancer cells from xenograft human tumors are enriched in tumorigenic and metastatic progenitor cells. Oncogene. 2006, 25: 1696-1708. 10.1038\/sj.onc.1209327.","journal-title":"Oncogene"},{"key":"339_CR36","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1016\/j.arcmed.2011.01.007","volume":"42","author":"J Su","year":"2011","unstructured":"Su J, Xu XH, Huang Q, Lu MQ, Li DJ, Xue F, Yi F, Ren JH, Wu YP: Identification of cancer stem-like CD44+ cells in human nasopharyngeal carcinoma cell line. Arch Med Res. 2011, 42: 15-21. 10.1016\/j.arcmed.2011.01.007.","journal-title":"Arch Med Res"},{"key":"339_CR37","doi-asserted-by":"publisher","first-page":"465","DOI":"10.1002\/alr.21068","volume":"2","author":"AM Janisiewicz","year":"2012","unstructured":"Janisiewicz AM, Shin JH, Murillo-Sauca O, Kwok S, Le QT, Kong C, Kaplan MJ, Sunwoo JB: CD44(+) cells have cancer stem cell-like properties in nasopharyngeal carcinoma. Int Forum Allergy Rhinol. 2012, 2: 465-470. 10.1002\/alr.21068.","journal-title":"Int Forum Allergy Rhinol"},{"key":"339_CR38","doi-asserted-by":"publisher","first-page":"375","DOI":"10.2147\/OTT.S38694","volume":"5","author":"E Allegra","year":"2012","unstructured":"Allegra E, Trapasso S: Cancer stem cells in head and neck cancer. Onco Targets Ther. 2012, 5: 375-383.","journal-title":"Onco Targets Ther"},{"key":"339_CR39","first-page":"379","volume":"6","author":"S Trapasso","year":"2012","unstructured":"Trapasso S, Allegra E: Role of CD44 as a marker of cancer stem cells in head and neck cancer. Biologics. 2012, 6: 379-383.","journal-title":"Biologics"},{"key":"339_CR40","doi-asserted-by":"crossref","first-page":"57","DOI":"10.3892\/or.2013.2408","volume":"30","author":"HW Zhuang","year":"2013","unstructured":"Zhuang HW, Mo TT, Hou WJ, Xiong GX, Zhu XL, Fu QL, Wen WP: Biological characteristics of CD133+ cells in nasopharyngeal carcinoma. Oncol Rep. 2013, 30: 57-63.","journal-title":"Oncol Rep"},{"key":"339_CR41","doi-asserted-by":"publisher","first-page":"1997","DOI":"10.1016\/j.biocel.2013.06.023","volume":"45","author":"CC Deng","year":"2013","unstructured":"Deng CC, Liang Y, Wu MS, Feng FT, Hu WR, Chen LZ, Feng QS, Bei JX, Zeng YX: Nigericin selectively targets cancer stem cells in nasopharyngeal carcinoma. Int J Biochem Cell Biol. 2013, 45: 1997-2006. 10.1016\/j.biocel.2013.06.023.","journal-title":"Int J Biochem Cell Biol"},{"key":"339_CR42","doi-asserted-by":"publisher","first-page":"206","DOI":"10.1186\/1477-7819-10-206","volume":"10","author":"E Allegra","year":"2012","unstructured":"Allegra E, Puzzo L, Zuccal\u00e0 V, Trapasso S, Vasquez E, Garozzo A, Caltabiano R: Nuclear BMI-1 expression in laryngeal carcinoma correlates with lymph node pathological status. World J Surg Oncol. 2012, 10: 206-10.1186\/1477-7819-10-206.","journal-title":"World J Surg Oncol"},{"key":"339_CR43","doi-asserted-by":"publisher","first-page":"847","DOI":"10.1002\/hed.23042","volume":"35","author":"E Allegra","year":"2012","unstructured":"Allegra E, Caltabiano R, Amorosi A, Vasquez E, Garozzo A, Puzzo L: Expression of BMI1 and p16 in laryngeal squamous cell carcinoma. Head Neck. 2012, 35: 847-851.","journal-title":"Head Neck"},{"key":"339_CR44","first-page":"5821","volume":"63","author":"SK Singh","year":"2003","unstructured":"Singh SK, Clarke ID, Terasaki M, Bonn VE, Hawkins C, Squire J, Dirks PB: Identification of a cancer stem cell in human brain tumors. Cancer Res. 2003, 63: 5821-5828.","journal-title":"Cancer Res"},{"key":"339_CR45","doi-asserted-by":"publisher","first-page":"9328","DOI":"10.1158\/0008-5472.CAN-05-1343","volume":"65","author":"D Fang","year":"2005","unstructured":"Fang D, Nguyen TK, Leishear K, Finko R, Kulp AN, Hotz S, Van Belle PA, Xu X, Elder DE, Herlyn M: A tumorigenic subpopulation with stem cell properties in melanomas. Cancer Res. 2005, 65: 9328-9337. 10.1158\/0008-5472.CAN-05-1343.","journal-title":"Cancer Res"},{"key":"339_CR46","doi-asserted-by":"publisher","first-page":"5506","DOI":"10.1158\/0008-5472.CAN-05-0626","volume":"65","author":"D Ponti","year":"2005","unstructured":"Ponti D, Costa A, Zaffaroni N, Pratesi G, Petrangolini G, Coradini D, Pilotti S, Pierotti MA, Daidone MG: Isolation and in vitro propagation of tumorigenic breast cancer cells with stem\/progenitor cell properties. Cancer Res. 2005, 65: 5506-5511. 10.1158\/0008-5472.CAN-05-0626.","journal-title":"Cancer Res"},{"key":"339_CR47","doi-asserted-by":"publisher","first-page":"4311","DOI":"10.1158\/0008-5472.CAN-08-0364","volume":"68","author":"S Zhang","year":"2008","unstructured":"Zhang S, Balch C, Chan MW, Lai HC, Matei D, Schilder JM, Yan PS, Huang TH, Nephew KP: Identification and characterization of ovarian cancer-initiating cells from primary human tumors. Cancer Res. 2008, 68: 4311-4320. 10.1158\/0008-5472.CAN-08-0364.","journal-title":"Cancer Res"},{"key":"339_CR48","first-page":"1381","volume":"34","author":"H Fujii","year":"2009","unstructured":"Fujii H, Honoki K, Tsujiuchi T, Kido A, Yoshitani K, Takakura Y: Sphere-forming stem-like cell populations with drug resistance in human sarcoma cell lines. Int J Oncol. 2009, 34: 1381-1386.","journal-title":"Int J Oncol"},{"key":"339_CR49","doi-asserted-by":"publisher","first-page":"e52426","DOI":"10.1371\/journal.pone.0052426","volume":"7","author":"SW Lun","year":"2012","unstructured":"Lun SW, Cheung ST, Cheung PF, To KF, Woo JK, Choy KW, Chow C, Cheung CC, Chung GT, Cheng AS, Ko CW, Tsao SW, Busson P, Ng MH, Lo KW: CD44+ cancer stem-like cells in EBV-associated nasopharyngeal carcinoma. PLoS One. 2012, 7: e52426-10.1371\/journal.pone.0052426.","journal-title":"PLoS One"},{"key":"339_CR50","doi-asserted-by":"publisher","first-page":"431","DOI":"10.1016\/S1044579X0200086X","volume":"12","author":"N Raab-Traub","year":"2002","unstructured":"Raab-Traub N: Epstein\u2013Barr virus in the pathogenesis of NPC. Semin Cancer Biol. 2002, 12: 431-441. 10.1016\/S1044579X0200086X.","journal-title":"Semin Cancer Biol"},{"key":"339_CR51","doi-asserted-by":"publisher","first-page":"693","DOI":"10.1056\/NEJM199509143331103","volume":"333","author":"R Pathmanathan","year":"1995","unstructured":"Pathmanathan R, Prasad U, Sadler R, Flynn K, Raab-Traub N: Clonal proliferations of cells infected with Epstein\u2013Barr virus in preinvasive lesions related to nasopharyngeal carcinoma. N Engl J Med. 1995, 333: 693-698. 10.1056\/NEJM199509143331103.","journal-title":"N Engl J Med"},{"key":"339_CR52","doi-asserted-by":"publisher","first-page":"151","DOI":"10.1002\/(SICI)1096-9896(199706)182:2<151::AID-PATH824>3.0.CO;2-3","volume":"182","author":"G Niedobitek","year":"1997","unstructured":"Niedobitek G, Agathanggelou A, Herbst H, Whitehead L, Wright DH, Young LS: Epstein\u2013Barr virus (EBV) infection in infectious mononucleosis: virus latency, replication and phenotype of EBV-infected cells. J Pathol. 1997, 182: 151-159. 10.1002\/(SICI)1096-9896(199706)182:2<151::AID-PATH824>3.0.CO;2-3.","journal-title":"J Pathol"},{"key":"339_CR53","doi-asserted-by":"publisher","first-page":"37","DOI":"10.1136\/mp.53.1.37","volume":"53","author":"G Niedobitek","year":"2000","unstructured":"Niedobitek G, Agathanggelou A, Steven N, Young LS: Epstein\u2013Barr virus (EBV) in infectious mononucleosis: detection of the virus in tonsillar B lymphocytes but not in desquamated oropharyngeal epithelial cells. Mol Pathol. 2000, 53: 37-42. 10.1136\/mp.53.1.37.","journal-title":"Mol Pathol"},{"key":"339_CR54","doi-asserted-by":"publisher","first-page":"367","DOI":"10.1016\/j.yexmp.2010.09.004","volume":"89","author":"HL Chen","year":"2013","unstructured":"Chen HL, Peng J, Zhu XB, Gao J, Xue JL, Wang MW, Xia HS: Detection of EBV in nasopharyngeal carcinoma by quantum dot fluorescent in situ hybridization. Exp Mol Pathol. 2013, 89: 367-371.","journal-title":"Exp Mol Pathol"},{"key":"339_CR55","doi-asserted-by":"publisher","first-page":"1970","DOI":"10.1158\/0008-5472.CAN-06-3933","volume":"67","author":"T Horikawa","year":"2007","unstructured":"Horikawa T, Yang J, Kondo S, Yoshizaki T, Joab I, Furukawa M, Pagano JS: Twist and epithelial\u2013mesenchymal transition are induced by the EBV oncoprotein latent membrane protein 1 and are associated with metastatic nasopharyngeal carcinoma. Cancer Res. 2007, 67: 1970-1978. 10.1158\/0008-5472.CAN-06-3933.","journal-title":"Cancer Res"},{"key":"339_CR56","doi-asserted-by":"publisher","first-page":"e1000940","DOI":"10.1371\/journal.ppat.1000940","volume":"6","author":"QL Kong","year":"2010","unstructured":"Kong QL, Hu LJ, Cao JY, Huang YJ, Xu LH, Liang Y, Xiong D, Guan S, Guo BH, Mai HQ, Chen QY, Zhang X, Li MZ, Shao JY, Qian CN, Xia YF, Song LB, Zeng YX, Zeng MS: Epstein\u2013Barr virus-encoded LMP2A induces an epithelial-mesenchymal transition and increases the number of side population stem-like cancer cells in nasopharyngeal carcinoma. PLoS Pathog. 2010, 6: e1000940-10.1371\/journal.ppat.1000940.","journal-title":"PLoS Pathog"},{"key":"339_CR57","doi-asserted-by":"publisher","first-page":"15430","DOI":"10.1128\/JVI.79.24.15430-15442.2005","volume":"79","author":"DM Pegtel","year":"2005","unstructured":"Pegtel DM, Subramanian A, Sheen TS, Tsai CH, Golub TR, Thorley-Lawson DA: Epstein\u2013Barr-virus-encoded LMP2A induces primary epithelial cell migration and invasion: possible role in nasopharyngeal carcinoma metastasis. J Virol. 2005, 79: 15430-15442. 10.1128\/JVI.79.24.15430-15442.2005.","journal-title":"J Virol"},{"key":"339_CR58","doi-asserted-by":"publisher","first-page":"374","DOI":"10.1002\/jcp.21223","volume":"213","author":"H Hugo","year":"2007","unstructured":"Hugo H, Ackland ML, Blick T, Lawrence MG, Clements JA, Williams ED, Thompson EW: Epithelial\u2013mesenchymal and mesenchymal\u2013epithelial transitions in carcinoma progression. J Cell Physiol. 2007, 213: 374-383. 10.1002\/jcp.21223.","journal-title":"J Cell Physiol"},{"key":"339_CR59","doi-asserted-by":"publisher","first-page":"383","DOI":"10.1007\/s10555-010-9233-4","volume":"29","author":"FH Sarkar","year":"2010","unstructured":"Sarkar FH, Li Y, Wang Z, Kong D: The role of nutraceuticals in the regulation of Wnt and Hedgehog signaling in cancer. Cancer Metastasis Rev. 2010, 29: 383-394. 10.1007\/s10555-010-9233-4.","journal-title":"Cancer Metastasis Rev"},{"key":"339_CR60","doi-asserted-by":"publisher","first-page":"4741","DOI":"10.1038\/onc.2010.215","volume":"29","author":"A Singh","year":"2010","unstructured":"Singh A, Settleman J: EMT, cancer stem cells and drug resistance: an emerging axis of evil in the war on cancer. Oncogene. 2010, 29: 4741-4751. 10.1038\/onc.2010.215.","journal-title":"Oncogene"},{"key":"339_CR61","doi-asserted-by":"publisher","first-page":"109","DOI":"10.1016\/j.drup.2010.07.001","volume":"13","author":"Z Wang","year":"2010","unstructured":"Wang Z, Li Y, Ahmad A, Azmi AS, Kong D, Banerjee S, Sarkar FH: Targeting miRNAs involved in cancer stem cell and EMT regulation: an emerging concept in overcoming drug resistance. Drug Resist Updat. 2010, 13: 109-118. 10.1016\/j.drup.2010.07.001.","journal-title":"Drug Resist Updat"},{"key":"339_CR62","doi-asserted-by":"publisher","first-page":"744","DOI":"10.1038\/nrc1694","volume":"5","author":"T Brabletz","year":"2005","unstructured":"Brabletz T, Jung A, Spaderna S, Hlubek F, Kirchner T: Opinion: migrating cancer stem cells \u2013 an integrated concept of malignant tumour progression. Nat Rev Cancer. 2005, 5: 744-749. 10.1038\/nrc1694.","journal-title":"Nat Rev Cancer"},{"key":"339_CR63","first-page":"590393","volume":"2013","author":"YA Shen","year":"2013","unstructured":"Shen YA, Lin CH, Chi WH, Wang CY, Hsieh YT, Wei YH, Chen YJ: Resveratrol impedes the stemness, epithelial\u2013mesenchymal transition, and metabolic reprogramming of cancer stem cells in nasopharyngeal carcinoma through p53 activation. Evid Based Complement Alternat Med. 2013, 2013: 590393-","journal-title":"Evid Based Complement Alternat Med"},{"key":"339_CR64","doi-asserted-by":"publisher","first-page":"201","DOI":"10.1186\/1472-6882-12-201","volume":"12","author":"CH Lin","year":"2012","unstructured":"Lin CH, Shen YA, Hung PH, Yu YB, Chen YJ: Epigallocathechin gallate, polyphenol present in green tea, inhibits stem-like characteristics and epithelial\u2013mesenchymal transition in nasopharyngeal cancer cell lines. BMC Complement Altern Med. 2012, 12: 201-10.1186\/1472-6882-12-201.","journal-title":"BMC Complement Altern Med"},{"key":"339_CR65","doi-asserted-by":"publisher","first-page":"1728","DOI":"10.1158\/1535-7163.MCT-13-0017","volume":"12","author":"MS Wu","year":"2013","unstructured":"Wu MS, Wang GF, Zhao ZQ, Liang Y, Wang HB, Wu MY, Min P, Chen LZ, Feng QS, Bei JX, Zeng YX, Yang D: Smac mimetics in combination with TRAIL selectively target cancer stem cells in nasopharyngeal carcinoma. Mol Cancer Ther. 2013, 12: 1728-1737. 10.1158\/1535-7163.MCT-13-0017.","journal-title":"Mol Cancer Ther"},{"key":"339_CR66","doi-asserted-by":"crossref","first-page":"561","DOI":"10.3892\/or.2012.1830","volume":"28","author":"S Yu","year":"2012","unstructured":"Yu S, Zhang R, Liu F, Wang H, Wu J, Wang Y: Notch inhibition suppresses nasopharyngeal carcinoma by depleting cancer stem-like side population cells. Oncol Rep. 2012, 28: 561-566.","journal-title":"Oncol Rep"},{"key":"339_CR67","doi-asserted-by":"publisher","first-page":"2027","DOI":"10.1111\/febs.12226","volume":"280","author":"L Ma","year":"2013","unstructured":"Ma L, Zhang G, Miao XB, Deng XB, Wu Y, Liu Y, Jin ZR, Li XQ, Liu QZ, Sun DX, Testa JR, Yao KT, Xiao GH: Cancer stem-like cell properties are regulated by EGFR\/AKT\/beta-catenin signaling and preferentially inhibited by gefitinib in nasopharyngeal carcinoma. Febs J. 2013, 280: 2027-2041. 10.1111\/febs.12226.","journal-title":"Febs J"},{"key":"339_CR68","doi-asserted-by":"publisher","first-page":"367","DOI":"10.1002\/path.4245","volume":"231","author":"RJ Port","year":"2013","unstructured":"Port RJ, Pinheiro-Maia S, Hu C, Arrand JR, Wei W, Young LS, Dawson CW: Epstein\u2013Barr virus induction of the Hedgehog signalling pathway imposes a stem cell phenotype on human epithelial cells. J Pathol. 2013, 231: 367-377.","journal-title":"J Pathol"},{"key":"339_CR69","doi-asserted-by":"publisher","first-page":"315","DOI":"10.1007\/s10238-012-0198-1","volume":"13","author":"Y Yue","year":"2013","unstructured":"Yue Y, Zhong W, Pei G, Xiao B, Zhang G, Jiang F, Zhang J, Chen C, Yang P, Dang H, Chang H: Aberrant activation of Hedgehog pathway in nasopharyngeal carcinoma. Clin Exp Med. 2013, 13: 315-322. 10.1007\/s10238-012-0198-1.","journal-title":"Clin Exp Med"},{"key":"339_CR70","doi-asserted-by":"publisher","first-page":"1462","DOI":"10.1093\/brain\/awt025","volume":"136","author":"A Golebiewska","year":"2013","unstructured":"Golebiewska A, Bougnaud S, Stieber D, Brons NH, Vallar L, Hertel F, Klink B, Schr\u00f6ck E, Bjerkvig R, Niclou SP: Side population in human glioblastoma is non-tumorigenic and characterizes brain endothelial cells. Brain. 2013, 136: 1462-1475. 10.1093\/brain\/awt025.","journal-title":"Brain"},{"key":"339_CR71","doi-asserted-by":"publisher","first-page":"1159","DOI":"10.1016\/j.ajpath.2011.11.015","volume":"180","author":"YC Wang","year":"2012","unstructured":"Wang YC, Yo YT, Lee HY, Liao YP, Chao TK, Su PH, Lai HC: ALDH1-bright epithelial ovarian cancer cells are associated with CD44 expression, drug resistance, and poor clinical outcome. Am J Pathol. 2012, 180: 1159-1169. 10.1016\/j.ajpath.2011.11.015.","journal-title":"Am J Pathol"},{"key":"339_CR72","doi-asserted-by":"publisher","first-page":"2131","DOI":"10.2353\/ajpath.2010.090712","volume":"176","author":"V Neumeister","year":"2010","unstructured":"Neumeister V, Agarwal S, Bordeaux J, Camp RL, Rimm DL: In situ identification of putative cancer stem cells by multiplexing ALDH1, CD44, and cytokeratin identifies breast cancer patients with poor prognosis. Am J Pathol. 2010, 176: 2131-2138. 10.2353\/ajpath.2010.090712.","journal-title":"Am J Pathol"}],"container-title":["Stem Cell Research &amp; Therapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/scrt433.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1186\/scrt433\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/scrt433.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,4,25]],"date-time":"2024-04-25T16:36:34Z","timestamp":1714062994000},"score":1,"resource":{"primary":{"URL":"https:\/\/stemcellres.biomedcentral.com\/articles\/10.1186\/scrt433"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,3,27]]},"references-count":72,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2014,6]]}},"alternative-id":["339"],"URL":"https:\/\/doi.org\/10.1186\/scrt433","relation":{},"ISSN":["1757-6512"],"issn-type":[{"value":"1757-6512","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,3,27]]},"assertion":[{"value":"27 March 2014","order":1,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"This content has been made available to all.","name":"free","label":"Free to read"}],"article-number":"44"}}