{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,18]],"date-time":"2026-04-18T14:09:28Z","timestamp":1776521368480,"version":"3.51.2"},"reference-count":45,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2012,5,16]],"date-time":"2012-05-16T00:00:00Z","timestamp":1337126400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/2.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["BMC Res Notes"],"published-print":{"date-parts":[[2012,12]]},"DOI":"10.1186\/1756-0500-5-244","type":"journal-article","created":{"date-parts":[[2012,5,16]],"date-time":"2012-05-16T20:04:32Z","timestamp":1337198672000},"source":"Crossref","is-referenced-by-count":51,"title":["Confocal laser scanning microscopy analysis of S. epidermidis biofilms exposed to farnesol, vancomycin and rifampicin"],"prefix":"10.1186","volume":"5","author":[{"given":"Nuno","family":"Cerca","sequence":"first","affiliation":[]},{"given":"Fernanda","family":"Gomes","sequence":"additional","affiliation":[]},{"given":"Sofia","family":"Pereira","sequence":"additional","affiliation":[]},{"given":"Pilar","family":"Teixeira","sequence":"additional","affiliation":[]},{"given":"Ros\u00e1rio","family":"Oliveira","sequence":"additional","affiliation":[]}],"member":"297","published-online":{"date-parts":[[2012,5,16]]},"reference":[{"key":"1707_CR1","doi-asserted-by":"publisher","first-page":"S14","DOI":"10.1016\/j.ijantimicag.2006.05.012","volume":"28 Suppl 1","author":"W Ziebuhr","year":"2006","unstructured":"Ziebuhr W, Hennig S, Eckart M, Kranzler H, Batzilla C, Kozitskaya S: Nosocomial infections by Staphylococcus epidermidis: how a commensal bacterium turns into a pathogen. Int J Antimicrob Agents. 2006, 28 Suppl 1: S14-S20.","journal-title":"Int J Antimicrob Agents"},{"key":"1707_CR2","doi-asserted-by":"publisher","first-page":"481","DOI":"10.1016\/S1286-4579(02)01563-0","volume":"4","author":"C Vuong","year":"2002","unstructured":"Vuong C, Otto M:Staphylococcus epidermidis infections. Microbes Infect. 2002, 4: 481-489. 10.1016\/S1286-4579(02)01563-0.","journal-title":"Microbes Infect"},{"key":"1707_CR3","doi-asserted-by":"publisher","first-page":"1367","DOI":"10.1046\/j.1365-2958.2002.02827.x","volume":"43","author":"F Gotz","year":"2002","unstructured":"Gotz F: Staphylococcus and biofilms. Mol Microbiol. 2002, 43: 1367-1378. 10.1046\/j.1365-2958.2002.02827.x.","journal-title":"Mol Microbiol"},{"key":"1707_CR4","doi-asserted-by":"publisher","first-page":"711","DOI":"10.1146\/annurev.mi.49.100195.003431","volume":"49","author":"J Costerton","year":"1995","unstructured":"Costerton J, Lewandowski Z, Caldwell DE, Korber D, Lappin-Scott H: Microbial biofilms. Annu Rev Microbiol. 1995, 49: 711-745. 10.1146\/annurev.mi.49.100195.003431.","journal-title":"Annu Rev Microbiol"},{"key":"1707_CR5","doi-asserted-by":"publisher","first-page":"207","DOI":"10.1007\/978-3-540-75418-3_10","volume":"322","author":"M Otto","year":"2008","unstructured":"Otto M: Staphylococcal biofilms. Curr Top Microbiol Immunol. 2008, 322: 207-228. 10.1007\/978-3-540-75418-3_10.","journal-title":"Curr Top Microbiol Immunol"},{"key":"1707_CR6","doi-asserted-by":"publisher","first-page":"555","DOI":"10.1038\/nrmicro2182","volume":"7","author":"M Otto","year":"2009","unstructured":"Otto M: Staphylococcus epidermidis\u2013the 'accidental' pathogen. Nat Rev Microbiol. 2009, 7: 555-567. 10.1038\/nrmicro2182.","journal-title":"Nat Rev Microbiol"},{"key":"1707_CR7","doi-asserted-by":"publisher","first-page":"1495","DOI":"10.1016\/S0142-9612(01)00275-7","volume":"23","author":"C Arciola","year":"2002","unstructured":"Arciola C, Campoccia D, Montanaro L: Effects on antibiotic resistance of Staphylococcus epidermidis following adhesion to polymethylmethacrylate and to silicone surfaces. Biomaterials. 2002, 23: 1495-1502. 10.1016\/S0142-9612(01)00275-7.","journal-title":"Biomaterials"},{"key":"1707_CR8","doi-asserted-by":"publisher","first-page":"1186","DOI":"10.1111\/j.1462-2920.2005.00797.x","volume":"7","author":"B Szomolay","year":"2005","unstructured":"Szomolay B, Klapper I, Dockery J, Stewart PS: Adaptive responses to antimicrobial agents in biofilms. Environ Microbiol. 2005, 7: 1186-1191. 10.1111\/j.1462-2920.2005.00797.x.","journal-title":"Environ Microbiol"},{"key":"1707_CR9","doi-asserted-by":"publisher","first-page":"331","DOI":"10.1093\/jac\/dki217","volume":"56","author":"N Cerca","year":"2005","unstructured":"Cerca N, Martins S, Cerca F, Jefferson KK, Pier GB, Oliveira R, Azeredo J: Comparative assessment of antibiotic susceptibility of coagulase-negative staphylococci in biofilm versus planktonic culture as assessed by bacterial enumeration or rapid XTT colorimetry. J Antimicrob Chemother. 2005, 56: 331-336. 10.1093\/jac\/dki217.","journal-title":"J Antimicrob Chemother"},{"key":"1707_CR10","doi-asserted-by":"publisher","first-page":"147","DOI":"10.1016\/S0924-8579(01)00357-0","volume":"18","author":"A Fluit","year":"2001","unstructured":"Fluit A, Schmitz F, Verhoef J: Multi-resistance to antimicrobial agents for the ten most frequently isolated bacterial pathogens. Int J Antimicrob Agents. 2001, 18: 147-160. 10.1016\/S0924-8579(01)00357-0.","journal-title":"Int J Antimicrob Agents"},{"key":"1707_CR11","doi-asserted-by":"publisher","first-page":"54881","DOI":"10.1074\/jbc.M411374200","volume":"279","author":"C Vuong","year":"2004","unstructured":"Vuong C, Kocianova S, Voyich JM, Yao Y, Fischer ER, DeLeo FR, Otto M: A crucial role for exopolysaccharide modification in bacterial biofilm formation, immune evasion, and virulence. J Biol Chem. 2004, 279: 54881-54886. 10.1074\/jbc.M411374200.","journal-title":"J Biol Chem"},{"key":"1707_CR12","doi-asserted-by":"publisher","first-page":"4849","DOI":"10.1128\/IAI.00230-06","volume":"74","author":"N Cerca","year":"2006","unstructured":"Cerca N, Jefferson K, Oliveira R, Pier GB, Azeredo J: Comparative antibody-mediated phagocytosis of Staphylococcus epidermidis cells grown in a biofilm or in the planktonic state. Infect Immun. 2006, 74: 4849-4855. 10.1128\/IAI.00230-06.","journal-title":"Infect Immun"},{"key":"1707_CR13","doi-asserted-by":"publisher","first-page":"135","DOI":"10.1093\/jac\/30.2.135","volume":"30","author":"B Jansen","year":"1992","unstructured":"Jansen B, Kristinsson K, Jansen S, Peters G, Pulverer G: In-vitro efficacy of a central venous catheter complexed with iodine to prevent bacterial colonization. J Antimicrob Chemother. 1992, 30: 135-139. 10.1093\/jac\/30.2.135.","journal-title":"J Antimicrob Chemother"},{"key":"1707_CR14","doi-asserted-by":"publisher","first-page":"2982","DOI":"10.1128\/AEM.67.7.2982-2992.2001","volume":"67","author":"J Hornby","year":"2001","unstructured":"Hornby J, Jensen E, Lisec A, Tasto J, Jahnke B, Shoemaker R, Dussault P, Nickerson K: Quorum sensing in the dimorphic fungus Candida albicans is mediated by farnesol. Appl Environ Microbiol. 2001, 67: 2982-2992. 10.1128\/AEM.67.7.2982-2992.2001.","journal-title":"Appl Environ Microbiol"},{"key":"1707_CR15","doi-asserted-by":"publisher","first-page":"1859","DOI":"10.1128\/AAC.01646-07","volume":"52","author":"K Weber","year":"2008","unstructured":"Weber K, Sohr R, Schulz B, Fleischhacker M, Ruhnke M: Secretion of E, E-farnesol and biofilm formation in eight different Candida species. Antimicrob Agents Chemother. 2008, 52: 1859-1861. 10.1128\/AAC.01646-07.","journal-title":"Antimicrob Agents Chemother"},{"key":"1707_CR16","doi-asserted-by":"publisher","first-page":"3357","DOI":"10.1128\/AAC.47.10.3357-3360.2003","volume":"47","author":"BF Brehm-Stecher","year":"2003","unstructured":"Brehm-Stecher BF, Johnson EA: Sensitization of Staphylococcus aureus and Escherichia coli to antibiotics by the sesquiterpenoids nerolidol, farnesol, bisabolol, and apritone. Antimicrob Agents Chemother. 2003, 47: 3357-3360. 10.1128\/AAC.47.10.3357-3360.2003.","journal-title":"Antimicrob Agents Chemother"},{"key":"1707_CR17","first-page":"325","volume":"237","author":"Y Inoue","year":"2004","unstructured":"Inoue Y, Shiraishi A, Hada T, Hirose K, Hamashima H, Shimada J: The antibacterial effects of terpene alcohols on Staphylococcus aureus and their mode of action. FEMS Microbiol Lett. 2004, 237: 325-331.","journal-title":"FEMS Microbiol Lett"},{"key":"1707_CR18","doi-asserted-by":"publisher","first-page":"1463","DOI":"10.1128\/AAC.50.4.1463-1469.2006","volume":"50","author":"MA Jabra-Rizk","year":"2006","unstructured":"Jabra-Rizk MA, Meiller TF, James CE, Shirtliff ME: Effect of farnesol on Staphylococcus aureus biofilm formation and antimicrobial susceptibility. Antimicrob Agents Chemother. 2006, 50: 1463-1469. 10.1128\/AAC.50.4.1463-1469.2006.","journal-title":"Antimicrob Agents Chemother"},{"key":"1707_CR19","doi-asserted-by":"publisher","first-page":"118","DOI":"10.1007\/s00284-009-9408-9","volume":"59","author":"FIA Gomes","year":"2009","unstructured":"Gomes FIA, Teixeira P, Azeredo J, Oliveira R: Effect of Farnesol on Planktonic and Biofilm Cells of Staphylococcus epidermidis. Curr Microbiol. 2009, 59: 118-122. 10.1007\/s00284-009-9408-9.","journal-title":"Curr Microbiol"},{"key":"1707_CR20","doi-asserted-by":"publisher","first-page":"191","DOI":"10.1097\/MAJ.0b013e3181fcf138","volume":"341","author":"FIA Gomes","year":"2011","unstructured":"Gomes FIA, Leite B, Teixeira P, Cerca N, Azeredo J, Oliveira R: Farnesol as antibiotics adjuvant in Staphylococcus epidermidis control in vitro. Am J Med Sci. 2011, 341: 191-195. 10.1097\/MAJ.0b013e3181fcf138.","journal-title":"Am J Med Sci"},{"key":"1707_CR21","doi-asserted-by":"publisher","first-page":"578","DOI":"10.1203\/PDR.0b013e318232a984","volume":"70","author":"M Pammi","year":"2011","unstructured":"Pammi M, Liang R, Hicks J, Barrish J, Versalovic J: Farnesol decreases biofilms of Staphylococcus epidermidis and exhibits synergy with nafcillin and vancomycin. Pediatr Res. 2011, 70: 578-583.","journal-title":"Pediatr Res"},{"key":"1707_CR22","doi-asserted-by":"publisher","first-page":"354","DOI":"10.1007\/s00284-011-9984-3","volume":"63","author":"FIA Gomes","year":"2011","unstructured":"Gomes FIA, Teixeira P, Cerca N, Azeredo J, Oliveira R: Effect of farnesol on structure and composition of Staphylococcus epidermidis biofilm matrix. Curr Microbiol. 2011, 63: 354-359. 10.1007\/s00284-011-9984-3.","journal-title":"Curr Microbiol"},{"key":"1707_CR23","doi-asserted-by":"publisher","first-page":"506","DOI":"10.1016\/j.resmic.2005.01.007","volume":"156","author":"N Cerca","year":"2005","unstructured":"Cerca N, Pier GB, Vilanova M, Oliveira R, Azeredo J: Quantitative analysis of adhesion and biofilm formation on hydrophilic and hydrophobic surfaces of clinical isolates of Staphylococcus epidermidis. Res Microbiol. 2005, 156: 506-514. 10.1016\/j.resmic.2005.01.007.","journal-title":"Res Microbiol"},{"key":"1707_CR24","doi-asserted-by":"crossref","first-page":"2048","DOI":"10.1128\/IAI.60.5.2048-2057.1992","volume":"60","author":"D Mack","year":"1992","unstructured":"Mack D, Siemssen N, Laufs R: Parallel induction by glucose of adherence and a polysaccharide antigen specific for plastic-adherent Staphylococcus epidermidis: evidence for functional relation to intercellular adhesion. Infect Immun. 1992, 60: 2048-2057.","journal-title":"Infect Immun"},{"key":"1707_CR25","doi-asserted-by":"publisher","first-page":"420","DOI":"10.1111\/j.1472-765X.2004.01601.x","volume":"39","author":"N Cerca","year":"2004","unstructured":"Cerca N, Pier GB, Vilanova M, Oliveira R, Azeredo J: Influence of batch or fed-batch growth on Staphylococcus epidermidis biofilm formation. Lett Appl Microbiol. 2004, 39: 420-424. 10.1111\/j.1472-765X.2004.01601.x.","journal-title":"Lett Appl Microbiol"},{"issue":"12","key":"1707_CR26","doi-asserted-by":"publisher","first-page":"8677","DOI":"10.1128\/AEM.71.12.8677-8682.2005","volume":"71","author":"N Cerca","year":"2005","unstructured":"Cerca N, Martins S, Sillankorva S, Jefferson KK, Pier GB, Oliveira R, Azeredo J: Effects of growth in the presence of subinhibitory concentrations of dicloxacillin on Staphylococcus epidermidis and Staphylococcus haemolyticus biofilms. Appl Environ Microbiol. 2005, 71 (12): 8677-8682. 10.1128\/AEM.71.12.8677-8682.2005.","journal-title":"Appl Environ Microbiol"},{"key":"1707_CR27","volume-title":"Braz J Microbiol","author":"F Gomes","year":"2012","unstructured":"Gomes F, Leite B, Teixeira P, Azeredo J, Oliveira R: Effect of farnesol in combination with N-acetylcysteine against Staphylococcus epidermidis planktonic and biofilm cells. Braz J Microbiol. 2012, in press"},{"key":"1707_CR28","doi-asserted-by":"publisher","first-page":"e28830","DOI":"10.1371\/journal.pone.0028830","volume":"6","author":"J Zhu","year":"2011","unstructured":"Zhu J, Krom BP, Sanglard D, Intapa C, Dawson CC, Peters BM, Shirliff ME, Jabra-Rizk MA: Farnesol-Induced Apoptosis in Candida albicans Is Mediated by Cdr1-p Extrusion and Depletion of Intracellular Glutathione. PLoS One. 2011, 6: e28830-10.1371\/journal.pone.0028830.","journal-title":"PLoS One"},{"key":"1707_CR29","doi-asserted-by":"publisher","first-page":"e14786","DOI":"10.1371\/journal.pone.0014786","volume":"6","author":"C Almeida","year":"2011","unstructured":"Almeida C, Azevedo NF, Santos S, Keevil CW, Vieira MJ: Discriminating multi-species populations in biofilms with peptide nucleic acid fluorescence in situ hybridization (PNA FISH). PLoS One. 2011, 6: e14786-10.1371\/journal.pone.0014786.","journal-title":"PLoS One"},{"key":"1707_CR30","doi-asserted-by":"publisher","first-page":"447","DOI":"10.1186\/1756-0500-4-447","volume":"4","author":"Q Ma","year":"2011","unstructured":"Ma Q, Zhang G, Wood TK: Escherichia coli BdcA controls biofilm dispersal in Pseudomonas aeruginosa and Rhizobium meliloti. BMC Res Notes. 2011, 4: 447-10.1186\/1756-0500-4-447.","journal-title":"BMC Res Notes"},{"key":"1707_CR31","doi-asserted-by":"publisher","first-page":"180","DOI":"10.1186\/1756-0500-4-180","volume":"4","author":"AM Bodor","year":"2011","unstructured":"Bodor AM, Jansch L, Wissing J, Wagner-Dobler I: The luxS mutation causes loosely-bound biofilms in Shewanella oneidensis. BMC Res Notes. 2011, 4: 180-10.1186\/1756-0500-4-180.","journal-title":"BMC Res Notes"},{"key":"1707_CR32","doi-asserted-by":"publisher","first-page":"145","DOI":"10.1016\/S0076-6879(99)10012-0","volume":"310","author":"TR Neu","year":"1999","unstructured":"Neu TR, Lawrence JR: Lectin-binding analysis in biofilm systems. Methods Enzymol. 1999, 310: 145-152.","journal-title":"Methods Enzymol"},{"key":"1707_CR33","doi-asserted-by":"publisher","first-page":"136","DOI":"10.1093\/jac\/dkn464","volume":"63","author":"K Flemming","year":"2009","unstructured":"Flemming K, Klingenberg C, Cavanagh JP, Sletteng M, Stensen W, Svendsen JS, Flaegstad T: High in vitro antimicrobial activity of synthetic antimicrobial peptidomimetics against staphylococcal biofilms. J Antimicrob Chemother. 2009, 63: 136-45.","journal-title":"J Antimicrob Chemother"},{"key":"1707_CR34","doi-asserted-by":"publisher","first-page":"673","DOI":"10.1111\/j.1348-0421.2011.00368.x","volume":"55","author":"F Cerca","year":"2011","unstructured":"Cerca F, Franca A, Guimaraes R, Hinzmann M, Cerca N, Lobo dC, Azeredo J: Vilanova M. Modulation of poly-N-acetylglucosamine accumulation within mature Staphylococcus epidermidis biofilms grown in excess glucose. Microbiol Immunol. 2011, 55: 673-682. 10.1111\/j.1348-0421.2011.00368.x.","journal-title":"Microbiol Immunol"},{"key":"1707_CR35","doi-asserted-by":"publisher","first-page":"5543","DOI":"10.1128\/AEM.69.9.5543-5554.2003","volume":"69","author":"JR Lawrence","year":"2003","unstructured":"Lawrence JR, Swerhone GD, Leppard GG, Araki T, Zhang X, West MM, Hitchcock AP: Scanning transmission X-ray, laser scanning, and transmission electron microscopy mapping of the exopolymeric matrix of microbial biofilms. Appl Environ Microbiol. 2003, 69: 5543-5554. 10.1128\/AEM.69.9.5543-5554.2003.","journal-title":"Appl Environ Microbiol"},{"key":"1707_CR36","doi-asserted-by":"publisher","first-page":"950","DOI":"10.1099\/jmm.0.026013-0","volume":"60","author":"JA Shapiro","year":"2011","unstructured":"Shapiro JA, Nguyen VL, Chamberlain NR: Evidence for persisters in Staphylococcus epidermidis RP62a planktonic cultures and biofilms. J Med Microbiol. 2011, 60: 950-960. 10.1099\/jmm.0.026013-0.","journal-title":"J Med Microbiol"},{"key":"1707_CR37","doi-asserted-by":"publisher","first-page":"2827","DOI":"10.1099\/mic.0.2007\/015768-0","volume":"154","author":"V Pintens","year":"2008","unstructured":"Pintens V, Massonet C, Merckx R, Vandecasteele S, Peetermans WE, Knobloch JK, Van Eldere J: The role of sigmaB in persistence of Staphylococcus epidermidis foreign body infection. Microbiology. 2008, 154: 2827-2836. 10.1099\/mic.0.2007\/015768-0.","journal-title":"Microbiology"},{"key":"1707_CR38","doi-asserted-by":"publisher","first-page":"950","DOI":"10.1099\/jmm.0.026013-0","volume":"60","author":"JA Shapiro","year":"2011","unstructured":"Shapiro JA, Nguyen VL, Chamberlain NR: Evidence for persisters in Staphylococcus epidermidis RP62a planktonic cultures and biofilms. J Med Microbiol. 2011, 60: 950-960. 10.1099\/jmm.0.026013-0.","journal-title":"J Med Microbiol"},{"key":"1707_CR39","doi-asserted-by":"publisher","first-page":"850","DOI":"10.1139\/w11-078","volume":"57","author":"F Cerca","year":"2011","unstructured":"Cerca F, Trigo G, Correia A, Cerca N, Azeredo J, Vilanova M: SYBR green as a fluorescent probe to evaluate the biofilm physiological state of Staphylococcus epidermidis, using flow cytometry. Can J Microbiol. 2011, 57: 850-856. 10.1139\/w11-078.","journal-title":"Can J Microbiol"},{"key":"1707_CR40","doi-asserted-by":"publisher","first-page":"1717","DOI":"10.1099\/jmm.0.031922-0","volume":"60","author":"F Cerca","year":"2011","unstructured":"Cerca F, Andrade F, Franca A, Andrade EB, Ribeiro A, Almeida AA, Cerca N, Pier G, Azeredo J, Vilanova M: Staphylococcus epidermidis biofilms with higher proportions of dormant bacteria induce a lower activation of murine macrophages. J Med Microbiol. 2011, 60: 1717-1724. 10.1099\/jmm.0.031922-0.","journal-title":"J Med Microbiol"},{"key":"1707_CR41","doi-asserted-by":"publisher","first-page":"238","DOI":"10.1172\/JCI42520","volume":"121","author":"R Wang","year":"2011","unstructured":"Wang R, Khan BA, Cheung GY, Bach TH, Jameson-Lee M, Kong KF, Queck SY, Otto M: Staphylococcus epidermidis surfactant peptides promote biofilm maturation and dissemination of biofilm-associated infection in mice. J Clin Invest. 2011, 121: 238-248. 10.1172\/JCI42520.","journal-title":"J Clin Invest"},{"key":"1707_CR42","doi-asserted-by":"publisher","first-page":"547","DOI":"10.1038\/ja.2011.49","volume":"64","author":"M Kaneko","year":"2011","unstructured":"Kaneko M, Togashi N, Hamashima H, Hirohara M, Inoue Y: Effect of farnesol on mevalonate pathway of Staphylococcus aureus. J Antibiot. 2011, 64: 547-549. 10.1038\/ja.2011.49.","journal-title":"J Antibiot"},{"key":"1707_CR43","doi-asserted-by":"publisher","first-page":"6530","DOI":"10.1128\/JB.00482-08","volume":"190","author":"N Cerca","year":"2008","unstructured":"Cerca N, Brooks JL, Jefferson KK: Regulation of the intercellular adhesin locus regulator (icaR) by SarA, sigmaB, and IcaR in Staphylococcus aureus. J Bacteriol. 2008, 190: 6530-6533. 10.1128\/JB.00482-08.","journal-title":"J Bacteriol"},{"key":"1707_CR44","doi-asserted-by":"publisher","first-page":"3406","DOI":"10.1128\/IAI.00078-07","volume":"75","author":"N Cerca","year":"2007","unstructured":"Cerca N, Jefferson K, Pier D, Kelly-Quintos C, Maira-Litr\u00e1n T, Goldmann D, Azeredo J, Pier G: Molecular basis for preferential protective efficacy of antibodies directed to the poorly-acetylated form of staphylococcal poly-N-acetyl-(1\u20136)-glucosamine (PNAG). Infect Immun. 2007, 75: 3406-3413. 10.1128\/IAI.00078-07.","journal-title":"Infect Immun"},{"key":"1707_CR45","doi-asserted-by":"publisher","first-page":"1485","DOI":"10.1128\/JB.185.5.1485-1491.2003","volume":"185","author":"PS Stewart","year":"2003","unstructured":"Stewart PS: Diffusion in biofilms. J Bacteriol. 2003, 185: 1485-1491. 10.1128\/JB.185.5.1485-1491.2003.","journal-title":"J Bacteriol"}],"container-title":["BMC Research Notes"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/1756-0500-5-244.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1186\/1756-0500-5-244\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/1756-0500-5-244.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,7,7]],"date-time":"2020-07-07T19:39:20Z","timestamp":1594150760000},"score":1,"resource":{"primary":{"URL":"https:\/\/bmcresnotes.biomedcentral.com\/articles\/10.1186\/1756-0500-5-244"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,5,16]]},"references-count":45,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2012,12]]}},"alternative-id":["1707"],"URL":"https:\/\/doi.org\/10.1186\/1756-0500-5-244","relation":{},"ISSN":["1756-0500"],"issn-type":[{"value":"1756-0500","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,5,16]]},"article-number":"244"}}