{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,17]],"date-time":"2026-01-17T07:10:27Z","timestamp":1768633827706,"version":"3.49.0"},"reference-count":44,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2008,10,3]],"date-time":"2008-10-03T00:00:00Z","timestamp":1222992000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/2.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["BMC Neurosci"],"published-print":{"date-parts":[[2008,12]]},"DOI":"10.1186\/1471-2202-9-97","type":"journal-article","created":{"date-parts":[[2008,10,22]],"date-time":"2008-10-22T14:13:46Z","timestamp":1224684826000},"source":"Crossref","is-referenced-by-count":25,"title":["The Adhesion GPCR GPR125 is specifically expressed in the choroid plexus and is upregulated following brain injury"],"prefix":"10.1186","volume":"9","author":[{"given":"Chris","family":"Pickering","sequence":"first","affiliation":[]},{"given":"Maria","family":"H\u00e4gglund","sequence":"additional","affiliation":[]},{"given":"Joanna","family":"Szmydynger-Chodobska","sequence":"additional","affiliation":[]},{"given":"Fernanda","family":"Marques","sequence":"additional","affiliation":[]},{"given":"Joana A","family":"Palha","sequence":"additional","affiliation":[]},{"given":"Linn","family":"Waller","sequence":"additional","affiliation":[]},{"given":"Adam","family":"Chodobski","sequence":"additional","affiliation":[]},{"given":"Robert","family":"Fredriksson","sequence":"additional","affiliation":[]},{"given":"Malin C","family":"Lagerstr\u00f6m","sequence":"additional","affiliation":[]},{"given":"Helgi B","family":"Schi\u00f6th","sequence":"additional","affiliation":[]}],"member":"297","published-online":{"date-parts":[[2008,10,3]]},"reference":[{"key":"780_CR1","doi-asserted-by":"publisher","first-page":"928","DOI":"10.1002\/1439-7633(20021004)3:10<928::AID-CBIC928>3.0.CO;2-5","volume":"3","author":"T Klabunde","year":"2002","unstructured":"Klabunde T, Hessler G: Drug design strategies for targeting G-protein-coupled receptors. Chembiochem. 2002, 3: 928-944. 10.1002\/1439-7633(20021004)3:10<928::AID-CBIC928>3.0.CO;2-5.","journal-title":"Chembiochem"},{"key":"780_CR2","doi-asserted-by":"publisher","first-page":"1256","DOI":"10.1124\/mol.63.6.1256","volume":"63","author":"R Fredriksson","year":"2003","unstructured":"Fredriksson R, Lagerstrom MC, Lundin LG, Schioth HB: The G-protein-coupled receptors in the human genome form five main families. Phylogenetic analysis, paralogon groups, and fingerprints. Mol Pharmacol. 2003, 63: 1256-1272. 10.1124\/mol.63.6.1256.","journal-title":"Mol Pharmacol"},{"key":"780_CR3","doi-asserted-by":"publisher","first-page":"REVIEWS3013","DOI":"10.1186\/gb-2001-2-12-reviews3013","volume":"2","author":"AJ Harmar","year":"2001","unstructured":"Harmar AJ: Family-B G-protein-coupled receptors. Genome Biol. 2001, 2: REVIEWS3013-10.1186\/gb-2001-2-12-reviews3013.","journal-title":"Genome Biol"},{"key":"780_CR4","doi-asserted-by":"publisher","first-page":"284","DOI":"10.1016\/S0968-0004(00)01583-8","volume":"25","author":"M Stacey","year":"2000","unstructured":"Stacey M, Lin HH, Gordon S, McKnight AJ: LNB-TM7, a group of seven-transmembrane proteins related to family-B G-protein-coupled receptors. Trends Biochem Sci. 2000, 25: 284-289. 10.1016\/S0968-0004(00)01583-8.","journal-title":"Trends Biochem Sci"},{"key":"780_CR5","doi-asserted-by":"publisher","first-page":"725","DOI":"10.1016\/S0006-291X(03)00026-3","volume":"301","author":"R Fredriksson","year":"2003","unstructured":"Fredriksson R, Gloriam DE, Hoglund PJ, Lagerstrom MC, Schioth HB: There exist at least 30 human G-protein-coupled receptors with long Ser\/Thr-rich N-termini. Biochem Biophys Res Commun. 2003, 301: 725-734. 10.1016\/S0006-291X(03)00026-3.","journal-title":"Biochem Biophys Res Commun"},{"key":"780_CR6","doi-asserted-by":"publisher","first-page":"23","DOI":"10.1016\/j.ygeno.2003.12.004","volume":"84","author":"TK Bjarnadottir","year":"2004","unstructured":"Bjarnadottir TK, Fredriksson R, Hoglund PJ, Gloriam DE, Lagerstrom MC, Schioth HB: The human and mouse repertoire of the adhesion family of G-protein-coupled receptors. Genomics. 2004, 84: 23-33. 10.1016\/j.ygeno.2003.12.004.","journal-title":"Genomics"},{"key":"780_CR7","doi-asserted-by":"publisher","first-page":"1129","DOI":"10.1111\/j.1471-4159.2006.04281.x","volume":"100","author":"MC Lagerstrom","year":"2007","unstructured":"Lagerstrom MC, Rabe N, Haitina T, Kalnina I, Hellstrom AR, Klovins J, Kullander K, Schioth HB: The evolutionary history and tissue mapping of GPR123: specific CNS expression pattern predominantly in thalamic nuclei and regions containing large pyramidal cells. J Neurochem. 2007, 100: 1129-1142. 10.1111\/j.1471-4159.2006.04281.x.","journal-title":"J Neurochem"},{"key":"780_CR8","doi-asserted-by":"publisher","first-page":"3889","DOI":"10.1038\/sj.onc.1207495","volume":"23","author":"Y Yamamoto","year":"2004","unstructured":"Yamamoto Y, Irie K, Asada M, Mino A, Mandai K, Takai Y: Direct binding of the human homologue of the Drosophila disc large tumor suppressor gene to seven-pass transmembrane proteins, tumor endothelial marker 5 (TEM5), and a novel TEM5-like protein. Oncogene. 2004, 23: 3889-3897. 10.1038\/sj.onc.1207495.","journal-title":"Oncogene"},{"key":"780_CR9","first-page":"6649","volume":"61","author":"EB Carson-Walter","year":"2001","unstructured":"Carson-Walter EB, Watkins DN, Nanda A, Vogelstein B, Kinzler KW, St Croix B: Cell surface tumor endothelial markers are conserved in mice and humans. Cancer Res. 2001, 61: 6649-6655.","journal-title":"Cancer Res"},{"key":"780_CR10","doi-asserted-by":"publisher","first-page":"149","DOI":"10.1016\/S0169-409X(00)00131-9","volume":"46","author":"RK Jain","year":"2001","unstructured":"Jain RK: Delivery of molecular and cellular medicine to solid tumors. Adv Drug Deliv Rev. 2001, 46: 149-168. 10.1016\/S0169-409X(00)00131-9.","journal-title":"Adv Drug Deliv Rev"},{"key":"780_CR11","doi-asserted-by":"publisher","first-page":"346","DOI":"10.1038\/nature06129","volume":"449","author":"M Seandel","year":"2007","unstructured":"Seandel M, James D, Shmelkov SV, Falciatori I, Kim J, Chavala S, Scherr DS, Zhang F, Torres R, Gale NW, et al: Generation of functional multipotent adult stem cells from GPR125+ germline progenitors. Nature. 2007, 449: 346-350. 10.1038\/nature06129.","journal-title":"Nature"},{"key":"780_CR12","doi-asserted-by":"publisher","first-page":"e54","DOI":"10.1371\/journal.pcbi.0020054","volume":"2","author":"MC Lagerstrom","year":"2006","unstructured":"Lagerstrom MC, Hellstrom AR, Gloriam DE, Larsson TP, Schioth HB, Fredriksson R: The G protein-coupled receptor subset of the chicken genome. PLoS Comput Biol. 2006, 2: e54-10.1371\/journal.pcbi.0020054.","journal-title":"PLoS Comput Biol"},{"key":"780_CR13","doi-asserted-by":"publisher","first-page":"4673","DOI":"10.1093\/nar\/22.22.4673","volume":"22","author":"JD Thompson","year":"1994","unstructured":"Thompson JD, Higgins DG, Gibson TJ: CLUSTAL W: improving the sensitivity of progressive multiple sequence alignment through sequence weighting, position-specific gap penalties and weight matrix choice. Nucleic Acids Res. 1994, 22: 4673-4680. 10.1093\/nar\/22.22.4673.","journal-title":"Nucleic Acids Res"},{"key":"780_CR14","doi-asserted-by":"publisher","first-page":"43","DOI":"10.1038\/nature03481","volume":"435","author":"L Eichinger","year":"2005","unstructured":"Eichinger L, Pachebat JA, Glockner G, Rajandream MA, Sucgang R, Berriman M, Song J, Olsen R, Szafranski K, Xu Q, et al: The genome of the social amoeba Dictyostelium discoideum. Nature. 2005, 435: 43-57. 10.1038\/nature03481.","journal-title":"Nature"},{"key":"780_CR15","first-page":"164","volume":"5","author":"J Felsenstein","year":"1989","unstructured":"Felsenstein J: PHYLIP-Phylogeny Inference Package (Version 3.2). Cladistics. 1989, 5: 164-166.","journal-title":"Cladistics"},{"key":"780_CR16","first-page":"275","volume":"8","author":"DT Jones","year":"1992","unstructured":"Jones DT, Taylor WR, Thornton JM: The rapid generation of mutation data matrices from protein sequences. Computer Applications in Biosciences. 1992, 8: 275-282.","journal-title":"Computer Applications in Biosciences"},{"key":"780_CR17","first-page":"357","volume":"12","author":"RDM Page","year":"1996","unstructured":"Page RDM: TREEVIEW: an application to display phylogenetic trees on personal computers. CABIOS. 1996, 12: 357-358.","journal-title":"CABIOS"},{"key":"780_CR18","doi-asserted-by":"publisher","first-page":"964","DOI":"10.1093\/oxfordjournals.molbev.a025664","volume":"13","author":"K Strimmer","year":"1996","unstructured":"Strimmer K, von Haeseler A: Quartet puzzling: a quartet maximum likelihood method for reconstructing tree topologies. Molecular Biology and Evolution. 1996, 13: 964-969.","journal-title":"Molecular Biology and Evolution"},{"key":"780_CR19","doi-asserted-by":"publisher","first-page":"RESEARCH0034","DOI":"10.1186\/gb-2002-3-7-research0034","volume":"3","author":"J Vandesompele","year":"2002","unstructured":"Vandesompele J, De Preter K, Pattyn F, Poppe B, Van Roy N, De Paepe A, Speleman F: Accurate normalization of real-time quantitative RT-PCR data by geometric averaging of multiple internal control genes. Genome Biol. 2002, 3: RESEARCH0034-10.1186\/gb-2002-3-7-research0034.","journal-title":"Genome Biol"},{"key":"780_CR20","doi-asserted-by":"publisher","first-page":"62","DOI":"10.1016\/S0304-3940(02)01423-4","volume":"339","author":"C Ramakers","year":"2003","unstructured":"Ramakers C, Ruijter JM, Deprez RH, Moorman AF: Assumption-free analysis of quantitative real-time polymerase chain reaction (PCR) data. Neurosci Lett. 2003, 339: 62-66. 10.1016\/S0304-3940(02)01423-4.","journal-title":"Neurosci Lett"},{"key":"780_CR21","doi-asserted-by":"publisher","first-page":"1920","DOI":"10.1074\/mcp.M500279-MCP200","volume":"4","author":"M Uhlen","year":"2005","unstructured":"Uhlen M, Bjorling E, Agaton C, Szigyarto CA, Amini B, Andersen E, Andersson AC, Angelidou P, Asplund A, Asplund C, et al: A human protein atlas for normal and cancer tissues based on antibody proteomics. Mol Cell Proteomics. 2005, 4: 1920-1932. 10.1074\/mcp.M500279-MCP200.","journal-title":"Mol Cell Proteomics"},{"key":"780_CR22","doi-asserted-by":"publisher","first-page":"424","DOI":"10.1016\/j.neuroscience.2006.09.029","volume":"144","author":"F Marques","year":"2007","unstructured":"Marques F, Sousa JC, Correia-Neves M, Oliveira P, Sousa N, Palha JA: The choroid plexus response to peripheral inflammatory stimulus. Neuroscience. 2007, 144: 424-430. 10.1016\/j.neuroscience.2006.09.029.","journal-title":"Neuroscience"},{"issue":"Suppl 11","key":"780_CR23","first-page":"161","volume":"57","author":"CL Pascale","year":"2006","unstructured":"Pascale CL, Szmydynger-Chodobska J, Sarri JE, Chodobski A: Traumatic brain injury results in a concomitant increase in neocortical expression of vasopressin and its V1a receptor. J Physiol Pharmacol. 2006, 57 (Suppl 11): 161-167.","journal-title":"J Physiol Pharmacol"},{"key":"780_CR24","doi-asserted-by":"publisher","first-page":"617","DOI":"10.1016\/S0306-4522(00)00294-3","volume":"100","author":"K Pierre","year":"2000","unstructured":"Pierre K, Pellerin L, Debernardi R, Riederer BM, Magistretti PJ: Cell-specific localization of monocarboxylate transporters, MCT1 and MCT2, in the adult mouse brain revealed by double immunohistochemical labeling and confocal microscopy. Neuroscience. 2000, 100: 617-627. 10.1016\/S0306-4522(00)00294-3.","journal-title":"Neuroscience"},{"key":"780_CR25","doi-asserted-by":"publisher","first-page":"2582","DOI":"10.1096\/fj.06-6500fje","volume":"20","author":"MJ Kwakkenbos","year":"2006","unstructured":"Kwakkenbos MJ, Matmati M, Madsen O, Pouwels W, Wang Y, Bontrop RE, Heidt PJ, Hoek RM, Hamann J: An unusual mode of concerted evolution of the EGF-TM7 receptor chimera EMR2. Faseb J. 2006, 20: 2582-2584. 10.1096\/fj.06-6500fje.","journal-title":"Faseb J"},{"key":"780_CR26","doi-asserted-by":"publisher","first-page":"864","DOI":"10.1016\/j.ympev.2006.11.007","volume":"43","author":"D Fridmanis","year":"2007","unstructured":"Fridmanis D, Fredriksson R, Kapa I, Schioth HB, Klovins J: Formation of new genes explains lower intron density in mammalian Rhodopsin G protein-coupled receptors. Mol Phylogenet Evol. 2007, 43: 864-880. 10.1016\/j.ympev.2006.11.007.","journal-title":"Mol Phylogenet Evol"},{"key":"780_CR27","doi-asserted-by":"publisher","first-page":"89","DOI":"10.1196\/annals.1327.011","volume":"1040","author":"R Fredriksson","year":"2005","unstructured":"Fredriksson R, Lagerstrom MC, Schioth HB: Expansion of the superfamily of G-protein-coupled receptors in chordates. Ann N Y Acad Sci. 2005, 1040: 89-94. 10.1196\/annals.1327.011.","journal-title":"Ann N Y Acad Sci"},{"key":"780_CR28","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1186\/1471-2148-8-9","volume":"8","author":"KJ Nordstrom","year":"2008","unstructured":"Nordstrom KJ, Fredriksson R, Schioth HB: The amphioxus (Branchiostoma floridae) genome contains a highly diversified set of G protein-coupled receptors. BMC Evol Biol. 2008, 8: 9-10.1186\/1471-2148-8-9.","journal-title":"BMC Evol Biol"},{"key":"780_CR29","doi-asserted-by":"publisher","first-page":"262","DOI":"10.1002\/bies.20193","volume":"27","author":"DF Emerich","year":"2005","unstructured":"Emerich DF, Skinner SJ, Borlongan CV, Vasconcellos AV, Thanos CG: The choroid plexus in the rise, fall and repair of the brain. Bioessays. 2005, 27: 262-274. 10.1002\/bies.20193.","journal-title":"Bioessays"},{"key":"780_CR30","doi-asserted-by":"publisher","first-page":"43","DOI":"10.1016\/j.neuroscience.2004.03.065","volume":"127","author":"AL Gard","year":"2004","unstructured":"Gard AL, Gavin E, Solodushko V, Pennica D: Cardiotrophin-1 in choroid plexus and the cerebrospinal fluid circulatory system. Neuroscience. 2004, 127: 43-52. 10.1016\/j.neuroscience.2004.03.065.","journal-title":"Neuroscience"},{"key":"780_CR31","first-page":"349","volume":"61","author":"G Brocklehurst","year":"1979","unstructured":"Brocklehurst G: The significance of the evolution of the cerebrospinal fluid system. Ann R Coll Surg Engl. 1979, 61: 349-356.","journal-title":"Ann R Coll Surg Engl"},{"key":"780_CR32","doi-asserted-by":"publisher","first-page":"339","DOI":"10.1038\/nrd2518","volume":"7","author":"MC Lagerstrom","year":"2008","unstructured":"Lagerstrom MC, Schioth HB: Structural diversity of G protein-coupled receptors and significance for drug discovery. Nat Rev Drug Discov. 2008, 7: 339-357. 10.1038\/nrd2518.","journal-title":"Nat Rev Drug Discov"},{"key":"780_CR33","doi-asserted-by":"publisher","first-page":"430","DOI":"10.1038\/nature06329","volume":"450","author":"D Park","year":"2007","unstructured":"Park D, Tosello-Trampont AC, Elliott MR, Lu M, Haney LB, Ma Z, Klibanov AL, Mandell JW, Ravichandran KS: BAI1 is an engulfment receptor for apoptotic cells upstream of the ELMO\/Dock180\/Rac module. Nature. 2007, 450: 430-434. 10.1038\/nature06329.","journal-title":"Nature"},{"key":"780_CR34","first-page":"785","volume":"18","author":"S Kudo","year":"2007","unstructured":"Kudo S, Konda R, Obara W, Kudo D, Tani K, Nakamura Y, Fujioka T: Inhibition of tumor growth through suppression of angiogenesis by brain-specific angiogenesis inhibitor 1 gene transfer in murine renal cell carcinoma. Oncol Rep. 2007, 18: 785-791.","journal-title":"Oncol Rep"},{"key":"780_CR35","doi-asserted-by":"publisher","first-page":"944","DOI":"10.1016\/j.str.2008.02.020","volume":"16","author":"I Vakonakis","year":"2008","unstructured":"Vakonakis I, Langenhan T, Promel S, Russ A, Campbell ID: Solution structure and sugar-binding mechanism of mouse latrophilin-1 RBL: a 7TM receptor-attached lectin-like domain. Structure. 2008, 16: 944-953. 10.1016\/j.str.2008.02.020.","journal-title":"Structure"},{"key":"780_CR36","doi-asserted-by":"publisher","first-page":"168","DOI":"10.1038\/nature05453","volume":"445","author":"ES Lein","year":"2007","unstructured":"Lein ES, Hawrylycz MJ, Ao N, Ayres M, Bensinger A, Bernard A, Boe AF, Boguski MS, Brockway KS, Byrnes EJ, et al: Genome-wide atlas of gene expression in the adult mouse brain. Nature. 2007, 445: 168-176. 10.1038\/nature05453.","journal-title":"Nature"},{"key":"780_CR37","doi-asserted-by":"publisher","first-page":"713","DOI":"10.1016\/j.neurobiolaging.2006.03.015","volume":"28","author":"JC Sousa","year":"2007","unstructured":"Sousa JC, Cardoso I, Marques F, Saraiva MJ, Palha JA: Transthyretin and Alzheimer's disease: where in the brain?. Neurobiol Aging. 2007, 28: 713-718. 10.1016\/j.neurobiolaging.2006.03.015.","journal-title":"Neurobiol Aging"},{"key":"780_CR38","doi-asserted-by":"publisher","first-page":"297","DOI":"10.1016\/S0006-8993(98)00042-0","volume":"793","author":"H Endo","year":"1998","unstructured":"Endo H, Sasaki K, Tonosaki A, Kayama T: Three-dimensional and ultrastructural ICAM-1 distribution in the choroid plexus, arachnoid membrane and dural sinus of inflammatory rats induced by LPS injection in the lateral ventricles. Brain Res. 1998, 793: 297-301. 10.1016\/S0006-8993(98)00042-0.","journal-title":"Brain Res"},{"key":"780_CR39","doi-asserted-by":"publisher","first-page":"477","DOI":"10.1007\/s00702-005-0409-y","volume":"113","author":"B Engelhardt","year":"2006","unstructured":"Engelhardt B: Molecular mechanisms involved in T cell migration across the blood-brain barrier. J Neural Transm. 2006, 113: 477-485. 10.1007\/s00702-005-0409-y.","journal-title":"J Neural Transm"},{"key":"780_CR40","doi-asserted-by":"publisher","first-page":"112","DOI":"10.1002\/1097-0029(20010101)52:1<112::AID-JEMT13>3.0.CO;2-5","volume":"52","author":"B Engelhardt","year":"2001","unstructured":"Engelhardt B, Wolburg-Buchholz K, Wolburg H: Involvement of the choroid plexus in central nervous system inflammation. Microsc Res Tech. 2001, 52: 112-129. 10.1002\/1097-0029(20010101)52:1<112::AID-JEMT13>3.0.CO;2-5.","journal-title":"Microsc Res Tech"},{"key":"780_CR41","doi-asserted-by":"publisher","first-page":"105","DOI":"10.1007\/PL00007412","volume":"99","author":"JM Serot","year":"2000","unstructured":"Serot JM, Bene MC, Foliguet B, Faure GC: Morphological alterations of the choroid plexus in late-onset Alzheimer's disease. Acta Neuropathol (Berl). 2000, 99: 105-108. 10.1007\/PL00007412.","journal-title":"Acta Neuropathol (Berl)"},{"key":"780_CR42","doi-asserted-by":"publisher","first-page":"s515","DOI":"10.2741\/1085","volume":"8","author":"JM Serot","year":"2003","unstructured":"Serot JM, Bene MC, Faure GC: Choroid plexus, aging of the brain, and Alzheimer's disease. Front Biosci. 2003, 8: s515-521. 10.2741\/1085.","journal-title":"Front Biosci"},{"key":"780_CR43","doi-asserted-by":"publisher","first-page":"537","DOI":"10.1016\/S0306-4522(99)00181-5","volume":"93","author":"M Ferrand-Drake","year":"1999","unstructured":"Ferrand-Drake M, Wieloch T: The time-course of DNA fragmentation in the choroid plexus and the CA1 region following transient global ischemia in the rat brain. The effect of intra-ischemic hypothermia. Neuroscience. 1999, 93: 537-549. 10.1016\/S0306-4522(99)00181-5.","journal-title":"Neuroscience"},{"key":"780_CR44","doi-asserted-by":"publisher","first-page":"65","DOI":"10.1002\/1097-0029(20010101)52:1<65::AID-JEMT9>3.0.CO;2-4","volume":"52","author":"A Chodobski","year":"2001","unstructured":"Chodobski A, Szmydynger-Chodobska J: Choroid plexus: target for polypeptides and site of their synthesis. Microsc Res Tech. 2001, 52: 65-82. 10.1002\/1097-0029(20010101)52:1<65::AID-JEMT9>3.0.CO;2-4.","journal-title":"Microsc Res Tech"}],"container-title":["BMC Neuroscience"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/1471-2202-9-97.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1186\/1471-2202-9-97\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/1471-2202-9-97.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,1,21]],"date-time":"2019-01-21T13:53:09Z","timestamp":1548078789000},"score":1,"resource":{"primary":{"URL":"https:\/\/bmcneurosci.biomedcentral.com\/articles\/10.1186\/1471-2202-9-97"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,10,3]]},"references-count":44,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2008,12]]}},"alternative-id":["780"],"URL":"https:\/\/doi.org\/10.1186\/1471-2202-9-97","relation":{},"ISSN":["1471-2202"],"issn-type":[{"value":"1471-2202","type":"electronic"}],"subject":[],"published":{"date-parts":[[2008,10,3]]},"article-number":"97"}}