{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T02:35:44Z","timestamp":1773282944883,"version":"3.50.1"},"reference-count":50,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2015,1,19]],"date-time":"2015-01-19T00:00:00Z","timestamp":1421625600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2015,1,19]],"date-time":"2015-01-19T00:00:00Z","timestamp":1421625600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Stem Cell Res Ther"],"abstract":"<jats:title>Abstract<\/jats:title><jats:sec>\n                        <jats:title>Introduction<\/jats:title>\n                        <jats:p>Percutaneous transluminal renal angioplasty (PTRA) fails to fully improve cardiac injury and dysfunction in patients with renovascular hypertension (RVH). Mesenchymal stem cells (MSCs) restore renal function, but their potential for attenuating cardiac injury after reversal of RVH has not been explored. We hypothesized that replenishment of MSCs during PTRA would improve cardiac function and oxygenation, and decrease myocardial injury in porcine RVH.<\/jats:p>\n                     <\/jats:sec><jats:sec>\n                        <jats:title>Methods<\/jats:title>\n                        <jats:p>Pigs were studied after 16\u00a0weeks of RVH, RVH treated 4\u00a0weeks earlier with PTRA with or without adjunct intra-renal delivery of MSC (10^6 cells), and controls. Cardiac structure, function (fast-computed tomography (CT)), and myocardial oxygenation (Blood-Oxygen-Level-Dependent- magnetic resonance imaging) were assessed <jats:italic>in-vivo<\/jats:italic>. Myocardial microvascular density (micro-CT) and myocardial injury were evaluated <jats:italic>ex-vivo<\/jats:italic>. Kidney venous and systemic blood levels of inflammatory markers were measured and their renal release calculated.<\/jats:p>\n                     <\/jats:sec><jats:sec>\n                        <jats:title>Results<\/jats:title>\n                        <jats:p>PTRA normalized blood pressure, yet stenotic-kidney glomerular filtration rate, similarly blunted in RVH and RVH\u2009+\u2009PTRA, normalized only in PTRA\u2009+\u2009MSC-treated pigs. PTRA attenuated left ventricular remodeling, whereas myocardial oxygenation, subendocardial microvascular density, and diastolic function remained decreased in RVH\u2009+\u2009PTRA, but normalized in RVH\u2009+\u2009PTRA-MSC. Circulating isoprostane levels and renal release of inflammatory cytokines increased in RVH and RVH\u2009+\u2009PTRA, but normalized in RVH\u2009+\u2009PTRA-MSC, as did myocardial oxidative stress, inflammation, collagen deposition, and fibrosis.<\/jats:p>\n                     <\/jats:sec><jats:sec>\n                        <jats:title>Conclusions<\/jats:title>\n                        <jats:p>Intra-renal MSC delivery during PTRA preserved stenotic-kidney function, reduced systemic oxidative stress and inflammation, and thereby improved cardiac function, oxygenation, and myocardial injury four weeks after revascularization, suggesting a therapeutic potential for adjunctive MSC delivery to preserve cardiac function and structure after reversal of experimental RVH.<\/jats:p>\n                     <\/jats:sec>","DOI":"10.1186\/scrt541","type":"journal-article","created":{"date-parts":[[2015,6,18]],"date-time":"2015-06-18T04:22:31Z","timestamp":1434601351000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":43,"title":["Intra-renal delivery of mesenchymal stem cells attenuates myocardial injury after reversal of hypertension in porcine renovascular disease"],"prefix":"10.1186","volume":"6","author":[{"given":"Alfonso","family":"Eirin","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiang-Yang","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christopher M","family":"Ferguson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Scott M","family":"Riester","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andre J","family":"van Wijnen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amir","family":"Lerman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lilach O","family":"Lerman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2015,1,19]]},"reference":[{"key":"423_CR1","doi-asserted-by":"publisher","first-page":"856","DOI":"10.2741\/E424","volume":"4","author":"D Green","year":"2012","unstructured":"Green D, Kalra PA: The heart in atherosclerotic renovascular disease.\n                           Front Biosci (Elite Ed) 2012, 4:856\u201364.","journal-title":"Front Biosci (Elite Ed)"},{"key":"423_CR2","doi-asserted-by":"publisher","first-page":"445","DOI":"10.1093\/ajh\/hpt203","volume":"27","author":"KK Khangura","year":"2014","unstructured":"Khangura KK, Eirin A, Kane GC, Misra S, Textor SC, Lerman A, et al.: Cardiac function in renovascular hypertensive patients with and without renal dysfunction.\n                           Am J Hypertens 2014, 27:445\u201353. 10.1093\/ajh\/hpt203","journal-title":"Am J Hypertens"},{"key":"423_CR3","doi-asserted-by":"publisher","first-page":"561","DOI":"10.2214\/ajr.183.3.1830561","volume":"183","author":"TP Murphy","year":"2004","unstructured":"Murphy TP, Soares G, Kim M: Increase in utilization of percutaneous renal artery interventions by medicare beneficiaries, 1996\u20132000.\n                           AJR Am J Roentgenol 2004, 183:561\u20138. 10.2214\/ajr.183.3.1830561","journal-title":"AJR Am J Roentgenol"},{"key":"423_CR4","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1056\/NEJMoa1310753","volume":"370","author":"CJ Cooper","year":"2014","unstructured":"Cooper CJ, Murphy TP, Cutlip DE, Jamerson K, Henrich W, Reid DM, et al.: Stenting and medical therapy for atherosclerotic renal-artery stenosis.\n                           N Engl J Med 2014, 370:13\u201322. 10.1056\/NEJMoa1310753","journal-title":"N Engl J Med"},{"key":"423_CR5","doi-asserted-by":"publisher","first-page":"154","DOI":"10.1097\/HJH.0b013e3283658a53","volume":"32","author":"A Eirin","year":"2014","unstructured":"Eirin A, Williams BJ, Ebrahimi B, Zhang X, Crane JA, Lerman A, et al.: Mitochondrial targeted peptides attenuate residual myocardial damage after reversal of experimental renovascular hypertension.\n                           J Hypertens 2014, 32:154\u201365. 10.1097\/HJH.0b013e3283658a53","journal-title":"J Hypertens"},{"key":"423_CR6","doi-asserted-by":"publisher","first-page":"350","DOI":"10.1016\/j.atherosclerosis.2011.10.005","volume":"221","author":"VH Urbieta-Caceres","year":"2012","unstructured":"Urbieta-Caceres VH, Zhu XY, Jordan KL, Tang H, Textor K, Lerman A, et al.: Selective improvement in renal function preserved remote myocardial microvascular integrity and architecture in experimental renovascular disease.\n                           Atherosclerosis 2012, 221:350\u20138. 10.1016\/j.atherosclerosis.2011.10.005","journal-title":"Atherosclerosis"},{"key":"423_CR7","doi-asserted-by":"publisher","first-page":"1276","DOI":"10.1111\/j.1476-5381.1996.tb16033.x","volume":"119","author":"BM Kromer","year":"1996","unstructured":"Kromer BM, Tippins JR: Coronary artery constriction by the isoprostane 8-epi prostaglandin f2 alpha.\n                           Br J Pharmacol 1996, 119:1276\u201380. 10.1111\/j.1476-5381.1996.tb16033.x","journal-title":"Br J Pharmacol"},{"key":"423_CR8","doi-asserted-by":"publisher","first-page":"274","DOI":"10.1093\/ndt\/gft305","volume":"29","author":"A Eirin","year":"2014","unstructured":"Eirin A, Zhang X, Zhu XY, Tang H, Jordan KL, Grande JP, et al.: Renal vein cytokine release as an index of renal parenchymal inflammation in chronic experimental renal artery stenosis.\n                           Nephrol Dial Transplant 2014, 29:274\u201382. 10.1093\/ndt\/gft305","journal-title":"Nephrol Dial Transplant"},{"key":"423_CR9","doi-asserted-by":"publisher","first-page":"548a","DOI":"10.1093\/eurheartj\/ehs197","volume":"34","author":"A Eirin","year":"2013","unstructured":"Eirin A, Gloviczki ML, Tang H, Gossl M, Jordan KL, Woollard JR, et al.: Inflammatory and injury signals released from the post-stenotic human kidney.\n                           Eur Heart J 2013, 34:548a.","journal-title":"Eur Heart J"},{"key":"423_CR10","doi-asserted-by":"publisher","first-page":"1006","DOI":"10.1161\/ATVBAHA.113.301164","volume":"33","author":"A Eirin","year":"2013","unstructured":"Eirin A, Zhu XY, Li Z, Ebrahimi B, Zhang X, Tang H, et al.: Endothelial outgrowth cells shift macrophage phenotype and improve kidney viability in swine renal artery stenosis.\n                           Arterioscler Thromb Vasc Biol 2013, 33:1006\u201313. 10.1161\/ATVBAHA.113.301164","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"423_CR11","doi-asserted-by":"publisher","first-page":"428","DOI":"10.1161\/CIRCINTERVENTIONS.113.000219","volume":"6","author":"A Saad","year":"2013","unstructured":"Saad A, Herrmann SM, Crane J, Glockner JF, McKusick MA, Misra S, et al.: Stent revascularization restores cortical blood flow and reverses tissue hypoxia in atherosclerotic renal artery stenosis but fails to reverse inflammatory pathways or glomerular filtration rate.\n                           Circ Cardiovasc Interv 2013, 6:428\u201335. 10.1161\/CIRCINTERVENTIONS.113.000219","journal-title":"Circ Cardiovasc Interv"},{"key":"423_CR12","first-page":"5","volume":"4","author":"P Lotfinegad","year":"2014","unstructured":"Lotfinegad P, Shamsasenjan K, Movassaghpour A, Majidi J, Baradaran B: Immunomodulatory nature and site specific affinity of mesenchymal stem cells: a hope in cell therapy.\n                           Adv Pharm Bull 2014, 4:5\u201313.","journal-title":"Adv Pharm Bull"},{"key":"423_CR13","doi-asserted-by":"publisher","first-page":"2412","DOI":"10.2174\/13816128113199990477","volume":"20","author":"ME Reinders","year":"2014","unstructured":"Reinders ME, Leuning DG, de Fijter JW, Hoogduijn MJ, Rabelink TJ: Mesenchymal stromal cell therapy for cardio renal disorders.\n                           Curr Pharm Des 2014, 20:2412\u201329. 10.2174\/13816128113199990477","journal-title":"Curr Pharm Des"},{"key":"423_CR14","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1111\/iep.12017","volume":"94","author":"AA Karpov","year":"2013","unstructured":"Karpov AA, Uspenskaya YK, Minasian SM, Puzanov MV, Dmitrieva RI, Bilibina AA, et al.: The effect of bone marrow- and adipose tissue-derived mesenchymal stem cell transplantation on myocardial remodelling in the rat model of ischaemic heart failure.\n                           Int J Exp Pathol 2013, 94:169\u201377.","journal-title":"Int J Exp Pathol"},{"key":"423_CR15","doi-asserted-by":"publisher","first-page":"1697","DOI":"10.3727\/096368911X627462","volume":"21","author":"J Otto Beitnes","year":"2012","unstructured":"Otto Beitnes J, Oie E, Shahdadfar A, Karlsen T, Muller RM, Aakhus S, et al.: Intramyocardial injections of human mesenchymal stem cells following acute myocardial infarction modulate scar formation and improve left ventricular function.\n                           Cell Transplant 2012, 21:1697\u2013709. 10.3727\/096368911X627462","journal-title":"Cell Transplant"},{"key":"423_CR16","doi-asserted-by":"publisher","first-page":"117","DOI":"10.1002\/stem.1263","volume":"31","author":"XY Zhu","year":"2013","unstructured":"Zhu XY, Urbieta-Caceres V, Krier JD, Textor SC, Lerman A, Lerman LO: Mesenchymal stem cells and endothelial progenitor cells decrease renal injury in experimental swine renal artery stenosis through different mechanisms.\n                           Stem Cells 2013, 31:117\u201325. 10.1002\/stem.1263","journal-title":"Stem Cells"},{"key":"423_CR17","doi-asserted-by":"publisher","first-page":"1030","DOI":"10.1002\/stem.1047","volume":"30","author":"A Eirin","year":"2012","unstructured":"Eirin A, Zhu XY, Krier JD, Tang H, Jordan KL, Grande JP, et al.: Adipose tissue-derived mesenchymal stem cells improve revascularization outcomes to restore renal function in swine atherosclerotic renal artery stenosis.\n                           Stem Cells 2012, 30:1030\u201341. 10.1002\/stem.1047","journal-title":"Stem Cells"},{"key":"423_CR18","doi-asserted-by":"publisher","first-page":"e67474","DOI":"10.1371\/journal.pone.0067474","volume":"8","author":"B Ebrahimi","year":"2013","unstructured":"Ebrahimi B, Eirin A, Li Z, Zhu XY, Zhang X, Lerman A, et al.: Mesenchymal stem cells improve medullary inflammation and fibrosis after revascularization of swine atherosclerotic renal artery stenosis.\n                           PLoS One 2013, 8:e67474. 10.1371\/journal.pone.0067474","journal-title":"PLoS One"},{"key":"423_CR19","doi-asserted-by":"publisher","first-page":"2109","DOI":"10.1161\/01.CIR.0000125742.65841.8B","volume":"109","author":"XY Zhu","year":"2004","unstructured":"Zhu XY, Rodriguez-Porcel M, Bentley MD, Chade AR, Sica V, Napoli C, et al.: Antioxidant intervention attenuates myocardial neovascularization in hypercholesterolemia.\n                           Circulation 2004, 109:2109\u201315. 10.1161\/01.CIR.0000125742.65841.8B","journal-title":"Circulation"},{"key":"423_CR20","doi-asserted-by":"publisher","first-page":"1706","DOI":"10.1096\/fj.05-5680fje","volume":"20","author":"AR Chade","year":"2006","unstructured":"Chade AR, Zhu X, Mushin OP, Napoli C, Lerman A, Lerman LO: Simvastatin promotes angiogenesis and prevents microvascular remodeling in chronic renal ischemia.\n                           FASEB J 2006, 20:1706\u20138. 10.1096\/fj.05-5680fje","journal-title":"FASEB J"},{"key":"423_CR21","doi-asserted-by":"publisher","first-page":"1854","DOI":"10.1161\/01.ATV.0000142443.52606.81","volume":"24","author":"XY Zhu","year":"2004","unstructured":"Zhu XY, Chade AR, Rodriguez-Porcel M, Bentley MD, Ritman EL, Lerman A, et al.: Cortical microvascular remodeling in the stenotic kidney: role of increased oxidative stress.\n                           Arterioscler Thromb Vasc Biol 2004, 24:1854\u20139. 10.1161\/01.ATV.0000142443.52606.81","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"423_CR22","doi-asserted-by":"publisher","first-page":"1209","DOI":"10.1681\/ASN.2006090976","volume":"18","author":"XY Zhu","year":"2007","unstructured":"Zhu XY, Daghini E, Chade AR, Napoli C, Ritman EL, Lerman A, et al.: Simvastatin prevents coronary microvascular remodeling in renovascular hypertensive pigs.\n                           J Am Soc Nephrol 2007, 18:1209\u201317. 10.1681\/ASN.2006090976","journal-title":"J Am Soc Nephrol"},{"key":"423_CR23","doi-asserted-by":"publisher","first-page":"720","DOI":"10.1161\/CIRCINTERVENTIONS.112.972596","volume":"5","author":"A Eirin","year":"2012","unstructured":"Eirin A, Ebrahimi B, Zhang X, Zhu XY, Tang H, Crane JA, et al.: Changes in glomerular filtration rate after renal revascularization correlate with microvascular hemodynamics and inflammation in swine renal artery stenosis.\n                           Circ Cardiovasc Interv 2012, 5:720\u20138. 10.1161\/CIRCINTERVENTIONS.112.972596","journal-title":"Circ Cardiovasc Interv"},{"key":"423_CR24","doi-asserted-by":"publisher","first-page":"1242","DOI":"10.1161\/HYPERTENSIONAHA.112.199919","volume":"60","author":"A Eirin","year":"2012","unstructured":"Eirin A, Li Z, Zhang X, Krier JD, Woollard JR, Zhu XY, et al.: A mitochondrial permeability transition pore inhibitor improves renal outcomes after revascularization in experimental atherosclerotic renal artery stenosis.\n                           Hypertension 2012, 60:1242\u20139. 10.1161\/HYPERTENSIONAHA.112.199919","journal-title":"Hypertension"},{"key":"423_CR25","doi-asserted-by":"publisher","first-page":"1165","DOI":"10.1161\/01.CIR.0000027105.02327.48","volume":"106","author":"AR Chade","year":"2002","unstructured":"Chade AR, Rodriguez-Porcel M, Grande JP, Krier JD, Lerman A, Romero JC, et al.: Distinct renal injury in early atherosclerosis and renovascular disease.\n                           Circulation 2002, 106:1165\u201371. 10.1161\/01.CIR.0000027105.02327.48","journal-title":"Circulation"},{"key":"423_CR26","doi-asserted-by":"publisher","first-page":"1295","DOI":"10.1161\/01.ATV.0000077477.40824.52","volume":"23","author":"AR Chade","year":"2003","unstructured":"Chade AR, Rodriguez-Porcel M, Grande JP, Zhu X, Sica V, Napoli C, et al.: Mechanisms of renal structural alterations in combined hypercholesterolemia and renal artery stenosis.\n                           Arterioscler Thromb Vasc Biol 2003, 23:1295\u2013301. 10.1161\/01.ATV.0000077477.40824.52","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"423_CR27","doi-asserted-by":"publisher","first-page":"405","DOI":"10.1148\/radiol.2432060655","volume":"243","author":"E Daghini","year":"2007","unstructured":"Daghini E, Primak AN, Chade AR, Krier JD, Zhu XY, Ritman EL, et al.: Assessment of renal hemodynamics and function in pigs with 64-section multidetector CT: comparison with electron-beam CT.\n                           Radiology 2007, 243:405\u201312. 10.1148\/radiol.2432060655","journal-title":"Radiology"},{"key":"423_CR28","doi-asserted-by":"publisher","first-page":"213","DOI":"10.1016\/S0008-6363(03)00250-5","volume":"58","author":"M Rodriguez-Porcel","year":"2003","unstructured":"Rodriguez-Porcel M, Lerman A, Herrmann J, Schwartz RS, Sawamura T, Condorelli M, et al.: Hypertension exacerbates the effect of hypercholesterolemia on the myocardial microvasculature.\n                           Cardiovasc Res 2003, 58:213\u201321. 10.1016\/S0008-6363(03)00250-5","journal-title":"Cardiovasc Res"},{"key":"423_CR29","doi-asserted-by":"publisher","first-page":"1810","DOI":"10.1161\/ATVBAHA.109.190546","volume":"29","author":"J Lin","year":"2009","unstructured":"Lin J, Zhu X, Chade AR, Jordan KL, Lavi R, Daghini E, et al.: Monocyte chemoattractant proteins mediate myocardial microvascular dysfunction in swine renovascular hypertension.\n                           Arterioscler Thromb Vasc Biol 2009, 29:1810\u20136. 10.1161\/ATVBAHA.109.190546","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"423_CR30","doi-asserted-by":"publisher","first-page":"1746","DOI":"10.1161\/01.ATV.0000227469.40826.01","volume":"26","author":"XY Zhu","year":"2006","unstructured":"Zhu XY, Daghini E, Chade AR, Rodriguez-Porcel M, Napoli C, Lerman A, et al.: Role of oxidative stress in remodeling of the myocardial microcirculation in hypertension.\n                           Arterioscler Thromb Vasc Biol 2006, 26:1746\u201352. 10.1161\/01.ATV.0000227469.40826.01","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"423_CR31","doi-asserted-by":"publisher","first-page":"H693","DOI":"10.1152\/ajpheart.00516.2010","volume":"300","author":"VH Urbieta Caceres","year":"2011","unstructured":"Urbieta Caceres VH, Lin J, Zhu XY, Favreau FD, Gibson ME, Crane JA, et al.: Early experimental hypertension preserves the myocardial microvasculature but aggravates cardiac injury distal to chronic coronary artery obstruction.\n                           Am J Physiol Heart Circ Physiol 2011, 300:H693\u2013701. 10.1152\/ajpheart.00516.2010","journal-title":"Am J Physiol Heart Circ Physiol"},{"key":"423_CR32","doi-asserted-by":"publisher","first-page":"H1087","DOI":"10.1152\/ajpheart.00052.2013","volume":"306","author":"ZL Li","year":"2014","unstructured":"Li ZL, Ebrahimi B, Zhang X, Eirin A, Woollard JR, Tang H, et al.: Obesity-metabolic derangement exacerbates cardiomyocyte loss distal to moderate coronary artery stenosis in pigs without affecting global cardiac function.\n                           Am J Physiol Heart Circ Physiol 2014, 306:H1087\u2013101. 10.1152\/ajpheart.00052.2013","journal-title":"Am J Physiol Heart Circ Physiol"},{"key":"423_CR33","doi-asserted-by":"publisher","first-page":"462","DOI":"10.1634\/stemcells.2004-0331","volume":"24","author":"PA Sotiropoulou","year":"2006","unstructured":"Sotiropoulou PA, Perez SA, Salagianni M, Baxevanis CN, Papamichail M: Characterization of the optimal culture conditions for clinical scale production of human mesenchymal stem cells.\n                           Stem Cells 2006, 24:462\u201371. 10.1634\/stemcells.2004-0331","journal-title":"Stem Cells"},{"key":"423_CR34","doi-asserted-by":"publisher","first-page":"801","DOI":"10.1016\/j.lfs.2008.09.029","volume":"83","author":"XY Zhu","year":"2008","unstructured":"Zhu XY, Daghini E, Chade AR, Lavi R, Napoli C, Lerman A, et al.: Disparate effects of simvastatin on angiogenesis during hypoxia and inflammation.\n                           Life Sci 2008, 83:801\u20139. 10.1016\/j.lfs.2008.09.029","journal-title":"Life Sci"},{"key":"423_CR35","doi-asserted-by":"publisher","first-page":"547","DOI":"10.1161\/CIRCULATIONAHA.108.788653","volume":"119","author":"AR Chade","year":"2009","unstructured":"Chade AR, Zhu X, Lavi R, Krier JD, Pislaru S, Simari RD, et al.: Endothelial progenitor cells restore renal function in chronic experimental renovascular disease.\n                           Circulation 2009, 119:547\u201357. 10.1161\/CIRCULATIONAHA.108.788653","journal-title":"Circulation"},{"key":"423_CR36","doi-asserted-by":"publisher","first-page":"958","DOI":"10.1097\/01.ASN.0000117774.83396.E9","volume":"15","author":"AR Chade","year":"2004","unstructured":"Chade AR, Rodriguez-Porcel M, Herrmann J, Zhu X, Grande JP, Napoli C, et al.: Antioxidant intervention blunts renal injury in experimental renovascular disease.\n                           J Am Soc Nephrol 2004, 15:958\u201366. 10.1097\/01.ASN.0000117774.83396.E9","journal-title":"J Am Soc Nephrol"},{"key":"423_CR37","doi-asserted-by":"publisher","first-page":"F1079","DOI":"10.1152\/ajprenal.00385.2003","volume":"286","author":"AR Chade","year":"2004","unstructured":"Chade AR, Krier JD, Rodriguez-Porcel M, Breen JF, McKusick MA, Lerman A, et al.: Comparison of acute and chronic antioxidant interventions in experimental renovascular disease.\n                           Am J Physiol Renal Physiol 2004, 286:F1079\u201386. 10.1152\/ajprenal.00385.2003","journal-title":"Am J Physiol Renal Physiol"},{"key":"423_CR38","doi-asserted-by":"publisher","first-page":"167","DOI":"10.1016\/S0741-5214(98)70212-5","volume":"28","author":"II Pipinos","year":"1998","unstructured":"Pipinos II, Nypaver TJ, Moshin SK, Careterro OA, Beierwaltes WH: Response to angiotensin inhibition in rats with sustained renovascular hypertension correlates with response to removing renal artery stenosis.\n                           J Vasc Surg 1998, 28:167\u201377. 10.1016\/S0741-5214(98)70212-5","journal-title":"J Vasc Surg"},{"key":"423_CR39","doi-asserted-by":"publisher","first-page":"458","DOI":"10.1038\/ajh.2010.259","volume":"24","author":"VH Urbieta-Caceres","year":"2011","unstructured":"Urbieta-Caceres VH, Zhu XY, Gibson ME, Favreau FD, Jordan K, Lerman A, et al.: Reversal of experimental renovascular hypertension restores coronary microvascular function and architecture.\n                           Am J Hypertens 2011, 24:458\u201365. 10.1038\/ajh.2010.259","journal-title":"Am J Hypertens"},{"key":"423_CR40","doi-asserted-by":"publisher","first-page":"1300","DOI":"10.1097\/HJH.0000000000000160","volume":"32","author":"KK Khangura","year":"2014","unstructured":"Khangura KK, Eirin A, Kane GC, Misra S, Textor SC, Lerman A, et al.: Extrarenal atherosclerotic disease blunts renal recovery in patients with renovascular hypertension.\n                           J Hypertens 2014, 32:1300\u20136. 10.1097\/HJH.0000000000000160","journal-title":"J Hypertens"},{"key":"423_CR41","doi-asserted-by":"publisher","first-page":"671","DOI":"10.1016\/j.amjcard.2005.09.113","volume":"97","author":"AY Chong","year":"2006","unstructured":"Chong AY, Freestone B, Patel J, Lim HS, Hughes E, Blann AD, et al.: Endothelial activation, dysfunction, and damage in congestive heart failure and the relation to brain natriuretic peptide and outcomes.\n                           Am J Cardiol 2006, 97:671\u20135. 10.1016\/j.amjcard.2005.09.113","journal-title":"Am J Cardiol"},{"key":"423_CR42","doi-asserted-by":"publisher","first-page":"832","DOI":"10.1097\/01.TA.0000057228.45839.3C","volume":"56","author":"GP Victorino","year":"2004","unstructured":"Victorino GP, Newton CR, Curran B: Endothelin-1 decreases microvessel permeability after endothelial activation.\n                           J Trauma 2004, 56:832\u20136. 10.1097\/01.TA.0000057228.45839.3C","journal-title":"J Trauma"},{"key":"423_CR43","doi-asserted-by":"publisher","first-page":"579","DOI":"10.1097\/FPC.0b013e3283493a05","volume":"21","author":"RM Gueant-Rodriguez","year":"2011","unstructured":"Gueant-Rodriguez RM, Juilliere Y, Battaglia-Hsu SF, Debard R, Gerard P, Reyes P, et al.: Association of il1b polymorphism with left ventricular systolic dysfunction: A relation with the release of interleukin-1beta in stress condition.\n                           Pharmacogenet Genomics 2011, 21:579\u201386. 10.1097\/FPC.0b013e3283493a05","journal-title":"Pharmacogenet Genomics"},{"key":"423_CR44","doi-asserted-by":"publisher","first-page":"81","DOI":"10.1023\/A:1011428824771","volume":"6","author":"CS Long","year":"2001","unstructured":"Long CS: The role of interleukin-1 in the failing heart.\n                           Heart Fail Rev 2001, 6:81\u201394. 10.1023\/A:1011428824771","journal-title":"Heart Fail Rev"},{"key":"423_CR45","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.yexmp.2012.10.010","volume":"94","author":"E Rizzi","year":"2013","unstructured":"Rizzi E, Ceron CS, Guimaraes DA, Prado CM, Rossi MA, Gerlach RF, et al.: Temporal changes in cardiac matrix metalloproteinase activity, oxidative stress, and TGF-\u03b2 in renovascular hypertension-induced cardiac hypertrophy.\n                           Exp Mol Pathol 2013, 94:1\u20139.","journal-title":"Exp Mol Pathol"},{"key":"423_CR46","doi-asserted-by":"publisher","first-page":"205","DOI":"10.2174\/157016106777698379","volume":"4","author":"K Schroecksnadel","year":"2006","unstructured":"Schroecksnadel K, Frick B, Winkler C, Fuchs D: Crucial role of interferon-gamma and stimulated macrophages in cardiovascular disease.\n                           Curr Vasc Pharmacol 2006, 4:205\u201313. 10.2174\/157016106777698379","journal-title":"Curr Vasc Pharmacol"},{"key":"423_CR47","doi-asserted-by":"publisher","first-page":"H2726","DOI":"10.1152\/ajpheart.00376.2007","volume":"293","author":"N Mariappan","year":"2007","unstructured":"Mariappan N, Soorappan RN, Haque M, Sriramula S, Francis J: TNF-alpha-induced mitochondrial oxidative stress and cardiac dysfunction: restoration by superoxide dismutase mimetic Tempol.\n                           Am J Physiol Heart Circ Physiol 2007, 293:H2726\u201337. 10.1152\/ajpheart.00376.2007","journal-title":"Am J Physiol Heart Circ Physiol"},{"key":"423_CR48","doi-asserted-by":"publisher","first-page":"5026","DOI":"10.1073\/pnas.87.13.5026","volume":"87","author":"JM Brown","year":"1990","unstructured":"Brown JM, White CW, Terada LS, Grosso MA, Shanley PF, Mulvin DW, et al.: Interleukin 1 pretreatment decreases ischemia\/reperfusion injury.\n                           Proc Natl Acad Sci U S A 1990, 87:5026\u201330. 10.1073\/pnas.87.13.5026","journal-title":"Proc Natl Acad Sci U S A"},{"key":"423_CR49","doi-asserted-by":"publisher","first-page":"55","DOI":"10.1016\/j.gene.2014.08.041","volume":"551","author":"A Eirin","year":"2014","unstructured":"Eirin A, Riester SM, Zhu XY, Tang H, Evans JM, O\u2019Brien D, et al.: MicroRNA and mRNA cargo of extracellular vesicles from porcine adipose tissue-derived mesenchymal stem cells.\n                           Gene 2014, 551:55\u201364. 10.1016\/j.gene.2014.08.041","journal-title":"Gene"},{"key":"423_CR50","doi-asserted-by":"publisher","first-page":"414","DOI":"10.1016\/j.exphem.2004.02.004","volume":"32","author":"EH Javazon","year":"2004","unstructured":"Javazon EH, Beggs KJ, Flake AW: Mesenchymal stem cells: paradoxes of passaging.\n                           Exp Hematol 2004, 32:414\u201325. 10.1016\/j.exphem.2004.02.004","journal-title":"Exp Hematol"}],"container-title":["Stem Cell Research &amp; Therapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/scrt541.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1186\/scrt541\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/scrt541.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,10,14]],"date-time":"2024-10-14T16:25:37Z","timestamp":1728923137000},"score":1,"resource":{"primary":{"URL":"https:\/\/stemcellres.biomedcentral.com\/articles\/10.1186\/scrt541"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,1,19]]},"references-count":50,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2015,12]]}},"alternative-id":["423"],"URL":"https:\/\/doi.org\/10.1186\/scrt541","relation":{},"ISSN":["1757-6512"],"issn-type":[{"value":"1757-6512","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,1,19]]},"assertion":[{"value":"17 September 2014","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"2 January 2015","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"5 January 2015","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"19 January 2015","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}}],"article-number":"7"}}