{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,27]],"date-time":"2025-09-27T01:11:35Z","timestamp":1758935495812},"reference-count":39,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2009,5,15]],"date-time":"2009-05-15T00:00:00Z","timestamp":1242345600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["BMC Cancer"],"published-print":{"date-parts":[[2009,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n          <jats:sec>\n            <jats:title>Background<\/jats:title>\n            <jats:p>A relevant role of septins in leukemogenesis has been uncovered by their involvement as fusion partners in <jats:italic>MLL<\/jats:italic>-related leukemia. Recently, we have established the <jats:italic>MLL-SEPT2<\/jats:italic> gene fusion as the molecular abnormality subjacent to the translocation t(2;11)(q37;q23) in therapy-related acute myeloid leukemia. In this work we quantified <jats:italic>MLL<\/jats:italic> and <jats:italic>SEPT2<\/jats:italic> gene expression in 58 acute myeloid leukemia patients selected to represent the major AML genetic subgroups, as well as in all three cases of <jats:italic>MLL-SEPT2<\/jats:italic>-associated myeloid neoplasms so far described in the literature.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Methods<\/jats:title>\n            <jats:p>Cytogenetics, fluorescence in situ hybridization (FISH) and molecular studies (RT-PCR, qRT-PCR and qMSP) were used to characterize 58 acute myeloid leukemia patients (AML) at diagnosis selected to represent the major AML genetic subgroups: <jats:italic>CBFB-MYH11<\/jats:italic> (n = 13), <jats:italic>PML-RARA<\/jats:italic> (n = 12); <jats:italic>RUNX1-RUNX1T1<\/jats:italic> (n = 12), normal karyotype (n = 11), and <jats:italic>MLL<\/jats:italic> gene fusions other than <jats:italic>MLL-SEPT2<\/jats:italic> (n = 10). We also studied all three <jats:italic>MLL-SEPT2<\/jats:italic> myeloid neoplasia cases reported in the literature, namely two AML patients and a t-MDS patient.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Results<\/jats:title>\n            <jats:p>When compared with normal controls, we found a 12.8-fold reduction of wild-type <jats:italic>SEPT2<\/jats:italic> and <jats:italic>MLL-SEPT2<\/jats:italic> combined expression in cases with the <jats:italic>MLL-SEPT2<\/jats:italic> gene fusion (p = 0.007), which is accompanied by a 12.4-fold down-regulation of wild-type <jats:italic>MLL<\/jats:italic> and <jats:italic>MLL-SEPT2<\/jats:italic> combined expression (p = 0.028). The down-regulation of <jats:italic>SEPT2<\/jats:italic> in <jats:italic>MLL-SEPT2<\/jats:italic> myeloid neoplasias was statistically significant when compared with all other leukemia genetic subgroups (including those with other <jats:italic>MLL<\/jats:italic> gene fusions). In addition, <jats:italic>MLL<\/jats:italic> expression was also down-regulated in the group of <jats:italic>MLL<\/jats:italic> fusions other than <jats:italic>MLL-SEPT2<\/jats:italic>, when compared with the normal control group (p = 0.023)<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusion<\/jats:title>\n            <jats:p>We found a significant down-regulation of both <jats:italic>SEPT2<\/jats:italic> and <jats:italic>MLL<\/jats:italic> in <jats:italic>MLL-SEPT2<\/jats:italic> myeloid neoplasias. In addition, we also found that <jats:italic>MLL<\/jats:italic> is under-expressed in AML patients with <jats:italic>MLL<\/jats:italic> fusions other than <jats:italic>MLL-SEPT2<\/jats:italic>.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1186\/1471-2407-9-147","type":"journal-article","created":{"date-parts":[[2009,5,15]],"date-time":"2009-05-15T19:28:48Z","timestamp":1242415728000},"update-policy":"http:\/\/dx.doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Both SEPT2 and MLL are down-regulated in MLL-SEPT2therapy-related myeloid neoplasia"],"prefix":"10.1186","volume":"9","author":[{"given":"Nuno","family":"Cerveira","sequence":"first","affiliation":[]},{"given":"Joana","family":"Santos","sequence":"additional","affiliation":[]},{"given":"Susana","family":"Bizarro","sequence":"additional","affiliation":[]},{"given":"Vera","family":"Costa","sequence":"additional","affiliation":[]},{"given":"Franclim R","family":"Ribeiro","sequence":"additional","affiliation":[]},{"given":"Susana","family":"Lisboa","sequence":"additional","affiliation":[]},{"given":"Cec\u00edlia","family":"Correia","sequence":"additional","affiliation":[]},{"given":"Lurdes","family":"Torres","sequence":"additional","affiliation":[]},{"given":"Joana","family":"Vieira","sequence":"additional","affiliation":[]},{"given":"Simone","family":"Snijder","sequence":"additional","affiliation":[]},{"given":"Jos\u00e9 M","family":"Mariz","sequence":"additional","affiliation":[]},{"given":"Luc\u00edlia","family":"Norton","sequence":"additional","affiliation":[]},{"given":"Clemens H","family":"Mellink","sequence":"additional","affiliation":[]},{"given":"Arjan","family":"Buijs","sequence":"additional","affiliation":[]},{"given":"Manuel R","family":"Teixeira","sequence":"additional","affiliation":[]}],"member":"297","published-online":{"date-parts":[[2009,5,15]]},"reference":[{"key":"1481_CR1","doi-asserted-by":"publisher","first-page":"478","DOI":"10.1038\/nrm2407","volume":"9","author":"CS Weirich","year":"2008","unstructured":"Weirich CS, Erzberger JP, Barral Y: The septin family of GTPases: architecture and dynamics. Nat Rev Mol Cell Biol. 2008, 9: 478-489. 10.1038\/nrm2407.","journal-title":"Nat Rev Mol Cell Biol"},{"key":"1481_CR2","doi-asserted-by":"publisher","first-page":"1120","DOI":"10.1038\/sj.embor.7401116","volume":"8","author":"AS Gladfelter","year":"2007","unstructured":"Gladfelter AS, Montagna C: Seeking truth on Monte Verita. Workshop on the molecular biology and biochemistry of septins and septin function. EMBO Rep. 2007, 8: 1120-1126. 10.1038\/sj.embor.7401116.","journal-title":"EMBO Rep"},{"key":"1481_CR3","doi-asserted-by":"publisher","first-page":"677","DOI":"10.1016\/j.devcel.2007.09.001","volume":"13","author":"E Joo","year":"2007","unstructured":"Joo E, Surka MC, Trimble WS: Mammalian SEPT2 is required for scaffolding nonmuscle myosin II and its kinases. Dev Cell. 2007, 13: 677-690. 10.1016\/j.devcel.2007.09.001.","journal-title":"Dev Cell"},{"key":"1481_CR4","doi-asserted-by":"publisher","first-page":"489","DOI":"10.1002\/path.1654","volume":"204","author":"PA Hall","year":"2004","unstructured":"Hall PA, Russell SE: The pathobiology of the septin gene family. J Pathol. 2004, 204: 489-505. 10.1002\/path.1654.","journal-title":"J Pathol"},{"key":"1481_CR5","doi-asserted-by":"publisher","first-page":"6147","DOI":"10.1038\/sj.onc.1209626","volume":"25","author":"N Cerveira","year":"2006","unstructured":"Cerveira N, Correia C, Bizarro S, Pinto C, Lisboa S, Mariz JM, Marques M, Teixeira MR: SEPT2 is a new fusion partner of MLL in acute myeloid leukemia with t(2;11)(q37;q23). Oncogene. 2006, 25: 6147-6152. 10.1038\/sj.onc.1209626.","journal-title":"Oncogene"},{"key":"1481_CR6","doi-asserted-by":"publisher","first-page":"72","DOI":"10.1016\/j.cancergencyto.2007.04.001","volume":"176","author":"E van Binsbergen","year":"2007","unstructured":"van Binsbergen E, de Weerdt O, Buijs A: A new subtype of MLL-SEPT2 fusion transcript in therapy-related acute myeloid leukemia with t(2;11)(q37;q23): a case report and literature review. Cancer Genet Cytogenet. 2007, 176: 72-75. 10.1016\/j.cancergencyto.2007.04.001.","journal-title":"Cancer Genet Cytogenet"},{"key":"1481_CR7","doi-asserted-by":"publisher","first-page":"149","DOI":"10.1016\/j.cancergencyto.2007.10.003","volume":"180","author":"S Snijder","year":"2008","unstructured":"Snijder S, Mellink CH, Lelie van der H: Translocation (2;11)(q37;q23) in therapy-related myelodysplastic syndrome after treatment for acute promyelocytic leukemia. Cancer Genet Cytogenet. 2008, 180: 149-152. 10.1016\/j.cancergencyto.2007.10.003.","journal-title":"Cancer Genet Cytogenet"},{"key":"1481_CR8","doi-asserted-by":"publisher","first-page":"62","DOI":"10.1016\/j.cancergencyto.2008.05.002","volume":"185","author":"N Cerveira","year":"2008","unstructured":"Cerveira N, Santos J, Pinheiro M, Snijder S, Lelie van der H, Mellink C, Teixeira MR: A novel MLL-SEPT2 fusion variant in therapy-related myelodysplastic syndrome. Cancer Genet Cytogenet. 2008, 185: 62-64. 10.1016\/j.cancergencyto.2008.05.002.","journal-title":"Cancer Genet Cytogenet"},{"key":"1481_CR9","doi-asserted-by":"publisher","first-page":"6413","DOI":"10.1073\/pnas.95.11.6413","volume":"95","author":"MD Megonigal","year":"1998","unstructured":"Megonigal MD, Rappaport EF, Jones DH, Williams TM, Lovett BD, Kelly KM, Lerou PH, Moulton T, Budarf ML, Felix CA: t(11;22)(q23;q11.2) in acute myeloid leukemia of infant twins fuses MLL with hCDCrel, a cell division cycle gene in the genomic region of deletion in DiGeorge and velocardiofacial syndromes. Proc Natl Acad Sci USA. 1998, 95: 6413-6418. 10.1073\/pnas.95.11.6413.","journal-title":"Proc Natl Acad Sci USA"},{"key":"1481_CR10","doi-asserted-by":"publisher","first-page":"6428","DOI":"10.1073\/pnas.96.11.6428","volume":"96","author":"M Osaka","year":"1999","unstructured":"Osaka M, Rowley JD, Zeleznik-Le NJ: MSF (MLL septin-like fusion), a fusion partner gene of MLL, in a therapy-related acute myeloid leukemia with a t(11;17)(q23;q25). Proc Natl Acad Sci USA. 1999, 96: 6428-6433. 10.1073\/pnas.96.11.6428.","journal-title":"Proc Natl Acad Sci USA"},{"key":"1481_CR11","first-page":"4261","volume":"59","author":"T Taki","year":"1999","unstructured":"Taki T, Ohnishi H, Shinohara K, Sako M, Bessho F, Yanagisawa M, Hayashi Y: AF17q25, a putative septin family gene, fuses the MLL gene in acute myeloid leukemia with t(11;17)(q23;q25). Cancer Res. 1999, 59: 4261-4265.","journal-title":"Cancer Res"},{"key":"1481_CR12","first-page":"333","volume":"62","author":"R Ono","year":"2002","unstructured":"Ono R, Taki T, Taketani T, Kawaguchi H, Taniwaki M, Okamura T, Kawa K, Hanada R, Kobayashi M, Hayashi Y: SEPTIN6, a human homologue to mouse Septin6, is fused to MLL in infant acute myeloid leukemia with complex chromosomal abnormalities involving 11q23 and Xq24. Cancer Res. 2002, 62: 333-337.","journal-title":"Cancer Res"},{"key":"1481_CR13","doi-asserted-by":"publisher","first-page":"998","DOI":"10.1038\/sj.leu.2403334","volume":"18","author":"K Kojima","year":"2004","unstructured":"Kojima K, Sakai I, Hasegawa A, Niiya H, Azuma T, Matsuo Y, Fujii N, Tanimoto M, Fujita S: FLJ10849, a septin family gene, fuses MLL in a novel leukemia cell line CNLBC1 derived from chronic neutrophilic leukemia in transformation with t(4;11)(q21;q23). Leukemia. 2004, 18: 998-1005. 10.1038\/sj.leu.2403334.","journal-title":"Leukemia"},{"key":"1481_CR14","volume-title":"ISCN 2005 An International System for Human Cytogenetic Nomenclature","author":"LG Shaffer","year":"1995","unstructured":"Shaffer LG, Tommerup N: ISCN 2005 An International System for Human Cytogenetic Nomenclature. 1995, Basel: Karger"},{"key":"1481_CR15","doi-asserted-by":"publisher","first-page":"1901","DOI":"10.1038\/sj.leu.2401592","volume":"13","author":"JJ van Dongen","year":"1999","unstructured":"van Dongen JJ, Macintyre EA, Gabert JA, Delabesse E, Rossi V, Saglio G, Gottardi E, Rambaldi A, Dotti G, Griesinger F, Parreira A, Gameiro P, Diaz MG, Malec M, Langerak AW, San Miguel JF, Biondi A: Standardized RT-PCR analysis of fusion gene transcripts from chromosome aberrations in acute leukemia for detection of minimal residual disease. Report of the BIOMED-1 Concerted Action: investigation of minimal residual disease in acute leukemia. Leukemia. 1999, 13: 1901-1928. 10.1038\/sj\/leu\/2401592.","journal-title":"Leukemia"},{"key":"1481_CR16","doi-asserted-by":"crossref","first-page":"2073","DOI":"10.1182\/blood.V86.6.2073.bloodjournal8662073","volume":"86","author":"T Chaplin","year":"1995","unstructured":"Chaplin T, Bernard O, Beverloo HB, Saha V, Hagemeijer A, Berger R, Young BD: The t(10;11) translocation in acute myeloid leukemia (M5) consistently fuses the leucine zipper motif of AF10 onto the HRX gene. Blood. 1995, 86: 2073-2076.","journal-title":"Blood"},{"key":"1481_CR17","doi-asserted-by":"crossref","first-page":"2496","DOI":"10.1182\/blood.V87.6.2496.bloodjournal8762496","volume":"87","author":"H Poirel","year":"1996","unstructured":"Poirel H, Rack K, Delabesse E, Radford-Weiss I, Troussard X, Debert C, Leboeuf D, Bastard C, Picard F, Veil-Buzyn A, Flandrin G, Bernard O, Macintyre E: Incidence and characterization of MLL gene (11q23) rearrangements in acute myeloid leukemia M1 and M5. Blood. 1996, 87: 2496-2505.","journal-title":"Blood"},{"key":"1481_CR18","doi-asserted-by":"publisher","first-page":"302","DOI":"10.1038\/sj.leu.2401299","volume":"13","author":"M Busson-Le Coniat","year":"1999","unstructured":"Busson-Le Coniat M, Salomon-Nguyen F, Hillion J, Bernard OA, Berger R: MLL-AF1q fusion resulting from t(1;11) in acute leukemia. Leukemia. 1999, 13: 302-306. 10.1038\/sj.leu.2401299.","journal-title":"Leukemia"},{"key":"1481_CR19","doi-asserted-by":"publisher","first-page":"218","DOI":"10.1038\/sj.leu.2404024","volume":"20","author":"LY Shih","year":"2006","unstructured":"Shih LY, Liang DC, Fu JF, Wu JH, Wang PN, Lin TL, Dunn P, Kuo MC, Tang TC, Lin TH, Lai CL: Characterization of fusion partner genes in 114 patients with de novo acute myeloid leukemia and MLL rearrangement. Leukemia. 2006, 20: 218-223. 10.1038\/sj.leu.2404024.","journal-title":"Leukemia"},{"key":"1481_CR20","doi-asserted-by":"publisher","first-page":"2318","DOI":"10.1038\/sj.leu.2403135","volume":"17","author":"J Gabert","year":"2003","unstructured":"Gabert J, Beillard E, Velden van der VH, Bi W, Grimwade D, Pallisgaard N, Barbany G, Cazzaniga G, Cayuela JM, Cav\u00e9 H, Pane F, Aerts JL, De Micheli D, Thirion X, Pradel V, Gonz\u00e1lez M, Viehmann S, Malec M, Saglio G, van Dongen JJ: Standardization and quality control studies of 'real-time' quantitative reverse transcriptase polymerase chain reaction of fusion gene transcripts for residual disease detection in leukemia \u2013 a Europe Against Cancer program. Leukemia. 2003, 17: 2318-2357. 10.1038\/sj.leu.2403135.","journal-title":"Leukemia"},{"key":"1481_CR21","doi-asserted-by":"publisher","first-page":"2474","DOI":"10.1038\/sj.leu.2403136","volume":"17","author":"E Beillard","year":"2003","unstructured":"Beillard E, Pallisgaard N, Velden van der VH, Bi W, Dee R, Schoot van der E, Delabesse E, Macintyre E, Gottardi E, Saglio G, Watzinger F, Lion T, van Dongen JJ, Hokland P, Gabert J: Evaluation of candidate control genes for diagnosis and residual disease detection in leukemic patients using 'real-time' quantitative reverse-transcriptase polymerase chain reaction (RQ-PCR) \u2013 a Europe against cancer program. Leukemia. 2003, 17: 2474-2486. 10.1038\/sj.leu.2403136.","journal-title":"Leukemia"},{"key":"1481_CR22","doi-asserted-by":"publisher","first-page":"2990","DOI":"10.1093\/nar\/22.15.2990","volume":"22","author":"SJ Clark","year":"1994","unstructured":"Clark SJ, Harrison J, Paul CL, Frommer M: High sensitivity mapping of methylated cytosines. Nucleic Acids Res. 1994, 22: 2990-2997. 10.1093\/nar\/22.15.2990.","journal-title":"Nucleic Acids Res"},{"key":"1481_CR23","first-page":"21","volume":"3","author":"D Takai","year":"2003","unstructured":"Takai D, Jones PA: The CpG island searcher. In Silico Biology. 2003, 3: 21-","journal-title":"In Silico Biology"},{"key":"1481_CR24","doi-asserted-by":"publisher","first-page":"923","DOI":"10.1006\/jmbi.1995.0349","volume":"249","author":"DS Prestridge","year":"1995","unstructured":"Prestridge DS: Predicting Pol II promoter sequences using transcription factor binding sites. J Mol Biol. 1995, 249: 923-932. 10.1006\/jmbi.1995.0349.","journal-title":"J Mol Biol"},{"key":"1481_CR25","doi-asserted-by":"publisher","first-page":"E32","DOI":"10.1093\/nar\/28.8.e32","volume":"28","author":"CA Eads","year":"2000","unstructured":"Eads CA, Danenberg KD, Kawakami K, Saltz LB, Blake C, Shibata D, Danenberg PV, Laird PW: MethyLight: a high-throughput assay to measure DNA methylation. Nucleic Acids Res. 2000, 28: E32-10.1093\/nar\/28.8.e32.","journal-title":"Nucleic Acids Res"},{"key":"1481_CR26","first-page":"3410","volume":"61","author":"CA Eads","year":"2001","unstructured":"Eads CA, Lord RV, Wickramasinghe K, Long TI, Kurumboor Sk, Bernstein L, Peters JH, DeMeester SR, DeMeester TR, Skinner KA, Laird PW: Epigenetic patterns in the progression of esophageal adenocarcinoma. Cancer Res. 2001, 61: 3410-3418.","journal-title":"Cancer Res"},{"key":"1481_CR27","doi-asserted-by":"publisher","first-page":"345","DOI":"10.1182\/blood-2005-01-0204","volume":"106","author":"SP Whitmann","year":"2005","unstructured":"Whitmann SP, Liu S, Vukosavljevic T, Rush LJ, Liu C, Klisovic MI, Maharry K, Guimond M, Strout MP, Becknell B, Dorrance A, Klisovic RB, Plass C, Bloomfield CD, Marcucci G, Caligiuri MA: The MLL partial tandem duplication: evidence for recessive gain-of-function in acute myeloid leukemia identifies a novel patient subgroup for molecular-targeted therapy. Blood. 2005, 106: 345-352. 10.1182\/blood-2005-01-0204.","journal-title":"Blood"},{"key":"1481_CR28","doi-asserted-by":"publisher","first-page":"1525","DOI":"10.1038\/sj.leu.2401534","volume":"13","author":"SA Schreiner","year":"1999","unstructured":"Schreiner SA, Garc\u00eda-Cu\u00e9llar MP, Fey GH, Slany RK: The leukemogenic fusion of MLL with ENL creates a novel transcriptional transactivator. Leukemia. 1999, 13: 1525-1533. 10.1038\/sj\/leu\/2401534.","journal-title":"Leukemia"},{"key":"1481_CR29","doi-asserted-by":"publisher","first-page":"359","DOI":"10.1038\/sj.leu.2402804","volume":"17","author":"BB Zeisig","year":"2003","unstructured":"Zeisig BB, Schreiner S, Garc\u00eda-Cu\u00e9llar MP, Slany RK: Transcriptional activation is a key function encoded by MLL fusion partners. Leukemia. 2003, 17: 359-365. 10.1038\/sj.leu.2402804.","journal-title":"Leukemia"},{"key":"1481_CR30","doi-asserted-by":"publisher","first-page":"1148","DOI":"10.1056\/NEJMra072067","volume":"358","author":"M Esteller","year":"2008","unstructured":"Esteller M: Epigenetics in cancer. N Engl J Med. 2008, 358: 1148-1159. 10.1056\/NEJMra072067.","journal-title":"N Engl J Med"},{"key":"1481_CR31","doi-asserted-by":"publisher","first-page":"1535","DOI":"10.1101\/gad.11.12.1535","volume":"11","author":"M Kinoshita","year":"1997","unstructured":"Kinoshita M, Kumar S, Mizoguchi A, Ide C, Kinoshita A, Haraguchi T, Hiraoka Y, Noda M: Nedd5, a mammalian septin, is a novel cytoskeletal component interacting with actin-based structures. Genes Dev. 1997, 11: 1535-1547. 10.1101\/gad.11.12.1535.","journal-title":"Genes Dev"},{"key":"1481_CR32","doi-asserted-by":"publisher","first-page":"1781","DOI":"10.1126\/science.1106823","volume":"307","author":"ET Spiliotis","year":"2005","unstructured":"Spiliotis ET, Kinoshita M, Nelson WJ: A mitotic septin scaffold required for Mammalian chromosome congression and segregation. Science. 2005, 307: 1781-1785. 10.1126\/science.1106823.","journal-title":"Science"},{"key":"1481_CR33","doi-asserted-by":"publisher","first-page":"4648","DOI":"10.1091\/mbc.E05-03-0267","volume":"16","author":"BE Kremer","year":"2005","unstructured":"Kremer BE, Haystead T, Macara IG: Mammalian septins regulate microtubule stability through interaction with the microtubule-binding protein MAP4. Mol Biol Cell. 2005, 16: 4648-4659. 10.1091\/mbc.E05-03-0267.","journal-title":"Mol Biol Cell"},{"key":"1481_CR34","doi-asserted-by":"publisher","first-page":"777","DOI":"10.1016\/j.cell.2007.06.053","volume":"130","author":"BE Kremer","year":"2007","unstructured":"Kremer BE, Haystead T, Macara IG: Septins regulate actin organization and cell-cycle arrest through nuclear accumulation of NCK mediated by SOCS7. Cell. 2007, 130: 777-779. 10.1016\/j.cell.2007.06.053.","journal-title":"Cell"},{"key":"1481_CR35","doi-asserted-by":"publisher","first-page":"5468","DOI":"10.1038\/sj.onc.1207725","volume":"23","author":"R Elhasid","year":"2004","unstructured":"Elhasid R, Sahar D, Merling A, Zivony Y, Rotem A, Ben-Arush M, Izraeli S, Bercovich D, Larisch S: Mitochondrial pro-apoptotic ARTS protein is lost in the majority of acute lymphoblastic leukemia patients. Oncogene. 2004, 23: 5468-5475. 10.1038\/sj.onc.1207725.","journal-title":"Oncogene"},{"key":"1481_CR36","doi-asserted-by":"publisher","first-page":"4494","DOI":"10.1158\/0008-5472.CAN-07-6509","volume":"68","author":"KL Bennett","year":"2008","unstructured":"Bennett KL, Karpenko M, Lin MT, Claus R, Arab K, Dyckhoff G, Plinkert P, Herpel E, Smiraglia D, Plass C: Frequently methylated tumor suppressor genes in head and neck squamous cell carcinoma. Cancer Res. 2008, 68: 4494-4499. 10.1158\/0008-5472.CAN-07-6509.","journal-title":"Cancer Res"},{"key":"1481_CR37","doi-asserted-by":"publisher","first-page":"777","DOI":"10.1038\/sj.leu.2404150","volume":"20","author":"C Meyer","year":"2006","unstructured":"Meyer C, Schneider B, Jakob S, Strehl S, Attarbaschi A, Schnittger S, Schoch C, Jansen MWJC, van Dongen JJM, den Boer ML, Pieters R, Ennas M-G, Angelucci E, Koehl U, Greil J, Griesinger F, zur Stadt U, Eckert C, Szczepa\u00f1ski T, Niggli FK, Sch\u00e4fer BW, Kempski H, Brady HJM, Zuna J, Trka J, Nigro LL, Biondi A, Delabesse E, Macintyre E, Stanulla M, Schrappe M, Haas OA, Burmeister T, Dingermann T, Klingebiel T, Marschalek R: The MLL recombinome of acute leukemias. Leukemia. 2006, 20: 777-784. 10.1038\/sj.leu.2404150.","journal-title":"Leukemia"},{"key":"1481_CR38","doi-asserted-by":"crossref","first-page":"3887","DOI":"10.1182\/blood.V96.12.3887","volume":"96","author":"JF DiMartino","year":"2000","unstructured":"DiMartino JF, Miller T, Ayton PM, Landewe T, Hess JL, Clearly ML, Shilatifard A: A carboxy-terminal domain of ELL is required and sufficient for immortalization of myeloid progenitors by MLL-ELL. Blood. 2000, 96: 3887-3893.","journal-title":"Blood"},{"key":"1481_CR39","doi-asserted-by":"publisher","first-page":"3780","DOI":"10.1182\/blood.V99.10.3780","volume":"99","author":"JF DiMartino","year":"2002","unstructured":"DiMartino JF, Ayton PM, Chen EH, Naftzger CC, Young BD, Clearly ML: The AF10 leucine zipper is required for leukemic transformation of myeloid progenitors by MLL-AF10. Blood. 2002, 99: 3780-3785. 10.1182\/blood.V99.10.3780.","journal-title":"Blood"}],"container-title":["BMC Cancer"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/1471-2407-9-147.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1186\/1471-2407-9-147\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/1471-2407-9-147","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/1471-2407-9-147.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,9,1]],"date-time":"2021-09-01T02:05:41Z","timestamp":1630461941000},"score":1,"resource":{"primary":{"URL":"https:\/\/bmccancer.biomedcentral.com\/articles\/10.1186\/1471-2407-9-147"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,5,15]]},"references-count":39,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2009,12]]}},"alternative-id":["1481"],"URL":"https:\/\/doi.org\/10.1186\/1471-2407-9-147","relation":{},"ISSN":["1471-2407"],"issn-type":[{"value":"1471-2407","type":"electronic"}],"subject":[],"published":{"date-parts":[[2009,5,15]]},"assertion":[{"value":"3 December 2008","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"15 May 2009","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"15 May 2009","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}}],"article-number":"147"}}