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Specific subcutaneous immunotherapy (SCIT) provides clear immunologic modulation in some immune cells, however its systemic effects on basophils are not well known.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Methods<\/jats:title>\n            <jats:p>Peripheral blood (PB) samples from 43 patients with allergic rhinitis mono-sensitized to <jats:italic>Dermatophagoides pteronyssinus<\/jats:italic> (Dpt) [33 of them under SCIT with allergoid Dpt extract, in maintenance dose (SCIT), with evaluation just before SCIT injection (SCIT-T0) and 4\u00a0hours later (SCIT-T4) and the other 10 Dpt allergic patients never having, in the past, undergone specific immunotherapy treatment (NSIT)], and 15 healthy age- and gender-matched controls (HG), were analyzed. For each sample, the total (t-IgE) and specific IgE (s-IgE) was performed, as well as, the relative frequency and absolute number of PB basophils and receptor-bound IgE and IgG expression were evaluated by flow cytometry and the <jats:italic>Histamine N-methyltransferase<\/jats:italic> (<jats:italic>HNMT<\/jats:italic>) and tryptase \u03b1\/\u03b21 (<jats:italic>TPSAB1<\/jats:italic>) gene expression was assessed by real-time PCR.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Results<\/jats:title>\n            <jats:p>Higher levels of receptor-bound IgE were observed in SCIT patients, which are correlated with the levels of serum t-IgE and s-IgE, whereas no significant differences were observed for receptor-bound IgG. Regarding <jats:italic>HNMT<\/jats:italic> mRNA expression, significantly lower expression levels were detected in AR patients compared to HG, independently of type of therapy. Moreover a negative correlation was found between <jats:italic>HNMT<\/jats:italic> gene expression and time under SCIT. Conversely, tryptase gene expression was significantly up-regulated in NSIT when compared to HG; however in SCIT patients, tryptase gene expression was significantly decreased than in NSIT patients. No differences were found for any parameter between SCIT-T0 and SCIT-T4 with exception of a transient increased expression of tryptase in SCIT-T4.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusion<\/jats:title>\n            <jats:p>PB basophils from patients with AR show altered functional features, which seems to be influenced by SCIT, suggesting that these cells could be useful to clarify the SCIT triggered mechanisms at a systemic level.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1186\/1710-1492-9-40","type":"journal-article","created":{"date-parts":[[2013,10,11]],"date-time":"2013-10-11T16:04:59Z","timestamp":1381507499000},"update-policy":"http:\/\/dx.doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Impact of allergic rhinitis and specific subcutaneous immunotherapy on peripheral blood basophils of patients sensitized to Dermatophagoides pteronyssinus"],"prefix":"10.1186","volume":"9","author":[{"given":"Ana","family":"Lopes","sequence":"first","affiliation":[]},{"given":"Patr\u00edcia","family":"Azenha","sequence":"additional","affiliation":[]},{"given":"Cristina","family":"Teod\u00f3sio","sequence":"additional","affiliation":[]},{"given":"Maria","family":"In\u00e1cio","sequence":"additional","affiliation":[]},{"given":"Isabel","family":"Silva","sequence":"additional","affiliation":[]},{"given":"Gra\u00e7a","family":"Loureiro","sequence":"additional","affiliation":[]},{"given":"Ant\u00f3nio","family":"Martinho","sequence":"additional","affiliation":[]},{"given":"Ant\u00f3nio S","family":"Lu\u00eds","sequence":"additional","affiliation":[]},{"given":"H\u00e9lder","family":"Trindade","sequence":"additional","affiliation":[]},{"given":"Celso","family":"Pereira","sequence":"additional","affiliation":[]},{"given":"Artur","family":"Paiva","sequence":"additional","affiliation":[]}],"member":"297","published-online":{"date-parts":[[2013,10,11]]},"reference":[{"key":"397_CR1","doi-asserted-by":"publisher","first-page":"S103","DOI":"10.1016\/j.jaci.2009.12.989","volume":"125","author":"MS Dykewicz","year":"2010","unstructured":"Dykewicz MS, Hamilos DL: Rhinitis and sinusitis. 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