{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,3]],"date-time":"2026-03-03T21:32:46Z","timestamp":1772573566061,"version":"3.50.1"},"reference-count":39,"publisher":"Springer Science and Business Media LLC","issue":"1","content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Nutr Metab (Lond)"],"published-print":{"date-parts":[[2011,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n          <jats:sec>\n            <jats:title>Background<\/jats:title>\n            <jats:p>Obesity is a chronic disease associated to an inflammatory process resulting in oxidative stress that leads to morpho-functional microvascular damage that could be improved by some dietary interventions. In this study, the intake of Brazil nuts (<jats:italic>Bertholletia excelsa<\/jats:italic>), composed of bioactive substances like selenium, \u03b1- e \u03b3- tocopherol, folate and polyunsaturated fatty acids, have been investigated on antioxidant capacity, lipid and metabolic profiles and nutritive skin microcirculation in obese adolescents.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Methods<\/jats:title>\n            <jats:p>Obese female adolescents (n = 17), 15.4 \u00b1 2.0 years and BMI of 35.6 \u00b1 3.3 kg\/m<jats:sup>2<\/jats:sup>, were randomized 1:1 in two groups with the diet supplemented either with Brazil nuts [BNG, n = 08, 15-25 g\/day (equivalent to 3 to 5 units\/day)] or placebo [PG (lactose), n = 09, one capsule\/day] and followed for 16 weeks. Anthropometry, metabolic-lipid profiles, oxidative stress and morphological (capillary diameters) and functional [functional capillary density, red blood cell velocity (RBCV) at baseline and peak (RBCV<jats:sub>max<\/jats:sub>) and time (TRBCV<jats:sub>max<\/jats:sub>) to reach it during post-occlusive reactive hyperemia, after 1 min arterial occlusion] microvascular variables were assessed by nailfold videocapillaroscopy at baseline (T0) and after intervention (T1).<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Results<\/jats:title>\n            <jats:p>T0 characteristics were similar between groups. At T1, BNG (intra-group variation) had increased selenium levels (<jats:italic>p<\/jats:italic> = 0.02), RBCV (<jats:italic>p<\/jats:italic> = 0.03) and RBCV<jats:sub>max<\/jats:sub> (<jats:italic>p<\/jats:italic> = 0.03) and reduced total (TC) (<jats:italic>p<\/jats:italic> = 0.02) and LDL-cholesterol (<jats:italic>p<\/jats:italic> = 0.02). Compared to PG, Brazil nuts intake reduced TC (<jats:italic>p<\/jats:italic> = 0.003), triglycerides (<jats:italic>p<\/jats:italic> = 0.05) and LDL-ox (<jats:italic>p<\/jats:italic> = 0.02) and increased RBCV (<jats:italic>p<\/jats:italic> = 0.03).<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusion<\/jats:title>\n            <jats:p>Brazil nuts intake improved the lipid profile and microvascular function in obese adolescents, possibly due to its high level of unsaturated fatty acids and bioactive substances.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Trial Registration<\/jats:title>\n            <jats:p>\n              <jats:bold>Clinical Trials.gov<\/jats:bold>\n              <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"http:\/\/www.clinicaltrials.gov\/ct2\/show\/NCT00937599\" ext-link-type=\"uri\">NCT00937599<\/jats:ext-link>\n            <\/jats:p>\n          <\/jats:sec>","DOI":"10.1186\/1743-7075-8-32","type":"journal-article","created":{"date-parts":[[2011,5,31]],"date-time":"2011-05-31T06:14:27Z","timestamp":1306822467000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":73,"title":["Brazil nuts intake improves lipid profile, oxidative stress and microvascular function in obese adolescents: a randomized controlled trial"],"prefix":"10.1186","volume":"8","author":[{"given":"Priscila A","family":"Maranh\u00e3o","sequence":"first","affiliation":[]},{"given":"Luiz G","family":"Kraemer-Aguiar","sequence":"additional","affiliation":[]},{"given":"Cecilia L","family":"de Oliveira","sequence":"additional","affiliation":[]},{"given":"Maria CC","family":"Kuschnir","sequence":"additional","affiliation":[]},{"given":"Yasmine R","family":"Vieira","sequence":"additional","affiliation":[]},{"given":"Maria GC","family":"Souza","sequence":"additional","affiliation":[]},{"given":"Josely C","family":"Koury","sequence":"additional","affiliation":[]},{"given":"Eliete","family":"Bouskela","sequence":"additional","affiliation":[]}],"member":"297","published-online":{"date-parts":[[2011,5,28]]},"reference":[{"key":"332_CR1","doi-asserted-by":"publisher","first-page":"1999","DOI":"10.1161\/01.CIR.0000161369.71722.10","volume":"111","author":"SR Daniels","year":"2005","unstructured":"Daniels SR, Arnett DK, Eckel RH, Gidding SS, Hayman LL, Kumanyika S: Overweight in children and adolescents: pathophysiology, consequences, prevention, and treatment. 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