{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,22]],"date-time":"2025-10-22T17:49:51Z","timestamp":1761155391402},"reference-count":41,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2010,6,22]],"date-time":"2010-06-22T00:00:00Z","timestamp":1277164800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/2.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Radiat Oncol"],"published-print":{"date-parts":[[2010,12]]},"DOI":"10.1186\/1748-717x-5-57","type":"journal-article","created":{"date-parts":[[2010,6,22]],"date-time":"2010-06-22T18:13:57Z","timestamp":1277230437000},"source":"Crossref","is-referenced-by-count":13,"title":["Radiobiological evaluation of forward and inverse IMRT using different fractionations for head and neck tumours"],"prefix":"10.1186","volume":"5","author":[{"given":"Brigida C","family":"Ferreira","sequence":"first","affiliation":[]},{"given":"Maria","family":"do Carmo Lopes","sequence":"additional","affiliation":[]},{"given":"Josefina","family":"Mateus","sequence":"additional","affiliation":[]},{"given":"Miguel","family":"Capela","sequence":"additional","affiliation":[]},{"given":"Panayiotis","family":"Mavroidis","sequence":"additional","affiliation":[]}],"member":"297","published-online":{"date-parts":[[2010,6,22]]},"reference":[{"key":"263_CR1","doi-asserted-by":"publisher","first-page":"156","DOI":"10.1016\/j.radonc.2007.04.002","volume":"85","author":"R Corv\u00f2","year":"2007","unstructured":"Corv\u00f2 R: Evidence-based radiation oncology in head and neck squamous cell carcinoma. Radiother Oncol 2007, 85: 156-70. 10.1016\/j.radonc.2007.04.002","journal-title":"Radiother Oncol"},{"key":"263_CR2","doi-asserted-by":"publisher","first-page":"725","DOI":"10.1080\/02841860152619142","volume":"40","author":"A Brahme","year":"2001","unstructured":"Brahme A, Nilsson J, Belkic D: Biologically optimized radiation therapy. Acta Oncol 2001, 40: 725-34. 10.1080\/02841860152619142","journal-title":"Acta Oncol"},{"issue":"4","key":"263_CR3","doi-asserted-by":"publisher","first-page":"981","DOI":"10.1016\/j.ijrobp.2006.06.013","volume":"66","author":"EH Pow","year":"2006","unstructured":"Pow EH, Kwong DL, McMillan AS, Wong MC, Sham JS, Leung LH, Leung WK: Xerostomia and quality of life after intensity-modulated radiotherapy vs. conventional radiotherapy for early-stage nasopharyngeal carcinoma: initial report on a randomized controlled clinical trial. Int J Radiat Oncol Biol Phys 2006,66(4):981-91.","journal-title":"Int J Radiat Oncol Biol Phys"},{"issue":"2","key":"263_CR4","doi-asserted-by":"publisher","first-page":"178","DOI":"10.1053\/j.semradonc.2003.12.008","volume":"14","author":"MA List","year":"2004","unstructured":"List MA, Bilir SP: Functional outcomes in head and neck cancer. Semin Radiat Oncol 2004,14(2):178-89. 10.1053\/j.semradonc.2003.12.008","journal-title":"Semin Radiat Oncol"},{"issue":"4","key":"263_CR5","doi-asserted-by":"publisher","first-page":"367","DOI":"10.1016\/S1470-2045(08)70098-6","volume":"9","author":"L Veldeman","year":"2008","unstructured":"Veldeman L, Madani I, Hulstaert F, De Meerleer G, Mareel M, De Neve W: Evidence behind use of intensity-modulated radiotherapy: a systematic review of comparative clinical studies. Lancet Oncol 2008,9(4):367-75. 10.1016\/S1470-2045(08)70098-6","journal-title":"Lancet Oncol"},{"key":"263_CR6","doi-asserted-by":"publisher","first-page":"271","DOI":"10.1016\/0167-8140(96)01784-7","volume":"40","author":"W De Neve","year":"1996","unstructured":"De Neve W, De Wagter C, De Jaeger K, Thienpont M, Colle C, Derycke S, Schelfhout J: Planning and delivering high doses to targets surrounding the spinal cord at the lower neck and upper mediastinal levels: static beam-segmentation technique executed with a multileaf collimator. Radiother Oncol 1996, 40: 271-9. 10.1016\/0167-8140(96)01784-7","journal-title":"Radiother Oncol"},{"key":"263_CR7","doi-asserted-by":"publisher","first-page":"251","DOI":"10.1016\/j.radonc.2003.08.002","volume":"69","author":"W B\u00e4r","year":"2003","unstructured":"B\u00e4r W, Schwarz M, Alber M, Bos LJ, Mijnheer BJ, Rasch C, Schneider C, N\u00fcsslin F, Damen EM: A comparison of forward and inverse treatment planning for intensity-modulated radiotherapy of head and neck cancer. Radiother Oncol 2003, 69: 251-8. 10.1016\/j.radonc.2003.08.002","journal-title":"Radiother Oncol"},{"key":"263_CR8","volume-title":"First International Symposium on Target volume definition in radiation oncology, Head and Neck, Breast, Lung and Prostate Cancer","author":"IC Kiricuta","year":"2001","unstructured":"Kiricuta IC: First International Symposium on Target volume definition in radiation oncology, Head and Neck, Breast, Lung and Prostate Cancer. Limburg, Germany; 2001."},{"issue":"2","key":"263_CR9","doi-asserted-by":"publisher","first-page":"584","DOI":"10.1016\/j.ijrobp.2004.02.005","volume":"59","author":"N Lee","year":"2004","unstructured":"Lee N, Akazawa C, Akazawa P, Quivey JM, Tang C, Verhey LJ, Xia P: A forward-planned treatment technique using multisegments in the treatment of head-and-neck cancer. Int J Radiat Oncol Biol Phys 2004,59(2):584-94.","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"263_CR10","volume-title":"Ph.D. Thesis","author":"J Rosello","year":"2006","unstructured":"Rosello J: Planificaci\u00f3n de tratamientos radioter\u00e1picos con intensidad modulada basados en la perspectiva de la anatom\u00eda que tiene el haz para su conformaci\u00f3n y fluencia. In Ph.D. Thesis. Spain: Seville University; 2006."},{"issue":"5","key":"263_CR11","doi-asserted-by":"publisher","first-page":"1480","DOI":"10.1016\/S0360-3016(03)01569-4","volume":"57","author":"N Dogan","year":"2003","unstructured":"Dogan N, King S, Emami B, Mohideen N, Mirkovic N, Leybovich LB, Sethi A: Assessment of different IMRT boost delivery methods on target coverage and normal-tissue sparing. Int J Radiat Oncol Biol Phys 2003,57(5):1480-91.","journal-title":"Int J Radiat Oncol Biol Phys"},{"issue":"3","key":"263_CR12","doi-asserted-by":"publisher","first-page":"267","DOI":"10.1016\/j.radonc.2003.10.003","volume":"69","author":"A Fogliata","year":"2003","unstructured":"Fogliata A, Bolsi A, Cozzi L, Bernier J: Comparative dosimetric evaluation of the simultaneous integrated boost with photon intensity modulation in head and neck cancer patients. Radiother Oncol 2003,69(3):267-75. 10.1016\/j.radonc.2003.10.003","journal-title":"Radiother Oncol"},{"issue":"2","key":"263_CR13","doi-asserted-by":"publisher","first-page":"148","DOI":"10.1016\/j.radonc.2005.09.011","volume":"77","author":"B Longobardi","year":"2005","unstructured":"Longobardi B, De Martin E, Fiorino C, Dell'oca I, Broggi S, Cattaneo GM, Calandrino R: Comparing 3DCRT and inversely optimized IMRT planning for head and neck cancer: equivalence between step-and-shoot and sliding window techniques. Radiother Oncol 2005,77(2):148-56. 10.1016\/j.radonc.2005.09.011","journal-title":"Radiother Oncol"},{"issue":"9","key":"263_CR14","doi-asserted-by":"publisher","first-page":"497","DOI":"10.1007\/s00066-007-1698-x","volume":"183","author":"C Fiorino","year":"2007","unstructured":"Fiorino C, Dell'Oca I, Pierelli A, Broggi S, Cattaneo GM, Chiara A, De Martin E, Di Muzio N, Fazio F, Calandrino R: Simultaneous integrated boost (SIB) for nasopharynx cancer with helical tomotherapy. Strahlenther Onkol 2007,183(9):497-505. 10.1007\/s00066-007-1698-x","journal-title":"Strahlenther Onkol"},{"key":"263_CR15","doi-asserted-by":"publisher","first-page":"21","DOI":"10.1016\/S0360-3016(99)00101-7","volume":"45","author":"EB Butler","year":"1999","unstructured":"Butler EB, Teh BS, Grant WH, Uhl BM, Kuppersmith RB, Chiu JK, Donovan DT, Woo SY: Smart (simultaneous modulated accelerated radiation therapy) boost: a new accelerated fractionation schedule for the treatment of head and neck cancer with intensity modulated radiotherapy. Int J Radiat Oncol Biol Phys 1999, 45: 21-32.","journal-title":"Int J Radiat Oncol Biol Phys"},{"issue":"2","key":"263_CR16","doi-asserted-by":"publisher","first-page":"374","DOI":"10.1016\/j.ijrobp.2004.03.010","volume":"60","author":"A Lauve","year":"2004","unstructured":"Lauve A, Morris M, Schmidt-Ullrich R, Wu Q, Mohan R, Abayomi O, Buck D, Holdford D, Dawson K, Dinardo L, Reiter E: Simultaneous integrated boost intensity-modulated radiotherapy for locally advanced head-and-neck squamous cell carcinomas: II-clinical results. Int J Radiat Oncol Biol Phys 2004,60(2):374-87.","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"263_CR17","doi-asserted-by":"publisher","first-page":"966","DOI":"10.1016\/j.ijrobp.2006.06.040","volume":"66","author":"NY Lee","year":"2006","unstructured":"Lee NY, de Arruda FF, Puri DR, Wu Q, Mohan R, Abayomi O, Buck D, Holdford D, Dawson K, Dinardo L, Reiter E: A comparison of intensity-modulated radiation therapy and concomitant boost radiotherapy in the setting of concurrent chemotherapy for locally advanced oropharyngeal carcinoma. Int J Radiat Oncol Biol Phys 2006, 66: 966-974.","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"263_CR18","first-page":"1","volume":"31","author":"G Studer","year":"2006","unstructured":"Studer G, Huguenin PU, Davis JB, Kunz G, L\u00fctolf UM, Glanzmann C: IMRT using simultaneously integrated boost (SIB) in head and neck cancer patients. Radiat Oncol 2006, 31: 1-7.","journal-title":"Radiat Oncol"},{"issue":"3","key":"263_CR19","doi-asserted-by":"publisher","first-page":"431","DOI":"10.1080\/02841860802372272","volume":"48","author":"KF Ho","year":"2009","unstructured":"Ho KF, Fowler JF, Sykes AJ, Yap BK, Lee LW, Slevin NJ: IMRT dose fractionation for head and neck cancer: variation in current approaches will make standardisation difficult. Acta Oncol 2009,48(3):431-9. 10.1080\/02841860802372272","journal-title":"Acta Oncol"},{"issue":"3","key":"263_CR20","doi-asserted-by":"publisher","first-page":"619","DOI":"10.1016\/S0360-3016(99)00438-1","volume":"46","author":"R Mohan","year":"2000","unstructured":"Mohan R, Wu Q, Manning M, Schmidt-Ullrich R: Radiobiological considerations in the design of fractionation strategies for intensity-modulated radiation therapy of head and neck cancers. Int J Radiat Oncol Biol Phys 2000,46(3):619-30.","journal-title":"Int J Radiat Oncol Biol Phys"},{"issue":"2","key":"263_CR21","doi-asserted-by":"publisher","first-page":"111","DOI":"10.1016\/j.critrevonc.2009.03.003","volume":"73","author":"E Orlandi","year":"2009","unstructured":"Orlandi E, Palazzi M, Pignoli E, Fallai C, Giostra A, Olmi P: Radiobiological basis and clinical results of the simultaneous integrated boost (SIB) in intensity modulated radiotherapy (IMRT) for head and neck cancer: A review. Crit Rev Oncol Hematol 2009,73(2):111-125. 10.1016\/j.critrevonc.2009.03.003","journal-title":"Crit Rev Oncol Hematol"},{"key":"263_CR22","doi-asserted-by":"publisher","first-page":"113","DOI":"10.1016\/j.clon.2007.11.003","volume":"20","author":"JF Fowler","year":"2008","unstructured":"Fowler JF: Optimum overall times II: Extended Modelling for head and neck radiotherapy. Clinical Oncol 2008, 20: 113-126. 10.1016\/j.clon.2007.11.003","journal-title":"Clinical Oncol"},{"issue":"1","key":"263_CR23","doi-asserted-by":"publisher","first-page":"64","DOI":"10.1016\/j.radonc.2008.04.008","volume":"89","author":"AC Houweling","year":"2008","unstructured":"Houweling AC, Dijkema T, Roesink JM, Terhaard CH, Raaijmakers CP: Sparing the contralateral submandibular gland in oropharyngeal cancer patients: a planning study. Radiother Oncol 2008,89(1):64-70. 10.1016\/j.radonc.2008.04.008","journal-title":"Radiother Oncol"},{"issue":"1","key":"263_CR24","doi-asserted-by":"publisher","first-page":"145","DOI":"10.1016\/S0360-3016(03)00075-0","volume":"56","author":"MK Kam","year":"2003","unstructured":"Kam MK, Chau RM, Suen J, Choi PH, Teo PM: Intensity-modulated radiotherapy in nasopharyngeal carcinoma: dosimetric advantage over conventional plans and feasibility of dose escalation. Int J Radiat Oncol Biol Phys 2003,56(1):145-57.","journal-title":"Int J Radiat Oncol Biol Phys"},{"issue":"3","key":"263_CR25","doi-asserted-by":"publisher","first-page":"577","DOI":"10.1016\/S0360-3016(99)00247-3","volume":"45","author":"A Eisbruch","year":"1999","unstructured":"Eisbruch A, Ten Haken RK, Kim HM, Marsh LH, Ship JA: Dose, volume, and function relationships in parotid salivary glands following conformal and intensity-modulated irradiation of head and neck cancer. Int J Radiat Oncol Biol Phys 1999,45(3):577-87.","journal-title":"Int J Radiat Oncol Biol Phys"},{"issue":"1","key":"263_CR26","doi-asserted-by":"publisher","first-page":"151","DOI":"10.1016\/0360-3016(95)00113-D","volume":"33","author":"S S\u00f6derstr\u00f6m","year":"1995","unstructured":"S\u00f6derstr\u00f6m S, Brahme A: Which is the most suitable number of photon beam portals in coplanar radiation therapy? Int J Radiat Oncol Biol Phys 1995,33(1):151-9.","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"263_CR27","doi-asserted-by":"publisher","first-page":"679","DOI":"10.1259\/0007-1285-62-740-679","volume":"62","author":"JF Fowler","year":"1989","unstructured":"Fowler JF: The linear quadratic formula and progress in fractionated radiotherapy. Br J Radiol 1989, 62: 679-694. 10.1259\/0007-1285-62-740-679","journal-title":"Br J Radiol"},{"issue":"9388","key":"263_CR28","doi-asserted-by":"publisher","first-page":"933","DOI":"10.1016\/S0140-6736(03)14361-9","volume":"362","author":"J Overgaard","year":"2003","unstructured":"Overgaard J, Hansen HS, Specht L, Overgaard M, Grau C, Andersen E, Bentzen J, Bastholt L, Hansen O, Johansen J, Andersen L, Evensen JF: Five compared with six fractions per week of conventional radiotherapy of squamous-cell carcinoma of head and neck: DAHANCA 6 and 7 randomised controlled trial. Lancet 2003,362(9388):933-40. 10.1016\/S0140-6736(03)14361-9","journal-title":"Lancet"},{"key":"263_CR29","doi-asserted-by":"publisher","first-page":"843","DOI":"10.1016\/S0140-6736(06)69121-6","volume":"368","author":"J Bourhis","year":"2006","unstructured":"Bourhis J, Overgaard J, Audry H, Ang KK, Saunders M, Bernier J, Horiot JC, Le Ma\u00eetre A, Pajak TF, Poulsen MG, O'Sullivan B, Dobrowsky W, Hliniak A, Skladowski K, Hay JH, Pinto LH, Fallai C, Fu KK, Sylvester R, Pignon JP, Meta-Analysis of Radiotherapy in Carcinomas of Head and neck (MARCH) Collaborative Group: Hyperfractionated or accelerated radiotherapy in head and neck cancer: a meta-analysis. Lancet 2006, 368: 843-54. 10.1016\/S0140-6736(06)69121-6","journal-title":"Lancet"},{"issue":"2","key":"263_CR30","doi-asserted-by":"publisher","first-page":"131","DOI":"10.3109\/02841868809090333","volume":"27","author":"HR Withers","year":"1988","unstructured":"Withers HR, Taylor JM, Maciejewski B: The hazard of accelerated tumor clonogen repopulation during radiotherapy. Acta Oncol 1988,27(2):131-46. 10.3109\/02841868809090333","journal-title":"Acta Oncol"},{"issue":"4","key":"263_CR31","doi-asserted-by":"publisher","first-page":"1227","DOI":"10.1016\/0360-3016(94)00475-Z","volume":"32","author":"P Okunieff","year":"1995","unstructured":"Okunieff P, Morgan D, Niemierko A, Suit HD: Radiation dose-response of human tumors. Int J Radiat Oncol Biol Phys 1995,32(4):1227-37.","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"263_CR32","volume-title":"Ph.D. Thesis","author":"A \u00c5gren","year":"1995","unstructured":"\u00c5gren A: Quantification of the response of heterogeneous tumours and organized normal tissues to fractionated radiotherapy. In Ph.D. Thesis. Stockholm University; 1995."},{"issue":"2","key":"263_CR33","doi-asserted-by":"publisher","first-page":"373","DOI":"10.1016\/S0360-3016(99)00420-4","volume":"46","author":"G Gagliardi","year":"2000","unstructured":"Gagliardi G, Bjohle J, Lax I, Ottolenghi A, Eriksson F, Liedberg A, Lind P, Rutqvist LE: Radiation pneumonitis after breast cancer irradiation: analysis of the complication probability using the relative seriality model. Int J Radiat Oncol Biol Phys 2000,46(2):373-81. 10.1016\/S0360-3016(99)00420-4","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"263_CR34","doi-asserted-by":"publisher","first-page":"865","DOI":"10.1080\/02841860310012833","volume":"42","author":"P Mavroidis","year":"2003","unstructured":"Mavroidis P, Laurell G, Kraepelien T, Fernberg JO, Lind BK, Brahme A: Determination and clinical verification of dose-response parameters for esophageal stricture from head and neck radiotherapy. Acta Oncol 2003, 42: 865-81. 10.1080\/02841860310012833","journal-title":"Acta Oncol"},{"issue":"2","key":"263_CR35","doi-asserted-by":"publisher","first-page":"249","DOI":"10.1080\/09553009214552071","volume":"62","author":"P K\u00e4llman","year":"1992","unstructured":"K\u00e4llman P, Agren A, Brahme A: Tumour and normal tissue responses to fractionated non-uniform dose delivery. Int J Radiat Biol 1992,62(2):249-62. 10.1080\/09553009214552071","journal-title":"Int J Radiat Biol"},{"issue":"7","key":"263_CR36","doi-asserted-by":"publisher","first-page":"529","DOI":"10.1016\/j.clon.2006.04.007","volume":"18","author":"P Mavroidis","year":"2006","unstructured":"Mavroidis P, Ferreira BC, Papanikolaou N, Svensson R, Kappas C, Lind BK, Brahme A: Assessing the difference between planned and delivered intensity-modulated radiotherapy dose distributions based on radiobiological measures. Clin Oncol (R Coll Radiol) 2006,18(7):529-38.","journal-title":"Clin Oncol (R Coll Radiol)"},{"issue":"4","key":"263_CR37","doi-asserted-by":"publisher","first-page":"976","DOI":"10.1016\/j.ijrobp.2006.10.028","volume":"67","author":"TF Fua","year":"2007","unstructured":"Fua TF, Corry J, Milner AD, Cramb J, Walsham SF, Peters LJ: Intensity-modulated radiotherapy for nasopharyngeal carcinoma: clinical correlation of dose to the pharyngo-esophageal axis and dysphagia. Int J Radiat Oncol Biol Phys 2007,67(4):976-81.","journal-title":"Int J Radiat Oncol Biol Phys"},{"issue":"2","key":"263_CR38","doi-asserted-by":"publisher","first-page":"468","DOI":"10.1016\/j.ijrobp.2009.05.018","volume":"77","author":"Diaz Roberto","year":"2010","unstructured":"Roberto Diaz, Jaboin JerryJ, Manuel Morales-Paliza, Koehler E, Phillips JG, Stinson S, Gilbert J, Chung CH, Murphy BA, Yarbrough WG, Murphy PB, Shyr Y, Cmelak AJ: Hypothyroidism as a Consequence of Intensity-Modulated Radiotherapy With Concurrent Taxane-Based Chemotherapy for Locally Advanced Head-and-Neck Cancer. Int J Radiat Oncol Biol Phys 2010,77(2):468-76.","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"263_CR39","doi-asserted-by":"publisher","first-page":"109","DOI":"10.1016\/0360-3016(91)90171-Y","volume":"21","author":"B Emami","year":"1991","unstructured":"Emami B, Lyman J, Brown A, Coia L, Goitein M, Munzenrider JE, Shank B, Solin LJ, Wesson M: Tolerance of normal tissue to therapeutic irradiation. Int J Radiat Oncol Biol Phys 1991, 21: 109-22.","journal-title":"Int J Radiat Oncol Biol Phys"},{"issue":"3 Suppl","key":"263_CR40","doi-asserted-by":"publisher","first-page":"S58","DOI":"10.1016\/j.ijrobp.2009.06.090","volume":"76","author":"JO Deasy","year":"2010","unstructured":"Deasy JO, Moiseenko V, Marks L, Chao KS, Nam J, Eisbruch A: Radiotherapy dose-volume effects on salivary gland function. Int J Radiat Oncol Biol Phys 2010,76(3 Suppl):S58-63.","journal-title":"Int J Radiat Oncol Biol Phys"},{"issue":"3","key":"263_CR41","doi-asserted-by":"publisher","first-page":"204","DOI":"10.1016\/j.clon.2008.11.017","volume":"21","author":"S Jefferies","year":"2009","unstructured":"Jefferies S, Taylor A, Reznek R: Radiotherapy Planning Working Party. 2009. Results of a national survey of radiotherapy planning and delivery in the UK in 2007. Clin Oncol (R Coll Radiol) 2009,21(3):204-17.","journal-title":"Clin Oncol (R Coll Radiol)"}],"container-title":["Radiation Oncology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/1748-717X-5-57.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1186\/1748-717X-5-57\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/1748-717X-5-57.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,1,23]],"date-time":"2019-01-23T04:43:48Z","timestamp":1548218628000},"score":1,"resource":{"primary":{"URL":"https:\/\/ro-journal.biomedcentral.com\/articles\/10.1186\/1748-717X-5-57"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,6,22]]},"references-count":41,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2010,12]]}},"alternative-id":["263"],"URL":"https:\/\/doi.org\/10.1186\/1748-717x-5-57","relation":{},"ISSN":["1748-717X"],"issn-type":[{"value":"1748-717X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2010,6,22]]},"article-number":"57"}}