{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,5]],"date-time":"2026-02-05T11:11:54Z","timestamp":1770289914969,"version":"3.49.0"},"reference-count":21,"publisher":"Springer Science and Business Media LLC","issue":"1","content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Occup Med Toxicol"],"published-print":{"date-parts":[[2011,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n          <jats:sec>\n            <jats:title>Introduction<\/jats:title>\n            <jats:p>Results of systematic screening of healthcare workers (HCWs) for tuberculosis (TB) with the tuberculin skin test (TST) and interferon-\u03b3 release assays (IGRA) in a Portuguese hospital from 2007 to 2010 are reported.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Methods<\/jats:title>\n            <jats:p>All HCWs are offered screening for TB. Screening is repeated depending on risk assessment. TST and QuantiFERON Gold In-Tube (QFT) are used simultaneously. X-ray is performed when TST is &gt; 10 mm, IGRA is positive or typical symptoms exist.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Results<\/jats:title>\n            <jats:p>The cohort comprises 2,889 HCWs. TST and IGRA were positive in 29.5%, TST-positive but IGRA-negative results were apparent in 43.4%. Active TB was diagnosed in twelve HCWs - eight cases were detected during screening and four cases were predicted by IGRA as well as by TST. However, the progression rate in IGRA-positive was higher than in TST-positive HCWs (0.4% vs. 0.2%, p-value 0.06).<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusions<\/jats:title>\n            <jats:p>The TB burden in this cohort was high (129.8 per 100,000 HCWs). However, the progression to active TB after a positive TST or positive IGRA was considerably lower than that reported in literature for close contacts in low-incidence countries. This may indicate that old LTBI prevails in these HCWs.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1186\/1745-6673-6-19","type":"journal-article","created":{"date-parts":[[2011,6,10]],"date-time":"2011-06-10T05:27:26Z","timestamp":1307683646000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":33,"title":["Screening for tuberculosis and prediction of disease in Portuguese healthcare workers"],"prefix":"10.1186","volume":"6","author":[{"given":"Jos\u00e9","family":"Torres Costa","sequence":"first","affiliation":[]},{"given":"Rui","family":"Silva","sequence":"additional","affiliation":[]},{"given":"Felix C","family":"Ringshausen","sequence":"additional","affiliation":[]},{"given":"Albert","family":"Nienhaus","sequence":"additional","affiliation":[]}],"member":"297","published-online":{"date-parts":[[2011,6,9]]},"reference":[{"issue":"RR-17","key":"169_CR1","first-page":"1","volume":"54","author":"PA Jensen","year":"2005","unstructured":"Jensen PA, Lambert LA, Iademarco MF, Ridzon R: Guidelines for preventing the transmission of Mycobacterium tuberculosis in Healthcare Settings. 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