{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,1,5]],"date-time":"2023-01-05T23:16:56Z","timestamp":1672960616492},"reference-count":7,"publisher":"Springer Science and Business Media LLC","issue":"1","content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Hematol Oncol"],"published-print":{"date-parts":[[2012,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n          <jats:p>Autologous stem cell transplantation (ASCT) is the gold standard therapy for suitable multiple myeloma (MM) patients after induction with high dose therapy. To date, the evidence of a reliable marker of prognosis in these cases remains scarce. Our aim was to evaluate appearance of unrelated atypical serum immunofixation patterns (ASIPs) as a marker of prognosis in MM patients submitted to ASCT. We retrospectively analysed data from 65 patients. Interestingly, we observed that presence of ASIPs was associated with longer progression-free survival and longer overall survival. Our results suggested that presence of ASIPs could be a novel marker of good prognosis in MM patients submitted to ASCT.<\/jats:p>","DOI":"10.1186\/1756-8722-5-33","type":"journal-article","created":{"date-parts":[[2012,6,27]],"date-time":"2012-06-27T12:34:17Z","timestamp":1340800457000},"update-policy":"http:\/\/dx.doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Prognostic value of unrelated atypical serum immunofixation patterns during Multiple Myeloma therapy"],"prefix":"10.1186","volume":"5","author":[{"given":"Cristina","family":"Guimar\u00e3es","sequence":"first","affiliation":[]},{"given":"Rui","family":"Bergantim","sequence":"additional","affiliation":[]},{"given":"Renata","family":"Ramalho","sequence":"additional","affiliation":[]},{"given":"Nuno","family":"Couto","sequence":"additional","affiliation":[]},{"given":"Jo\u00e3o T","family":"Guimar\u00e3es","sequence":"additional","affiliation":[]},{"given":"Fernanda","family":"Trigo","sequence":"additional","affiliation":[]}],"member":"297","published-online":{"date-parts":[[2012,6,26]]},"reference":[{"key":"238_CR1","doi-asserted-by":"publisher","first-page":"439","DOI":"10.1016\/j.ccr.2004.10.020","volume":"6","author":"CS Mitsiades","year":"2004","unstructured":"Mitsiades CS, Mitsiades N, Munshi NC, Anderson KC: Focus on multiple myeloma. 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Bone Marrow Transplant. 2000, 25: 723-728. 10.1038\/sj.bmt.1702194.","journal-title":"Bone Marrow Transplant"},{"key":"238_CR4","doi-asserted-by":"crossref","first-page":"3518","DOI":"10.1182\/blood.V91.9.3518","volume":"91","author":"CS Zent","year":"1998","unstructured":"Zent CS, Wilson CS, Tricot G, Jagannath S, Siegel D, Desikan KR, Munshi N, Bracy D, Barlogie B, Butch AW: Oligoclonal protein bands and Ig isotype switching in multiple myeloma treated with high-dose therapy and hematopoietic cell transplantation. 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Br J Haematol. 2008, 143: 654-660. 10.1111\/j.1365-2141.2008.07374.x.","journal-title":"Br J Haematol"},{"key":"238_CR6","doi-asserted-by":"publisher","first-page":"727","DOI":"10.1515\/CCLM.2010.050","volume":"48","author":"ME Alejandre","year":"2010","unstructured":"Alejandre ME, Madalena LB, Pavlovsky MA, Facio ML, Corrado C, Milone G, Bresciani PD, Fraind SA, Pavlovsky S, Pizzolato MA: Oligoclonal bands and immunoglobulin isotype switch during monitoring of patients with multiple myeloma and autologous hematopoietic cell transplantation: a 16-year experience. Clin Chem Lab Med. 2010, 48: 727-731.","journal-title":"Clin Chem Lab Med"},{"key":"238_CR7","doi-asserted-by":"publisher","first-page":"2985","DOI":"10.1182\/blood-2011-04-349175","volume":"118","author":"RK Wadhera","year":"2011","unstructured":"Wadhera RK, Kyle RA, Larson DR, Dispenzieri A, Kumar S, Lazarus HM, Rajkumar SV: Incidence, clinical course, and prognosis of secondary monoclonal gammopathy of undetermined significance in patients with multiple myeloma. Blood. 2011, 118: 2985-2987. 10.1182\/blood-2011-04-349175.","journal-title":"Blood"}],"container-title":["Journal of Hematology &amp; Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/1756-8722-5-33.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,9,1]],"date-time":"2021-09-01T14:08:03Z","timestamp":1630505283000},"score":1,"resource":{"primary":{"URL":"https:\/\/jhoonline.biomedcentral.com\/articles\/10.1186\/1756-8722-5-33"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,6,26]]},"references-count":7,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2012,12]]}},"alternative-id":["238"],"URL":"https:\/\/doi.org\/10.1186\/1756-8722-5-33","relation":{},"ISSN":["1756-8722"],"issn-type":[{"value":"1756-8722","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,6,26]]},"assertion":[{"value":"30 March 2012","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"23 April 2012","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"26 June 2012","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}}],"article-number":"33"}}