{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,26]],"date-time":"2026-02-26T02:12:59Z","timestamp":1772071979012,"version":"3.50.1"},"reference-count":70,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2013,4,5]],"date-time":"2013-04-05T00:00:00Z","timestamp":1365120000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/2.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Malar J"],"published-print":{"date-parts":[[2013,12]]},"DOI":"10.1186\/1475-2875-12-118","type":"journal-article","created":{"date-parts":[[2013,4,5]],"date-time":"2013-04-05T12:15:20Z","timestamp":1365164120000},"source":"Crossref","is-referenced-by-count":60,"title":["Artemisinin resistance in rodent malaria - mutation in the AP2 adaptor \u03bc-chain suggests involvement of endocytosis and membrane protein trafficking"],"prefix":"10.1186","volume":"12","author":[{"given":"Gisela","family":"Henriques","sequence":"first","affiliation":[]},{"given":"Axel","family":"Martinelli","sequence":"additional","affiliation":[]},{"given":"Louise","family":"Rodrigues","sequence":"additional","affiliation":[]},{"given":"Katarzyna","family":"Modrzynska","sequence":"additional","affiliation":[]},{"given":"Richard","family":"Fawcett","sequence":"additional","affiliation":[]},{"given":"Douglas R","family":"Houston","sequence":"additional","affiliation":[]},{"given":"Sofia T","family":"Borges","sequence":"additional","affiliation":[]},{"given":"Umberto","family":"d\u2019Alessandro","sequence":"additional","affiliation":[]},{"given":"Halidou","family":"Tinto","sequence":"additional","affiliation":[]},{"given":"Corine","family":"Karema","sequence":"additional","affiliation":[]},{"given":"Paul","family":"Hunt","sequence":"additional","affiliation":[]},{"given":"Pedro","family":"Cravo","sequence":"additional","affiliation":[]}],"member":"297","published-online":{"date-parts":[[2013,4,5]]},"reference":[{"key":"2766_CR1","doi-asserted-by":"publisher","first-page":"4688","DOI":"10.1111\/j.1742-4658.2007.05999.x","volume":"274","author":"JE Hyde","year":"2007","unstructured":"Hyde JE: Drug-resistant malaria-an insight. FEBS J. 2007, 274: 4688-4698. 10.1111\/j.1742-4658.2007.05999.x.","journal-title":"FEBS J"},{"key":"2766_CR2","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1002\/ddr.20344","volume":"71","author":"RJ Maude","year":"2010","unstructured":"Maude RJ, Woodrow CJ, White LJ: Artemisinin antimalarials: preserving the \"magic bullet\". Drug Dev Res. 2010, 71: 12-19.","journal-title":"Drug Dev Res"},{"key":"2766_CR3","doi-asserted-by":"publisher","first-page":"1705","DOI":"10.3390\/molecules15031705","volume":"15","author":"PM O'Neill","year":"2010","unstructured":"O'Neill PM, Barton VE, Ward SA: The molecular mechanism of action of artemisinin-the debate continues. Molecules. 2010, 15: 1705-1721. 10.3390\/molecules15031705.","journal-title":"Molecules"},{"key":"2766_CR4","doi-asserted-by":"publisher","first-page":"73","DOI":"10.1016\/j.pt.2010.11.006","volume":"27","author":"XC Ding","year":"2011","unstructured":"Ding XC, Beck HP, Raso G: Plasmodium sensitivity to artemisinins: magic bullets hit elusive targets. Trends Parasitol. 2011, 27: 73-81. 10.1016\/j.pt.2010.11.006.","journal-title":"Trends Parasitol"},{"key":"2766_CR5","doi-asserted-by":"publisher","first-page":"322","DOI":"10.1016\/j.bcp.2008.10.015","volume":"77","author":"CL Hartwig","year":"2009","unstructured":"Hartwig CL, Rosenthal AS, D'Angelo J, Griffin CE, Posner GH, Cooper RA: Accumulation of artemisinin trioxane derivatives within neutral lipids of Plasmodium falciparum malaria parasites is endoperoxide-dependent. Biochem Pharmacol. 2009, 77: 322-336. 10.1016\/j.bcp.2008.10.015.","journal-title":"Biochem Pharmacol"},{"issue":"52","key":"2766_CR6","doi-asserted-by":"publisher","first-page":"98","DOI":"10.1128\/AAC.00609-07","volume":"2008","author":"M del Pilar Crespo","year":"2008","unstructured":"del Pilar Crespo M, Avery TD, Hanssen E, Fox E, Robinson TV, Valente P, Taylor DK, Tilley L: Artemisinin and a series of novel endoperoxide antimalarials exert early effects on digestive vacuole morphology. Antimicrob Agents Chemother. 2008, 2008 (52): 98-109.","journal-title":"Antimicrob Agents Chemother"},{"key":"2766_CR7","doi-asserted-by":"publisher","first-page":"11405","DOI":"10.1073\/pnas.1104063108","volume":"108","author":"N Klonis","year":"2011","unstructured":"Klonis N, Crespo-Ortiz MP, Bottova I, Abu-Bakar N, Kenny S, Rosenthal PJ, Tilley L: Artemisinin activity against Plasmodium falciparum requires haemoglobin uptake and digestion. Proc Natl Acad Sci USA. 2011, 108: 11405-11410. 10.1073\/pnas.1104063108.","journal-title":"Proc Natl Acad Sci USA"},{"key":"2766_CR8","doi-asserted-by":"publisher","first-page":"957","DOI":"10.1038\/nature01813","volume":"424","author":"U Eckstein-Ludwig","year":"2003","unstructured":"Eckstein-Ludwig U, Webb RJ, Van Goethem ID, East JM, Lee AG, Kimura M, O'Neill PM, Bray PG, Ward SA, Krishna S: Artemisinins target the SERCA of Plasmodium falciparum. Nature. 2003, 424: 957-961. 10.1038\/nature01813.","journal-title":"Nature"},{"key":"2766_CR9","doi-asserted-by":"publisher","first-page":"2619","DOI":"10.1056\/NEJMc0805011","volume":"359","author":"H Noedl","year":"2008","unstructured":"Noedl H, Se Y, Schaecher K, Smith BL, Socheat D, Fukuda MM: Artemisinin Resistance in Cambodia 1 (ARC1) Study Consortium: Evidence of artemisinin-resistant malaria in western Cambodia. N Engl J Med. 2008, 359: 2619-2620. 10.1056\/NEJMc0805011.","journal-title":"N Engl J Med"},{"key":"2766_CR10","doi-asserted-by":"publisher","first-page":"455","DOI":"10.1056\/NEJMoa0808859","volume":"361","author":"AM Dondorp","year":"2009","unstructured":"Dondorp AM, Nosten F, Yi P, Das D, Phyo AP, Tarning J, Lwin KM, Ariey F, Hanpithakpong W, Lee SJ, Ringwald P, Silamut K, Imwong M, Chotivanich K, Lim P, Herdman T, An SS, Yeung S, Singhasivanon P, Day NPJ, Lindegardh N, Socheat D, White NJ: Artemisinin resistance in Plasmodium falciparum malaria. N Engl J Med. 2009, 361: 455-467. 10.1056\/NEJMoa0808859.","journal-title":"N Engl J Med"},{"key":"2766_CR11","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1186\/1475-2875-8-11","volume":"8","author":"P Lim","year":"2009","unstructured":"Lim P, Alker AP, Khim N, Shah NK, Incardona S, Doung S, Yi P, Bouth DM, Bouchier C, Puijalon OM, Meshnick SR, Wongsrichanalai C, Fandeur T, Le Bras J, Ringwald P, Ariey F: Pfmdr1 copy number and arteminisin derivatives combination therapy failure in falciparum malaria in Cambodia. Malar J. 2009, 8: 11-10.1186\/1475-2875-8-11.","journal-title":"Malar J"},{"key":"2766_CR12","doi-asserted-by":"publisher","first-page":"540","DOI":"10.1056\/NEJMc0900231","volume":"361","author":"H Noedl","year":"2009","unstructured":"Noedl H, Socheat D, Satimai W: Artemisinin-resistant malaria in Asia. N Engl J Med. 2009, 361: 540-541. 10.1056\/NEJMc0900231.","journal-title":"N Engl J Med"},{"key":"2766_CR13","doi-asserted-by":"publisher","first-page":"10","DOI":"10.1186\/1475-2875-8-10","volume":"8","author":"WO Rogers","year":"2009","unstructured":"Rogers WO, Sem R, Tero T, Chim P, Lim PS, Socheat D, Ariey F, Wongsrichanalai C: Failure of artesunate-mefloquine combination therapy for uncomplicated Plasmodium falciparum malaria in southern Cambodia. Malar J. 2009, 8: 10-10.1186\/1475-2875-8-10.","journal-title":"Malar J"},{"key":"2766_CR14","doi-asserted-by":"publisher","first-page":"1960","DOI":"10.1016\/S0140-6736(12)60484-X","volume":"379","author":"AP Phyo","year":"2012","unstructured":"Phyo AP, Nkhoma S, Stepniewska K, Ashley EA, Nair S, McGready R, Ler Moo C, Al-Saai S, Dondorp AM, Lwin KM, Singhasivanon P, Day NP, White NJ, Anderson TJ, Nosten F: Emergence of artemisinin-resistant malaria on the western border of Thailand: a longitudinal study. Lancet. 2012, 379: 1960-1966. 10.1016\/S0140-6736(12)60484-X.","journal-title":"Lancet"},{"key":"2766_CR15","doi-asserted-by":"publisher","first-page":"1960","DOI":"10.1016\/S0140-6736(05)67787-2","volume":"366","author":"R Jambou","year":"2005","unstructured":"Jambou R, Legrand E, Niang M, Khim N, Lim P, Volney B, Ekala MT, Bouchier C, Esterre P, Fandeur T, Mercereau-Puijalon OS: Resistance of Plasmodium falciparum field isolates to in-vitro artemether and point mutations of the SERCA-type PfATPase6. Lancet. 2005, 366: 1960-1963. 10.1016\/S0140-6736(05)67787-2.","journal-title":"Lancet"},{"key":"2766_CR16","doi-asserted-by":"publisher","first-page":"628","DOI":"10.1038\/nsmb947","volume":"12","author":"A-C Uhlemann","year":"2005","unstructured":"Uhlemann A-C, Cameron A, Eckstein-Ludwig U, Fischbarg J, Iserovich P, Zuniga FA, East M, Lee A, Brady L, Haynes RK, Krishna S: A single amino acid can determine sensitivity of SERCAs to artemisinins. Nat Struct Mol Biol. 2005, 12: 628-629. 10.1038\/nsmb947.","journal-title":"Nat Struct Mol Biol"},{"key":"2766_CR17","doi-asserted-by":"publisher","first-page":"906","DOI":"10.1038\/35002615","volume":"403","author":"MB Reed","year":"2000","unstructured":"Reed MB, Saliba KJ, Caruana SR, Kirk K, Cowman AF: Pgh1 modulates sensitivity and resistance to multiple antimalarials in Plasmodium falciparum. Nature. 2000, 403: 906-909. 10.1038\/35002615.","journal-title":"Nature"},{"key":"2766_CR18","doi-asserted-by":"publisher","first-page":"438","DOI":"10.1016\/S0140-6736(04)16767-6","volume":"364","author":"RN Price","year":"2004","unstructured":"Price RN, Uhlemann AC, Brockman A, McGready R, Ashley E, Phaipun L, Patel R, Laing K, Looareesuwan S, White NJ, Nosten F, Krishna S: Mefloquine resistance in Plasmodium falciparum and increased pfmdr1 gene copy number. Lancet. 2004, 364: 438-447. 10.1016\/S0140-6736(04)16767-6.","journal-title":"Lancet"},{"key":"2766_CR19","doi-asserted-by":"publisher","first-page":"528","DOI":"10.1086\/507115","volume":"194","author":"ABS Sidhu","year":"2006","unstructured":"Sidhu ABS, Uhlemann A-C, Valderramos SG, Valderramos J-C, Krishna S, Fidock DA: Decreasing pfmdr1 copy number in Plasmodium falciparum malaria heightens susceptibility to mefloquine, lumefantrine, halofantrine, quinine, and artemisinin. J Infect Dis. 2006, 194: 528-535. 10.1086\/507115.","journal-title":"J Infect Dis"},{"key":"2766_CR20","doi-asserted-by":"publisher","first-page":"2886","DOI":"10.1128\/AAC.00032-10","volume":"54","author":"M Imwong","year":"2010","unstructured":"Imwong M, Dondorp AM, Nosten F, Yi P, Mungthin M, Hanchana S, Das D, Phyo AP, Lwin KM, Pukrittayakamee S, Lee SJ, Saisung S, Koecharoen K, Nguon C, Day NP, Socheat D, White NJ: Exploring the contribution of candidate genes to artemisinin resistance in Plasmodium falciparum. Antimicrob Agents Chemother. 2010, 54: 2886-2892. 10.1128\/AAC.00032-10.","journal-title":"Antimicrob Agents Chemother"},{"key":"2766_CR21","doi-asserted-by":"publisher","first-page":"79","DOI":"10.1126\/science.1215966","volume":"336","author":"IH Cheeseman","year":"2012","unstructured":"Cheeseman IH, Miller BA, Nair S, Nkhoma S, Tan A, Tan JC, Al Saai S, Phyo AP, Moo CL, Lwin KM, McGready R, Ashley E, Imwong M, Stepniewska K, Yi P, Dondorp AM, Mayxay M, Newton PN, White NJ, Nosten F, Ferdig MT, Anderson TJ: A major genome region underlying artemisinin resistance in malaria. Science. 2012, 336: 79-82. 10.1126\/science.1215966.","journal-title":"Science"},{"key":"2766_CR22","doi-asserted-by":"publisher","first-page":"2455","DOI":"10.1128\/AAC.00947-09","volume":"54","author":"M Chavchich","year":"2010","unstructured":"Chavchich M, Gerena L, Peters J, Chen N, Cheng Q, Kyle DE: Induction of resistance to artemisinin derivatives in Plasmodium falciparum: Role of Pfmdr1 amplification and expression. Antimicrob Agent Chemother. 2010, 54: 2455-2464. 10.1128\/AAC.00947-09.","journal-title":"Antimicrob Agent Chemother"},{"key":"2766_CR23","doi-asserted-by":"publisher","first-page":"27","DOI":"10.1111\/j.1365-2958.2007.05753.x","volume":"65","author":"P Hunt","year":"2007","unstructured":"Hunt P, Afonso A, Creasey A, Culleton R, Sidhu AB, Logan J, Valderramos SG, McNae I, Cheesman S, Do Rosario V, Carter R, Fidock DA, Cravo P: Gene encoding a deubiquitinating enzyme is mutated in artesunate- and chloroquine-resistant rodent malaria parasites. Mol Microbiol. 2007, 65: 27-40. 10.1111\/j.1365-2958.2007.05753.x.","journal-title":"Mol Microbiol"},{"key":"2766_CR24","doi-asserted-by":"publisher","first-page":"50","DOI":"10.1128\/AAC.00916-10","volume":"55","author":"D Beez","year":"2011","unstructured":"Beez D, Sanchez CP, Stein WD, Lanzer M: Genetic predisposition favors the acquisition of stable artemisinin resistance in malaria parasites. Antimicrob Agents Chemother. 2011, 55: 50-55. 10.1128\/AAC.00916-10.","journal-title":"Antimicrob Agents Chemother"},{"key":"2766_CR25","doi-asserted-by":"publisher","first-page":"499","DOI":"10.1186\/1471-2164-11-499","volume":"11","author":"P Hunt","year":"2010","unstructured":"Hunt P, Martinelli A, Borges S, Modrzynska K, Creasey A, Rodrigues L, Beraldi D, Loewe L, Kumar S, Thomson M, Urmi T, Otto T, Pain A, Blaxter M, Cravo P: Experimental evolution, genetic analysis and genome re-sequencing reveals the mutation conferring artemisinin resistance in an isogenic lineage of malaria parasites. BMC Genomics. 2010, 11: 499-10.1186\/1471-2164-11-499.","journal-title":"BMC Genomics"},{"key":"2766_CR26","doi-asserted-by":"publisher","first-page":"106","DOI":"10.1186\/1471-2164-13-106","volume":"13","author":"K Modrzynska","year":"2012","unstructured":"Modrzynska K, Creasey A, Loewe L, Cezard T, Borges S, Martinelli A, Rodrigues L, Cravo P, Blaxter M, Carter R, Hunt P: Quantitative genome re-sequencing defines multiple mutations conferring chloroquine resistance in rodent malaria. BMC Genomics. 2012, 13: 106-10.1186\/1471-2164-13-106.","journal-title":"BMC Genomics"},{"key":"2766_CR27","doi-asserted-by":"publisher","first-page":"4858","DOI":"10.1128\/AAC.01748-10","volume":"55","author":"S Borges","year":"2011","unstructured":"Borges S, Cravo P, Creasey A, Fawcett R, Modrzynska K, Rodrigues L, Martinelli A, Hunt P: Genomewide scan reveals amplification of mdr1 as a common denominator of resistance to mefloquine, lumefantrine, and artemisinin in Plasmodium chabaudi malaria parasites. Antimicrob Agents Chemother. 2011, 55: 4858-4865. 10.1128\/AAC.01748-10.","journal-title":"Antimicrob Agents Chemother"},{"key":"2766_CR28","doi-asserted-by":"publisher","first-page":"165","DOI":"10.1016\/j.ijpara.2010.08.008","volume":"41","author":"A Martinelli","year":"2011","unstructured":"Martinelli A, Henriques G, Cravo P, Hunt P: Whole genome resequencing identifies a mutation in an ABC transporter (mdr2) in a Plasmodium chabaudi clone with altered sensitivity to antifolate drugs. Int J Parasitol. 2011, 41: 165-171. 10.1016\/j.ijpara.2010.08.008.","journal-title":"Int J Parasitol"},{"key":"2766_CR29","doi-asserted-by":"publisher","first-page":"480","DOI":"10.1128\/AAC.50.2.480-489.2006","volume":"50","author":"A Afonso","year":"2006","unstructured":"Afonso A, Hunt P, Cheesman S, Alves AC, Cunha CV, Do Ros\u00e1rio V, Cravo P: Malaria parasites can develop stable resistance to artemisinin but lack mutations in candidate genes atp6 (encoding the sarcoplasmic and endoplasmic reticutlum Ca2+ ATPase), tctp, mdr1 and cg10. Antimicrob Agents Chemother. 2006, 50: 480-489. 10.1128\/AAC.50.2.480-489.2006.","journal-title":"Antimicrob Agents Chemother"},{"key":"2766_CR30","doi-asserted-by":"publisher","first-page":"19","DOI":"10.1017\/S0031182000048824","volume":"70","author":"D Walliker","year":"1975","unstructured":"Walliker D, Carter R, Sanderson A: Genetic studies on Plasmodium chabaudi: recombination between enzyme markers. Parasitology. 1975, 70: 19-24. 10.1017\/S0031182000048824.","journal-title":"Parasitology"},{"key":"2766_CR31","doi-asserted-by":"publisher","first-page":"585","DOI":"10.1038\/261585a0","volume":"261","author":"VE Rosario","year":"1976","unstructured":"Rosario VE: Genetics of chloroquine resistance in malaria parasites. Nature. 1976, 261: 585-586. 10.1038\/261585a0.","journal-title":"Nature"},{"key":"2766_CR32","doi-asserted-by":"publisher","first-page":"419","DOI":"10.1016\/0014-4894(81)90101-6","volume":"52","author":"RA Padua","year":"1981","unstructured":"Padua RA: Plasmodium chabaudi: genetics of resistance to chloroquine. Exp Parasitol. 1981, 52: 419-426. 10.1016\/0014-4894(81)90101-6.","journal-title":"Exp Parasitol"},{"key":"2766_CR33","doi-asserted-by":"publisher","first-page":"709","DOI":"10.1128\/AAC.47.2.709-718.2003","volume":"47","author":"PVL Cravo","year":"2003","unstructured":"Cravo PVL, Carlton JM-R, Hunt P, Bisoni L, Padua RA, Walliker D: Genetics of mefloquine resistance in the rodent malaria Plasmodium chabaudi. Antimicrob Agents Chemother. 2003, 47: 709-718. 10.1128\/AAC.47.2.709-718.2003.","journal-title":"Antimicrob Agents Chemother"},{"key":"2766_CR34","doi-asserted-by":"publisher","first-page":"236","DOI":"10.1016\/S1471-4922(01)01899-2","volume":"17","author":"JM Carlton","year":"2001","unstructured":"Carlton JM, Hayton K, Cravo PV, Walliker D: Of mice and malaria mutants: unravelling the genetics of drug resistance using rodent malaria models. Trends Parasitol. 2001, 17: 236-242. 10.1016\/S1471-4922(01)01899-2.","journal-title":"Trends Parasitol"},{"key":"2766_CR35","doi-asserted-by":"publisher","first-page":"95","DOI":"10.1016\/S0166-6851(02)00142-1","volume":"123","author":"K Grech","year":"2002","unstructured":"Grech K, Martinelli A, Pathirana S, Walliker D, Hunt P, Carter R: Numerous, robust genetic markers for Plasmodium chabaudi by the method of amplified fragment length polymorphism. Mol Biochem Parasitol. 2002, 123: 95-104. 10.1016\/S0166-6851(02)00142-1.","journal-title":"Mol Biochem Parasitol"},{"key":"2766_CR36","unstructured":"Wellcome Trust Sanger Institute. http:\/\/ftp.sanger.ac.uk\/pub\/pathogens\/P_chabaudi\/Archive\/September_2009_assembly\/ ,"},{"key":"2766_CR37","doi-asserted-by":"publisher","first-page":"1851","DOI":"10.1101\/gr.078212.108","volume":"18","author":"H Li","year":"2008","unstructured":"Li H, Ruan J, Durbin R: Mapping short DNA sequencing reads and calling variants using mapping quality scores. Genome Res. 2008, 18: 1851-1858. 10.1101\/gr.078212.108.","journal-title":"Genome Res"},{"key":"2766_CR38","doi-asserted-by":"publisher","first-page":"1725","DOI":"10.1101\/gr.194201","volume":"11","author":"Z Ning","year":"2001","unstructured":"Ning Z, Cox AJ, Mullikin JC: SSAHA: a fast search method for large DNA databases. Genome Res. 2001, 11: 1725-1729. 10.1101\/gr.194201.","journal-title":"Genome Res"},{"key":"2766_CR39","doi-asserted-by":"publisher","first-page":"2078","DOI":"10.1093\/bioinformatics\/btp352","volume":"25","author":"H Li","year":"2009","unstructured":"Li H, Handsaker B, Wysoker A, Fennell T, Ruan J, Homer N, Marth G, Abecasis G, Durbin R: 1000 Genome Project Data Processing Subgroup: The Sequence alignment\/map (SAM) format and SAMtools. Bioinformatics. 2009, 25: 2078-2079. 10.1093\/bioinformatics\/btp352.","journal-title":"Bioinformatics"},{"key":"2766_CR40","doi-asserted-by":"publisher","first-page":"725","DOI":"10.1038\/nprot.2010.5","volume":"5","author":"R Ambrish","year":"2010","unstructured":"Ambrish R, Alper K, Yang Z: I-TASSER: a unified platform for automated protein structure and function prediction. Nat Prot. 2010, 5: 725-738. 10.1038\/nprot.2010.5.","journal-title":"Nat Prot"},{"key":"2766_CR41","doi-asserted-by":"crossref","first-page":"565","DOI":"10.4269\/ajtmh.1995.52.565","volume":"52","author":"CV Plowe","year":"1995","unstructured":"Plowe CV, Djimde A, Bouare M, Doumbo O, Wellems TE: Pyrimethamine and proguanil resistance-conferring mutations in Plasmodium falciparum dihydrofolate reductase: polymerase chain reaction methods for surveillance in Africa. Am J Trop Med Hyg. 1995, 52: 565-568.","journal-title":"Am J Trop Med Hyg"},{"key":"2766_CR42","doi-asserted-by":"publisher","first-page":"509","DOI":"10.1016\/j.trstmh.2005.09.018","volume":"100","author":"H Tinto","year":"2006","unstructured":"Tinto H, Rwagacondo C, Karema C, Mupfasoni D, Vandoren W, Rusanganwa E, Erhart A, Van Overmeir C, Van Marck E, D'Alessandro U: In-vitro susceptibility of Plasmodium falciparum to monodesethylamodiaquine, dihydroartemisinin and quinine in an area of high chloroquine resistance in Rwanda. Trans R Soc Trop Med Hyg. 2006, 100: 509-514. 10.1016\/j.trstmh.2005.09.018.","journal-title":"Trans R Soc Trop Med Hyg"},{"key":"2766_CR43","doi-asserted-by":"publisher","first-page":"353","DOI":"10.1111\/j.1365-3156.2006.01789.x","volume":"12","author":"ID Ferreira","year":"2007","unstructured":"Ferreira ID, Lopes D, Martinelli A, Ferreira C, Do Ros\u00e1rio VE, Cravo P: In vitro assessment of artesunate, artemether and amodiaquine susceptibility and molecular analysis of putative resistance-associated mutations of Plasmodium falciparum from S\u00e3o Tom\u00e9 & Pr\u00edncipe. Trop Med Int Health. 2007, 12: 353-362. 10.1111\/j.1365-3156.2006.01789.x.","journal-title":"Trop Med Int Health"},{"key":"2766_CR44","doi-asserted-by":"publisher","first-page":"199","DOI":"10.1111\/j.1365-3156.2007.01991.x","volume":"13","author":"ID Ferreira","year":"2008","unstructured":"Ferreira ID, Martinelli A, Rodrigues LA, Do Carmo EL, Do Ros\u00e1rio VE, Povoa MM, Cravo P: Plasmodium falciparum from Par\u00e1 state (Brazil) shows satisfactory in vitro response to artemisinin derivatives and absence of the S769N mutation in the SERCA-type PfATPase6. Trop Med Int Health. 2008, 13: 199-207. 10.1111\/j.1365-3156.2007.01991.x.","journal-title":"Trop Med Int Health"},{"key":"2766_CR45","doi-asserted-by":"publisher","first-page":"583","DOI":"10.1038\/nrm2751","volume":"10","author":"LM Traub","year":"2009","unstructured":"Traub LM: Tickets to ride: selecting cargo for clathrin-regulated internalisation. Nat Rev Mol Cell Biol. 2009, 10: 583-596. 10.1038\/nrm2751.","journal-title":"Nat Rev Mol Cell Biol"},{"key":"2766_CR46","doi-asserted-by":"publisher","first-page":"1691","DOI":"10.1534\/genetics.107.070805","volume":"176","author":"M Brandstr\u00f6m","year":"2007","unstructured":"Brandstr\u00f6m M, Ellegren H: The genomic landscape of short insertion and deletion polymorphisms in the chicken (Gallus gallus) Genome: a high frequency of deletions in tandem duplicates. Genetics. 2007, 176: 1691-1701. 10.1534\/genetics.107.070805.","journal-title":"Genetics"},{"key":"2766_CR47","doi-asserted-by":"publisher","first-page":"R180","DOI":"10.1186\/gb-2007-8-9-r180","volume":"8","author":"TG Clark","year":"2007","unstructured":"Clark TG, Andrew T, Cooper GM, Margulies EH, Mullikin JC, Balding DJ: Functional constraint and small insertions and deletions in the ENCODE regions of the human genome. Genome Biol. 2007, 8: R180-10.1186\/gb-2007-8-9-r180.","journal-title":"Genome Biol"},{"key":"2766_CR48","doi-asserted-by":"publisher","first-page":"1061","DOI":"10.1038\/nature09534","volume":"467","author":"1000 Genomes Project Consortium","year":"2010","unstructured":"1000 Genomes Project Consortium: A map of human genome variation from population-scale sequencing. Nature. 2010, 467: 1061-1073. 10.1038\/nature09534.","journal-title":"Nature"},{"key":"2766_CR49","doi-asserted-by":"publisher","first-page":"395","DOI":"10.1146\/annurev.biochem.72.121801.161800","volume":"72","author":"JS Bonifacino","year":"2003","unstructured":"Bonifacino JS, Traub LM: Signals for sorting of transmembrane proteins to endosomes and lysosomes. Annu Rev Biochem. 2003, 72: 395-447. 10.1146\/annurev.biochem.72.121801.161800.","journal-title":"Annu Rev Biochem"},{"key":"2766_CR50","doi-asserted-by":"publisher","first-page":"896","DOI":"10.1016\/S0960-9822(01)00240-8","volume":"11","author":"O Olusanya","year":"2001","unstructured":"Olusanya O, Andrews PD, Swedlow JR, Smythe E: Phosphorylation of threonine 156 of the mu2 subunit of AP2 complex is essential for endocytosis in vitro and in vivo. Curr Biol. 2001, 11: 896-900. 10.1016\/S0960-9822(01)00240-8.","journal-title":"Curr Biol"},{"key":"2766_CR51","doi-asserted-by":"publisher","first-page":"523","DOI":"10.1016\/S0092-8674(02)00735-3","volume":"109","author":"BM Collins","year":"2002","unstructured":"Collins BM, McCoy AJ, Kent HM, Evans PR, Owen DJ: Molecular Architecture and fundtional model of the endocytic AP2 complex. Cell. 2002, 109: 523-535. 10.1016\/S0092-8674(02)00735-3.","journal-title":"Cell"},{"key":"2766_CR52","doi-asserted-by":"publisher","first-page":"1220","DOI":"10.1016\/j.cell.2010.05.006","volume":"141","author":"LP Jackson","year":"2010","unstructured":"Jackson LP, Kelly BT, McCoy AJ, Gaffry T, James LC, Collins BM, H\u00f6ning S, Evans PR, Owen DJ: A large-scale conformational change couples membrane recruitment to cargo binding in the AP2 clathrin adaptor complex. Cell. 2010, 141: 1220-1229. 10.1016\/j.cell.2010.05.006.","journal-title":"Cell"},{"key":"2766_CR53","doi-asserted-by":"publisher","first-page":"153","DOI":"10.1146\/annurev.cellbio.20.010403.104543","volume":"20","author":"DJ Owen","year":"2004","unstructured":"Owen DJ, Collins BM, Evans PR: Adaptors for clathrin coats: structure and function. Ann Rev Cell Dev Biol. 2004, 20: 153-191. 10.1146\/annurev.cellbio.20.010403.104543.","journal-title":"Ann Rev Cell Dev Biol"},{"key":"2766_CR54","doi-asserted-by":"publisher","first-page":"3897","DOI":"10.1093\/emboj\/18.14.3897","volume":"18","author":"KM Heung","year":"1999","unstructured":"Heung KM, D\u2019Hondt K, Riezman H, Lemmon SK: Clathrin functions in the absence of heterotetrameric adaptors and AP180-related proteins in yeast. EMBO J. 1999, 18: 3897-3908. 10.1093\/emboj\/18.14.3897.","journal-title":"EMBO J"},{"key":"2766_CR55","doi-asserted-by":"publisher","first-page":"3643","DOI":"10.1091\/mbc.10.11.3643","volume":"10","author":"BG Yeung","year":"1999","unstructured":"Yeung BG, Phan HL, Payne GS: Adaptor complex-independent clathrin function in yeast. Mol Biol Cell. 1999, 10: 3643-3659.","journal-title":"Mol Biol Cell"},{"key":"2766_CR56","doi-asserted-by":"publisher","first-page":"1362","DOI":"10.1086\/656476","volume":"202","author":"F Teuscher","year":"2010","unstructured":"Teuscher F, Gatton ML, Chen N, Peters J, Kyle DE, Cheng Q: Artemisinin-induced dormancy in Plasmodium falciparum: duration, recovery rates, and implications in treatment failure. J Infect Dis. 2010, 202: 1362-1368. 10.1086\/656476.","journal-title":"J Infect Dis"},{"key":"2766_CR57","doi-asserted-by":"publisher","first-page":"1872","DOI":"10.1128\/AAC.01636-09","volume":"54","author":"B Witkowski","year":"2010","unstructured":"Witkowski B, Lelievre J, Barragan MJL, Laurent V, Su X-Z, Berry A, Francoise B: Increased tolerance to artemisinin in Plasmodium falciparum is mediated by a quiescence mechanism. Antimicrob Agents Chemother. 2010, 54: 1872-1877. 10.1128\/AAC.01636-09.","journal-title":"Antimicrob Agents Chemother"},{"key":"2766_CR58","doi-asserted-by":"publisher","first-page":"e1512","DOI":"10.1371\/journal.pntd.0001512","volume":"6","author":"AC Coelho","year":"2012","unstructured":"Coelho AC, Boisvert S, Mukherjee A, Leprohon P, Corbeil J, Ouellette M: Multiple mutations in heterogeneous miltefosine-resistant Leishmania major population as determined by whole genome sequencing. PLoS Negl Trop Dis. 2012, 6: e1512-10.1371\/journal.pntd.0001512.","journal-title":"PLoS Negl Trop Dis"},{"key":"2766_CR59","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1038\/nature10771","volume":"482","author":"S Alsford","year":"2012","unstructured":"Alsford S, Eckert S, Baker N, Glover L, Sanchez-Flores A, Leung KF, Turner DJ, Field MC, Berrriman M, Horn D: High-throughput decoding of antitrypanosomal drug efficacy and resistance. Nature. 2012, 482: 232-236.","journal-title":"Nature"},{"key":"2766_CR60","doi-asserted-by":"publisher","first-page":"441","DOI":"10.1242\/jcs.061499","volume":"123","author":"N Abu-Bakar","year":"2010","unstructured":"Abu-Bakar N, Klonis N, Hanssen E, Chan C, Tilley L: Digestive-vacuole genesis and endocytic processes in the early intraerythrocytic stages of Plasmodium falciparum. J Cell Sci. 2010, 123: 441-550. 10.1242\/jcs.061499.","journal-title":"J Cell Sci"},{"key":"2766_CR61","doi-asserted-by":"publisher","first-page":"2500","DOI":"10.1182\/blood-2009-08-238972","volume":"115","author":"A Vaid","year":"2010","unstructured":"Vaid A, Ranjan R, Smythe WA, Hoppe HC, Sharma P: PfPI3K, a phosphatidylinositol-3 kinase from Plasmodium falciparum, is exported to the host erythrocyte and is involved in haemoglobin trafficking. Blood. 2010, 115: 2500-2507. 10.1182\/blood-2009-08-238972.","journal-title":"Blood"},{"key":"2766_CR62","doi-asserted-by":"publisher","first-page":"2370","DOI":"10.1128\/AAC.48.7.2370-2378.2004","volume":"48","author":"HC Hoppe","year":"2004","unstructured":"Hoppe HC, van Schalkwyk DA, Wiehart UIM, Meredith SA, Egan J, Weber BW: Antimalarial quinolines and artemisinin inhibit endocytosis in Plasmodium falciparum. Antimicrob Agents Chemother. 2004, 48: 2370-2378. 10.1128\/AAC.48.7.2370-2378.2004.","journal-title":"Antimicrob Agents Chemother"},{"key":"2766_CR63","doi-asserted-by":"publisher","first-page":"1840","DOI":"10.1128\/AAC.01478-07","volume":"52","author":"L Roberts","year":"2008","unstructured":"Roberts L, Egan TJ, Joiner KA, Hoppe HC: Differential effects of quinoline antimalarials on endocytosis in Plasmodium falciparum. Antimicrob Agents Chemother. 2008, 52: 1840-1842. 10.1128\/AAC.01478-07.","journal-title":"Antimicrob Agents Chemother"},{"key":"2766_CR64","doi-asserted-by":"publisher","first-page":"236","DOI":"10.1016\/j.bcp.2011.04.018","volume":"82","author":"TS Feng","year":"2011","unstructured":"Feng TS, Guantai EM, Nell M, van Rensburgh CEJ, Ncokazi K, Egan TJ, Hoppe HC, Chibale K: Effects of highly active novel artemisinin-chloroquinoline hybrid compounds on @b-hematin formation, parasite morphology and endocytosis in Plasmodium falciparum. Biochem Pharmacol. 2011, 82: 236-247. 10.1016\/j.bcp.2011.04.018.","journal-title":"Biochem Pharmacol"},{"key":"2766_CR65","doi-asserted-by":"publisher","first-page":"236","DOI":"10.1111\/j.1600-0854.2009.01018.x","volume":"11","author":"Y Kuhn","year":"2010","unstructured":"Kuhn Y, Sanchez CP, Ayoub D, Saridaki T, van Dorsselaer A, Lanzer M: Trafficking of the phosphoprotein PfCRT to the digestive vacuolar membrane in Plasmodium falciparum. Traffic. 2010, 11: 236-249. 10.1111\/j.1600-0854.2009.01018.x.","journal-title":"Traffic"},{"key":"2766_CR66","doi-asserted-by":"publisher","first-page":"237","DOI":"10.1016\/0001-706X(93)90096-T","volume":"54","author":"ELM Vansterkenburg","year":"1993","unstructured":"Vansterkenburg ELM, Coppens I, Wilting J, Bos OJM, Fischer MJE, Janssen LHM, Opperdoes FR: The uptake of the trypanocidal drug suramin in combination with low-density lipoproteins by Trypanosoma brucei and its possible mode of action. Acta Trop. 1993, 54: 237-250. 10.1016\/0001-706X(93)90096-T.","journal-title":"Acta Trop"},{"key":"2766_CR67","doi-asserted-by":"publisher","first-page":"217","DOI":"10.1016\/S0166-6851(02)00096-8","volume":"122","author":"A Pal","year":"2002","unstructured":"Pal A, Hall BS, Field MC: Evidence for a non-LDL-mediated entry route for the trypanocidal drug suramin in Trypanosoma brucei. Mol Biochem Parasitol. 2002, 122: 217-221. 10.1016\/S0166-6851(02)00096-8.","journal-title":"Mol Biochem Parasitol"},{"key":"2766_CR68","doi-asserted-by":"publisher","first-page":"201","DOI":"10.1126\/science.1127085","volume":"315","author":"D Mukhopadhyay","year":"2007","unstructured":"Mukhopadhyay D, Riezman H: Proteasome-independent functions of ubiquitin in endocytosis and signaling. Science. 2007, 315: 201-215. 10.1126\/science.1127085.","journal-title":"Science"},{"key":"2766_CR69","first-page":"452","volume":"10","author":"WA Smythe","year":"2008","unstructured":"Smythe WA, Joiner KA, Hoppe HC: Actin is required for endocytic trafficking in the malaria parasite Plasmodium falciparum. Cell Microbiol. 2008, 10: 452-464.","journal-title":"Cell Microbiol"},{"issue":"1","key":"2766_CR70","doi-asserted-by":"publisher","first-page":"240","DOI":"10.1073\/pnas.1211205110","volume":"110","author":"S Takala-Harrison","year":"2013","unstructured":"Takala-Harrison S, Clark TG, Jacob CG, Cummings MP, Miotto O, Dondorp AM, Fukuda MM, Nosten F, Noedl H, Imwong M, Bethell D, Se Y, Lon C, Tyner SD, Saunders DL, Socheat D, Ariey F, Phyo AP, Starzengruber P, Fuehrer HP, Swoboda P, Stepniewska K, Flegg J, Arze C, Cerqueira GC, Silva JC, Ricklefs SM, Porcella SF, Stephens RM, Adams M, Kenefic LJ, Campino S, Auburn S, MacInnis B, Kwiatkowski DP, Su XZ, White NJ, Ringwald P, Plowe CV: Genetic loci associated with delayed clearance of Plasmodium falciparum following artemisinin treatment in Southeast Asia. Proc Natl Acad Sci USA. 2013, 110 (1): 240-245. 10.1073\/pnas.1211205110.","journal-title":"Proc Natl Acad Sci USA"}],"container-title":["Malaria Journal"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/1475-2875-12-118.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1186\/1475-2875-12-118\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/1475-2875-12-118.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,8]],"date-time":"2024-05-08T11:02:38Z","timestamp":1715166158000},"score":1,"resource":{"primary":{"URL":"https:\/\/malariajournal.biomedcentral.com\/articles\/10.1186\/1475-2875-12-118"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,4,5]]},"references-count":70,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2013,12]]}},"alternative-id":["2766"],"URL":"https:\/\/doi.org\/10.1186\/1475-2875-12-118","relation":{},"ISSN":["1475-2875"],"issn-type":[{"value":"1475-2875","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,4,5]]},"article-number":"118"}}