{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,19]],"date-time":"2026-01-19T07:49:15Z","timestamp":1768808955834,"version":"3.49.0"},"reference-count":30,"publisher":"Springer Science and Business Media LLC","issue":"1","content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["BMC Neurosci"],"published-print":{"date-parts":[[2014,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n          <jats:sec>\n            <jats:title>Background<\/jats:title>\n            <jats:p>\n              <jats:italic>Olig1<\/jats:italic> and <jats:italic>Olig2<\/jats:italic>, encoding closely related basic helix-loop-helix transcription factors, were originally identified in screens for glial-specific genes. <jats:italic>Olig1<\/jats:italic> and <jats:italic>Olig2<\/jats:italic> are both expressed in restricted parts of the neuroepithelium of the embryonic spinal cord and telencephalon and subsequently in oligodendrocyte lineage cells throughout life. In the spinal cord, Olig2 plays a crucial role in the development of oligodendrocytes and motor neurons, and both cell types are lost from <jats:italic>Olig2<\/jats:italic> null mutant mice. The role of Olig1 has been more cryptic. It was initially reported that <jats:italic>Olig1<\/jats:italic> null mice (with a <jats:italic>Cre-Pgk-Neo<\/jats:italic> cassette at the <jats:italic>Olig1<\/jats:italic> locus) have a mild developmental phenotype characterized by a slight delay in oligodendrocyte differentiation. However, a subsequent study of the same line following removal of <jats:italic>Pgk-Neo<\/jats:italic> (leaving <jats:italic>Olig1-Cre<\/jats:italic>) found severe disruption of oligodendrocyte production, myelination failure and early postnatal lethality. A plausible explanation was proposed, that the highly expressed <jats:italic>Pgk-Neo<\/jats:italic> cassette in the original line might have up-regulated the neighbouring <jats:italic>Olig2<\/jats:italic> gene, compensating for loss of Olig1. However, this was not tested, so the importance of Olig1 for oligodendrocyte development has remained unclear.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Results<\/jats:title>\n            <jats:p>We generated two independent lines of <jats:italic>Olig1<\/jats:italic> null mice. Both lines had a mild phenotype featuring slightly delayed oligodendrocyte differentiation and maturation but no long-term effect. In addition, we found that <jats:italic>Olig2<\/jats:italic> transcripts were not up-regulated in our <jats:italic>Olig1<\/jats:italic> null mice.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusions<\/jats:title>\n            <jats:p>Our findings support the original conclusion that Olig1 plays a minor and non-essential role in oligodendrocyte development and have implications for the interpretation of studies based on <jats:italic>Olig1<\/jats:italic> deficient mice (and perhaps <jats:italic>Olig1-Cre<\/jats:italic> mice) from different sources.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1186\/1471-2202-15-12","type":"journal-article","created":{"date-parts":[[2014,1,14]],"date-time":"2014-01-14T20:03:20Z","timestamp":1389729800000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":25,"title":["New Olig1null mice confirm a non-essential role for Olig1 in oligodendrocyte development"],"prefix":"10.1186","volume":"15","author":[{"given":"Joana","family":"Paes de Faria","sequence":"first","affiliation":[]},{"given":"Nicoletta","family":"Kessaris","sequence":"additional","affiliation":[]},{"given":"Paul","family":"Andrew","sequence":"additional","affiliation":[]},{"given":"William D","family":"Richardson","sequence":"additional","affiliation":[]},{"given":"Huiliang","family":"Li","sequence":"additional","affiliation":[]}],"member":"297","published-online":{"date-parts":[[2014,1,14]]},"reference":[{"key":"3471_CR1","doi-asserted-by":"publisher","first-page":"75","DOI":"10.1016\/S0092-8674(02)00678-5","volume":"109","author":"QR Lu","year":"2002","unstructured":"Lu QR, Sun T, Zhu Z, Ma N, Garcia M, Stiles CD, et al: Common developmental requirement for Olig function indicates a motor neuron\/oligodendrocyte connection. 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