{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,6]],"date-time":"2026-03-06T04:10:23Z","timestamp":1772770223115,"version":"3.50.1"},"reference-count":85,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[2014,4,22]],"date-time":"2014-04-22T00:00:00Z","timestamp":1398124800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2014,4,22]],"date-time":"2014-04-22T00:00:00Z","timestamp":1398124800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Stem Cell Res Ther"],"DOI":"10.1186\/scrt445","type":"journal-article","created":{"date-parts":[[2014,4,22]],"date-time":"2014-04-22T11:20:12Z","timestamp":1398165612000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":42,"title":["Ocular stem cells: a status update!"],"prefix":"10.1186","volume":"5","author":[{"given":"Kamesh","family":"Dhamodaran","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Murali","family":"Subramani","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Murugeswari","family":"Ponnalagu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Reshma","family":"Shetty","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Debashish","family":"Das","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2014,4,22]]},"reference":[{"key":"336_CR1","doi-asserted-by":"publisher","first-page":"642","DOI":"10.1634\/stemcells.2008-0721","volume":"27","author":"EA Blazejewska","year":"2009","unstructured":"Blazejewska EA, Schlotzer-Schrehardt U, Zenkel M, Bachmann B, Chankiewitz E, Jacobi C, Kruse FE: Corneal limbal microenvironment can induce transdifferentiation of hair follicle stem cells into corneal epithelial-like cells. Stem Cells. 2009, 27: 642-652. 10.1634\/stemcells.2008-0721.","journal-title":"Stem Cells"},{"key":"336_CR2","doi-asserted-by":"publisher","first-page":"53","DOI":"10.1016\/j.semcdb.2003.09.003","volume":"15","author":"I Ahmad","year":"2004","unstructured":"Ahmad I, Das AV, James J, Bhattacharya S, Zhao X: Neural stem cells in the mammalian eye: types and regulation. Semin Cell Dev Biol. 2004, 15: 53-62. 10.1016\/j.semcdb.2003.09.003.","journal-title":"Semin Cell Dev Biol"},{"key":"336_CR3","doi-asserted-by":"crossref","unstructured":"Abstracts of the 30th meeting of the Association for Eye Research including the annual meeting of the European Club for Ocular Fine Structure. Montpellier, France, 4\u20137 October 1989. Doc Ophthalmol. 1990, 76: 105-218.","DOI":"10.1007\/BF00141904"},{"key":"336_CR4","doi-asserted-by":"publisher","first-page":"101","DOI":"10.1007\/s10616-007-9063-6","volume":"53","author":"F O'Sullivan","year":"2007","unstructured":"O'Sullivan F, Clynes M: Limbal stem cells, a review of their identification and culture for clinical use. Cytotechnology. 2007, 53: 101-106. 10.1007\/s10616-007-9063-6.","journal-title":"Cytotechnology"},{"key":"336_CR5","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1517\/14712598.7.1.1","volume":"7","author":"JT Daniels","year":"2007","unstructured":"Daniels JT, Notara M, Shortt AJ, Secker G, Harris A, Tuft SJ: Limbal epithelial stem cell therapy. Expert Opin Biol Ther. 2007, 7: 1-3. 10.1517\/14712598.7.1.1.","journal-title":"Expert Opin Biol Ther"},{"key":"336_CR6","doi-asserted-by":"publisher","first-page":"201","DOI":"10.1016\/0092-8674(89)90958-6","volume":"57","author":"G Cotsarelis","year":"1989","unstructured":"Cotsarelis G, Cheng SZ, Dong G, Sun TT, Lavker RM: Existence of slow-cycling limbal epithelial basal cells that can be preferentially stimulated to proliferate: implications on epithelial stem cells. Cell. 1989, 57: 201-209. 10.1016\/0092-8674(89)90958-6.","journal-title":"Cell"},{"key":"336_CR7","doi-asserted-by":"publisher","first-page":"3631","DOI":"10.1167\/iovs.05-0343","volume":"46","author":"P Arpitha","year":"2005","unstructured":"Arpitha P, Prajna NV, Srinivasan M, Muthukkaruppan V: High expression of p63 combined with a large N\/C ratio defines a subset of human limbal epithelial cells: implications on epithelial stem cells. Invest Ophthalmol Vis Sci. 2005, 46: 3631-3636. 10.1167\/iovs.05-0343.","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"336_CR8","doi-asserted-by":"publisher","first-page":"553","DOI":"10.2217\/rme.13.43","volume":"8","author":"G Pellegrini","year":"2013","unstructured":"Pellegrini G, Rama P, Matuska S, Lambiase A, Bonini S, Pocobelli A, Colabelli RG, Spadea L, Fasciani R, Balestrazzi E, Vinciguerra P, Rosetta P, Tortori A, Nardi M, Gabbriellini G, Traverso CE, Macaluso C, Losi L, Percesepe A, Venturi B, Corradini F, Panaras A, Di Rocco A, Guatelli P, De Luca M: Biological parameters determining the clinical outcome of autologous cultures of limbal stem cells. Regen Med. 2013, 8: 553-567. 10.2217\/rme.13.43.","journal-title":"Regen Med"},{"key":"336_CR9","doi-asserted-by":"publisher","first-page":"1470","DOI":"10.1038\/nprot.2010.115","volume":"5","author":"I Mariappan","year":"2010","unstructured":"Mariappan I, Maddileti S, Savy S, Tiwari S, Gaddipati S, Fatima A, Sangwan VS, Balasubramanian D, Vemuganti GK: In vitro culture and expansion of human limbal epithelial cells. Nat Protoc. 2010, 5: 1470-1479. 10.1038\/nprot.2010.115.","journal-title":"Nat Protoc"},{"key":"336_CR10","doi-asserted-by":"publisher","first-page":"211","DOI":"10.1002\/bies.201200086","volume":"35","author":"C Osei-Bempong","year":"2013","unstructured":"Osei-Bempong C, Figueiredo FC, Lako M: The limbal epithelium of the eye - a review of limbal stem cell biology, disease and treatment. Bioessays. 2013, 35: 211-219. 10.1002\/bies.201200086.","journal-title":"Bioessays"},{"key":"336_CR11","doi-asserted-by":"publisher","first-page":"355","DOI":"10.1634\/stemcells.22-3-355","volume":"22","author":"Z Chen","year":"2004","unstructured":"Chen Z, de Paiva CS, Luo L, Kretzer FL, Pflugfelder SC, Li DQ: Characterization of putative stem cell phenotype in human limbal epithelia. Stem Cells. 2004, 22: 355-366. 10.1634\/stemcells.22-3-355.","journal-title":"Stem Cells"},{"key":"336_CR12","doi-asserted-by":"publisher","first-page":"877","DOI":"10.1038\/sj.eye.6700573","volume":"17","author":"HS Dua","year":"2003","unstructured":"Dua HS, Joseph A, Shanmuganathan VA, Jones RE: Stem cell differentiation and the effects of deficiency. Eye (Lond). 2003, 17: 877-885. 10.1038\/sj.eye.6700573.","journal-title":"Eye (Lond)"},{"key":"336_CR13","doi-asserted-by":"publisher","first-page":"S73","DOI":"10.1097\/01.ico.0000247218.10672.7e","volume":"25","author":"S Amano","year":"2006","unstructured":"Amano S, Yamagami S, Mimura T, Uchida S, Yokoo S: Corneal stromal and endothelial cell precursors. Cornea. 2006, 25: S73-S77. 10.1097\/01.ico.0000247218.10672.7e.","journal-title":"Cornea"},{"key":"336_CR14","doi-asserted-by":"publisher","first-page":"2714","DOI":"10.1634\/stemcells.2006-0156","volume":"24","author":"S Yoshida","year":"2006","unstructured":"Yoshida S, Shimmura S, Nagoshi N, Fukuda K, Matsuzaki Y, Okano H, Tsubota K: Isolation of multipotent neural crest-derived stem cells from the adult mouse cornea. Stem Cells. 2006, 24: 2714-2722. 10.1634\/stemcells.2006-0156.","journal-title":"Stem Cells"},{"key":"336_CR15","doi-asserted-by":"publisher","first-page":"1059","DOI":"10.1002\/stem.1100","volume":"30","author":"N Pinnamaneni","year":"2012","unstructured":"Pinnamaneni N, Funderburgh JL: Concise review: Stem cells in the corneal stroma. Stem Cells. 2012, 30: 1059-1063. 10.1002\/stem.1100.","journal-title":"Stem Cells"},{"key":"336_CR16","doi-asserted-by":"publisher","first-page":"1266","DOI":"10.1634\/stemcells.2004-0256","volume":"23","author":"Y Du","year":"2005","unstructured":"Du Y, Funderburgh ML, Mann MM, SundarRaj N, Funderburgh JL: Multipotent stem cells in human corneal stroma. Stem Cells. 2005, 23: 1266-1275. 10.1634\/stemcells.2004-0256.","journal-title":"Stem Cells"},{"key":"336_CR17","doi-asserted-by":"publisher","first-page":"805","DOI":"10.1016\/j.semcdb.2007.09.011","volume":"18","author":"G Pellegrini","year":"2007","unstructured":"Pellegrini G, De Luca M, Arsenijevic Y: Towards therapeutic application of ocular stem cells. Semin Cell Dev Biol. 2007, 18: 805-818. 10.1016\/j.semcdb.2007.09.011.","journal-title":"Semin Cell Dev Biol"},{"key":"336_CR18","doi-asserted-by":"publisher","first-page":"769","DOI":"10.1083\/jcb.145.4.769","volume":"145","author":"G Pellegrini","year":"1999","unstructured":"Pellegrini G, Golisano O, Paterna P, Lambiase A, Bonini S, Rama P, De Luca M: Location and clonal analysis of stem cells and their differentiated progeny in the human ocular surface. J Cell Biol. 1999, 145: 769-782. 10.1083\/jcb.145.4.769.","journal-title":"J Cell Biol"},{"key":"336_CR19","doi-asserted-by":"publisher","first-page":"1641","DOI":"10.1038\/eye.2011.230","volume":"25","author":"CG Priya","year":"2011","unstructured":"Priya CG, Arpitha P, Vaishali S, Prajna NV, Usha K, Sheetal K, Muthukkaruppan V: Adult human buccal epithelial stem cells: identification, ex-vivo expansion, and transplantation for corneal surface reconstruction. Eye (Lond). 2011, 25: 1641-1649. 10.1038\/eye.2011.230.","journal-title":"Eye (Lond)"},{"key":"336_CR20","doi-asserted-by":"publisher","first-page":"29","DOI":"10.4103\/0301-4738.21611","volume":"54","author":"VS Sangwan","year":"2006","unstructured":"Sangwan VS, Matalia HP, Vemuganti GK, Fatima A, Ifthekar G, Singh S, Nutheti R, Rao GN: Clinical outcome of autologous cultivated limbal epithelium transplantation. Indian J Ophthalmol. 2006, 54: 29-34. 10.4103\/0301-4738.21611.","journal-title":"Indian J Ophthalmol"},{"key":"336_CR21","first-page":"347","volume-title":"Tissue Engineering for Tissue and Organ Regeneration","author":"T Mimura","year":"2010","unstructured":"Mimura T, Tabata Y, Amano S: Transplantation of corneal stroma reconstructed with gelatin and multipotent precursor cells from corneal stroma. Tissue Engineering for Tissue and Organ Regeneration. Edited by: Eberli D. 2010, : Rijeka, InTech, 347-362."},{"key":"336_CR22","doi-asserted-by":"publisher","first-page":"1635","DOI":"10.1002\/stem.91","volume":"27","author":"Y Du","year":"2009","unstructured":"Du Y, Carlson EC, Funderburgh ML, Birk DE, Pearlman E, Guo N, Kao WW, Funderburgh JL: Stem cell therapy restores transparency to defective murine corneas. Stem Cells. 2009, 27: 1635-1642. 10.1002\/stem.91.","journal-title":"Stem Cells"},{"key":"336_CR23","doi-asserted-by":"publisher","first-page":"180","DOI":"10.1002\/jcp.22215","volume":"225","author":"H Qi","year":"2010","unstructured":"Qi H, Zheng X, Yuan X, Pflugfelder SC, Li DQ: Potential localization of putative stem\/progenitor cells in human bulbar conjunctival epithelium. J Cell Physiol. 2010, 225: 180-185. 10.1002\/jcp.22215.","journal-title":"J Cell Physiol"},{"key":"336_CR24","doi-asserted-by":"publisher","first-page":"739","DOI":"10.1387\/ijdb.062198ar","volume":"51","author":"A Rosellini","year":"2007","unstructured":"Rosellini A, Papini S, Giannarini C, Nardi M, Revoltella RP: Human conjunctival epithelial precursor cells and their progeny in 3D organotypic culture. Int J Dev Biol. 2007, 51: 739-743. 10.1387\/ijdb.062198ar.","journal-title":"Int J Dev Biol"},{"key":"336_CR25","doi-asserted-by":"publisher","first-page":"3820","DOI":"10.1167\/iovs.06-0293","volume":"47","author":"H Tanioka","year":"2006","unstructured":"Tanioka H, Kawasaki S, Yamasaki K, Ang LP, Koizumi N, Nakamura T, Yokoi N, Komuro A, Inatomi T, Kinoshita S: Establishment of a cultivated human conjunctival epithelium as an alternative tissue source for autologous corneal epithelial transplantation. Invest Ophthalmol Vis Sci. 2006, 47: 3820-3827. 10.1167\/iovs.06-0293.","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"336_CR26","doi-asserted-by":"publisher","first-page":"221","DOI":"10.1097\/ICO.0b013e31825034be","volume":"32","author":"JR Ricardo","year":"2013","unstructured":"Ricardo JR, Cristovam PC, Filho PA, Farias CC, de Araujo AL, Loureiro RR, Covre JL, de Barros JN, Barreiro TP, dos Santos MS, Gomes JA: Transplantation of conjunctival epithelial cells cultivated ex vivo in patients with total limbal stem cell deficiency. Cornea. 2013, 32: 221-228. 10.1097\/ICO.0b013e31825034be.","journal-title":"Cornea"},{"key":"336_CR27","doi-asserted-by":"publisher","first-page":"105","DOI":"10.1167\/iovs.05-0512","volume":"47","author":"LP Ang","year":"2006","unstructured":"Ang LP, Cheng ZY, Beuerman RW, Teoh SH, Zhu X, Tan DT: The development of a serum-free derived bioengineered conjunctival epithelial equivalent using an ultrathin poly(epsilon-caprolactone) membrane substrate. Invest Ophthalmol Vis Sci. 2006, 47: 105-112. 10.1167\/iovs.05-0512.","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"336_CR28","doi-asserted-by":"publisher","first-page":"S176","DOI":"10.1016\/S0039-6257(02)00304-1","volume":"47","author":"I Grierson","year":"2002","unstructured":"Grierson I, Pfeiffer N, Cracknell KP, Appleton P: Histology and fine structure of the iris and outflow system following latanoprost therapy. Surv Ophthalmol. 2002, 47: S176-S184.","journal-title":"Surv Ophthalmol"},{"key":"336_CR29","doi-asserted-by":"publisher","first-page":"410","DOI":"10.1016\/j.expneurol.2004.02.015","volume":"187","author":"S Arnhold","year":"2004","unstructured":"Arnhold S, Semkova I, Andressen C, Lenartz D, Meissner G, Sturm V, Kochanek S, Addicks K, Schraermeyer U: Iris pigment epithelial cells: a possible cell source for the future treatment of neurodegenerative diseases. Exp Neurol. 2004, 187: 410-417. 10.1016\/j.expneurol.2004.02.015.","journal-title":"Exp Neurol"},{"key":"336_CR30","doi-asserted-by":"publisher","first-page":"e35611","DOI":"10.1371\/journal.pone.0035611","volume":"7","author":"Y Seko","year":"2012","unstructured":"Seko Y, Azuma N, Kaneda M, Nakatani K, Miyagawa Y, Noshiro Y, Kurokawa R, Okano H, Umezawa A: Derivation of human differential photoreceptor-like cells from the iris by defined combinations of CRX, RX and NEUROD. PLoS One. 2012, 7: e35611-10.1371\/journal.pone.0035611.","journal-title":"PLoS One"},{"key":"336_CR31","doi-asserted-by":"publisher","first-page":"615","DOI":"10.1016\/j.exer.2006.07.012","volume":"84","author":"HR Napier","year":"2007","unstructured":"Napier HR, Kidson SH: Molecular events in early development of the ciliary body: a question of folding. Exp Eye Res. 2007, 84: 615-625. 10.1016\/j.exer.2006.07.012.","journal-title":"Exp Eye Res"},{"key":"336_CR32","doi-asserted-by":"publisher","first-page":"1674","DOI":"10.1167\/iovs.06-1034","volume":"48","author":"H Xu","year":"2007","unstructured":"Xu H, Sta Iglesia DD, Kielczewski JL, Valenta DF, Pease ME, Zack DJ, Quigley HA: Characteristics of progenitor cells derived from adult ciliary body in mouse, rat, and human eyes. Invest Ophthalmol Vis Sci. 2007, 48: 1674-1682. 10.1167\/iovs.06-1034.","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"336_CR33","doi-asserted-by":"publisher","first-page":"1048","DOI":"10.1002\/stem.423","volume":"28","author":"S Gualdoni","year":"2010","unstructured":"Gualdoni S, Baron M, Lakowski J, Decembrini S, Smith AJ, Pearson RA, Ali RR, Sowden JC: Adult ciliary epithelial cells, previously identified as retinal stem cells with potential for retinal repair, fail to differentiate into new rod photoreceptors. Stem Cells. 2010, 28: 1048-1059. 10.1002\/stem.423.","journal-title":"Stem Cells"},{"key":"336_CR34","doi-asserted-by":"publisher","first-page":"471","DOI":"10.1016\/j.exer.2005.08.005","volume":"82","author":"Y Yanagi","year":"2006","unstructured":"Yanagi Y, Inoue Y, Kawase Y, Uchida S, Tamaki Y, Araie M, Okochi H: Properties of growth and molecular profiles of rat progenitor cells from ciliary epithelium. Exp Eye Res. 2006, 82: 471-478. 10.1016\/j.exer.2005.08.005.","journal-title":"Exp Eye Res"},{"key":"336_CR35","doi-asserted-by":"publisher","first-page":"6685","DOI":"10.1073\/pnas.0901596106","volume":"106","author":"SA Cicero","year":"2009","unstructured":"Cicero SA, Johnson D, Reyntjens S, Frase S, Connell S, Chow LM, Baker SJ, Sorrentino BP, Dyer MA: Cells previously identified as retinal stem cells are pigmented ciliary epithelial cells. Proc Natl Acad Sci U S A. 2009, 106: 6685-6690. 10.1073\/pnas.0901596106.","journal-title":"Proc Natl Acad Sci U S A"},{"key":"336_CR36","doi-asserted-by":"publisher","first-page":"237","DOI":"10.1242\/bio.2012027","volume":"1","author":"BG Ballios","year":"2012","unstructured":"Ballios BG, Clarke L, Coles BL, Shoichet MS, Van Der Kooy D: The adult retinal stem cell is a rare cell in the ciliary epithelium whose progeny can differentiate into photoreceptors. Biol Open. 2012, 1: 237-246. 10.1242\/bio.2012027.","journal-title":"Biol Open"},{"key":"336_CR37","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1002\/stem.279","volume":"28","author":"T Inoue","year":"2010","unstructured":"Inoue T, Coles BL, Dorval K, Bremner R, Bessho Y, Kageyama R, Hino S, Matsuoka M, Craft CM, McInnes RR, Tremblay F, Prusky GT, van der Kooy D: Maximizing functional photoreceptor differentiation from adult human retinal stem cells. Stem Cells. 2010, 28: 489-500.","journal-title":"Stem Cells"},{"key":"336_CR38","doi-asserted-by":"publisher","first-page":"1566","DOI":"10.1167\/iovs.11-9134","volume":"53","author":"Y Du","year":"2012","unstructured":"Du Y, Roh DS, Mann MM, Funderburgh ML, Funderburgh JL, Schuman JS: Multipotent stem cells from trabecular meshwork become phagocytic TM cells. Invest Ophthalmol Vis Sci. 2012, 53: 1566-1575. 10.1167\/iovs.11-9134.","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"336_CR39","doi-asserted-by":"publisher","first-page":"1389","DOI":"10.1167\/iovs.03-0537","volume":"45","author":"P Gonzalez","year":"2004","unstructured":"Gonzalez P, Caballero M, Liton PB, Stamer WD, Epstein DL: Expression analysis of the matrix GLA protein and VE-cadherin gene promoters in the outflow pathway. Invest Ophthalmol Vis Sci. 2004, 45: 1389-1395. 10.1167\/iovs.03-0537.","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"336_CR40","doi-asserted-by":"publisher","first-page":"183","DOI":"10.1167\/iovs.04-0330","volume":"46","author":"PB Liton","year":"2005","unstructured":"Liton PB, Liu X, Stamer WD, Challa P, Epstein DL, Gonzalez P: Specific targeting of gene expression to a subset of human trabecular meshwork cells using the chitinase 3-like 1 promoter. Invest Ophthalmol Vis Sci. 2005, 46: 183-190. 10.1167\/iovs.04-0330.","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"336_CR41","doi-asserted-by":"publisher","first-page":"1095","DOI":"10.3109\/02713689508995815","volume":"14","author":"WD Stamer","year":"1995","unstructured":"Stamer WD, Seftor RE, Snyder RW, Regan JW: Cultured human trabecular meshwork cells express aquaporin-1 water channels. Curr Eye Res. 1995, 14: 1095-1100. 10.3109\/02713689508995815.","journal-title":"Curr Eye Res"},{"key":"336_CR42","doi-asserted-by":"publisher","first-page":"1381","DOI":"10.1089\/scd.2011.0655","volume":"21","author":"CY Tay","year":"2012","unstructured":"Tay CY, Sathiyanathan P, Chu SW, Stanton LW, Wong TT: Identification and characterization of mesenchymal stem cells derived from the trabecular meshwork of the human eye. Stem Cells Dev. 2012, 21: 1381-1390. 10.1089\/scd.2011.0655.","journal-title":"Stem Cells Dev"},{"key":"336_CR43","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/0002-9394(89)90805-2","volume":"107","author":"TS Acott","year":"1989","unstructured":"Acott TS, Samples JR, Bradley JM, Bacon DR, Bylsma SS, Van Buskirk EM: Trabecular repopulation by anterior trabecular meshwork cells after laser trabeculoplasty. Am J Ophthalmol. 1989, 107: 1-6.","journal-title":"Am J Ophthalmol"},{"key":"336_CR44","doi-asserted-by":"publisher","first-page":"1450","DOI":"10.1167\/iovs.12-11056","volume":"54","author":"Y Du","year":"2013","unstructured":"Du Y, Yun H, Yang E, Schuman JS: Stem cells from trabecular meshwork home to TM tissue in vivo. Invest Ophthalmol Vis Sci. 2013, 54: 1450-1459. 10.1167\/iovs.12-11056.","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"336_CR45","doi-asserted-by":"publisher","first-page":"412743","DOI":"10.1155\/2011\/412743","volume":"2011","author":"WY Yu","year":"2011","unstructured":"Yu WY, Sheridan C, Grierson I, Mason S, Kearns V, Lo AC, Wong D: Progenitors for the corneal endothelium and trabecular meshwork: a potential source for personalized stem cell therapy in corneal endothelial diseases and glaucoma. J Biomed Biotechnol. 2011, 2011: 412743-","journal-title":"J Biomed Biotechnol"},{"key":"336_CR46","doi-asserted-by":"publisher","first-page":"22","DOI":"10.1186\/1742-4682-4-22","volume":"4","author":"SG Remington","year":"2007","unstructured":"Remington SG, Meyer RA: Lens stem cells may reside outside the lens capsule: an hypothesis. Theor Biol Med Model. 2007, 4: 22-10.1186\/1742-4682-4-22.","journal-title":"Theor Biol Med Model"},{"key":"336_CR47","doi-asserted-by":"publisher","first-page":"161","DOI":"10.1016\/j.exer.2003.10.022","volume":"78","author":"PA Tsonis","year":"2004","unstructured":"Tsonis PA, Del Rio-Tsonis K: Lens and retina regeneration: transdifferentiation, stem cells and clinical applications. Exp Eye Res. 2004, 78: 161-172. 10.1016\/j.exer.2003.10.022.","journal-title":"Exp Eye Res"},{"key":"336_CR48","doi-asserted-by":"publisher","first-page":"e32612","DOI":"10.1371\/journal.pone.0032612","volume":"7","author":"X Qiu","year":"2012","unstructured":"Qiu X, Yang J, Liu T, Jiang Y, Le Q, Lu Y: Efficient generation of lens progenitor cells from cataract patient-specific induced pluripotent stem cells. PLoS One. 2012, 7: e32612-10.1371\/journal.pone.0032612.","journal-title":"PLoS One"},{"key":"336_CR49","doi-asserted-by":"publisher","first-page":"981","DOI":"10.1038\/eye.2011.92","volume":"25","author":"M Laouri","year":"2011","unstructured":"Laouri M, Chen E, Looman M, Gallagher M: The burden of disease of retinal vein occlusion: review of the literature. Eye (Lond). 2011, 25: 981-988. 10.1038\/eye.2011.92.","journal-title":"Eye (Lond)"},{"key":"336_CR50","doi-asserted-by":"publisher","first-page":"503","DOI":"10.1007\/s00417-008-0977-2","volume":"247","author":"N Li","year":"2009","unstructured":"Li N, Li XR, Yuan JQ: Effects of bone-marrow mesenchymal stem cells transplanted into vitreous cavity of rat injured by ischemia\/reperfusion. Graefes Arch Clin Exp Ophthalmol. 2009, 247: 503-514. 10.1007\/s00417-008-1009-y.","journal-title":"Graefes Arch Clin Exp Ophthalmol"},{"key":"336_CR51","doi-asserted-by":"publisher","first-page":"246","DOI":"10.1634\/stemcells.2005-0009","volume":"24","author":"E Banin","year":"2006","unstructured":"Banin E, Obolensky A, Idelson M, Hemo I, Reinhardtz E, Pikarsky E, Ben-Hur T, Reubinoff B: Retinal incorporation and differentiation of neural precursors derived from human embryonic stem cells. Stem Cells. 2006, 24: 246-257. 10.1634\/stemcells.2005-0009.","journal-title":"Stem Cells"},{"key":"336_CR52","doi-asserted-by":"publisher","first-page":"203","DOI":"10.1038\/nature05161","volume":"444","author":"RE MacLaren","year":"2006","unstructured":"MacLaren RE, Pearson RA, MacNeil A, Douglas RH, Salt TE, Akimoto M, Swaroop A, Sowden JC, Ali RR: Retinal repair by transplantation of photoreceptor precursors. Nature. 2006, 444: 203-207. 10.1038\/nature05161.","journal-title":"Nature"},{"key":"336_CR53","doi-asserted-by":"publisher","first-page":"42","DOI":"10.1038\/472042a","volume":"472","author":"RR Ali","year":"2011","unstructured":"Ali RR, Sowden JC: Regenerative medicine: DIY eye. Nature. 2011, 472: 42-43. 10.1038\/472042a.","journal-title":"Nature"},{"key":"336_CR54","doi-asserted-by":"publisher","first-page":"51","DOI":"10.1038\/nature09941","volume":"472","author":"M Eiraku","year":"2011","unstructured":"Eiraku M, Takata N, Ishibashi H, Kawada M, Sakakura E, Okuda S, Sekiguchi K, Adachi T, Sasai Y: Self-organizing optic-cup morphogenesis in three-dimensional culture. Nature. 2011, 472: 51-56. 10.1038\/nature09941.","journal-title":"Nature"},{"key":"336_CR55","doi-asserted-by":"publisher","first-page":"1159","DOI":"10.1001\/archopht.122.8.1159","volume":"122","author":"ND Radtke","year":"2004","unstructured":"Radtke ND, Aramant RB, Seiler MJ, Petry HM, Pidwell D: Vision change after sheet transplant of fetal retina with retinal pigment epithelium to a patient with retinitis pigmentosa. Arch Ophthalmol. 2004, 122: 1159-1165. 10.1001\/archopht.122.8.1159.","journal-title":"Arch Ophthalmol"},{"key":"336_CR56","doi-asserted-by":"publisher","first-page":"226","DOI":"10.1097\/ICU.0b013e328352407d","volume":"23","author":"MD Tibbetts","year":"2012","unstructured":"Tibbetts MD, Samuel MA, Chang TS, Ho AC: Stem cell therapy for retinal disease. Curr Opin Ophthalmol. 2012, 23: 226-234. 10.1097\/ICU.0b013e328352407d.","journal-title":"Curr Opin Ophthalmol"},{"key":"336_CR57","doi-asserted-by":"publisher","first-page":"e8763","DOI":"10.1371\/journal.pone.0008763","volume":"5","author":"DA Lamba","year":"2010","unstructured":"Lamba DA, McUsic A, Hirata RK, Wang PR, Russell D, Reh TA: Generation, purification and transplantation of photoreceptors derived from human induced pluripotent stem cells. PLoS One. 2010, 5: e8763-10.1371\/journal.pone.0008763.","journal-title":"PLoS One"},{"key":"336_CR58","doi-asserted-by":"publisher","first-page":"354","DOI":"10.1073\/pnas.1212677110","volume":"110","author":"AC Barber","year":"2013","unstructured":"Barber AC, Hippert C, Duran Y, West EL, Bainbridge JW, Warre-Cornish K, Luhmann UF, Lakowski J, Sowden JC, Ali RR, Pearson RA: Repair of the degenerate retina by photoreceptor transplantation. Proc Natl Acad Sci U S A. 2013, 110: 354-359. 10.1073\/pnas.1212677110.","journal-title":"Proc Natl Acad Sci U S A"},{"key":"336_CR59","doi-asserted-by":"publisher","first-page":"1101","DOI":"10.1073\/pnas.1119416110","volume":"110","author":"MS Singh","year":"2013","unstructured":"Singh MS, Charbel Issa P, Butler R, Martin C, Lipinski DM, Sekaran S, Barnard AR, MacLaren RE: Reversal of end-stage retinal degeneration and restoration of visual function by photoreceptor transplantation. Proc Natl Acad Sci U S A. 2013, 110: 1101-1106. 10.1073\/pnas.1119416110.","journal-title":"Proc Natl Acad Sci U S A"},{"key":"336_CR60","doi-asserted-by":"publisher","first-page":"e18992","DOI":"10.1371\/journal.pone.0018992","volume":"6","author":"BA Tucker","year":"2011","unstructured":"Tucker BA, Park IH, Qi SD, Klassen HJ, Jiang C, Yao J, Redenti S, Daley GQ, Young MJ: Transplantation of adult mouse iPS cell-derived photoreceptor precursors restores retinal structure and function in degenerative mice. PLoS One. 2011, 6: e18992-10.1371\/journal.pone.0018992.","journal-title":"PLoS One"},{"key":"336_CR61","doi-asserted-by":"publisher","first-page":"215","DOI":"10.1038\/nbt1384","volume":"26","author":"F Osakada","year":"2008","unstructured":"Osakada F, Ikeda H, Mandai M, Wataya T, Watanabe K, Yoshimura N, Akaike A, Sasai Y, Takahashi M: Toward the generation of rod and cone photoreceptors from mouse, monkey and human embryonic stem cells. Nat Biotechnol. 2008, 26: 215-224. 10.1038\/nbt1384.","journal-title":"Nat Biotechnol"},{"key":"336_CR62","doi-asserted-by":"publisher","first-page":"1424","DOI":"10.1002\/stem.1123","volume":"30","author":"EL West","year":"2012","unstructured":"West EL, Gonzalez-Cordero A, Hippert C, Osakada F, Martinez-Barbera JP, Pearson RA, Sowden JC, Takahashi M, Ali RR: Defining the integration capacity of embryonic stem cell-derived photoreceptor precursors. Stem Cells. 2012, 30: 1424-1435. 10.1002\/stem.1123.","journal-title":"Stem Cells"},{"key":"336_CR63","doi-asserted-by":"publisher","first-page":"741","DOI":"10.1038\/nbt.2643","volume":"31","author":"A Gonzalez-Cordero","year":"2013","unstructured":"Gonzalez-Cordero A, West EL, Pearson RA, Duran Y, Carvalho LS, Chu CJ, Naeem A, Blackford SJ, Georgiadis A, Lakowski J, Hubank M, Smith AJ, Bainbridge JW, Sowden JC, Ali RR: Photoreceptor precursors derived from three-dimensional embryonic stem cell cultures integrate and mature within adult degenerate retina. Nat Biotechnol. 2013, 31: 741-747. 10.1038\/nbt.2643.","journal-title":"Nat Biotechnol"},{"key":"336_CR64","doi-asserted-by":"publisher","first-page":"16","DOI":"10.5966\/sctm.2012-0040","volume":"2","author":"BA Tucker","year":"2013","unstructured":"Tucker BA, Anfinson KR, Mullins RF, Stone EM, Young MJ: Use of a synthetic xeno-free culture substrate for induced pluripotent stem cell induction and retinal differentiation. Stem Cells Transl Med. 2013, 2: 16-24. 10.5966\/sctm.2012-0040.","journal-title":"Stem Cells Transl Med"},{"key":"336_CR65","doi-asserted-by":"publisher","first-page":"415","DOI":"10.1016\/S1350-9462(01)00003-9","volume":"20","author":"RD Lund","year":"2001","unstructured":"Lund RD, Kwan AS, Keegan DJ, Sauve Y, Coffey PJ, Lawrence JM: Cell transplantation as a treatment for retinal disease. Prog Retin Eye Res. 2001, 20: 415-449. 10.1016\/S1350-9462(01)00003-9.","journal-title":"Prog Retin Eye Res"},{"key":"336_CR66","doi-asserted-by":"publisher","first-page":"2081","DOI":"10.1016\/j.ophtha.2005.06.029","volume":"112","author":"RE MacLaren","year":"2005","unstructured":"MacLaren RE, Bird AC, Sathia PJ, Aylward GW: Long-term results of submacular surgery combined with macular translocation of the retinal pigment epithelium in neovascular age-related macular degeneration. Ophthalmology. 2005, 112: 2081-2087. 10.1016\/j.ophtha.2005.06.029.","journal-title":"Ophthalmology"},{"key":"336_CR67","unstructured":"Safety and Tolerability of Sub-retinal Transplantation of Human Embryonic Stem Cell Derived Retinal Pigmented Epithelial (hESC-RPE) Cells in Patients With Stargardt's Macular Dystrophy (SMD). A Phase I\/II, Open-Label, Multi-Center interventional trial. http:\/\/clinicaltrial.gov\/ct2\/show\/NCT01469832]"},{"key":"336_CR68","unstructured":"Sub-retinal Transplantation of hESC Derived RPE (MA09-hRPE) Cells in Patients With Stargardt's Macular Dystrophy. A Phase I\/II, Open-Label, Multi-Center interventional trial. http:\/\/clinicaltrial.gov\/ct2\/show\/NCT01345006]"},{"key":"336_CR69","doi-asserted-by":"crossref","first-page":"1391","DOI":"10.1002\/stem.694","volume":"29","author":"J Lakowski","year":"2011","unstructured":"Lakowski J, Han YT, Pearson RA, Gonzalez-Cordero A, West EL, Gualdoni S, Barber AC, Hubank M, Ali RR, Sowden JC: Effective transplantation of photoreceptor precursor cells selected via cell surface antigen expression. Stem Cells. 2011, 29: 1391-1404.","journal-title":"Stem Cells"},{"key":"336_CR70","doi-asserted-by":"publisher","first-page":"5481","DOI":"10.1167\/iovs.11-7676","volume":"52","author":"CL Tsai","year":"2011","unstructured":"Tsai CL, Wu PC, Fini ME, Shi S: Identification of multipotent stem\/progenitor cells in murine sclera. Invest Ophthalmol Vis Sci. 2011, 52: 5481-5487. 10.1167\/iovs.11-7676.","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"336_CR71","doi-asserted-by":"publisher","first-page":"799","DOI":"10.1167\/iovs.02-0267","volume":"44","author":"Y Arsenijevic","year":"2003","unstructured":"Arsenijevic Y, Taverney N, Kostic C, Tekaya M, Riva F, Zografos L, Schorderet D, Munier F: Non-neural regions of the adult human eye: a potential source of neurons?. Invest Ophthalmol Vis Sci. 2003, 44: 799-807. 10.1167\/iovs.02-0267.","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"336_CR72","doi-asserted-by":"publisher","first-page":"27","DOI":"10.1016\/0014-4835(79)90164-7","volume":"29","author":"MC Johnston","year":"1979","unstructured":"Johnston MC, Noden DM, Hazelton RD, Coulombre JL, Coulombre AJ: Origins of avian ocular and periocular tissues. Exp Eye Res. 1979, 29: 27-43. 10.1016\/0014-4835(79)90164-7.","journal-title":"Exp Eye Res"},{"key":"336_CR73","doi-asserted-by":"publisher","first-page":"255","DOI":"10.1089\/ten.tea.2010.0106","volume":"17","author":"JH Ho","year":"2011","unstructured":"Ho JH, Ma WH, Tseng TC, Chen YF, Chen MH, Lee OK: Isolation and characterization of multi-potent stem cells from human orbital fat tissues. Tissue Eng Part A. 2011, 17: 255-266. 10.1089\/ten.tea.2010.0106.","journal-title":"Tissue Eng Part A"},{"key":"336_CR74","doi-asserted-by":"publisher","first-page":"1245","DOI":"10.1097\/CCM.0b013e31823bc89a","volume":"40","author":"MH Chien","year":"2012","unstructured":"Chien MH, Bien MY, Ku CC, Chang YC, Pao HY, Yang YL, Hsiao M, Chen CL, Ho JH: Systemic human orbital fat-derived stem\/stromal cell transplantation ameliorates acute inflammation in lipopolysaccharide-induced acute lung injury. Crit Care Med. 2012, 40: 1245-1253. 10.1097\/CCM.0b013e31823bc89a.","journal-title":"Crit Care Med"},{"key":"336_CR75","doi-asserted-by":"publisher","first-page":"72","DOI":"10.1186\/scrt223","volume":"4","author":"KJ Lin","year":"2013","unstructured":"Lin KJ, Loi MX, Lien GS, Cheng CF, Pao HY, Chang YC, Ji AT, Ho JH: Topical administration of orbital fat-derived stem cells promotes corneal tissue regeneration. Stem Cell Res Ther. 2013, 4: 72-10.1186\/scrt223.","journal-title":"Stem Cell Res Ther"},{"key":"336_CR76","doi-asserted-by":"publisher","first-page":"5125","DOI":"10.1167\/iovs.03-0628","volume":"44","author":"AC Romano","year":"2003","unstructured":"Romano AC, Espana EM, Yoo SH, Budak MT, Wolosin JM, Tseng SC: Different cell sizes in human limbal and central corneal basal epithelia measured by confocal microscopy and flow cytometry. Invest Ophthalmol Vis Sci. 2003, 44: 5125-5129. 10.1167\/iovs.03-0628.","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"336_CR77","doi-asserted-by":"publisher","first-page":"1594","DOI":"10.1038\/mt.2009.145","volume":"17","author":"N Sengupta","year":"2009","unstructured":"Sengupta N, Caballero S, Sullivan SM, Chang LJ, Afzal A, Li Calzi S, Kielczewski JL, Prabarakan S, Ellis EA, Moldovan L, Moldovan NI, Boulton ME, Grant MB, Scott EW, Harris JR: Regulation of adult hematopoietic stem cells fate for enhanced tissue-specific repair. Mol Ther. 2009, 17: 1594-1604. 10.1038\/mt.2009.145.","journal-title":"Mol Ther"},{"key":"336_CR78","doi-asserted-by":"publisher","first-page":"638","DOI":"10.1007\/s00417-003-0764-z","volume":"242","author":"A Lappas","year":"2004","unstructured":"Lappas A, Foerster AM, Weinberger AW, Coburger S, Schrage NF, Kirchhof B: Translocation of iris pigment epithelium in patients with exudative age-related macular degeneration: long-term results. Graefes Arch Clin Exp Ophthalmol. 2004, 242: 638-647. 10.1007\/s00417-003-0764-z.","journal-title":"Graefes Arch Clin Exp Ophthalmol"},{"key":"336_CR79","doi-asserted-by":"publisher","first-page":"183","DOI":"10.1001\/archopht.124.2.183","volume":"124","author":"S Aisenbrey","year":"2006","unstructured":"Aisenbrey S, Lafaut BA, Szurman P, Hilgers RD, Esser P, Walter P, Bartz-Schmidt KU, Thumann G: Iris pigment epithelial translocation in the treatment of exudative macular degeneration: a 3-year follow-up. Arch Ophthalmol. 2006, 124: 183-188. 10.1001\/archopht.124.2.183.","journal-title":"Arch Ophthalmol"},{"key":"336_CR80","doi-asserted-by":"publisher","first-page":"2410","DOI":"10.1167\/iovs.12-11210","volume":"54","author":"JY Lee","year":"2013","unstructured":"Lee JY, Lee KH, Shin HM, Chung KH, Kim GI, Lew H: Orbital volume augmentation after injection of human orbital adipose-derived stem cells in rabbits. Invest Ophthalmol Vis Sci. 2013, 54: 2410-2416. 10.1167\/iovs.12-11210.","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"336_CR81","doi-asserted-by":"publisher","first-page":"763","DOI":"10.1007\/s00417-009-1263-7","volume":"248","author":"SR Hynes","year":"2010","unstructured":"Hynes SR, Lavik EB: A tissue-engineered approach towards retinal repair: scaffolds for cell transplantation to the subretinal space. Graefes Arch Clin Exp Ophthalmol. 2010, 248: 763-778. 10.1007\/s00417-009-1263-7.","journal-title":"Graefes Arch Clin Exp Ophthalmol"},{"key":"336_CR82","doi-asserted-by":"publisher","first-page":"443","DOI":"10.1163\/092050610X487738","volume":"22","author":"S Sodha","year":"2011","unstructured":"Sodha S, Wall K, Redenti S, Klassen H, Young MJ, Tao SL: Microfabrication of a three-dimensional polycaprolactone thin-film scaffold for retinal progenitor cell encapsulation. J Biomater Sci Polym Ed. 2011, 22: 443-456. 10.1163\/092050610X487738.","journal-title":"J Biomater Sci Polym Ed"},{"key":"336_CR83","doi-asserted-by":"publisher","first-page":"1396","DOI":"10.1016\/j.biomaterials.2011.10.083","volume":"33","author":"AC McUsic","year":"2012","unstructured":"McUsic AC, Lamba DA, Reh TA: Guiding the morphogenesis of dissociated newborn mouse retinal cells and hES cell-derived retinal cells by soft lithography-patterned microchannel PLGA scaffolds. Biomaterials. 2012, 33: 1396-1405. 10.1016\/j.biomaterials.2011.10.083.","journal-title":"Biomaterials"},{"key":"336_CR84","doi-asserted-by":"publisher","first-page":"133","DOI":"10.1159\/000324045","volume":"46","author":"F Thieltges","year":"2011","unstructured":"Thieltges F, Stanzel BV, Liu Z, Holz FG: A nanofibrillar surface promotes superior growth characteristics in cultured human retinal pigment epithelium. Ophthalmic Res. 2011, 46: 133-140. 10.1159\/000324045.","journal-title":"Ophthalmic Res"},{"key":"336_CR85","doi-asserted-by":"publisher","first-page":"1206","DOI":"10.1002\/stem.674","volume":"29","author":"JS Meyer","year":"2011","unstructured":"Meyer JS, Howden SE, Wallace KA, Verhoeven AD, Wright LS, Capowski EE, Pinilla I, Martin JM, Tian S, Stewart R, Pattnaik B, Thomson JA, Gamm DM: Optic vesicle-like structures derived from human pluripotent stem cells facilitate a customized approach to retinal disease treatment. Stem Cells. 2011, 29: 1206-1218. 10.1002\/stem.674.","journal-title":"Stem Cells"}],"container-title":["Stem Cell Research &amp; Therapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/scrt445.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1186\/scrt445\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/scrt445.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,4,25]],"date-time":"2024-04-25T16:36:38Z","timestamp":1714062998000},"score":1,"resource":{"primary":{"URL":"https:\/\/stemcellres.biomedcentral.com\/articles\/10.1186\/scrt445"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,4,22]]},"references-count":85,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2014,6]]}},"alternative-id":["336"],"URL":"https:\/\/doi.org\/10.1186\/scrt445","relation":{},"ISSN":["1757-6512"],"issn-type":[{"value":"1757-6512","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,4,22]]},"assertion":[{"value":"19 October 2013","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"14 April 2014","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"22 April 2014","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"This content has been made available to all.","name":"free","label":"Free to read"}],"article-number":"56"}}