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The change in<jats:italic>Troponin T<\/jats:italic>(<jats:italic>TnT<\/jats:italic>), a pivotal protein in the assembly of skeletal muscles sarcomeres and a modulator of calcium driven muscle contraction, during flatfish metamophosis is studied.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In the present study five cDNAs for halibut<jats:italic>TnT<\/jats:italic>genes were cloned; three were splice variants arising from a single<jats:italic>fast TnT<\/jats:italic>(<jats:italic>fTnT<\/jats:italic>) gene; a fourth encoded a novel teleost specific fTnT-like cDNA (<jats:italic>AfTnT<\/jats:italic>) expressed exclusively in slow muscle and the fifth encoded the teleost specific<jats:italic>sTnT2<\/jats:italic>. THs modified the expression of halibut<jats:italic>fTnT<\/jats:italic>isoforms which changed from predominantly basic to acidic isoforms during natural and T4 induced metamorphosis. In contrast, expression of red muscle specific genes,<jats:italic>AfTnT<\/jats:italic>and<jats:italic>sTnT2<\/jats:italic>, did not change during natural metamorphosis or after T4 treatment. Prior to and after metamorphosis no change in the dorso-ventral symmetry or temporal-spatial expression pattern of<jats:italic>TnT<\/jats:italic>genes and muscle fibre organization occurred in halibut musculature.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Muscle organisation in halibut remains symmetrical even after metamorphosis suggesting TH driven changes are associated with molecular adaptations. We hypothesize that species specific differences in<jats:italic>TnT<\/jats:italic>gene expression in teleosts underlies different larval muscle developmental programs which better adapts them to the specific ecological constraints.<\/jats:p><\/jats:sec>","DOI":"10.1186\/1471-213x-7-71","type":"journal-article","created":{"date-parts":[[2007,6,19]],"date-time":"2007-06-19T06:14:00Z","timestamp":1182233640000},"update-policy":"http:\/\/dx.doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":22,"title":["Troponin T isoform expression is modulated during Atlantic Halibut metamorphosis"],"prefix":"10.1186","volume":"7","author":[{"given":"Marco A","family":"Campinho","sequence":"first","affiliation":[]},{"given":"N\u00e1dia","family":"Silva","sequence":"additional","affiliation":[]},{"given":"Mari A","family":"Nowell","sequence":"additional","affiliation":[]},{"given":"Lynda","family":"Llewellyn","sequence":"additional","affiliation":[]},{"given":"Glen E","family":"Sweeney","sequence":"additional","affiliation":[]},{"given":"Deborah M","family":"Power","sequence":"additional","affiliation":[]}],"member":"297","published-online":{"date-parts":[[2007,6,18]]},"reference":[{"key":"213_CR1","doi-asserted-by":"publisher","first-page":"145","DOI":"10.1042\/BJ20041240","volume":"386","author":"R Marco-Ferreres","year":"2005","unstructured":"Marco-Ferreres R, Arredondo JJ, Fraile B, Cervera M: Overexpression of troponin T in Drosophila muscles causes a decrease in the levels of thin-filament proteins. 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