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We performed painting with human autosomes and X-chromosome specific probes on metaphases of two three-toed sloths:<jats:italic>Bradypus torquatus<\/jats:italic>and<jats:italic>B. variegatus<\/jats:italic>. These species represent the fourth of the five extant Xenarthra families to be studied with this approach.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Eleven human chromosomes were conserved as one block in both<jats:italic>B. torquatus<\/jats:italic>and<jats:italic>B. variegatus<\/jats:italic>: (HSA 5, 6, 9, 11, 13, 14, 15, 17, 18, 20, 21 and the X chromosome).<jats:italic>B. torquatus<\/jats:italic>, three additional human chromosomes were conserved intact (HSA 1, 3 and 4). The remaining human chromosomes were represented by two or three segments on each sloth. Seven associations between human chromosomes were detected in the karyotypes of both<jats:italic>B. torquatus<\/jats:italic>and<jats:italic>B. variegatus<\/jats:italic>: HSA 3\/21, 4\/8, 7\/10, 7\/16, 12\/22, 14\/15 and 17\/19. The ancestral Eutherian association 16\/19 was not detected in the<jats:italic>Bradypus<\/jats:italic>species.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Our results together with previous reports enabled us to propose a hypothetical ancestral Xenarthran karyotype with 48 chromosomes that would differ from the proposed ancestral Eutherian karyotype by the presence of the association HSA 7\/10 and by the split of HSA 8 into three blocks, instead of the two found in the Eutherian ancestor. These same chromosome features point to the monophyly of Xenarthra, making this the second supraorder of placental mammals to have a chromosome signature supporting its monophyly.<\/jats:p><\/jats:sec>","DOI":"10.1186\/1471-2148-12-36","type":"journal-article","created":{"date-parts":[[2012,3,19]],"date-time":"2012-03-19T13:14:27Z","timestamp":1332162867000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Chromosome painting in three-toed sloths: a cytogenetic signature and ancestral karyotype for Xenarthra"],"prefix":"10.1186","volume":"12","author":[{"given":"Nath\u00e1lia F","family":"Azevedo","sequence":"first","affiliation":[]},{"given":"Marta","family":"Svartman","sequence":"additional","affiliation":[]},{"given":"Andrea","family":"Manchester","sequence":"additional","affiliation":[]},{"given":"N\u00e1dia","family":"de Moraes-Barros","sequence":"additional","affiliation":[]},{"given":"Roscoe","family":"Stanyon","sequence":"additional","affiliation":[]},{"given":"Angela M","family":"Vianna-Morgante","sequence":"additional","affiliation":[]}],"member":"297","published-online":{"date-parts":[[2012,3,19]]},"reference":[{"key":"2035_CR1","first-page":"51","volume-title":"The evolution and ecology of armadillos, sloths, and vermilinguas","author":"B Glass","year":"1985","unstructured":"Glass B: History of classification and nomenclature in Xenarthra (Edentata). 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