{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,8]],"date-time":"2026-02-08T07:12:44Z","timestamp":1770534764421,"version":"3.49.0"},"reference-count":38,"publisher":"Springer Science and Business Media LLC","issue":"1","content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Lipids Health Dis"],"published-print":{"date-parts":[[2014,12]]},"DOI":"10.1186\/1476-511x-13-16","type":"journal-article","created":{"date-parts":[[2014,1,15]],"date-time":"2014-01-15T12:03:38Z","timestamp":1389787418000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":121,"title":["LDL-cholesterol signaling induces breast cancer proliferation and invasion"],"prefix":"10.1186","volume":"13","author":[{"given":"Catarina","family":"Rodrigues dos Santos","sequence":"first","affiliation":[]},{"given":"Germana","family":"Domingues","sequence":"additional","affiliation":[]},{"given":"In\u00eas","family":"Matias","sequence":"additional","affiliation":[]},{"given":"Jo\u00e3o","family":"Matos","sequence":"additional","affiliation":[]},{"given":"Isabel","family":"Fonseca","sequence":"additional","affiliation":[]},{"given":"Jos\u00e9 Mendes","family":"de Almeida","sequence":"additional","affiliation":[]},{"given":"S\u00e9rgio","family":"Dias","sequence":"additional","affiliation":[]}],"member":"297","published-online":{"date-parts":[[2014,1,15]]},"reference":[{"issue":"5961","key":"1016_CR1","doi-asserted-by":"publisher","first-page":"46","DOI":"10.1126\/science.1174621","volume":"327","author":"D Lingwood","year":"2010","unstructured":"Lingwood D, Simons K: Lipid rafts as a membrane-organizing principle. Science. 2010, 327 (5961): 46-50. 10.1126\/science.1174621","journal-title":"Science"},{"issue":"10","key":"1016_CR2","doi-asserted-by":"publisher","first-page":"763","DOI":"10.1038\/nrc2222","volume":"7","author":"JA Menendez","year":"2007","unstructured":"Menendez JA, Lupu R: Fatty acid synthase and the lipogenic phenotype in cancer pathogenesis. Nat Rev Cancer. 2007, 7 (10): 763-777. 10.1038\/nrc2222","journal-title":"Nat Rev Cancer"},{"issue":"1","key":"1016_CR3","doi-asserted-by":"publisher","first-page":"49","DOI":"10.1016\/j.cell.2009.11.027","volume":"140","author":"DK Nomura","year":"2010","unstructured":"Nomura DK, Long JZ, Niessen S, Hoover HS, Ng SW, Cravatt BF: Monoacylglycerol lipase regulates a fatty acid network that promotes cancer pathogenesis. Cell. 2010, 140 (1): 49-61. 10.1016\/j.cell.2009.11.027","journal-title":"Cell"},{"issue":"8","key":"1016_CR4","doi-asserted-by":"publisher","first-page":"733","DOI":"10.1007\/s10585-011-9405-9","volume":"28","author":"CJ Antalis","year":"2011","unstructured":"Antalis CJ, Uchida A, Buhman KK, Siddiqui RA: Migration of MDA-MB-231 breast cancer cells depends on the availability of exogenous lipids and cholesterol esterification. Clin Exp Metastasis. 2011, 28 (8): 733-741. 10.1007\/s10585-011-9405-9","journal-title":"Clin Exp Metastasis"},{"key":"1016_CR5","first-page":"372","volume":"2","author":"G Swyer","year":"1942","unstructured":"Swyer G: The cholesterol content of normal and enlarged prostates. Cancer Res. 1942, 2: 372-375.","journal-title":"Cancer Res"},{"issue":"3","key":"1016_CR6","doi-asserted-by":"crossref","first-page":"621","DOI":"10.1016\/S0022-5347(17)52265-X","volume":"129","author":"RV Clayman","year":"1983","unstructured":"Clayman RV, Gonzalez R, Elliott AY, Gleason DE, Dempsey ME: Cholesterol accumulation in heterotransplanted renal cell cancer. J Urol. 1983, 129 (3): 621-624.","journal-title":"J Urol"},{"issue":"3","key":"1016_CR7","doi-asserted-by":"publisher","first-page":"661","DOI":"10.1007\/s10549-009-0594-8","volume":"122","author":"CJ Antalis","year":"2010","unstructured":"Antalis CJ, Arnold T, Rasool T, Lee B, Buhman KK, Siddiqui RA: High ACAT1 expression in estrogen receptor negative basal-like breast cancer cells is associated with LDL-induced proliferation. Breast Cancer Res Treat. 2010, 122 (3): 661-670. 10.1007\/s10549-009-0594-8","journal-title":"Breast Cancer Res Treat"},{"issue":"11","key":"1016_CR8","doi-asserted-by":"publisher","first-page":"2679","DOI":"10.1002\/ijc.24668","volume":"125","author":"H Iso","year":"2009","unstructured":"Iso H, Ikeda A, Inoue M, Sato S, Tsugane S: Serum cholesterol levels in relation to the incidence of cancer: the JPHC study cohorts. Int J Cancer. 2009, 125 (11): 2679-2686. 10.1002\/ijc.24668","journal-title":"Int J Cancer"},{"issue":"11","key":"1016_CR9","doi-asserted-by":"publisher","first-page":"861","DOI":"10.1016\/0021-9681(86)90034-2","volume":"39","author":"RA Hiatt","year":"1986","unstructured":"Hiatt RA, Fireman BH: Serum cholesterol and the incidence of cancer in a large cohort. J Chronic Dis. 1986, 39 (11): 861-870. 10.1016\/0021-9681(86)90034-2","journal-title":"J Chronic Dis"},{"issue":"5","key":"1016_CR10","doi-asserted-by":"publisher","first-page":"403","DOI":"10.1007\/BF00051352","volume":"3","author":"AP Hoyer","year":"1992","unstructured":"Hoyer AP, Engholm G: Serum lipids and breast cancer risk: a cohort study of 5, 207 Danish women. Cancer Causes Control. 1992, 3 (5): 403-408. 10.1007\/BF00051352","journal-title":"Cancer Causes Control"},{"issue":"19","key":"1016_CR11","doi-asserted-by":"publisher","first-page":"2264","DOI":"10.1001\/archinte.165.19.2264","volume":"165","author":"AH Eliassen","year":"2005","unstructured":"Eliassen AH, Colditz GA, Rosner B, Willett WC, Hankinson SE: Serum lipids, lipid-lowering drugs, and the risk of breast cancer. Arch Intern Med. 2005, 165 (19): 2264-2271. 10.1001\/archinte.165.19.2264","journal-title":"Arch Intern Med"},{"issue":"6","key":"1016_CR12","doi-asserted-by":"publisher","first-page":"501","DOI":"10.1007\/BF01831377","volume":"5","author":"M Gaard","year":"1994","unstructured":"Gaard M, Tretli S, Urdal P: Risk of breast cancer in relation to blood lipids: a prospective study of 31, 209 Norwegian women. Cancer Causes Control. 1994, 5 (6): 501-509. 10.1007\/BF01831377","journal-title":"Cancer Causes Control"},{"issue":"12","key":"1016_CR13","doi-asserted-by":"publisher","first-page":"1592","DOI":"10.1200\/JCO.2010.31.5200","volume":"29","author":"CM Kitahara","year":"2011","unstructured":"Kitahara CM, Berrington De Gonzalez A, Freedman ND, Huxley R, Mok Y, Jee SH, Samet JM: Total cholesterol and cancer risk in a large prospective study in Korea. J Clin Oncol. 2011, 29 (12): 1592-1598. 10.1200\/JCO.2010.31.5200","journal-title":"J Clin Oncol"},{"issue":"9","key":"1016_CR14","doi-asserted-by":"publisher","first-page":"1436","DOI":"10.1038\/sj.bjc.6600267","volume":"86","author":"JA Kaye","year":"2002","unstructured":"Kaye JA, Meier CR, Walker AM, Jick H: Statin use, hyperlipidaemia, and the risk of breast cancer. Br J Cancer. 2002, 86 (9): 1436-1439. 10.1038\/sj.bjc.6600267","journal-title":"Br J Cancer"},{"key":"1016_CR15","doi-asserted-by":"publisher","first-page":"671","DOI":"10.1038\/nmeth.2089","volume":"9","author":"CA Schneider","year":"2012","unstructured":"Schneider CA, Rasband WS, Eliceiri KW: NIH Image to ImageJ: 25 years of image analysis. Nature Methods. 2012, 9: 671-675.http:\/\/www.nature.com\/nmeth\/journal\/v9\/n7\/full\/nmeth.2089.html,  10.1038\/nmeth.2089","journal-title":"Nature Methods"},{"issue":"17","key":"1016_CR16","doi-asserted-by":"publisher","first-page":"1625","DOI":"10.1056\/NEJMoa021423","volume":"348","author":"EE Calle","year":"2003","unstructured":"Calle EE, Rodriguez C, Walker-Thurmond K, Thun MJ: Overweight, obesity, and mortality from cancer in a prospectively studied cohort of U.S. adults. N Engl J Med. 2003, 348 (17): 1625-1638. 10.1056\/NEJMoa021423","journal-title":"N Engl J Med"},{"issue":"2","key":"1016_CR17","doi-asserted-by":"publisher","first-page":"82","DOI":"10.1046\/j.1440-6047.2001.00229.x","volume":"10","author":"DR Sullivan","year":"2001","unstructured":"Sullivan DR: Cardiovascular risk in the Asia-Pacific region from a nutrition and metabolic point of view: visceral obesity. Asia Pac J Clin Nutr. 2001, 10 (2): 82-84. 10.1046\/j.1440-6047.2001.00229.x","journal-title":"Asia Pac J Clin Nutr"},{"issue":"11","key":"1016_CR18","doi-asserted-by":"publisher","first-page":"1124","DOI":"10.1056\/NEJMsa050467","volume":"353","author":"J He","year":"2005","unstructured":"He J, Gu D, Wu X, Reynolds K, Duan X, Yao C, Wang J, Chen CS, Chen J, Wildman RP: Major causes of death among men and women in China. N Engl J Med. 2005, 353 (11): 1124-1134. 10.1056\/NEJMsa050467","journal-title":"N Engl J Med"},{"issue":"6","key":"1016_CR19","doi-asserted-by":"publisher","first-page":"1420","DOI":"10.1172\/JCI39104","volume":"119","author":"R Kalluri","year":"2009","unstructured":"Kalluri R, Weinberg RA: The basics of epithelial-mesenchymal transition. J Clin Invest. 2009, 119 (6): 1420-1428. 10.1172\/JCI39104","journal-title":"J Clin Invest"},{"issue":"5","key":"1016_CR20","doi-asserted-by":"publisher","first-page":"875","DOI":"10.1002\/ijc.2910430523","volume":"43","author":"M Rotheneder","year":"1989","unstructured":"Rotheneder M, Kostner GM: Effects of low- and high-density lipoproteins on the proliferation of human breast cancer cells in vitro: differences between hormone-dependent and hormone-independent cell lines. Int J Cancer. 1989, 43 (5): 875-879. 10.1002\/ijc.2910430523","journal-title":"Int J Cancer"},{"issue":"9","key":"1016_CR21","first-page":"3704","volume":"42","author":"D Gospodarowicz","year":"1982","unstructured":"Gospodarowicz D, Lui GM, Gonzalez R: High-density lipoproteins and the proliferation of human tumor cells maintained on extracellular matrix-coated dishes and exposed to defined medium. Cancer Res. 1982, 42 (9): 3704-3713.","journal-title":"Cancer Res"},{"issue":"6","key":"1016_CR22","doi-asserted-by":"publisher","first-page":"515","DOI":"10.1016\/j.ccr.2006.10.008","volume":"10","author":"RM Neve","year":"2006","unstructured":"Neve RM, Chin K, Fridlyand J, Yeh J, Baehner FL, Fevr T, Clark L, Bayani N, Coppe JP, Tong F: A collection of breast cancer cell lines for the study of functionally distinct cancer subtypes. Cancer Cell. 2006, 10 (6): 515-527. 10.1016\/j.ccr.2006.10.008","journal-title":"Cancer Cell"},{"issue":"2 Supplement","key":"1016_CR23","first-page":"100","volume":"19","author":"CR Santos","year":"2012","unstructured":"Santos CR, Mendes Almeida JC, Dias S: Systemic LDL Promotes Breast Cancer Progression. Ann Surg Oncol. 2012, 19 (2 Supplement): 100-101.","journal-title":"Ann Surg Oncol"},{"issue":"4717","key":"1016_CR24","doi-asserted-by":"publisher","first-page":"974","DOI":"10.1126\/science.2992089","volume":"229","author":"CR King","year":"1985","unstructured":"King CR, Kraus MH, Aaronson SA: Amplification of a novel v-erbB-related gene in a human mammary carcinoma. Science. 1985, 229 (4717): 974-976. 10.1126\/science.2992089","journal-title":"Science"},{"issue":"32","key":"1016_CR25","doi-asserted-by":"publisher","first-page":"10315","DOI":"10.1021\/bi025943i","volume":"41","author":"LJ Pike","year":"2002","unstructured":"Pike LJ, Casey L: Cholesterol levels modulate EGF receptor-mediated signaling by altering receptor function and trafficking. Biochemistry. 2002, 41 (32): 10315-10322. 10.1021\/bi025943i","journal-title":"Biochemistry"},{"issue":"Pt 6","key":"1016_CR26","doi-asserted-by":"crossref","first-page":"1331","DOI":"10.1242\/jcs.115.6.1331","volume":"115","author":"T Ringerike","year":"2002","unstructured":"Ringerike T, Blystad FD, Levy FO, Madshus IH, Stang E: Cholesterol is important in control of EGF receptor kinase activity but EGF receptors are not concentrated in caveolae. J Cell Sci. 2002, 115 (Pt 6): 1331-1340.","journal-title":"J Cell Sci"},{"issue":"2","key":"1016_CR27","doi-asserted-by":"publisher","first-page":"1362","DOI":"10.1529\/biophysj.104.056192","volume":"89","author":"G Orr","year":"2005","unstructured":"Orr G, Hu D, Ozcelik S, Opresko LK, Wiley HS, Colson SD: Cholesterol dictates the freedom of EGF receptors and HER2 in the plane of the membrane. Biophys J. 2005, 89 (2): 1362-1373. 10.1529\/biophysj.104.056192","journal-title":"Biophys J"},{"issue":"51","key":"1016_CR28","doi-asserted-by":"publisher","first-page":"49631","DOI":"10.1074\/jbc.M208327200","volume":"277","author":"X Chen","year":"2002","unstructured":"Chen X, Resh MD: Cholesterol depletion from the plasma membrane triggers ligand-independent activation of the epidermal growth factor receptor. J Biol Chem. 2002, 277 (51): 49631-49637. 10.1074\/jbc.M208327200","journal-title":"J Biol Chem"},{"issue":"1","key":"1016_CR29","doi-asserted-by":"publisher","first-page":"402","DOI":"10.1016\/j.ajpath.2010.11.005","volume":"178","author":"G Llaverias","year":"2011","unstructured":"Llaverias G, Danilo C, Mercier I, Daumer K, Capozza F, Williams TM, Sotgia F, Lisanti MP, Frank PG: Role of cholesterol in the development and progression of breast cancer. Am J Pathol. 2011, 178 (1): 402-412. 10.1016\/j.ajpath.2010.11.005","journal-title":"Am J Pathol"},{"issue":"6","key":"1016_CR30","doi-asserted-by":"publisher","first-page":"3180","DOI":"10.2353\/ajpath.2010.100568","volume":"177","author":"G Llaverias","year":"2010","unstructured":"Llaverias G, Danilo C, Wang Y, Witkiewicz AK, Daumer K, Lisanti MP, Frank PG: A Western-type diet accelerates tumor progression in an autochthonous mouse model of prostate cancer. Am J Pathol. 2010, 177 (6): 3180-3191. 10.2353\/ajpath.2010.100568","journal-title":"Am J Pathol"},{"issue":"10","key":"1016_CR31","doi-asserted-by":"publisher","first-page":"1504","DOI":"10.1038\/sj.bjc.6603756","volume":"96","author":"E De Azambuja","year":"2007","unstructured":"De Azambuja E, Cardoso F, De Castro G, Colozza M, Mano MS, Durbecq V, Sotiriou C, Larsimont D, Piccart-Gebhart MJ, Paesmans M: Ki-67 as prognostic marker in early breast cancer: a meta-analysis of published studies involving 12, 155 patients. Br J Cancer. 2007, 96 (10): 1504-1513. 10.1038\/sj.bjc.6603756","journal-title":"Br J Cancer"},{"issue":"1","key":"1016_CR32","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1016\/S0021-9150(98)00141-5","volume":"140","author":"BR Krause","year":"1998","unstructured":"Krause BR, Princen HM: Lack of predictability of classical animal models for hypolipidemic activity: a good time for mice?. Atherosclerosis. 1998, 140 (1): 15-24. 10.1016\/S0021-9150(98)00141-5","journal-title":"Atherosclerosis"},{"issue":"30","key":"1016_CR33","doi-asserted-by":"publisher","first-page":"4808","DOI":"10.1200\/JCO.2006.06.3560","volume":"24","author":"S Bonovas","year":"2006","unstructured":"Bonovas S, Filioussi K, Tsavaris N, Sitaras NM: Statins and cancer risk: a literature-based meta-analysis and meta-regression analysis of 35 randomized controlled trials. J Clin Oncol. 2006, 24 (30): 4808-4817. 10.1200\/JCO.2006.06.3560","journal-title":"J Clin Oncol"},{"issue":"1","key":"1016_CR34","doi-asserted-by":"publisher","first-page":"74","DOI":"10.1001\/jama.295.1.74","volume":"295","author":"KM Dale","year":"2006","unstructured":"Dale KM, Coleman CI, Henyan NN, Kluger J, White CM: Statins and cancer risk: a meta-analysis. JAMA. 2006, 295 (1): 74-80. 10.1001\/jama.295.1.74","journal-title":"JAMA"},{"issue":"19","key":"1016_CR35","doi-asserted-by":"publisher","first-page":"1792","DOI":"10.1056\/NEJMoa1201735","volume":"367","author":"SF Nielsen","year":"2012","unstructured":"Nielsen SF, Nordestgaard BG, Bojesen SE: Statin use and reduced cancer-related mortality. N Engl J Med. 2012, 367 (19): 1792-1802. 10.1056\/NEJMoa1201735","journal-title":"N Engl J Med"},{"key":"1016_CR36","doi-asserted-by":"publisher","first-page":"574","DOI":"10.1056\/NEJMc1214827","volume":"368","author":"SF Nielsen","year":"2013","unstructured":"Nielsen SF, Nordestgaard BG, Bojesen SE: Correspondence. Statin Use and Reduced Cancer-Related Mortality. N Engl J Med. 2013, 368: 574-577. February 7, 2013. DOI: 10.1056\/NEJMc1214827,","journal-title":"N Engl J Med"},{"issue":"34","key":"1016_CR37","doi-asserted-by":"publisher","first-page":"15051","DOI":"10.1073\/pnas.0910258107","volume":"107","author":"JW Clendening","year":"2010","unstructured":"Clendening JW, Pandyra A, Boutros PC, El Ghamrasni S, Khosravi F, Trentin GA, Martirosyan A, Hakem A, Hakem R, Jurisica I: Dysregulation of the mevalonate pathway promotes transformation. Proceedings of the National Academy of Sciences of the United States of America. 2010, 107 (34): 15051-15056. 10.1073\/pnas.0910258107","journal-title":"Proceedings of the National Academy of Sciences of the United States of America"},{"issue":"2","key":"1016_CR38","doi-asserted-by":"publisher","first-page":"499","DOI":"10.1007\/s10549-013-2473-6","volume":"138","author":"O Bjarnadottir","year":"2013","unstructured":"Bjarnadottir O, Romero Q, Bendahl PO, Jirstrom K, Ryden L, Loman N, Uhlen M, Johannesson H, Rose C, Grabau D: Targeting HMG-CoA reductase with statins in a window-of-opportunity breast cancer trial. Breast Cancer Res Treat. 2013, 138 (2): 499-508. 10.1007\/s10549-013-2473-6","journal-title":"Breast Cancer Res Treat"}],"container-title":["Lipids in Health and Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/1476-511X-13-16.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,9,2]],"date-time":"2021-09-02T19:15:32Z","timestamp":1630610132000},"score":1,"resource":{"primary":{"URL":"https:\/\/lipidworld.biomedcentral.com\/articles\/10.1186\/1476-511X-13-16"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,1,15]]},"references-count":38,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2014,12]]}},"alternative-id":["1016"],"URL":"https:\/\/doi.org\/10.1186\/1476-511x-13-16","relation":{},"ISSN":["1476-511X"],"issn-type":[{"value":"1476-511X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,1,15]]},"assertion":[{"value":"4 October 2013","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"10 January 2014","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"15 January 2014","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}}],"article-number":"16"}}