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Brazilian flora, the most diverse in the world, is an interesting spot to prospect for new chemical leads, being an important source of new anticancer drugs. Plant-derived alkaloids have traditionally been of interest due to their pronounced physiological activities. We investigated the anti-angiogenic potential of the naturally occurring guanidine alkaloid pterogynidine (Pt) isolated from the Brazilian plant <jats:italic>Alchornea glandulosa<\/jats:italic>. The purpose of this study was to examine which features of the angiogenic process could be disturbed by Pt.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Methods<\/jats:title>\n            <jats:p>Human umbilical vein endothelial cells (HUVEC) were incubated with 8 \u03bcM Pt and cell viability, proliferation, apoptosis, invasion and capillary-like structures formation were addressed. Nuclear factor \u03baB (NF\u03baB), a transcription factor implicated in these processes, was also evaluated in HUVEC incubated with Pt. Quantifications were expressed as mean \u00b1 SD of five independent experiments and one-way analysis of variance (ANOVA) followed by the Dunnet test was used.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Results<\/jats:title>\n            <jats:p>A significant decrease in proliferation and invasion capacity and an effective increase in apoptosis as assessed by bromodeoxyuridine (BrdU), double-chamber and terminal transferase dUTP nick end labeling (TUNEL) assay, respectively, have been found. Pt also led to a drastic reduction in the number of capillary-like structures formation when HUVEC were cultured on growth factor reduced-Matrigel (GFR-Matrigel) coated plates. In addition, incubation of HUVEC with Pt resulted in reduced NF\u03baB activity.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusion<\/jats:title>\n            <jats:p>These findings emphasize the potential use of Pt against pathological situations where angiogenesis is stimulated as tumor development.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1186\/1472-6882-9-15","type":"journal-article","created":{"date-parts":[[2009,5,22]],"date-time":"2009-05-22T18:15:26Z","timestamp":1243016126000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Anti-angiogenic effects of pterogynidine alkaloid isolated from Alchornea glandulosa"],"prefix":"10.1186","volume":"9","author":[{"given":"Fl\u00e1via CM","family":"Lopes","sequence":"first","affiliation":[]},{"given":"Ana","family":"Rocha","sequence":"additional","affiliation":[]},{"given":"Ana","family":"Pirraco","sequence":"additional","affiliation":[]},{"given":"Luis O","family":"Regasini","sequence":"additional","affiliation":[]},{"given":"Dulce HS","family":"Silva","sequence":"additional","affiliation":[]},{"given":"Vanderlan S","family":"Bolzani","sequence":"additional","affiliation":[]},{"given":"Isabel","family":"Azevedo","sequence":"additional","affiliation":[]},{"given":"Iracilda Z","family":"Carlos","sequence":"additional","affiliation":[]},{"given":"Raquel","family":"Soares","sequence":"additional","affiliation":[]}],"member":"297","published-online":{"date-parts":[[2009,5,22]]},"reference":[{"key":"240_CR1","doi-asserted-by":"publisher","first-page":"27","DOI":"10.1038\/nm0195-27","volume":"1","author":"J Folkman","year":"1995","unstructured":"Folkman J: Angiogenesis in cancer, vascular, rheumatoid and other disease. 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