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Propolis has been shown to possess many biological and pharmacological properties, such as antimicrobial, antioxidant, immunostimulant and antitumor activities. Due to this bioactivity profile, this resin can become an alternative, economic and safe source of natural bioactive compounds.<\/jats:p>\n            <jats:p>Antitumor action has been reported <jats:italic>in vitro<\/jats:italic> and <jats:italic>in vivo<\/jats:italic> for propolis extracts or its isolated compounds; however, Portuguese propolis has been little explored. The aim of this work was to evaluate the <jats:italic>in vitro<\/jats:italic> antitumor activity of Portuguese propolis on the human colon carcinoma cell line HCT-15, assessing the effect of different fractions (hexane, chloroform and ethanol residual) of a propolis ethanol extract on cell viability, proliferation, metabolism and death.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Methods<\/jats:title>\n            <jats:p>Propolis from Angra do Hero\u00edsmo (Azores) was extracted with ethanol and sequentially fractionated in solvents with increasing polarity, n-hexane and chloroform. To assess cell viability, cell proliferation and cell death, Sulforhodamine B, BrDU incorporation assay and Anexin V\/Propidium iodide were used, respectively. Glycolytic metabolism was estimated using specific kits.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Results<\/jats:title>\n            <jats:p>All propolis samples exhibited a cytotoxic effect against tumor cells, in a dose- and time-dependent way. Chloroform fraction, the most enriched in phenolic compounds, appears to be the most active, both in terms of inhibition of viability and cell death. Data also show that this cytotoxicity involves disturbance in tumor cell glycolytic metabolism, seen by a decrease in glucose consumption and lactate production.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusion<\/jats:title>\n            <jats:p>Our results show that Portuguese propolis from Angra do Hero\u00edsmo (Azores) can be a potential therapeutic agent against human colorectal cancer.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1186\/1472-6882-13-184","type":"journal-article","created":{"date-parts":[[2013,7,19]],"date-time":"2013-07-19T14:14:32Z","timestamp":1374243272000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":23,"title":["Portuguese propolis disturbs glycolytic metabolism of human colorectal cancer in vitro"],"prefix":"10.1186","volume":"13","author":[{"given":"Isabel","family":"Valen\u00e7a","sequence":"first","affiliation":[]},{"given":"Filipa","family":"Morais-Santos","sequence":"additional","affiliation":[]},{"given":"Vera","family":"Miranda-Gon\u00e7alves","sequence":"additional","affiliation":[]},{"given":"Ana Margarida","family":"Ferreira","sequence":"additional","affiliation":[]},{"given":"Cristina","family":"Almeida-Aguiar","sequence":"additional","affiliation":[]},{"given":"F\u00e1tima","family":"Baltazar","sequence":"additional","affiliation":[]}],"member":"297","published-online":{"date-parts":[[2013,7,19]]},"reference":[{"key":"1432_CR1","doi-asserted-by":"publisher","first-page":"471","DOI":"10.1021\/np50028a007","volume":"46","author":"VS Bankova","year":"1983","unstructured":"Bankova VS, Popov SS, Marekov NL: A study on flavonoids of propolis. 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