{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,9]],"date-time":"2026-03-09T00:53:48Z","timestamp":1773017628053,"version":"3.50.1"},"reference-count":34,"publisher":"Springer Science and Business Media LLC","issue":"1","content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["BMC Biochem"],"DOI":"10.1186\/1471-2091-4-1","type":"journal-article","created":{"date-parts":[[2003,5,1]],"date-time":"2003-05-01T12:27:54Z","timestamp":1051792074000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":25,"title":["Glycosaminoglycans in human retinoblastoma cells: Heparan sulfate, a modulator of the pigment epithelium-derived factor-receptor interactions"],"prefix":"10.1186","volume":"4","author":[{"given":"Elena M","family":"Alberdi","sequence":"first","affiliation":[]},{"given":"John E","family":"Weldon","sequence":"additional","affiliation":[]},{"given":"S Patricia","family":"Becerra","sequence":"additional","affiliation":[]}],"member":"297","published-online":{"date-parts":[[2003,2,19]]},"reference":[{"key":"53_CR1","doi-asserted-by":"publisher","first-page":"729","DOI":"10.1146\/annurev.biochem.68.1.729","volume":"68","author":"M Bernfield","year":"1999","unstructured":"Bernfield M, Gotte M, Park PW, Reizes O, Fitzgerald ML, Lincecum J, Zako M: Functions of cell surface heparan sulfate proteoglycans. Annu Rev Biochem. 1999, 68: 729-777. 10.1146\/annurev.biochem.68.1.729.","journal-title":"Annu Rev Biochem"},{"key":"53_CR2","doi-asserted-by":"publisher","first-page":"29923","DOI":"10.1074\/jbc.R000008200","volume":"275","author":"PW Park","year":"2000","unstructured":"Park PW, Reizes O, Bernfield M: Cell surface heparan sulfate proteoglycans: selective regulators of ligand-receptor encounters. J Biol Chem. 2000, 275: 29923-29926. 10.1074\/jbc.R000008200.","journal-title":"J Biol Chem"},{"key":"53_CR3","doi-asserted-by":"publisher","first-page":"1526","DOI":"10.1073\/pnas.90.4.1526","volume":"90","author":"FR Steele","year":"1993","unstructured":"Steele FR, Chader GJ, Johnson LV, Tombran-Tink J: Pigment epithelium-derived factor: neurotrophic activity and identification as a member of the serine protease inhibitor gene family. Proc Natl Acad Sci U S A. 1993, 90: 1526-1530.","journal-title":"Proc Natl Acad Sci U S A"},{"key":"53_CR4","doi-asserted-by":"publisher","first-page":"523","DOI":"10.1006\/nbdi.1999.0263","volume":"6","author":"M Cayouette","year":"1999","unstructured":"Cayouette M, Smith SB, Becerra SP, Gravel C: Pigment epithelium-derived factor delays the death of photoreceptors in mouse models of inherited retinal degenerations. Neurobiol Dis. 1999, 6: 523-532. 10.1006\/nbdi.1999.0263.","journal-title":"Neurobiol Dis"},{"key":"53_CR5","doi-asserted-by":"publisher","first-page":"789","DOI":"10.1002\/(SICI)1097-4547(19990915)57:6<789::AID-JNR4>3.0.CO;2-M","volume":"57","author":"W Cao","year":"1999","unstructured":"Cao W, Tombran-Tink J, Chen W, Mrazek D, Elias R, McGinnis JF: Pigment epithelium-derived factor protects cultured retinal neurons against hydrogen peroxide-induced cell death. J Neurosci Res. 1999, 57: 789-800. 10.1002\/(SICI)1097-4547(19990915)57:6<789::AID-JNR4>3.0.CO;2-M.","journal-title":"J Neurosci Res"},{"key":"53_CR6","doi-asserted-by":"crossref","first-page":"7149","DOI":"10.1523\/JNEUROSCI.20-19-07149.2000","volume":"20","author":"MM Jablonski","year":"2000","unstructured":"Jablonski MM, Tombran-Tink J, Mrazek DA, Iannaccone A: Pigment epithelium-derived factor supports normal development of photoreceptor neurons and opsin expression after retinal pigment epithelium removal. J Neurosci. 2000, 20: 7149-7157.","journal-title":"J Neurosci"},{"key":"53_CR7","doi-asserted-by":"publisher","first-page":"2509","DOI":"10.1046\/j.1471-4159.1995.64062509.x","volume":"64","author":"T Taniwaki","year":"1995","unstructured":"Taniwaki T, Becerra SP, Chader GJ, Schwartz JP: Pigment epithelium-derived factor is a survival factor for cerebellar granule cells in culture. J Neurochem. 1995, 64: 2509-2517.","journal-title":"J Neurochem"},{"key":"53_CR8","doi-asserted-by":"publisher","first-page":"26","DOI":"10.1046\/j.1471-4159.1997.68010026.x","volume":"68","author":"T Taniwaki","year":"1997","unstructured":"Taniwaki T, Hirashima N, Becerra SP, Chader GJ, Etcheberrigaray R, Schwartz JP: Pigment epithelium-derived factor protects cultured cerebellar granule cells against glutamate-induced neurotoxicity. J Neurochem. 1997, 68: 26-32.","journal-title":"J Neurochem"},{"key":"53_CR9","doi-asserted-by":"publisher","first-page":"7","DOI":"10.1002\/(SICI)1097-4547(19980701)53:1<7::AID-JNR2>3.0.CO;2-F","volume":"53","author":"T Araki","year":"1998","unstructured":"Araki T, Taniwaki T, Becerra SP, Chader GJ, Schwartz JP: Pigment epithelium-derived factor (PEDF) differentially protects immature but not mature cerebellar granule cells against apoptotic cell death. J Neurosci Res. 1998, 53: 7-15. 10.1002\/(SICI)1097-4547(19980701)53:1<7::AID-JNR2>3.0.CO;2-F.","journal-title":"J Neurosci Res"},{"key":"53_CR10","doi-asserted-by":"publisher","first-page":"604","DOI":"10.1002\/(SICI)1097-4547(19990615)56:6<604::AID-JNR6>3.0.CO;2-B","volume":"56","author":"MA DeCoster","year":"1999","unstructured":"DeCoster MA, Schabelman E, Tombran-Tink J, Bazan NG: Neuroprotection by pigment epithelial-derived factor against glutamate toxicity in developing primary hippocampal neurons. J Neurosci Res. 1999, 56: 604-610. 10.1002\/(SICI)1097-4547(19990615)56:6<604::AID-JNR6>3.0.CO;2-B.","journal-title":"J Neurosci Res"},{"key":"53_CR11","doi-asserted-by":"publisher","first-page":"719","DOI":"10.1097\/00005072-199907000-00006","volume":"58","author":"MM Bilak","year":"1999","unstructured":"Bilak MM, Corse AM, Bilak SR, Lehar M, Tombran-Tink J, Kuncl RW: Pigment epithelium-derived factor (PEDF) protects motor neurons from chronic glutamate-mediated neurodegeneration. J Neuropathol Exp Neurol. 1999, 58: 719-728.","journal-title":"J Neuropathol Exp Neurol"},{"key":"53_CR12","doi-asserted-by":"publisher","first-page":"506","DOI":"10.1002\/(SICI)1096-9861(19990927)412:3<506::AID-CNE9>3.0.CO;2-E","volume":"412","author":"LJ Houenou","year":"1999","unstructured":"Houenou LJ, D'Costa AP, Li L, Turgeon VL, Enyadike C, Alberdi E, Becerra SP: Pigment epithelium-derived factor promotes the survival and differentiation of developing spinal motor neurons. J Comp Neurol. 1999, 412: 506-514. 10.1002\/(SICI)1096-9861(19990927)412:3<506::AID-CNE9>3.0.CO;2-E.","journal-title":"J Comp Neurol"},{"key":"53_CR13","doi-asserted-by":"publisher","first-page":"447","DOI":"10.1006\/prep.1995.1060","volume":"6","author":"YQ Wu","year":"1995","unstructured":"Wu YQ, Notario V, Chader GJ, Becerra SP: Identification of pigment epithelium-derived factor in the interphotoreceptor matrix of bovine eyes. Protein Expr Purif. 1995, 6: 447-456. 10.1006\/prep.1995.1060.","journal-title":"Protein Expr Purif"},{"key":"53_CR14","doi-asserted-by":"publisher","first-page":"10643","DOI":"10.1021\/bi9802317","volume":"37","author":"E Alberdi","year":"1998","unstructured":"Alberdi E, Hyde CC, Becerra SP: Pigment epithelium-derived factor (PEDF) binds to glycosaminoglycans: analysis of the binding site. Biochemistry. 1998, 37: 10643-10652. 10.1021\/bi9802317.","journal-title":"Biochemistry"},{"key":"53_CR15","doi-asserted-by":"publisher","first-page":"223","DOI":"10.1007\/978-1-4615-5391-5_21","volume":"425","author":"SP Becerra","year":"1997","unstructured":"Becerra SP: Structure-function studies on PEDF. A noninhibitory serpin with neurotrophic activity. Adv Exp Med Biol. 1997, 425: 223-237.","journal-title":"Adv Exp Med Biol"},{"key":"53_CR16","doi-asserted-by":"crossref","first-page":"23148","DOI":"10.1016\/S0021-9258(19)49439-8","volume":"268","author":"SP Becerra","year":"1993","unstructured":"Becerra SP, Palmer I, Kumar A, Steele F, Shiloach J, Notario V, Chader GJ: Overexpression of fetal human pigment epithelium-derived factor in Escherichia coli. A functionally active neurotrophic factor. J Biol Chem. 1993, 268: 23148-2356.","journal-title":"J Biol Chem"},{"key":"53_CR17","doi-asserted-by":"publisher","first-page":"25992","DOI":"10.1074\/jbc.270.43.25992","volume":"270","author":"SP Becerra","year":"1995","unstructured":"Becerra SP, Sagasti A, Spinella P, Notario V: Pigment epithelium-derived factor behaves like a noninhibitory serpin. Neurotrophic activity does not require the serpin reactive loop. J Biol Chem. 1995, 270: 25992-2599. 10.1074\/jbc.270.43.25992.","journal-title":"J Biol Chem"},{"key":"53_CR18","doi-asserted-by":"publisher","first-page":"31605","DOI":"10.1074\/jbc.274.44.31605","volume":"274","author":"E Alberdi","year":"1999","unstructured":"Alberdi E, Aymerich MS, Becerra SP: Binding of pigment epithelium-derived factor (PEDF) to retinoblastoma cells and cerebellar granule neurons. Evidence for a PEDF receptor. J Biol Chem. 1999, 274: 31605-31612. 10.1074\/jbc.274.44.31605.","journal-title":"J Biol Chem"},{"key":"53_CR19","doi-asserted-by":"publisher","first-page":"2575","DOI":"10.1002\/pro.5560051220","volume":"5","author":"E Stratikos","year":"1996","unstructured":"Stratikos E, Alberdi E, Gettins PG, Becerra SP: Recombinant human pigment epithelium-derived factor (PEDF): characterization of PEDF overexpressed and secreted by eukaryotic cells. Protein Sci. 1996, 5: 2575-2582.","journal-title":"Protein Sci"},{"key":"53_CR20","doi-asserted-by":"publisher","first-page":"11131","DOI":"10.1073\/pnas.211268598","volume":"98","author":"M Simonovic","year":"2001","unstructured":"Simonovic M, Gettins PGW, Volz K: Crystal structure of human PEDF, a potent antiangigenioc and neurite growth-promoting factor. Proc Natl Acad Sci U S A. 2001, 98: 11131-11135. 10.1073\/pnas.211268598.","journal-title":"Proc Natl Acad Sci U S A"},{"key":"53_CR21","doi-asserted-by":"publisher","first-page":"1705","DOI":"10.1126\/science.1646484","volume":"252","author":"AC Rapraeger","year":"1991","unstructured":"Rapraeger AC, Kruftka A, Olevin BB: Requirement of heparan sulfate for bFGF-mediated fibroblast growth and myoblast differentiation. Science. 1991, 252: 1705-1708.","journal-title":"Science"},{"key":"53_CR22","doi-asserted-by":"publisher","first-page":"206","DOI":"10.1016\/0003-9861(87)90337-7","volume":"258","author":"JE Morris","year":"1987","unstructured":"Morris JE, Yanagishita M, Hascall VC: Proteoglycans synthesized by embryonic chicken retina in culture: composition and compartmentalization. Arch Biochem Biophys. 1987, 258: 206-218.","journal-title":"Arch Biochem Biophys"},{"key":"53_CR23","doi-asserted-by":"publisher","first-page":"579","DOI":"10.1007\/BF00741447","volume":"11","author":"F Murillo-Lopez","year":"1991","unstructured":"Murillo-Lopez F, Politi L, Adler R, Hewitt AT: Proteoglycan synthesis in cultures of murine retinal neurons and photoreceptors. Cell Mol Neurobiol. 1991, 11: 579-591.","journal-title":"Cell Mol Neurobiol"},{"key":"53_CR24","doi-asserted-by":"publisher","first-page":"127","DOI":"10.1076\/ceyr.16.2.127.5089","volume":"16","author":"JS Bollineni","year":"1997","unstructured":"Bollineni JS, Alluru I, Reddi AS: Heparan sulfate proteoglycan synthesis and its expression are decreased in the retina of diabetic rats. Curr Eye Res. 1997, 16: 127-130. 10.1076\/ceyr.16.2.127.5089.","journal-title":"Curr Eye Res"},{"key":"53_CR25","doi-asserted-by":"publisher","first-page":"1227","DOI":"10.1093\/glycob\/8.12.1227","volume":"8","author":"G Normand","year":"1998","unstructured":"Normand G, Hicks D, Dreyfus H: Neurotrophic growth factors stimulate glycosaminoglycan synthesis in identified retinal cell populations in vitro. Glycobiology. 1998, 8: 1227-1235. 10.1093\/glycob\/8.12.1227.","journal-title":"Glycobiology"},{"key":"53_CR26","doi-asserted-by":"publisher","first-page":"146","DOI":"10.1076\/ceyr.19.2.146.5324","volume":"19","author":"RM Goes","year":"1999","unstructured":"Goes RM, Laicine EM, Porcionatto MA, Bonciani Nader H, Haddad A: Glycosaminoglycans in components of the rabbit eye: synthesis and characterization. Curr Eye Res. 1999, 19: 146-153. 10.1076\/ceyr.19.2.146.5324.","journal-title":"Curr Eye Res"},{"key":"53_CR27","doi-asserted-by":"publisher","first-page":"143","DOI":"10.1093\/glycob\/9.2.143","volume":"9","author":"MH Herndon","year":"1999","unstructured":"Herndon MH, Stipp CS, Lander AD: Interactions of neural glycosaminoglycans and proteoglycans with protein ligands: assessment of selectivity, heterogeneity and the participation of core proteins in binding. Glycobiology. 1999, 9: 143-155. 10.1093\/glycob\/9.2.143.","journal-title":"Glycobiology"},{"key":"53_CR28","doi-asserted-by":"publisher","first-page":"255","DOI":"10.1111\/j.1768-322X.1988.tb00728.x","volume":"62","author":"P Levy","year":"1988","unstructured":"Levy P, Robert A, Picard J: Biosynthesis of glycosaminoglycans in the human colonic tumor cell line Caco-2: structural changes occurring with the morphological differentiation of the cells. Biol Cell. 1988, 62: 255-264. 10.1016\/0248-4900(88)90020-2.","journal-title":"Biol Cell"},{"key":"53_CR29","doi-asserted-by":"publisher","first-page":"265","DOI":"10.1002\/jcb.240430307","volume":"43","author":"W Knudson","year":"1990","unstructured":"Knudson W, Subbaiah S, Pauli BU: Proteoglycan synthesis by normal and neoplastic human transitional epithelial cells. J Cell Biochem. 1990, 43: 265-279.","journal-title":"J Cell Biochem"},{"key":"53_CR30","doi-asserted-by":"crossref","first-page":"23815","DOI":"10.1016\/S0021-9258(18)35910-6","volume":"267","author":"B Lelongt","year":"1992","unstructured":"Lelongt B, Piedagnel R, Chatelet F, Baudouin B, Brenchley PE, Verroust PJ, Cassingena R, Vandewalle A, Ronco PM: Dramatic changes of sulfated proteoglycans composition in a tumorigenic SV-40-transformed renal proximal-tubule cell line. J Biol Chem. 1992, 267: 23815-23822.","journal-title":"J Biol Chem"},{"key":"53_CR31","doi-asserted-by":"publisher","first-page":"1029","DOI":"10.1093\/glycob\/8.10.1029","volume":"8","author":"M Salmivirta","year":"1998","unstructured":"Salmivirta M, Safaiyan F, Prydz K, Andresen MS, Aryan M, Kolset SO: Differentiation-associated modulation of heparan sulfate structure and function in CaCo-2 colon carcinoma cells. Glycobiology. 1998, 8: 1029-1036. 10.1093\/glycob\/8.10.1029.","journal-title":"Glycobiology"},{"key":"53_CR32","doi-asserted-by":"publisher","first-page":"74","DOI":"10.1016\/0003-2697(83)90427-X","volume":"132","author":"RF Bruns","year":"1983","unstructured":"Bruns RF, Lawson-Wendling K, Pugsley TA: A rapid filtration assay for soluble receptors using polyethylenimine-treated filters. Analytical Biochemistry. 1983, 132: 74-81.","journal-title":"Analytical Biochemistry"},{"key":"53_CR33","doi-asserted-by":"crossref","first-page":"6170","DOI":"10.1016\/S0021-9258(18)62674-2","volume":"245","author":"P Hovingh","year":"1970","unstructured":"Hovingh P, Linker A: The enzymatic degradation of heparin and heparitin sulfate. 3. Purification of a heparitinase and a heparinase from flavobacteria:. J Biol Chem. 1970, 245: 6170-6175.","journal-title":"J Biol Chem"},{"key":"53_CR34","doi-asserted-by":"publisher","first-page":"390","DOI":"10.1016\/0076-6879(94)30026-7","volume":"230","author":"VC Hascall","year":"1994","unstructured":"Hascall VC, Calabro A, Midura RJ, Yanagishita M: Isolation and characterization of proteoglycans. Methods Enzymol. 1994, 230: 390-417.","journal-title":"Methods Enzymol"}],"container-title":["BMC Biochemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/1471-2091-4-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,9,13]],"date-time":"2024-09-13T15:57:29Z","timestamp":1726243049000},"score":1,"resource":{"primary":{"URL":"https:\/\/bmcbiochem.biomedcentral.com\/articles\/10.1186\/1471-2091-4-1"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2003,2,19]]},"references-count":34,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2003,12]]}},"alternative-id":["53"],"URL":"https:\/\/doi.org\/10.1186\/1471-2091-4-1","relation":{},"ISSN":["1471-2091"],"issn-type":[{"value":"1471-2091","type":"electronic"}],"subject":[],"published":{"date-parts":[[2003,2,19]]},"assertion":[{"value":"11 December 2002","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"19 February 2003","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"19 February 2003","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}}],"article-number":"1"}}