{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,25]],"date-time":"2026-01-25T15:59:50Z","timestamp":1769356790990,"version":"3.49.0"},"reference-count":26,"publisher":"Springer Science and Business Media LLC","issue":"1","content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Parasites Vectors"],"published-print":{"date-parts":[[2012,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n          <jats:sec>\n            <jats:title>Background<\/jats:title>\n            <jats:p>Canine leishmaniosis (CanL) caused by <jats:italic>Leishmania infantum<\/jats:italic> is an endemic zoonosis in southern European countries. Infected dogs can present rare or atypical forms of the disease and diagnosis can be challenging. The present report describes a case of tongue nodules in a 3-year-old neutered female Labrador Retriever dog with leishmaniosis.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Findings<\/jats:title>\n            <jats:p>A fine needle aspiration of the lingual nodules revealed amastigote forms of <jats:italic>Leishmania<\/jats:italic> inside macrophages. Differential diagnosis ruled out neoplasia, <jats:italic>calcinosis circumscripta<\/jats:italic>, solar glossitis, vasculitis, amyloidosis, eosinophilic granulomas, chemical and electrical burns, uremic glossitis and autoimmune diseases. Combined therapy with antimoniate meglumine and allopurinol for 30\u2009days resulted in the normalization of hematological and biochemical parameters. Two months after diagnosis and the beginning of treatment, a mild inflammatory infiltrate was observed by histopathology, but an anti-<jats:italic>Leishmania<\/jats:italic> immunofluorescence antibody test (IFAT) was negative as well as a PCR on both tongue lesions and a bone marrow aspirate. Seven months after diagnosis, the dog\u2019s general condition appeared good, there were no tongue lesions and a new IFAT was negative. Fifteen months after diagnosis this clinically favourable outcome continued.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusions<\/jats:title>\n            <jats:p>The dog could have suffered a relapsing episode of CanL, but a new systemic or local infection cannot be excluded. Regular clinical re-evaluation should be maintained, as a future relapse can potentially occur. In conclusion, CanL should be considered in the differential diagnosis of nodular glossitis in dogs.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1186\/1756-3305-5-120","type":"journal-article","created":{"date-parts":[[2012,6,27]],"date-time":"2012-06-27T13:16:13Z","timestamp":1340802973000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Tongue nodules in canine leishmaniosis \u2014 a case report"],"prefix":"10.1186","volume":"5","author":[{"given":"Carlos","family":"Viegas","sequence":"first","affiliation":[]},{"given":"Jo\u00e3o","family":"Requicha","sequence":"additional","affiliation":[]},{"given":"Carlos","family":"Albuquerque","sequence":"additional","affiliation":[]},{"given":"Teresa","family":"Sargo","sequence":"additional","affiliation":[]},{"given":"Jo\u00e3o","family":"Machado","sequence":"additional","affiliation":[]},{"given":"Isabel","family":"Dias","sequence":"additional","affiliation":[]},{"given":"Maria A","family":"Pires","sequence":"additional","affiliation":[]},{"given":"Lenea","family":"Campino","sequence":"additional","affiliation":[]},{"given":"Lu\u00eds","family":"Cardoso","sequence":"additional","affiliation":[]}],"member":"297","published-online":{"date-parts":[[2012,6,15]]},"reference":[{"key":"581_CR1","doi-asserted-by":"publisher","first-page":"324","DOI":"10.1016\/j.pt.2008.04.001","volume":"24","author":"G Baneth","year":"2008","unstructured":"Baneth G, Koutinas AF, Solano-Gallego L, Bourdeau P, Ferrer L: Canine leishmaniosis - new concepts and insights on an expanding zoonosis: part one. 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